MX2017012231A - Secuencias de oligonucleotidos dirigidos al factor de transcripcion tsc22d4 para el tratamiento de la resistencia a la insulina. - Google Patents

Secuencias de oligonucleotidos dirigidos al factor de transcripcion tsc22d4 para el tratamiento de la resistencia a la insulina.

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Publication number
MX2017012231A
MX2017012231A MX2017012231A MX2017012231A MX2017012231A MX 2017012231 A MX2017012231 A MX 2017012231A MX 2017012231 A MX2017012231 A MX 2017012231A MX 2017012231 A MX2017012231 A MX 2017012231A MX 2017012231 A MX2017012231 A MX 2017012231A
Authority
MX
Mexico
Prior art keywords
treatment
tsc22d4
insulin resistance
transcription factor
oligonucleotide sequences
Prior art date
Application number
MX2017012231A
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English (en)
Inventor
BERRIEL DIAZ Mauricio
Herzig Stephan
Schafmeier Tobias
Original Assignee
Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts
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Publication date
Application filed by Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts filed Critical Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts
Publication of MX2017012231A publication Critical patent/MX2017012231A/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
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  • Endocrinology (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se refiere a inhibidores de oligonucleótidos de la actividad o expresión TSC22D4 y sus usos para la prevención, tratamiento y/o regulación de la resistencia a la insulina, síndrome metabólico y/o diabetes y/o para mejorar la sensibilidad a la insulina en un mamífero.
MX2017012231A 2015-03-23 2016-02-12 Secuencias de oligonucleotidos dirigidos al factor de transcripcion tsc22d4 para el tratamiento de la resistencia a la insulina. MX2017012231A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15160259.6A EP3072969A1 (en) 2015-03-23 2015-03-23 Oligonucleotide sequences targeting transcription factor TSC22D4 for the treatment of insulin resistance
PCT/EP2016/053050 WO2016150618A1 (en) 2015-03-23 2016-02-12 Oligonucleotide sequences targeting transcription factor tsc22d4 for the treatment of insulin resistance

Publications (1)

Publication Number Publication Date
MX2017012231A true MX2017012231A (es) 2018-01-30

Family

ID=52784935

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017012231A MX2017012231A (es) 2015-03-23 2016-02-12 Secuencias de oligonucleotidos dirigidos al factor de transcripcion tsc22d4 para el tratamiento de la resistencia a la insulina.

Country Status (12)

Country Link
US (2) US10676739B2 (es)
EP (2) EP3072969A1 (es)
JP (1) JP2018513841A (es)
KR (1) KR20170128348A (es)
CN (1) CN107278229A (es)
BR (1) BR112017016021A2 (es)
CA (1) CA2979115A1 (es)
DK (1) DK3274455T3 (es)
ES (1) ES2837085T3 (es)
MX (1) MX2017012231A (es)
RU (1) RU2723091C2 (es)
WO (1) WO2016150618A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7289510B2 (ja) * 2019-05-08 2023-06-12 国立大学法人高知大学 認知症治療薬のスクリーニング方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU780454B2 (en) * 1999-06-03 2005-03-24 Jessie L.S. Au Methods and compositions for modulating cell proliferation and cell death
JP2006507841A (ja) * 2002-11-14 2006-03-09 ダーマコン， インコーポレイテッド 機能的ｓｉＲＮＡおよび超機能的ｓｉＲＮＡ
JP4869942B2 (ja) 2003-12-11 2012-02-08 ベス・イスラエル・ディーコネス・メディカル・センター，インコーポレイテッド インスリン感受性／抵抗性、糖尿病および肥満におけるｒｂｐ４
CN101052717A (zh) * 2004-05-11 2007-10-10 α基因株式会社 诱发rna干扰的多核苷酸以及使用该多核苷酸的基因表达抑制方法
US7943306B2 (en) * 2005-01-12 2011-05-17 The Board Of Trustees Of The Leland Stanford Junior University Gene expression signature for prediction of human cancer progression
WO2012158123A1 (en) 2011-05-13 2012-11-22 Agency For Science, Technology And Research Compounds and methods for treating insulin resistance syndrome
GB201120317D0 (en) 2011-11-24 2012-01-04 Queen Mary & Westfield College Screening method
EP2816356A1 (en) 2013-06-17 2014-12-24 Ruprecht-Karls-Universität Heidelberg Treatment of insulin resistance through inhibitors of transcription factor TSC22D4
RU2573450C1 (ru) * 2014-08-11 2016-01-20 Федеральное Государственное Бюджетное Учреждение Науки Институт Молекулярной Биологии Им. В.А. Энгельгардта Российской Академии Наук (Имб Ран) Способ выявления генов-мишеней для диагностики и терапии лейкозов человека

Also Published As

Publication number Publication date
EP3274455A1 (en) 2018-01-31
BR112017016021A2 (pt) 2018-03-20
CN107278229A (zh) 2017-10-20
WO2016150618A1 (en) 2016-09-29
US20200255834A1 (en) 2020-08-13
EP3274455B1 (en) 2020-10-14
US10676739B2 (en) 2020-06-09
RU2017131900A3 (es) 2019-06-10
ES2837085T3 (es) 2021-06-29
EP3072969A1 (en) 2016-09-28
KR20170128348A (ko) 2017-11-22
CA2979115A1 (en) 2016-09-29
US11053499B2 (en) 2021-07-06
RU2723091C2 (ru) 2020-06-08
DK3274455T3 (da) 2020-12-14
RU2017131900A (ru) 2019-04-23
US20180023078A1 (en) 2018-01-25
JP2018513841A (ja) 2018-05-31

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