JP2018510887A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018510887A5 JP2018510887A5 JP2017552479A JP2017552479A JP2018510887A5 JP 2018510887 A5 JP2018510887 A5 JP 2018510887A5 JP 2017552479 A JP2017552479 A JP 2017552479A JP 2017552479 A JP2017552479 A JP 2017552479A JP 2018510887 A5 JP2018510887 A5 JP 2018510887A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- item
- immune cells
- subject
- antigens
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims description 76
- 102000036639 antigens Human genes 0.000 claims description 72
- 108091007433 antigens Proteins 0.000 claims description 72
- 210000002865 immune cell Anatomy 0.000 claims description 49
- 238000000034 method Methods 0.000 claims description 40
- 239000003795 chemical substances by application Substances 0.000 claims description 28
- 230000001483 mobilizing effect Effects 0.000 claims description 23
- 208000023275 Autoimmune disease Diseases 0.000 claims description 17
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 16
- 229920000642 polymer Polymers 0.000 claims description 16
- 108010012236 Chemokines Proteins 0.000 claims description 14
- 102000019034 Chemokines Human genes 0.000 claims description 14
- 201000010099 disease Diseases 0.000 claims description 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 14
- -1 LICAM Proteins 0.000 claims description 13
- 206010028980 Neoplasm Diseases 0.000 claims description 13
- 239000012634 fragment Substances 0.000 claims description 12
- 239000008194 pharmaceutical composition Substances 0.000 claims description 12
- 241000700605 Viruses Species 0.000 claims description 10
- 210000004443 dendritic cell Anatomy 0.000 claims description 10
- 201000011510 cancer Diseases 0.000 claims description 9
- 230000001717 pathogenic effect Effects 0.000 claims description 9
- 102100021943 C-C motif chemokine 2 Human genes 0.000 claims description 8
- 244000052769 pathogen Species 0.000 claims description 8
- 102100032367 C-C motif chemokine 5 Human genes 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 102100027522 Baculoviral IAP repeat-containing protein 7 Human genes 0.000 claims description 6
- 101710177963 Baculoviral IAP repeat-containing protein 7 Proteins 0.000 claims description 6
- 239000003361 porogen Substances 0.000 claims description 5
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 4
- 108060000903 Beta-catenin Proteins 0.000 claims description 4
- 102000015735 Beta-catenin Human genes 0.000 claims description 4
- 102000004127 Cytokines Human genes 0.000 claims description 4
- 108090000695 Cytokines Proteins 0.000 claims description 4
- 102100025012 Dipeptidyl peptidase 4 Human genes 0.000 claims description 4
- 101000930822 Giardia intestinalis Dipeptidyl-peptidase 4 Proteins 0.000 claims description 4
- 101000797762 Homo sapiens C-C motif chemokine 5 Proteins 0.000 claims description 4
- 101000880770 Homo sapiens Protein SSX2 Proteins 0.000 claims description 4
- 229920000954 Polyglycolide Polymers 0.000 claims description 4
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 4
- 102100037686 Protein SSX2 Human genes 0.000 claims description 4
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims description 4
- LVTKHGUGBGNBPL-UHFFFAOYSA-N Trp-P-1 Chemical compound N1C2=CC=CC=C2C2=C1C(C)=C(N)N=C2C LVTKHGUGBGNBPL-UHFFFAOYSA-N 0.000 claims description 4
- 210000004027 cell Anatomy 0.000 claims description 4
- 229920002674 hyaluronan Polymers 0.000 claims description 4
- 229960003160 hyaluronic acid Drugs 0.000 claims description 4
- 210000002540 macrophage Anatomy 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 229920001983 poloxamer Polymers 0.000 claims description 4
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims description 4
- 229920000083 poly(allylamine) Polymers 0.000 claims description 4
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims description 4
- 239000004633 polyglycolic acid Substances 0.000 claims description 4
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 4
- 230000011664 signaling Effects 0.000 claims description 4
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 3
- 210000002237 B-cell of pancreatic islet Anatomy 0.000 claims description 3
- 241000894006 Bacteria Species 0.000 claims description 3
- 102100032366 C-C motif chemokine 7 Human genes 0.000 claims description 3
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims description 3
- 229940045513 CTLA4 antagonist Drugs 0.000 claims description 3
- 108010055166 Chemokine CCL5 Proteins 0.000 claims description 3
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims description 3
- 241000233866 Fungi Species 0.000 claims description 3
- 208000018522 Gastrointestinal disease Diseases 0.000 claims description 3
- 101000797758 Homo sapiens C-C motif chemokine 7 Proteins 0.000 claims description 3
- 101000804764 Homo sapiens Lymphotactin Proteins 0.000 claims description 3
- 101000617130 Homo sapiens Stromal cell-derived factor 1 Proteins 0.000 claims description 3
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 3
- 102000015696 Interleukins Human genes 0.000 claims description 3
- 108010063738 Interleukins Proteins 0.000 claims description 3
- 102100035304 Lymphotactin Human genes 0.000 claims description 3
- 101710139349 Mucosal addressin cell adhesion molecule 1 Proteins 0.000 claims description 3
- 102100028793 Mucosal addressin cell adhesion molecule 1 Human genes 0.000 claims description 3
- 102100021669 Stromal cell-derived factor 1 Human genes 0.000 claims description 3
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 3
- 108010000134 Vascular Cell Adhesion Molecule-1 Proteins 0.000 claims description 3
- 102100023543 Vascular cell adhesion protein 1 Human genes 0.000 claims description 3
- 102000019997 adhesion receptor Human genes 0.000 claims description 3
- 108010013985 adhesion receptor Proteins 0.000 claims description 3
- 229940072056 alginate Drugs 0.000 claims description 3
- 229920000615 alginic acid Polymers 0.000 claims description 3
- 235000010443 alginic acid Nutrition 0.000 claims description 3
- 210000000988 bone and bone Anatomy 0.000 claims description 3
- 229920001577 copolymer Polymers 0.000 claims description 3
- 210000003061 neural cell Anatomy 0.000 claims description 3
- 244000045947 parasite Species 0.000 claims description 3
- 238000007920 subcutaneous administration Methods 0.000 claims description 3
- FFILOTSTFMXQJC-QCFYAKGBSA-N (2r,4r,5s,6s)-2-[3-[(2s,3s,4r,6s)-6-[(2s,3r,4r,5s,6r)-5-[(2s,3r,4r,5r,6r)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-[(2r,3s,4r,5r,6r)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(e)-3-hydroxy-2-(octadecanoylamino)octadec-4-enoxy]oxan-3-yl]oxy-3-hy Chemical compound O[C@@H]1[C@@H](O)[C@H](OCC(NC(=O)CCCCCCCCCCCCCCCCC)C(O)\C=C\CCCCCCCCCCCCC)O[C@H](CO)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@]2(O[C@@H]([C@@H](N)[C@H](O)C2)C(O)C(O)CO[C@]2(O[C@@H]([C@@H](N)[C@H](O)C2)C(O)C(O)CO)C(O)=O)C(O)=O)[C@@H](O[C@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](CO)O1 FFILOTSTFMXQJC-QCFYAKGBSA-N 0.000 claims description 2
- APHFXDBDLKPMTA-UHFFFAOYSA-N 2-(3-decanoyl-4,5,7-trihydroxynaphthalen-2-yl)acetic acid Chemical compound CCCCCCCCCC(=O)c1c(CC(O)=O)cc2cc(O)cc(O)c2c1O APHFXDBDLKPMTA-UHFFFAOYSA-N 0.000 claims description 2
- LKKMLIBUAXYLOY-UHFFFAOYSA-N 3-Amino-1-methyl-5H-pyrido[4,3-b]indole Chemical compound N1C2=CC=CC=C2C2=C1C=C(N)N=C2C LKKMLIBUAXYLOY-UHFFFAOYSA-N 0.000 claims description 2
- 101710169336 5'-deoxyadenosine deaminase Proteins 0.000 claims description 2
- 102100030310 5,6-dihydroxyindole-2-carboxylic acid oxidase Human genes 0.000 claims description 2
- 101710163881 5,6-dihydroxyindole-2-carboxylic acid oxidase Proteins 0.000 claims description 2
- 229920000936 Agarose Polymers 0.000 claims description 2
- 101000874387 Astacus leptodactylus Sarcoplasmic calcium-binding protein 1 Proteins 0.000 claims description 2
- 102100035526 B melanoma antigen 1 Human genes 0.000 claims description 2
- 102100021663 Baculoviral IAP repeat-containing protein 5 Human genes 0.000 claims description 2
- 102100033680 Bombesin receptor-activated protein C6orf89 Human genes 0.000 claims description 2
- 102100023702 C-C motif chemokine 13 Human genes 0.000 claims description 2
- 101710155857 C-C motif chemokine 2 Proteins 0.000 claims description 2
- 102100034871 C-C motif chemokine 8 Human genes 0.000 claims description 2
- 101150104494 CAV1 gene Proteins 0.000 claims description 2
- 101150012716 CDK1 gene Proteins 0.000 claims description 2
- 102000000905 Cadherin Human genes 0.000 claims description 2
- 108050007957 Cadherin Proteins 0.000 claims description 2
- 101100455063 Caenorhabditis elegans lmp-1 gene Proteins 0.000 claims description 2
- 101100355609 Caenorhabditis elegans rae-1 gene Proteins 0.000 claims description 2
- 102100025570 Cancer/testis antigen 1 Human genes 0.000 claims description 2
- 102100025475 Carcinoembryonic antigen-related cell adhesion molecule 5 Human genes 0.000 claims description 2
- 102100026548 Caspase-8 Human genes 0.000 claims description 2
- 108090000538 Caspase-8 Proteins 0.000 claims description 2
- 102000004225 Cathepsin B Human genes 0.000 claims description 2
- 108090000712 Cathepsin B Proteins 0.000 claims description 2
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 claims description 2
- 102000008186 Collagen Human genes 0.000 claims description 2
- 108010035532 Collagen Proteins 0.000 claims description 2
- 108010025464 Cyclin-Dependent Kinase 4 Proteins 0.000 claims description 2
- 102100036252 Cyclin-dependent kinase 4 Human genes 0.000 claims description 2
- 102100038281 Cytospin-A Human genes 0.000 claims description 2
- 102100040606 Dermatan-sulfate epimerase Human genes 0.000 claims description 2
- 101100216227 Dictyostelium discoideum anapc3 gene Proteins 0.000 claims description 2
- 102100024400 Diphthine methyltransferase Human genes 0.000 claims description 2
- 108010055196 EphA2 Receptor Proteins 0.000 claims description 2
- 102100030340 Ephrin type-A receptor 2 Human genes 0.000 claims description 2
- 102000009123 Fibrin Human genes 0.000 claims description 2
- 108010073385 Fibrin Proteins 0.000 claims description 2
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims description 2
- 102000003817 Fos-related antigen 1 Human genes 0.000 claims description 2
- 108090000123 Fos-related antigen 1 Proteins 0.000 claims description 2
- 102100039717 G antigen 1 Human genes 0.000 claims description 2
- 102000040452 GAGE family Human genes 0.000 claims description 2
- 108091072337 GAGE family Proteins 0.000 claims description 2
- 102100024405 GPI-linked NAD(P)(+)-arginine ADP-ribosyltransferase 1 Human genes 0.000 claims description 2
- 102100030525 Gap junction alpha-4 protein Human genes 0.000 claims description 2
- 108010010803 Gelatin Proteins 0.000 claims description 2
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims description 2
- 102000007390 Glycogen Phosphorylase Human genes 0.000 claims description 2
- 108010046163 Glycogen Phosphorylase Proteins 0.000 claims description 2
- 102100034153 Golgin subfamily A member 6B Human genes 0.000 claims description 2
- 102100030595 HLA class II histocompatibility antigen gamma chain Human genes 0.000 claims description 2
- 102100031624 Heat shock protein 105 kDa Human genes 0.000 claims description 2
- 102100038970 Histone-lysine N-methyltransferase EZH2 Human genes 0.000 claims description 2
- 101000874316 Homo sapiens B melanoma antigen 1 Proteins 0.000 claims description 2
- 101000984746 Homo sapiens BRCA1-associated protein Proteins 0.000 claims description 2
- 101000944524 Homo sapiens Bombesin receptor-activated protein C6orf89 Proteins 0.000 claims description 2
- 101000978379 Homo sapiens C-C motif chemokine 13 Proteins 0.000 claims description 2
- 101000946794 Homo sapiens C-C motif chemokine 8 Proteins 0.000 claims description 2
- 101000856237 Homo sapiens Cancer/testis antigen 1 Proteins 0.000 claims description 2
- 101000914324 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 5 Proteins 0.000 claims description 2
- 101000914321 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 7 Proteins 0.000 claims description 2
- 101000721661 Homo sapiens Cellular tumor antigen p53 Proteins 0.000 claims description 2
- 101000884816 Homo sapiens Cytospin-A Proteins 0.000 claims description 2
- 101000816698 Homo sapiens Dermatan-sulfate epimerase Proteins 0.000 claims description 2
- 101001053233 Homo sapiens Diphthine methyltransferase Proteins 0.000 claims description 2
- 101001024566 Homo sapiens Ecto-ADP-ribosyltransferase 4 Proteins 0.000 claims description 2
- 101000886137 Homo sapiens G antigen 1 Proteins 0.000 claims description 2
- 101100449143 Homo sapiens GOLGA6B gene Proteins 0.000 claims description 2
- 101000981252 Homo sapiens GPI-linked NAD(P)(+)-arginine ADP-ribosyltransferase 1 Proteins 0.000 claims description 2
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims description 2
- 101001082627 Homo sapiens HLA class II histocompatibility antigen gamma chain Proteins 0.000 claims description 2
- 101000866478 Homo sapiens Heat shock protein 105 kDa Proteins 0.000 claims description 2
- 101000882127 Homo sapiens Histone-lysine N-methyltransferase EZH2 Proteins 0.000 claims description 2
- 101100232357 Homo sapiens IL13RA1 gene Proteins 0.000 claims description 2
- 101100232360 Homo sapiens IL13RA2 gene Proteins 0.000 claims description 2
- 101001001418 Homo sapiens Inhibitor of growth protein 4 Proteins 0.000 claims description 2
- 101000991061 Homo sapiens MHC class I polypeptide-related sequence B Proteins 0.000 claims description 2
- 101000578784 Homo sapiens Melanoma antigen recognized by T-cells 1 Proteins 0.000 claims description 2
- 101000623901 Homo sapiens Mucin-16 Proteins 0.000 claims description 2
- 101000979578 Homo sapiens NK-tumor recognition protein Proteins 0.000 claims description 2
- 101000801664 Homo sapiens Nucleoprotein TPR Proteins 0.000 claims description 2
- 101100029612 Homo sapiens PHF20 gene Proteins 0.000 claims description 2
- 101000662592 Homo sapiens Poly [ADP-ribose] polymerase tankyrase-2 Proteins 0.000 claims description 2
- 101000872170 Homo sapiens Polycomb complex protein BMI-1 Proteins 0.000 claims description 2
- 101000617725 Homo sapiens Pregnancy-specific beta-1-glycoprotein 2 Proteins 0.000 claims description 2
- 101000583459 Homo sapiens Progesterone-induced-blocking factor 1 Proteins 0.000 claims description 2
- 101001069749 Homo sapiens Prospero homeobox protein 1 Proteins 0.000 claims description 2
- 101001136592 Homo sapiens Prostate stem cell antigen Proteins 0.000 claims description 2
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims description 2
- 101001062222 Homo sapiens Receptor-binding cancer antigen expressed on SiSo cells Proteins 0.000 claims description 2
- 101000584743 Homo sapiens Recombining binding protein suppressor of hairless Proteins 0.000 claims description 2
- 101000727472 Homo sapiens Reticulon-4 Proteins 0.000 claims description 2
- 101000849300 Homo sapiens Ribosomal RNA processing protein 36 homolog Proteins 0.000 claims description 2
- 101000873927 Homo sapiens Squamous cell carcinoma antigen recognized by T-cells 3 Proteins 0.000 claims description 2
- 101000664703 Homo sapiens Transcription factor SOX-10 Proteins 0.000 claims description 2
- 101000825086 Homo sapiens Transcription factor SOX-11 Proteins 0.000 claims description 2
- 101000687905 Homo sapiens Transcription factor SOX-2 Proteins 0.000 claims description 2
- 101000836268 Homo sapiens U4/U6.U5 tri-snRNP-associated protein 1 Proteins 0.000 claims description 2
- 101000621309 Homo sapiens Wilms tumor protein Proteins 0.000 claims description 2
- 101000823796 Homo sapiens Y-box-binding protein 1 Proteins 0.000 claims description 2
- 108010043496 Immunoglobulin Idiotypes Proteins 0.000 claims description 2
- 102100035677 Inhibitor of growth protein 4 Human genes 0.000 claims description 2
- 102100025390 Integrin beta-2 Human genes 0.000 claims description 2
- 102000014150 Interferons Human genes 0.000 claims description 2
- 108010050904 Interferons Proteins 0.000 claims description 2
- 102000007482 Interleukin-13 Receptor alpha2 Subunit Human genes 0.000 claims description 2
- 108010085418 Interleukin-13 Receptor alpha2 Subunit Proteins 0.000 claims description 2
- 102100020791 Interleukin-13 receptor subunit alpha-1 Human genes 0.000 claims description 2
- 108020003285 Isocitrate lyase Proteins 0.000 claims description 2
- 102100031413 L-dopachrome tautomerase Human genes 0.000 claims description 2
- 101710093778 L-dopachrome tautomerase Proteins 0.000 claims description 2
- 108010064548 Lymphocyte Function-Associated Antigen-1 Proteins 0.000 claims description 2
- 102100030301 MHC class I polypeptide-related sequence A Human genes 0.000 claims description 2
- 102100030300 MHC class I polypeptide-related sequence B Human genes 0.000 claims description 2
- 101710167887 Major outer membrane protein P.IA Proteins 0.000 claims description 2
- 102100022430 Melanocyte protein PMEL Human genes 0.000 claims description 2
- 102100028389 Melanoma antigen recognized by T-cells 1 Human genes 0.000 claims description 2
- 102100024197 Membrane metallo-endopeptidase-like 1 Human genes 0.000 claims description 2
- 108050004622 Membrane metallo-endopeptidase-like 1 Proteins 0.000 claims description 2
- 102100030335 Midkine Human genes 0.000 claims description 2
- 108010092801 Midkine Proteins 0.000 claims description 2
- 102100034256 Mucin-1 Human genes 0.000 claims description 2
- 108010008707 Mucin-1 Proteins 0.000 claims description 2
- 102100023123 Mucin-16 Human genes 0.000 claims description 2
- 102100023384 NK-tumor recognition protein Human genes 0.000 claims description 2
- 102000008730 Nestin Human genes 0.000 claims description 2
- 108010088225 Nestin Proteins 0.000 claims description 2
- 102000019040 Nuclear Antigens Human genes 0.000 claims description 2
- 108010051791 Nuclear Antigens Proteins 0.000 claims description 2
- 102100033615 Nucleoprotein TPR Human genes 0.000 claims description 2
- 102100036878 PHD finger protein 20 Human genes 0.000 claims description 2
- 101150038998 PLAUR gene Proteins 0.000 claims description 2
- 102000036673 PRAME Human genes 0.000 claims description 2
- 108060006580 PRAME Proteins 0.000 claims description 2
- 102100034640 PWWP domain-containing DNA repair factor 3A Human genes 0.000 claims description 2
- 108050007154 PWWP domain-containing DNA repair factor 3A Proteins 0.000 claims description 2
- 102100040283 Peptidyl-prolyl cis-trans isomerase B Human genes 0.000 claims description 2
- 102100021768 Phosphoserine aminotransferase Human genes 0.000 claims description 2
- 102100037477 Poly [ADP-ribose] polymerase tankyrase-2 Human genes 0.000 claims description 2
- 102100034937 Poly(A) RNA polymerase, mitochondrial Human genes 0.000 claims description 2
- 229920002732 Polyanhydride Polymers 0.000 claims description 2
- 102100033566 Polycomb complex protein BMI-1 Human genes 0.000 claims description 2
- 102100031015 Progesterone-induced-blocking factor 1 Human genes 0.000 claims description 2
- 102100033880 Prospero homeobox protein 1 Human genes 0.000 claims description 2
- 102100038280 Prostaglandin G/H synthase 2 Human genes 0.000 claims description 2
- 108050003267 Prostaglandin G/H synthase 2 Proteins 0.000 claims description 2
- 102100036735 Prostate stem cell antigen Human genes 0.000 claims description 2
- 108010072866 Prostate-Specific Antigen Proteins 0.000 claims description 2
- 102100022491 RNA-binding protein NOB1 Human genes 0.000 claims description 2
- 101710100968 Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims description 2
- 102100029165 Receptor-binding cancer antigen expressed on SiSo cells Human genes 0.000 claims description 2
- 102100030000 Recombining binding protein suppressor of hairless Human genes 0.000 claims description 2
- 102100029831 Reticulon-4 Human genes 0.000 claims description 2
- 102100033981 Ribosomal RNA processing protein 36 homolog Human genes 0.000 claims description 2
- 101710173693 Short transient receptor potential channel 1 Proteins 0.000 claims description 2
- 101710173694 Short transient receptor potential channel 2 Proteins 0.000 claims description 2
- 102100035748 Squamous cell carcinoma antigen recognized by T-cells 3 Human genes 0.000 claims description 2
- 101800001271 Surface protein Proteins 0.000 claims description 2
- 108010002687 Survivin Proteins 0.000 claims description 2
- 108091008874 T cell receptors Proteins 0.000 claims description 2
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 2
- 101150006914 TRP1 gene Proteins 0.000 claims description 2
- 102100038808 Transcription factor SOX-10 Human genes 0.000 claims description 2
- 102100022415 Transcription factor SOX-11 Human genes 0.000 claims description 2
- 102100024270 Transcription factor SOX-2 Human genes 0.000 claims description 2
- 102100039094 Tyrosinase Human genes 0.000 claims description 2
- 108060008724 Tyrosinase Proteins 0.000 claims description 2
- 102100027244 U4/U6.U5 tri-snRNP-associated protein 1 Human genes 0.000 claims description 2
- 101150042088 UL16 gene Proteins 0.000 claims description 2
- 102100036976 X-ray repair cross-complementing protein 6 Human genes 0.000 claims description 2
- 101710124907 X-ray repair cross-complementing protein 6 Proteins 0.000 claims description 2
- 102100022224 Y-box-binding protein 1 Human genes 0.000 claims description 2
- 108010016200 Zinc Finger Protein GLI1 Proteins 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 102000013529 alpha-Fetoproteins Human genes 0.000 claims description 2
- 108010026331 alpha-Fetoproteins Proteins 0.000 claims description 2
- 230000006472 autoimmune response Effects 0.000 claims description 2
- 210000004556 brain Anatomy 0.000 claims description 2
- 229920001436 collagen Polymers 0.000 claims description 2
- 229960005188 collagen Drugs 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- 238000000748 compression moulding Methods 0.000 claims description 2
- 108010015408 connexin 37 Proteins 0.000 claims description 2
- 108010048032 cyclophilin B Proteins 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 108010087914 epidermal growth factor receptor VIII Proteins 0.000 claims description 2
- 229950003499 fibrin Drugs 0.000 claims description 2
- 108010006620 fodrin Proteins 0.000 claims description 2
- 230000008014 freezing Effects 0.000 claims description 2
- 238000007710 freezing Methods 0.000 claims description 2
- 102000054078 gamma Catenin Human genes 0.000 claims description 2
- 108010084448 gamma Catenin Proteins 0.000 claims description 2
- 150000002270 gangliosides Chemical class 0.000 claims description 2
- 229920000159 gelatin Polymers 0.000 claims description 2
- 239000008273 gelatin Substances 0.000 claims description 2
- 229940014259 gelatin Drugs 0.000 claims description 2
- 235000019322 gelatine Nutrition 0.000 claims description 2
- 235000011852 gelatine desserts Nutrition 0.000 claims description 2
- 150000004676 glycans Chemical class 0.000 claims description 2
- 229920000578 graft copolymer Polymers 0.000 claims description 2
- 239000003102 growth factor Substances 0.000 claims description 2
- 230000002163 immunogen Effects 0.000 claims description 2
- 102000006495 integrins Human genes 0.000 claims description 2
- 108010044426 integrins Proteins 0.000 claims description 2
- 238000007918 intramuscular administration Methods 0.000 claims description 2
- 238000007912 intraperitoneal administration Methods 0.000 claims description 2
- 238000001990 intravenous administration Methods 0.000 claims description 2
- 238000002386 leaching Methods 0.000 claims description 2
- 239000006166 lysate Substances 0.000 claims description 2
- 239000010445 mica Substances 0.000 claims description 2
- 229910052618 mica group Inorganic materials 0.000 claims description 2
- 108010066416 multidrug resistance-associated protein 3 Proteins 0.000 claims description 2
- 210000005055 nestin Anatomy 0.000 claims description 2
- 108010044156 peptidyl-prolyl cis-trans isomerase b Proteins 0.000 claims description 2
- 229920001308 poly(aminoacid) Polymers 0.000 claims description 2
- 229920002627 poly(phosphazenes) Polymers 0.000 claims description 2
- 229920001481 poly(stearyl methacrylate) Polymers 0.000 claims description 2
- 229920000058 polyacrylate Polymers 0.000 claims description 2
- 229920000728 polyester Polymers 0.000 claims description 2
- 239000004626 polylactic acid Substances 0.000 claims description 2
- 229920005862 polyol Polymers 0.000 claims description 2
- 150000003077 polyols Chemical class 0.000 claims description 2
- 229920001184 polypeptide Polymers 0.000 claims description 2
- 108040000983 polyphosphate:AMP phosphotransferase activity proteins Proteins 0.000 claims description 2
- 229920001282 polysaccharide Polymers 0.000 claims description 2
- 239000005017 polysaccharide Substances 0.000 claims description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 102000016914 ras Proteins Human genes 0.000 claims description 2
- 108010014186 ras Proteins Proteins 0.000 claims description 2
- 210000003289 regulatory T cell Anatomy 0.000 claims description 2
- 125000003011 styrenyl group Chemical class [H]\C(*)=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 102100036842 C-C motif chemokine 19 Human genes 0.000 claims 1
- 101000713106 Homo sapiens C-C motif chemokine 19 Proteins 0.000 claims 1
- 108010074338 Lymphokines Proteins 0.000 claims 1
- 102000008072 Lymphokines Human genes 0.000 claims 1
- 229940047124 interferons Drugs 0.000 claims 1
- 229940047122 interleukins Drugs 0.000 claims 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 4
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 4
- 241000915524 Entamoeba sp. Species 0.000 description 3
- IYMAXBFPHPZYIK-BQBZGAKWSA-N Arg-Gly-Asp Chemical compound NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(O)=O IYMAXBFPHPZYIK-BQBZGAKWSA-N 0.000 description 2
- 241000498849 Chlamydiales Species 0.000 description 2
- 208000011231 Crohn disease Diseases 0.000 description 2
- 241000709661 Enterovirus Species 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 241000224470 Giardia sp. Species 0.000 description 2
- 241000701806 Human papillomavirus Species 0.000 description 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 2
- 108091034117 Oligonucleotide Proteins 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 241000223996 Toxoplasma Species 0.000 description 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 2
- 108010072041 arginyl-glycyl-aspartic acid Proteins 0.000 description 2
- 208000010643 digestive system disease Diseases 0.000 description 2
- 208000018685 gastrointestinal system disease Diseases 0.000 description 2
- 201000006417 multiple sclerosis Diseases 0.000 description 2
- 206010039073 rheumatoid arthritis Diseases 0.000 description 2
- 241000894007 species Species 0.000 description 2
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 description 1
- 241000224424 Acanthamoeba sp. Species 0.000 description 1
- 241001490776 Babesia sp. Species 0.000 description 1
- 241000193738 Bacillus anthracis Species 0.000 description 1
- 241000934150 Balamuthia Species 0.000 description 1
- 206010005003 Bladder cancer Diseases 0.000 description 1
- 206010005949 Bone cancer Diseases 0.000 description 1
- 208000018084 Bone neoplasm Diseases 0.000 description 1
- 241000588832 Bordetella pertussis Species 0.000 description 1
- 241000589972 Borrelia sp. Species 0.000 description 1
- 241000589969 Borreliella burgdorferi Species 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 101100346189 Caenorhabditis elegans mpc-1 gene Proteins 0.000 description 1
- 241000589875 Campylobacter jejuni Species 0.000 description 1
- 241000222178 Candida tropicalis Species 0.000 description 1
- 206010008342 Cervix carcinoma Diseases 0.000 description 1
- 241001495184 Chlamydia sp. Species 0.000 description 1
- 241000193403 Clostridium Species 0.000 description 1
- 241000193464 Clostridium sp. Species 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 241000711573 Coronaviridae Species 0.000 description 1
- 241000186227 Corynebacterium diphtheriae Species 0.000 description 1
- 241000607078 Coxiella sp. (in: Bacteria) Species 0.000 description 1
- 241000709687 Coxsackievirus Species 0.000 description 1
- 201000007336 Cryptococcosis Diseases 0.000 description 1
- 241000221204 Cryptococcus neoformans Species 0.000 description 1
- 241000694959 Cryptococcus sp. Species 0.000 description 1
- 241000295636 Cryptosporidium sp. Species 0.000 description 1
- 241000701022 Cytomegalovirus Species 0.000 description 1
- 241000725619 Dengue virus Species 0.000 description 1
- 241001115402 Ebolavirus Species 0.000 description 1
- 241000224431 Entamoeba Species 0.000 description 1
- 241001495410 Enterococcus sp. Species 0.000 description 1
- 241000991587 Enterovirus C Species 0.000 description 1
- 208000000832 Equine Encephalomyelitis Diseases 0.000 description 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 description 1
- 241000589602 Francisella tularensis Species 0.000 description 1
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 description 1
- 241000606841 Haemophilus sp. Species 0.000 description 1
- 241000711549 Hepacivirus C Species 0.000 description 1
- 241000700721 Hepatitis B virus Species 0.000 description 1
- 241000724675 Hepatitis E virus Species 0.000 description 1
- 208000037262 Hepatitis delta Diseases 0.000 description 1
- 241000724709 Hepatitis delta virus Species 0.000 description 1
- 241000709721 Hepatovirus A Species 0.000 description 1
- 241000228404 Histoplasma capsulatum Species 0.000 description 1
- 241000701085 Human alphaherpesvirus 3 Species 0.000 description 1
- 241000701044 Human gammaherpesvirus 4 Species 0.000 description 1
- 241000725303 Human immunodeficiency virus Species 0.000 description 1
- 102000000589 Interleukin-1 Human genes 0.000 description 1
- 108010002352 Interleukin-1 Proteins 0.000 description 1
- 102000003814 Interleukin-10 Human genes 0.000 description 1
- 108090000174 Interleukin-10 Proteins 0.000 description 1
- 102000013462 Interleukin-12 Human genes 0.000 description 1
- 108010065805 Interleukin-12 Proteins 0.000 description 1
- 102000013691 Interleukin-17 Human genes 0.000 description 1
- 108050003558 Interleukin-17 Proteins 0.000 description 1
- 102000000588 Interleukin-2 Human genes 0.000 description 1
- 108010002350 Interleukin-2 Proteins 0.000 description 1
- 102000004388 Interleukin-4 Human genes 0.000 description 1
- 108090000978 Interleukin-4 Proteins 0.000 description 1
- 102000000743 Interleukin-5 Human genes 0.000 description 1
- 108010002616 Interleukin-5 Proteins 0.000 description 1
- 241000701460 JC polyomavirus Species 0.000 description 1
- 241000710842 Japanese encephalitis virus Species 0.000 description 1
- 208000008839 Kidney Neoplasms Diseases 0.000 description 1
- 241000222722 Leishmania <genus> Species 0.000 description 1
- 241000186779 Listeria monocytogenes Species 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 description 1
- 241001115401 Marburgvirus Species 0.000 description 1
- 241000712079 Measles morbillivirus Species 0.000 description 1
- 208000025370 Middle East respiratory syndrome Diseases 0.000 description 1
- 241000186359 Mycobacterium Species 0.000 description 1
- 241000186366 Mycobacterium bovis Species 0.000 description 1
- 241000186362 Mycobacterium leprae Species 0.000 description 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 description 1
- 241000204031 Mycoplasma Species 0.000 description 1
- 241000202934 Mycoplasma pneumoniae Species 0.000 description 1
- 241001502502 Naegleria sp. Species 0.000 description 1
- 241000588652 Neisseria gonorrhoeae Species 0.000 description 1
- 241000588650 Neisseria meningitidis Species 0.000 description 1
- 241001440871 Neisseria sp. Species 0.000 description 1
- 241000187678 Nocardia asteroides Species 0.000 description 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 description 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
- 241001631646 Papillomaviridae Species 0.000 description 1
- 208000002606 Paramyxoviridae Infections Diseases 0.000 description 1
- 241000709664 Picornaviridae Species 0.000 description 1
- 241000223960 Plasmodium falciparum Species 0.000 description 1
- 241001442539 Plasmodium sp. Species 0.000 description 1
- 241000142787 Pneumocystis jirovecii Species 0.000 description 1
- 241000966057 Pneumocystis sp. Species 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 241000125945 Protoparvovirus Species 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 241000589774 Pseudomonas sp. Species 0.000 description 1
- 206010037742 Rabies Diseases 0.000 description 1
- 206010038389 Renal cancer Diseases 0.000 description 1
- 241000702263 Reovirus sp. Species 0.000 description 1
- 241000725643 Respiratory syncytial virus Species 0.000 description 1
- 241000606726 Rickettsia typhi Species 0.000 description 1
- 241000713124 Rift Valley fever virus Species 0.000 description 1
- 241000702670 Rotavirus Species 0.000 description 1
- 241000710799 Rubella virus Species 0.000 description 1
- 241000315672 SARS coronavirus Species 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 241001439627 Schistostoma Species 0.000 description 1
- 241000607768 Shigella Species 0.000 description 1
- 241000700584 Simplexvirus Species 0.000 description 1
- 241001279364 Stachybotrys chartarum Species 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 241000194019 Streptococcus mutans Species 0.000 description 1
- 241000193996 Streptococcus pyogenes Species 0.000 description 1
- 241000194022 Streptococcus sp. Species 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 208000024313 Testicular Neoplasms Diseases 0.000 description 1
- 206010057644 Testis cancer Diseases 0.000 description 1
- 241000223997 Toxoplasma gondii Species 0.000 description 1
- 241000589884 Treponema pallidum Species 0.000 description 1
- 241000589906 Treponema sp. Species 0.000 description 1
- 241000220979 Trichomonas sp. Species 0.000 description 1
- 241000224527 Trichomonas vaginalis Species 0.000 description 1
- 241000223104 Trypanosoma Species 0.000 description 1
- 241000223093 Trypanosoma sp. Species 0.000 description 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 1
- 241000700647 Variola virus Species 0.000 description 1
- 241000607284 Vibrio sp. Species 0.000 description 1
- 241000710772 Yellow fever virus Species 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 229940065181 bacillus anthracis Drugs 0.000 description 1
- 201000010881 cervical cancer Diseases 0.000 description 1
- 208000029742 colonic neoplasm Diseases 0.000 description 1
- 201000004101 esophageal cancer Diseases 0.000 description 1
- 229940118764 francisella tularensis Drugs 0.000 description 1
- 208000005017 glioblastoma Diseases 0.000 description 1
- 201000010536 head and neck cancer Diseases 0.000 description 1
- 208000014829 head and neck neoplasm Diseases 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
- 201000010982 kidney cancer Diseases 0.000 description 1
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 201000002528 pancreatic cancer Diseases 0.000 description 1
- 208000008443 pancreatic carcinoma Diseases 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000001855 preneoplastic effect Effects 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 201000003120 testicular cancer Diseases 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
- 229940051021 yellow-fever virus Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562146205P | 2015-04-10 | 2015-04-10 | |
| US62/146,205 | 2015-04-10 | ||
| PCT/US2016/026617 WO2016164705A1 (en) | 2015-04-10 | 2016-04-08 | Immune cell trapping devices and methods for making and using the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021000075A Division JP2021048879A (ja) | 2015-04-10 | 2021-01-04 | 免疫細胞捕捉デバイスおよびその製造および使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018510887A JP2018510887A (ja) | 2018-04-19 |
| JP2018510887A5 true JP2018510887A5 (enExample) | 2019-05-16 |
| JP7094533B2 JP7094533B2 (ja) | 2022-07-04 |
Family
ID=57072140
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017552479A Active JP7094533B2 (ja) | 2015-04-10 | 2016-04-08 | 免疫細胞捕捉デバイスおよびその製造および使用方法 |
| JP2021000075A Withdrawn JP2021048879A (ja) | 2015-04-10 | 2021-01-04 | 免疫細胞捕捉デバイスおよびその製造および使用方法 |
| JP2023151662A Pending JP2023166584A (ja) | 2015-04-10 | 2023-09-19 | 免疫細胞捕捉デバイスおよびその製造および使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021000075A Withdrawn JP2021048879A (ja) | 2015-04-10 | 2021-01-04 | 免疫細胞捕捉デバイスおよびその製造および使用方法 |
| JP2023151662A Pending JP2023166584A (ja) | 2015-04-10 | 2023-09-19 | 免疫細胞捕捉デバイスおよびその製造および使用方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US11150242B2 (enExample) |
| EP (1) | EP3280464A4 (enExample) |
| JP (3) | JP7094533B2 (enExample) |
| CN (2) | CN114099793A (enExample) |
| HK (1) | HK1249452A1 (enExample) |
| WO (1) | WO2016164705A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2804472T3 (es) | 2005-12-13 | 2021-02-08 | Harvard College | Estructuras para trasplante celular |
| EP2254602B1 (en) | 2008-02-13 | 2018-11-21 | President and Fellows of Harvard College | Continuous cell programming devices |
| WO2012048165A2 (en) | 2010-10-06 | 2012-04-12 | President And Fellows Of Harvard College | Injectable, pore-forming hydrogels for materials-based cell therapies |
| US9675561B2 (en) | 2011-04-28 | 2017-06-13 | President And Fellows Of Harvard College | Injectable cryogel vaccine devices and methods of use thereof |
| CN104244929B (zh) | 2012-04-16 | 2017-04-05 | 哈佛学院董事会 | 用于调节免疫反应的介孔二氧化硅组合物 |
| EP3137105A4 (en) | 2014-04-30 | 2017-12-27 | President and Fellows of Harvard College | Combination vaccine devices and methods of killing cancer cells |
| US11786457B2 (en) | 2015-01-30 | 2023-10-17 | President And Fellows Of Harvard College | Peritumoral and intratumoral materials for cancer therapy |
| JP7138864B2 (ja) | 2016-02-06 | 2022-09-20 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 免疫を再構成するための造血ニッチの再現 |
| US11555177B2 (en) | 2016-07-13 | 2023-01-17 | President And Fellows Of Harvard College | Antigen-presenting cell-mimetic scaffolds and methods for making and using the same |
| CA3032505A1 (en) | 2016-08-02 | 2018-02-08 | President And Fellows Of Harvard College | Biomaterials for modulating immune responses |
| RU2762607C2 (ru) | 2016-09-13 | 2021-12-21 | Аллерган, Инк. | Стабилизированные небелковые композиции клостридиального токсина |
| GB201707048D0 (en) * | 2017-05-03 | 2017-06-14 | King S College London | Expansion of gamma delta cells, compositions, and methods of use thereof |
| CN109459569A (zh) * | 2018-07-28 | 2019-03-12 | 南昌大学 | 一种免血样肿瘤早期监测的方法 |
| CN110836966A (zh) * | 2018-08-15 | 2020-02-25 | 王镕 | 用于抗原特异性t细胞含量检测的检测纳米颗粒、检测方法及试剂盒等 |
| WO2020061129A1 (en) | 2018-09-19 | 2020-03-26 | President And Fellows Of Harvard College | Compositions and methods for labeling and modulation of cells in vitro and in vivo |
| WO2020131582A1 (en) * | 2018-12-17 | 2020-06-25 | President And Fellows Of Harvard College | Bioengineered scaffolds for modulation of immune system and the uses thereof |
| US11904000B2 (en) | 2019-05-06 | 2024-02-20 | Brown University | Compositions and methods to enhance cutaneous wound healing |
| WO2020257423A1 (en) * | 2019-06-21 | 2020-12-24 | North Carolina State University | In situ recruitment, reprogramming, and release of car-t cells |
| CN110632308B (zh) * | 2019-10-25 | 2021-07-23 | 四川大学华西医院 | Casp8自身抗体检测试剂在制备肺癌筛查试剂盒中的用途 |
| CN113884682B (zh) * | 2021-04-30 | 2023-07-21 | 中国医学科学院血液病医院(中国医学科学院血液学研究所) | 检测巨核细胞或血小板表面标志分子的产品在制备检测感染的产品中的用途 |
| CN114870772B (zh) * | 2022-03-10 | 2024-07-12 | 上海威高医疗技术发展有限公司 | 一种脱细胞反应釜装置及脱细胞方法 |
| CN118976106B (zh) * | 2024-07-31 | 2025-12-09 | 湖南大学 | 一种藻酸盐基热遗传学cxcl12释放器及其制备方法和应用 |
Family Cites Families (239)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5132405A (en) | 1987-05-21 | 1992-07-21 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| GB9206504D0 (en) | 1992-03-25 | 1992-05-06 | Jevco Ltd | Heteromorphic sponges as wound implants |
| WO1995016464A1 (en) | 1993-12-14 | 1995-06-22 | Johns Hopkins University School Of Medicine | Controlled release of pharmaceutically active substances for immunotherapy |
| US5538733A (en) | 1994-07-07 | 1996-07-23 | Willmar Poultry Company, Inc. | Method of priming an immune response in a one-day old animal |
| US6429199B1 (en) | 1994-07-15 | 2002-08-06 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules for activating dendritic cells |
| DK0772619T4 (da) | 1994-07-15 | 2011-02-21 | Univ Iowa Res Found | Immunmodulatoriske oligonukleotider |
| US5625048A (en) | 1994-11-10 | 1997-04-29 | The Regents Of The University Of California | Modified green fluorescent proteins |
| US6251396B1 (en) | 1994-11-18 | 2001-06-26 | Neurocrine Biosciences, Inc. | Methods for treatment of multiple sclerosis using peptide analogs of human myelin basic protein |
| US6329499B1 (en) | 1994-11-18 | 2001-12-11 | Neurocrine Biosciences, Inc. | Methods for treatment of multiple sclerosis using peptide analogues of human myelin basic protein |
| JP2000516911A (ja) | 1996-03-28 | 2000-12-19 | ホワイトヘッド インスティテュート フォー バイオメディカル リサーチ | オプソニン強化細胞、および抗原に対する免疫応答を調節する方法 |
| IL118376A0 (en) | 1996-05-22 | 1996-09-12 | Univ Ben Gurion | Polysaccharide sponges for cell culture and transplantation |
| EP0915967A1 (en) | 1996-05-28 | 1999-05-19 | The Board Of Regents Of The University Of Michigan | Engineering oral tissues |
| US6124128A (en) | 1996-08-16 | 2000-09-26 | The Regents Of The University Of California | Long wavelength engineered fluorescent proteins |
| JP4335316B2 (ja) | 1996-09-19 | 2009-09-30 | ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガン | アルギネートまたは修飾アルギネートのようなポリサッカライドを含むポリマー |
| US5863551A (en) | 1996-10-16 | 1999-01-26 | Organogel Canada Ltee | Implantable polymer hydrogel for therapeutic uses |
| GB2318577B (en) | 1996-10-28 | 2000-02-02 | Johnson & Johnson Medical | Solvent dried polysaccharide sponges |
| GB2323282B (en) | 1997-03-17 | 2001-03-07 | Bristol Myers Squibb Co | Improvements relating to hygiene and medical products |
| EP0991705B1 (en) | 1997-03-31 | 2003-09-10 | The Regents Of The University Of Michigan | Open pore biodegradable matrices |
| WO1998053768A1 (en) | 1997-05-30 | 1998-12-03 | Osteobiologics, Inc. | Fiber-reinforced, porous, biodegradable implant device |
| KR100497849B1 (ko) | 1997-08-21 | 2005-06-29 | 다카라 바이오 가부시키가이샤 | 제암제 |
| ATE266434T1 (de) | 1998-02-23 | 2004-05-15 | Massachusetts Inst Technology | Bioabbaubare polymere mit formgedächtnis |
| WO1999044583A2 (en) | 1998-03-02 | 1999-09-10 | Applied Vaccine Technologies Corp. | Methods and devices for modulating the immune response |
| DE69935507T2 (de) | 1998-04-03 | 2007-12-06 | University Of Iowa Research Foundation | Verfahren und produkte zur stimulierung des immunsystems mittels immunotherapeutischer oligonukleotide und zytokine |
| US7427602B1 (en) | 1998-05-13 | 2008-09-23 | The Regents Of The University Of Michigan | Sustained DNA delivery from structural matrices |
| US7244714B1 (en) | 1998-06-12 | 2007-07-17 | Aradigm Corporation | Methods of delivering aerosolized polynucleotides to the respiratory tract |
| FR2780730B1 (fr) | 1998-07-01 | 2000-10-13 | Corneal Ind | Compositions biphasiques injectables, notamment utiles en chirurgies reparatrice et esthetique |
| EP2311485A1 (en) | 1998-07-30 | 2011-04-20 | The Government of the United States of America, as represented by the Secretary of Health and Human Services | Thymosin beta 4 promotes wound repair |
| JP2002527408A (ja) | 1998-10-09 | 2002-08-27 | ミシガン大学 | ドラッグデリバリー用ヒドロゲル及び水溶性ポリマーキャリアー |
| US7109003B2 (en) | 1998-12-23 | 2006-09-19 | Abgenix, Inc. | Methods for expressing and recovering human monoclonal antibodies to CTLA-4 |
| US6974698B1 (en) | 1999-01-15 | 2005-12-13 | The United States Of America As Represented By The Department Of Health And Human Services | Methods for delivering biologically active molecules into cells |
| EP1574210B1 (en) | 1999-02-26 | 2016-04-06 | Novartis Vaccines and Diagnostics, Inc. | Microemulsions with adsorbed macromolecules |
| US6767928B1 (en) | 1999-03-19 | 2004-07-27 | The Regents Of The University Of Michigan | Mineralization and biological modification of biomaterial surfaces |
| DK1163018T3 (da) | 1999-03-19 | 2003-09-29 | Univ Michigan Technology Man W | Mineralisering og cellulær mønstring på biomaterialeoverflader |
| EP1163019B1 (en) | 1999-03-25 | 2007-10-24 | Metabolix, Inc. | Medical devices and applications of polyhydroxyalkanoate polymers |
| EP1169378A4 (en) | 1999-04-09 | 2004-06-02 | Univ Michigan | PREPARATION OF HYDROGEL-BASED PRODUCTS |
| AU782297B2 (en) | 1999-06-30 | 2005-07-14 | Ethicon Inc. | Porous tissue scaffoldings for the repair or regeneration of tissue |
| US8084258B2 (en) | 1999-07-12 | 2011-12-27 | University Of Basel | Manipulation of tissue of organ type using the notch pathway |
| CN1378445B (zh) | 1999-08-06 | 2013-02-06 | 得克萨斯系统大学评议会 | 药物释放生物可降解纤维植入物 |
| US7015205B1 (en) | 1999-10-18 | 2006-03-21 | St. Vincent's Hospital And Medical Center Of New York | Melanoma vaccine and methods of making and using same |
| WO2001035932A2 (en) | 1999-11-18 | 2001-05-25 | The Regents Of The University Of Michigan | Sustained drug delivery from structural matrices |
| US6682754B2 (en) | 1999-11-24 | 2004-01-27 | Willmar Poultry Company, Inc. | Ovo delivery of an immunogen containing implant |
| US6790840B1 (en) | 1999-11-26 | 2004-09-14 | The Regents Of The University Of Michigan | Reversibly cross-linked hydrogels |
| US20020061587A1 (en) | 2000-07-31 | 2002-05-23 | Piero Anversa | Methods and compositions for the repair and/or regeneration of damaged myocardium |
| WO2002016557A2 (en) | 2000-08-21 | 2002-02-28 | Rice University | Tissue engineering scaffolds promoting matrix protein production |
| CN1484709A (zh) | 2000-09-09 | 2004-03-24 | ŦԼ������ѧ�о������ | 分离转移性癌细胞的方法与组合物,及其在检测癌转移性上的应用 |
| US6748954B2 (en) | 2000-10-27 | 2004-06-15 | The Regents Of The University Of Michigan | Drug release from polymer matrices through mechanical stimulation |
| WO2002040071A1 (en) | 2000-11-14 | 2002-05-23 | Osteogenesis Co., Ltd. | Compositions for forming bone or periodontium and injections for forming bone or periodontium |
| EP1349573A1 (en) | 2000-11-27 | 2003-10-08 | Jens Christian Jensenius | Collectins as adjuvants |
| US20070198739A1 (en) | 2001-01-19 | 2007-08-23 | Streamworks Technologies, Inc. | System and method for routing media |
| JP2004520043A (ja) | 2001-01-24 | 2004-07-08 | シェーリング コーポレイション | 免疫応答のアジュバントとしてのケモカイン |
| US7029697B2 (en) | 2001-02-14 | 2006-04-18 | Northwestern University | Controlled surface-associated delivery of genes and oligonucleotides |
| CA2439400A1 (en) | 2001-02-26 | 2002-09-06 | The Regents Of The University Of California | Non-oligomerizing tandem fluorescent proteins |
| US20020131953A1 (en) | 2001-03-14 | 2002-09-19 | Ut Southwestern Medical Center | In situ langerhans cell vaccine |
| JP2002263981A (ja) | 2001-03-14 | 2002-09-17 | Murata Mach Ltd | 板材吸着持ち上げ装置の吸着制御装置 |
| US6656488B2 (en) | 2001-04-11 | 2003-12-02 | Ethicon Endo-Surgery, Inc. | Bioabsorbable bag containing bioabsorbable materials of different bioabsorption rates for tissue engineering |
| US20030082806A1 (en) | 2001-04-27 | 2003-05-01 | Xcyte Therapies, Inc. | Maturation of antigen-presenting cells using activated T cells |
| WO2002092054A2 (en) * | 2001-05-11 | 2002-11-21 | Ortho-Mcneil Pharmaceutical, Inc. | Immune modulation device for use in animals |
| US20030118630A1 (en) | 2001-12-07 | 2003-06-26 | Anthony Cerami | Immune modulation device for use in animals |
| EP1407261A4 (en) | 2001-06-13 | 2006-11-22 | Massachusetts Inst Technology | BIOREACTORS FOR IN VIVO REACTIONS |
| US7297343B2 (en) | 2001-07-31 | 2007-11-20 | Biosurface Engineering Technologies, Inc. | Bioactive medical films |
| US7354909B2 (en) | 2001-08-14 | 2008-04-08 | The United States Of America As Represented By Secretary Of The Department Of Health And Human Services | Method for rapid generation of mature dendritic cells |
| CA2412012C (en) | 2001-11-20 | 2011-08-02 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Resorbable extracellular matrix containing collagen i and collagen ii for reconstruction of cartilage |
| US7101862B2 (en) | 2001-12-31 | 2006-09-05 | Area Laboratories, Llc | Hemostatic compositions and methods for controlling bleeding |
| US7575759B2 (en) | 2002-01-02 | 2009-08-18 | The Regents Of The University Of Michigan | Tissue engineering scaffolds |
| US20070026518A1 (en) | 2005-03-29 | 2007-02-01 | The Regents Of The University Of California | Controlling stem cell destiny with tunable matrices |
| US20080233181A1 (en) | 2002-04-12 | 2008-09-25 | Nagy Jon O | Nanoparticle adjuvants for sub-unit vaccines |
| US6811777B2 (en) | 2002-04-13 | 2004-11-02 | Allan Mishra | Compositions and minimally invasive methods for treating incomplete connective tissue repair |
| WO2003089506A1 (en) | 2002-04-22 | 2003-10-30 | Purdue Research Foundation | Hydrogels having enhanced elasticity and mechanical strength properties |
| KR101092043B1 (ko) | 2002-04-22 | 2011-12-12 | 바이오니취 라이프 사이언시즈 인코포레이티드 | 올리고뉴클레오티드 조성물 및 면역 반응 조절시 이의 용도 |
| AU2003249606A1 (en) | 2002-05-13 | 2003-12-02 | Massachusetts Institute Of Technology | Angiogenesis and cardiac tissue engineering with peptide hydrogels and related compositions and methods of use thereof |
| AUPS312602A0 (en) | 2002-06-21 | 2002-07-18 | James Cook University | Organ arrest, protection, preservation and recovery |
| US7332160B2 (en) | 2002-07-12 | 2008-02-19 | Boston Scientific Scimed, Inc. | Medical device and method for tissue removal and repair |
| EP1548032B9 (en) | 2002-09-12 | 2009-10-28 | Oncotherapy Science, Inc. | Kdr peptides and vaccines comprising the same |
| US20040136968A1 (en) | 2002-09-27 | 2004-07-15 | Verigen Ag | Autologous cells on a support matrix for tissue repair |
| US20040063206A1 (en) | 2002-09-30 | 2004-04-01 | Rowley Jon A. | Programmable scaffold and method for making and using the same |
| AU2003272805A1 (en) | 2002-10-01 | 2004-04-23 | Peter K. Law | Bioactive implants |
| JP2004159849A (ja) | 2002-11-12 | 2004-06-10 | National Institute Of Advanced Industrial & Technology | 細胞接着性生体吸収材料、人工血管およびそれらの製造方法 |
| WO2004056875A1 (en) | 2002-12-23 | 2004-07-08 | Wyeth | Antibodies against pd-1 and uses therefor |
| US8940292B2 (en) | 2003-01-28 | 2015-01-27 | Wake Forest University Health Sciences | Enhancement of angiogenesis to grafts using cells engineered to produce growth factors |
| SE0301109D0 (sv) | 2003-04-14 | 2003-04-14 | Mallen Huang | Nucleotide vaccine composition |
| JP2006525405A (ja) | 2003-05-05 | 2006-11-09 | ベン‐グリオン ユニバーシティ オブ ザ ネゲヴ リサーチ アンド デベロップメント オーソリティ | 注入可能な架橋されたポリマー調製物およびその使用 |
| EP1475434A1 (en) | 2003-05-09 | 2004-11-10 | Oncoscience AG | Method for storing tumor cells |
| AU2004263094A1 (en) | 2003-07-09 | 2005-02-17 | Vaxdesign Corporation | Programmed immune responses using a vaccination node |
| US20060264380A1 (en) | 2003-07-21 | 2006-11-23 | Mats Hellstrom | Compounds and Methods for Promoting Angiogenesis |
| JP2007500721A (ja) | 2003-07-31 | 2007-01-18 | エンダセア,インク. | 抗原応答を生じさせる方法及び組成物 |
| GB0317999D0 (en) | 2003-07-31 | 2003-09-03 | Univ Liege | Improvements in or relating to drug delivery systems |
| CA2535857A1 (en) | 2003-08-29 | 2005-03-10 | Mayo Foundation For Medical Education And Research | Hydrogel porogens for fabricating biodegradable scaffolds |
| EP2481422A3 (en) | 2003-09-03 | 2013-04-03 | Dendritherapeutics, Inc. | Multiplex vaccines |
| GB0321615D0 (en) | 2003-09-15 | 2003-10-15 | Glaxo Group Ltd | Improvements in vaccination |
| EP2591786B1 (en) | 2003-10-16 | 2017-04-12 | Cancure Limited | Immunomodulating compositions and uses therefor |
| EP1689289B1 (en) | 2003-11-07 | 2016-12-21 | Carnegie Mellon University | Robot for minimally invasive interventions |
| CA2448995A1 (en) | 2003-11-12 | 2005-05-12 | James Keenan | Device and method for attracting diseased cells and foreign substances |
| JP2005160669A (ja) | 2003-12-02 | 2005-06-23 | Olympus Corp | 生体組織補填体の製造方法 |
| JP2005170816A (ja) | 2003-12-09 | 2005-06-30 | Naoki Ishiguro | 軟骨修復用材料、およびその製造方法 |
| JP4772693B2 (ja) | 2003-12-11 | 2011-09-14 | ヴァックスデザイン・コーポレーション | 免疫治療組成物、その製造方法及び使用方法 |
| US11395865B2 (en) | 2004-02-09 | 2022-07-26 | DePuy Synthes Products, Inc. | Scaffolds with viable tissue |
| US7192693B2 (en) | 2004-02-24 | 2007-03-20 | University Of Washington | Methods for photopatterning hydrogels |
| EP1740192B1 (en) | 2004-03-15 | 2012-06-13 | David K. R. Karaolis | Cyclic dinucleotide for stimulating the immune of inflammatory response |
| EP1758985B1 (en) | 2004-04-28 | 2015-06-03 | Sanofi Pasteur VaxDesign Corporation | Artificial immune system: methods for making and use |
| JP2008501807A (ja) | 2004-06-08 | 2008-01-24 | コーリー ファーマシューティカル ゲーエムベーハー | 抗原ならびに免疫活性化アゴニストおよび免疫活性化アンタゴニストのための担体基本骨格としての無塩基オリゴヌクレオチド |
| US8080245B2 (en) | 2004-08-04 | 2011-12-20 | University Of Massachusetts | Anti-pathogen immunoadhesins |
| JP2008511336A (ja) | 2004-09-01 | 2008-04-17 | アメリカ合衆国 | 免疫原性が増加したアデノウイルスベクターをインビボで用いる方法 |
| US7235592B2 (en) | 2004-10-12 | 2007-06-26 | Zimmer Gmbh | PVA hydrogel |
| MX2007004261A (es) | 2004-10-12 | 2007-06-18 | Fmc Biopolymer As | Sistemas de alginato auto-gelificantes y usos de los mismos. |
| US7999161B2 (en) | 2005-01-22 | 2011-08-16 | Alexander Oraevsky | Laser-activated nanothermolysis of cells |
| US7569850B2 (en) | 2005-01-24 | 2009-08-04 | Lawrence Livermore National Security, Llc | Lipid bilayers on nano-templates |
| EP1877000B1 (en) | 2005-03-23 | 2012-10-17 | Mayo Foundation For Medical Education And Research | Photocrosslinkable oligo(poly (ethylene glycol) fumarate) hydrogels for cell and drug delivery |
| EP1712238A1 (en) | 2005-04-11 | 2006-10-18 | Institut Gustave Roussy | Anthracyclin induced immunogenic dead or dying cells composition |
| US8828433B2 (en) | 2005-04-19 | 2014-09-09 | Advanced Cardiovascular Systems, Inc. | Hydrogel bioscaffoldings and biomedical device coatings |
| US20070003595A1 (en) | 2005-04-19 | 2007-01-04 | Shaopeng Wang | Three dimensional micro-environments and methods of making and using same |
| CN101355928B (zh) | 2005-04-26 | 2013-05-22 | 卫材R&D管理株式会社 | 用于癌症免疫疗法的组合物和方法 |
| WO2006119619A1 (en) | 2005-05-06 | 2006-11-16 | Replicor Inc. | Oligonucleotides inhibiting cell proliferation |
| ITPI20050071A1 (it) | 2005-06-20 | 2006-12-21 | Giuseppe Calvosa | Composizione biocompatibile per la sostituzione/rigenerazione di tessuti |
| US7645742B2 (en) | 2005-06-22 | 2010-01-12 | Advocare International, L.P. | Composition for enhancing cellular energy |
| CN1302050C (zh) | 2005-07-07 | 2007-02-28 | 复旦大学 | 一种互穿网络聚合物超多孔水凝胶及其制备方法和应用 |
| WO2007022188A2 (en) | 2005-08-15 | 2007-02-22 | New York Society For The Relief Of The Ruptured And Crippled Maintaining The Hospital For Special Surgery | A porous non-biodegradable hydrogel admixed with a chemoattractant for tissue replacement |
| BRPI0503817A (pt) | 2005-09-12 | 2007-05-15 | Cristalia Prod Quimicos Farm | complexo imunogênico formado por antìgenos vacinais encapsulados por sìlica mesoporosa nanoestruturada |
| WO2007039150A2 (en) | 2005-09-23 | 2007-04-12 | Cellerix, S.L. | Cell populations having immunoregulatory activity, method for isolation and uses |
| WO2007041190A2 (en) | 2005-09-30 | 2007-04-12 | The University Of Iowa Research Foundation | Polymer-based delivery system for immunotherapy of cancer |
| EA200801045A1 (ru) | 2005-10-12 | 2008-10-30 | Кэнсер Рисерч Текнолоджи Лтд. | Способы и композиции для лечения иммунных нарушений |
| US8029575B2 (en) | 2005-10-25 | 2011-10-04 | Globus Medical, Inc. | Porous and nonporous materials for tissue grafting and repair |
| US20070116680A1 (en) | 2005-11-18 | 2007-05-24 | Rensselaer Polytechnic Institute | Stem cells within gel microenvironments |
| PT2119450E (pt) | 2005-11-29 | 2013-04-26 | Actogenix Nv | Indução de tolerância da mucosa a autoantigénios de células beta de ilhéus pancreáticos |
| KR100687281B1 (ko) | 2005-11-30 | 2007-02-27 | 한국과학기술연구원 | 생리 활성 물질이 결합된 조직 재생용 주입형 온도 감응성플루로닉 유도체 하이드로겔 및 이의 제조 방법 |
| US8367628B2 (en) | 2005-12-01 | 2013-02-05 | Pronai Therapeutics, Inc. | Amphoteric liposome formulation |
| ES2804472T3 (es) | 2005-12-13 | 2021-02-08 | Harvard College | Estructuras para trasplante celular |
| AU2015264807A1 (en) | 2005-12-13 | 2015-12-17 | President And Fellows Of Harvard College | Scaffolds for Cell Transplantation |
| CN101330934B (zh) | 2005-12-14 | 2013-03-20 | Scil技术有限公司 | 一种用于骨再生的可模压的生物材料及其制备方法和用途 |
| EP1806395A1 (en) | 2006-01-06 | 2007-07-11 | Stichting Sanquin Bloedvoorziening | Maturation of dendritic cells |
| US7615556B2 (en) | 2006-01-27 | 2009-11-10 | Bristol-Myers Squibb Company | Piperazinyl derivatives as modulators of chemokine receptor activity |
| US20070178159A1 (en) | 2006-01-30 | 2007-08-02 | Alza Corporation | In-Situ Forming Porous Scaffold |
| CA2676601A1 (en) | 2006-01-31 | 2007-08-09 | Medivas, Llc | Vaccine delivery compositions and methods of use |
| US20100015709A1 (en) | 2006-02-10 | 2010-01-21 | Trustees Of The University Of Pennsylvania | Regulating Stem Cell Differentiation By Controlling 2D and 3D Matrix Elasticity |
| US20070190646A1 (en) | 2006-02-10 | 2007-08-16 | The Trustees Of The University Of Pennsylvania | Regulating stem cell differentiation by controlling matrix elasticity |
| EP1988938A4 (en) | 2006-02-27 | 2011-09-28 | Agency Science Tech & Res | CEMENT BONE CURABLE |
| US9456860B2 (en) | 2006-03-14 | 2016-10-04 | Kci Licensing, Inc. | Bioresorbable foaming tissue dressing |
| GB0605521D0 (en) | 2006-03-18 | 2006-04-26 | Isis Innovation | Adjuvant |
| WO2008127256A1 (en) | 2006-06-01 | 2008-10-23 | Massachusetts Institute Of Technology | Control of cells and cell multipotentiality in three dimensional matrices |
| WO2007146319A2 (en) | 2006-06-13 | 2007-12-21 | Symphony Medical, Inc. | Methods and apparatus for using polymer-based beads and hydrogels for cardiac applications |
| US20070298067A1 (en) | 2006-06-22 | 2007-12-27 | Boston Scientific Scimed, Inc. | Control release drug coating for medical devices |
| CA2690973A1 (en) | 2006-06-23 | 2007-12-27 | Paul M. Simon | Targeted immune conjugates |
| US8535719B2 (en) | 2006-07-07 | 2013-09-17 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Biohybrid elastomeric scaffolds and methods of use thereof |
| US7993918B2 (en) | 2006-08-04 | 2011-08-09 | Anthrogenesis Corporation | Tumor suppression using placental stem cells |
| KR100802139B1 (ko) | 2006-08-08 | 2008-02-11 | 한국생명공학연구원 | 자성 나노입자를 함유하는 골드 나노케이지 |
| KR100818708B1 (ko) | 2006-08-18 | 2008-04-01 | 주식회사 하이닉스반도체 | 표면 세정을 포함하는 반도체소자 제조방법 |
| ITMI20061726A1 (it) | 2006-09-11 | 2008-03-12 | Fidia Farmaceutici | Derivati crosslinkati a base di acido ialuronico reticolato via click chemistry |
| AU2007297611B2 (en) | 2006-09-21 | 2013-02-07 | Purdue Research Foundation | Collagen preparation and method of isolation |
| EP2077821B1 (en) | 2006-10-12 | 2019-08-14 | The University Of Queensland | Compositions and methods for modulating immune responses |
| US20080114277A1 (en) | 2006-11-09 | 2008-05-15 | Archel Ambrosio | Porous bioresorbable dressing conformable to a wound and methods of making same |
| WO2008086486A1 (en) | 2007-01-10 | 2008-07-17 | The Regents Of The University Of Michigan | Porous objects having immobilized encapsulated biomolecules |
| EP2131856B1 (en) | 2007-03-07 | 2014-09-17 | UTI Limited Partnership | Compositions and methods for the prevention and treatment of autoimmune conditions |
| JP2010522540A (ja) | 2007-03-21 | 2010-07-08 | アイディー バイオメディカル コーポレイション オブ ケベック | キメラ抗原 |
| WO2008118392A2 (en) | 2007-03-22 | 2008-10-02 | The Regents Of The University Of California | Synthetic cell platforms and methods of use thereof |
| EP1975230A1 (en) | 2007-03-30 | 2008-10-01 | Capsulution Nanoscience AG | Method for forming glucose sensing micro-particles, use of micro-particles, and kit |
| WO2008131074A1 (en) | 2007-04-19 | 2008-10-30 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Use of toll-like receptor-9 agonists, toll-like receptor-4 antagonists, and/or nuclear oligomerization domain-2 agonists for the treatment or prevention of toll-like receptor-4-associated disorders |
| US20100183602A1 (en) | 2007-06-05 | 2010-07-22 | Novartis Ag | Induction of Tolerogenic Phenotype in Mature Dendritic Cells |
| JP2010531138A (ja) | 2007-06-13 | 2010-09-24 | ラ ホヤ インスティテュート フォア アラージー アンド イムノロジー | 制御性t細胞ならびに同製造および使用方法 |
| US9770535B2 (en) * | 2007-06-21 | 2017-09-26 | President And Fellows Of Harvard College | Scaffolds for cell collection or elimination |
| CN101855337B (zh) | 2007-06-29 | 2017-10-31 | 船木真理 | 用于进行干细胞调节的软凝胶系统 |
| CN102317303A (zh) | 2007-07-31 | 2012-01-11 | 约翰·霍普金斯大学 | 用于肿瘤或感染性疾病的免疫预防或免疫治疗的多肽-核酸偶联物 |
| GB0716264D0 (en) | 2007-08-21 | 2007-09-26 | Isis Innovation | Bilayers |
| US20090192079A1 (en) | 2007-10-09 | 2009-07-30 | Genzyme Corporation | Prolonged delivery of heparin-binding growth factors from heparin-derivatized collagen |
| KR100900837B1 (ko) | 2007-12-07 | 2009-06-04 | (주)두비엘 | 리포펩타이드와 폴리(i:c)를 아쥬반트로 포함하는 강력한백신 조성물 |
| EP2072617A1 (en) | 2007-12-12 | 2009-06-24 | Trimed Biotech GmbH | Method for producing dendritic cells |
| DE102008008522A1 (de) | 2008-02-11 | 2009-08-13 | Magforce Nanotechnologies Ag | Implantierbare Nanopartikel-enthaltende Produkte |
| EP2254602B1 (en) | 2008-02-13 | 2018-11-21 | President and Fellows of Harvard College | Continuous cell programming devices |
| US9370558B2 (en) * | 2008-02-13 | 2016-06-21 | President And Fellows Of Harvard College | Controlled delivery of TLR agonists in structural polymeric devices |
| WO2011063336A2 (en) | 2009-11-20 | 2011-05-26 | President And Fellows Of Harvard College | Secondary site of antigen stimulation for therapeutic vaccination |
| WO2009117721A1 (en) | 2008-03-21 | 2009-09-24 | 3D Biotek, Llc | Hybrid biomedical device fabricated from biomaterials and coated with a cell culture derived ecm coating |
| AU2009241645B2 (en) * | 2008-05-02 | 2014-07-17 | Blink Therapeutics Limited | Products and methods for stimulating an immune response |
| WO2009146456A1 (en) | 2008-05-30 | 2009-12-03 | President And Fellows Of Harvard College | Controlled release of growth factors and signaling molecules for promoting angiogenesis |
| US20110182957A1 (en) | 2008-06-19 | 2011-07-28 | Nicoll Steven B | Cellulosics for tissue replacement |
| EA023148B1 (ru) | 2008-08-25 | 2016-04-29 | Эмплиммьюн, Инк. | Композиции на основе антагонистов pd-1 и их применение |
| US8889124B2 (en) | 2008-09-25 | 2014-11-18 | The Board Of Trustees Of The Leland Stanford Junior University | Tolerogenic populations of dendritic cells |
| US8940331B2 (en) | 2008-11-22 | 2015-01-27 | The Board Of Trustees Of The Leland Stanford Junior University | Hydrogels, methods of making hydrogels, methods of using hydrogels, and methods of isolating, trapping, attracting, and/or killing cancer cells |
| KR101132732B1 (ko) | 2008-11-26 | 2012-04-06 | 한국과학기술연구원 | 인 시튜 조직재생용 지능형 다공성 생분해 고분자 지지체 및 이의 제조방법 |
| US8273373B2 (en) | 2008-12-30 | 2012-09-25 | Case Western Reserve University | Photocrosslinked biodegradable hydrogel |
| EP2385980B1 (en) | 2009-01-08 | 2018-04-18 | Albert Einstein College of Medicine, Inc. | Bacterial vaccines with cell wall-associated ceramide-like glycolipids and uses thereof |
| JP2010227012A (ja) | 2009-03-27 | 2010-10-14 | Seiko Epson Corp | がん細胞捕捉デバイス |
| WO2010120749A2 (en) | 2009-04-13 | 2010-10-21 | President And Fellow Of Harvard College | Harnessing cell dynamics to engineer materials |
| US8551749B2 (en) | 2009-04-23 | 2013-10-08 | The Invention Science Fund I, Llc | Device including bone cage and method for treatment of disease in a subject |
| CA2768552A1 (en) | 2009-07-31 | 2011-02-03 | President And Fellows Of Harvard College | Programming of cells for tolerogenic therapies |
| CN101655611B (zh) | 2009-09-11 | 2011-06-08 | 中国科学院长春应用化学研究所 | 一种具有双层杂化结构的反蛋白石水凝胶光子晶体的制备方法 |
| WO2011043835A1 (en) | 2009-10-09 | 2011-04-14 | Anaphore, Inc. | Polypeptides that bind il-23r |
| CA2776954A1 (en) | 2009-10-09 | 2011-04-14 | Anaphore, Inc. | Combinatorial libraries based on c-type lectin domain |
| US20110207166A1 (en) | 2009-11-06 | 2011-08-25 | Sarah Rivkah Vaiselbuh | Human bone marrow microenvironments and uses thereof |
| US8889044B2 (en) | 2009-12-18 | 2014-11-18 | Kao Corporation | Method for producing mesoporous silica particles |
| JP5603063B2 (ja) | 2009-12-21 | 2014-10-08 | 花王株式会社 | 複合シリカ粒子の製造方法 |
| CA2787376A1 (en) | 2010-01-19 | 2011-07-28 | President And Fellows Of Harvard College | Engineered opsonin for pathogen detection and treatment |
| US9795990B2 (en) | 2010-02-22 | 2017-10-24 | Incredible Foods, Inc. | Enclosing materials in natural transport systems |
| EP2542343B1 (en) | 2010-03-02 | 2017-11-08 | King Abdullah University Of Science And Technology | High surface area fibrous silica nanoparticles |
| JP5647669B2 (ja) | 2010-03-04 | 2015-01-07 | 地方独立行政法人東京都立産業技術研究センター | 多孔質シリカの製造方法 |
| US9610328B2 (en) | 2010-03-05 | 2017-04-04 | President And Fellows Of Harvard College | Enhancement of skeletal muscle stem cell engraftment by dual delivery of VEGF and IGF-1 |
| EP2547371A1 (en) | 2010-03-15 | 2013-01-23 | Ferrosan Medical Devices A/S | A method for promotion of hemostasis and/or wound healing |
| US20110256184A1 (en) | 2010-04-14 | 2011-10-20 | Battelle Memorial Institute | Non-ordered Mesoporous Silica Structure for Biomolecule Loading and Release |
| US20110300186A1 (en) | 2010-04-14 | 2011-12-08 | Battelle Memorial Institute | Functionalized Nano- and Micro-materials for Medical Therapies |
| CN106177940A (zh) | 2010-05-26 | 2016-12-07 | 西莱克塔生物科技公司 | 含有佐剂的合成纳米载体的剂量选择 |
| GB201009273D0 (en) | 2010-06-03 | 2010-07-21 | Glaxosmithkline Biolog Sa | Novel vaccine |
| US9693954B2 (en) | 2010-06-25 | 2017-07-04 | President And Fellows Of Harvard College | Co-delivery of stimulatory and inhibitory factors to create temporally stable and spatially restricted zones |
| CN103118678A (zh) | 2010-07-16 | 2013-05-22 | 约翰斯·霍普金斯大学 | 用于癌症免疫治疗的方法和组合物 |
| JP5894989B2 (ja) | 2010-08-04 | 2016-03-30 | ジョージア テック リサーチ コーポレイション | 癌細胞を摘出するための装置、システム、及び方法 |
| WO2012048165A2 (en) | 2010-10-06 | 2012-04-12 | President And Fellows Of Harvard College | Injectable, pore-forming hydrogels for materials-based cell therapies |
| WO2012064697A2 (en) | 2010-11-08 | 2012-05-18 | President And Fellows Of Harvard College | Materials presenting notch signaling molecules to control cell behavior |
| US10647959B2 (en) | 2011-04-27 | 2020-05-12 | President And Fellows Of Harvard College | Cell-friendly inverse opal hydrogels for cell encapsulation, drug and protein delivery, and functional nanoparticle encapsulation |
| US9675561B2 (en) | 2011-04-28 | 2017-06-13 | President And Fellows Of Harvard College | Injectable cryogel vaccine devices and methods of use thereof |
| US10045947B2 (en) | 2011-04-28 | 2018-08-14 | President And Fellows Of Harvard College | Injectable preformed macroscopic 3-dimensional scaffolds for minimally invasive administration |
| AU2012249553A1 (en) | 2011-04-29 | 2013-10-24 | Selecta Biociences, Inc. | Tolerogenic synthetic nanocarriers for allergy therapy |
| WO2012167230A1 (en) | 2011-06-03 | 2012-12-06 | President And Fellows Of Harvard College | In situ antigen-generating cancer vaccine |
| KR20190015600A (ko) | 2011-06-24 | 2019-02-13 | 아르퀼 인코포레이티드 | 치환된 이미다조피리디닐-아미노피리딘 화합물 |
| WO2013012924A2 (en) | 2011-07-18 | 2013-01-24 | President And Fellows Of Harvard College | Engineered microbe-targeting molecules and uses thereof |
| US20130145488A1 (en) | 2011-12-06 | 2013-06-06 | Iowa State University Research Foundation, Inc. | Mesoporous silica nanoparticles suitable for co-delivery |
| JP6293674B2 (ja) * | 2012-01-13 | 2018-03-14 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 構造化ポリマー装置におけるtlrアゴニストの制御送達 |
| WO2013135359A1 (en) | 2012-03-16 | 2013-09-19 | Merck Patent Gmbh | Targeting aminoacid lipids |
| CN104244929B (zh) | 2012-04-16 | 2017-04-05 | 哈佛学院董事会 | 用于调节免疫反应的介孔二氧化硅组合物 |
| EP2849567B1 (en) * | 2012-05-17 | 2022-03-23 | Extend Biosciences, Inc. | Carriers for improved drug delivery |
| NZ622452A (en) | 2012-06-21 | 2017-10-27 | Compugen Ltd | Lsr antibodies, and uses thereof for treatment of cancer |
| US20140072510A1 (en) * | 2012-09-13 | 2014-03-13 | Northwestern University | Synthetic Scaffolds for Metastasis Detection |
| CN105209074A (zh) | 2012-10-20 | 2015-12-30 | 得克萨斯大学体系董事会 | 癌细胞陷阱 |
| CA2902841A1 (en) | 2013-03-13 | 2014-10-02 | Creatics Llc | Methods and compositions for detecting pancreatic cancer |
| SI2996473T1 (sl) | 2013-05-18 | 2019-12-31 | Aduro Biotech, Inc. | Sestavki in postopki za aktiviranje signaliziranja, odvisnega od "stimulator interferonskih genov" |
| EP3848045A1 (en) | 2013-05-21 | 2021-07-14 | President and Fellows of Harvard College | Engineered heme-binding compositions and uses thereof |
| WO2014190229A1 (en) | 2013-05-24 | 2014-11-27 | President And Fellows Of Harvard College | Methods of isolating microorganisms and uses thereof |
| CA2929277C (en) | 2013-11-01 | 2018-01-16 | Yale University | Delivery vehicles comprising il-2 and losartan |
| WO2015154078A1 (en) | 2014-04-04 | 2015-10-08 | President And Fellows Of Harvard College | Click-crosslinked hydrogels and methods of use |
| EP3137105A4 (en) | 2014-04-30 | 2017-12-27 | President and Fellows of Harvard College | Combination vaccine devices and methods of killing cancer cells |
| US11065362B2 (en) | 2014-06-12 | 2021-07-20 | President And Fellows Of Harvard College | Viscoelastic hydrogels with fast stress relaxation |
| WO2016004068A1 (en) | 2014-06-30 | 2016-01-07 | Jae-Won Shin | Hydrogel compositions comprising encapsulated cells and methods of use thereof |
| US11786457B2 (en) | 2015-01-30 | 2023-10-17 | President And Fellows Of Harvard College | Peritumoral and intratumoral materials for cancer therapy |
| US20180117171A1 (en) | 2015-04-01 | 2018-05-03 | President And Fellows Of Harvard College | Immunoconjugates for programming or reprogramming of cells |
| WO2017024114A1 (en) | 2015-08-06 | 2017-02-09 | President And Fellows Of Harvard College | Improved microbe-binding molecules and uses thereof |
| JP7138864B2 (ja) | 2016-02-06 | 2022-09-20 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 免疫を再構成するための造血ニッチの再現 |
| US10813988B2 (en) | 2016-02-16 | 2020-10-27 | President And Fellows Of Harvard College | Pathogen vaccines and methods of producing and using the same |
| US11555177B2 (en) | 2016-07-13 | 2023-01-17 | President And Fellows Of Harvard College | Antigen-presenting cell-mimetic scaffolds and methods for making and using the same |
| CA3032505A1 (en) | 2016-08-02 | 2018-02-08 | President And Fellows Of Harvard College | Biomaterials for modulating immune responses |
-
2016
- 2016-04-08 WO PCT/US2016/026617 patent/WO2016164705A1/en not_active Ceased
- 2016-04-08 US US15/564,905 patent/US11150242B2/en active Active
- 2016-04-08 CN CN202111373327.XA patent/CN114099793A/zh active Pending
- 2016-04-08 HK HK18109141.9A patent/HK1249452A1/zh unknown
- 2016-04-08 CN CN201680027983.5A patent/CN107708756A/zh active Pending
- 2016-04-08 JP JP2017552479A patent/JP7094533B2/ja active Active
- 2016-04-08 EP EP16777342.3A patent/EP3280464A4/en active Pending
-
2021
- 2021-01-04 JP JP2021000075A patent/JP2021048879A/ja not_active Withdrawn
- 2021-10-14 US US17/501,821 patent/US20220107308A1/en not_active Abandoned
-
2023
- 2023-09-19 JP JP2023151662A patent/JP2023166584A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018510887A5 (enExample) | ||
| JP2023166584A (ja) | 免疫細胞捕捉デバイスおよびその製造および使用方法 | |
| JP7348708B2 (ja) | 組み合わせワクチン装置および癌細胞を殺滅する方法 | |
| Becher et al. | Brain‐immune connection: immuno‐regulatory properties of CNS‐resident cells | |
| Xiao et al. | Programming for CD8 T cell memory development requires IL-12 or type I IFN | |
| JP5690143B2 (ja) | 持続的細胞プログラミング装置 | |
| JP6293674B2 (ja) | 構造化ポリマー装置におけるtlrアゴニストの制御送達 | |
| US20220339274A1 (en) | Biomaterial-based antigen free vaccine and the use thereof | |
| Butler et al. | Immunologic considerations for generating memory CD8 T cells through vaccination | |
| JP2019522486A5 (enExample) | ||
| US20110027181A1 (en) | Device including altered microorganisms, and methods and systems of use | |
| CN110418651A (zh) | 用于调节免疫应答的生物材料 | |
| US20110172826A1 (en) | Device including altered microorganisms, and methods and systems of use | |
| US20110028945A1 (en) | Device including altered microorganisms, and methods and systems of use | |
| Bonato et al. | Immune regulatory effect of pHSP65 DNA therapy in pulmonary tuberculosis: activation of CD8+ cells, interferon‐γ recovery and reduction of lung injury | |
| JP2007523863A5 (enExample) | ||
| Nawwab Al-Deen et al. | Design of magnetic polyplexes taken up efficiently by dendritic cell for enhanced DNA vaccine delivery | |
| JP2012524793A (ja) | 免疫調節性生体分子を組み合わせて送達するためのヒドロゲル | |
| JP2019509715A5 (enExample) | ||
| US20230050258A1 (en) | Immunotherapeutic treatment of cancer | |
| Woo et al. | Role of natural killer cell function in dendritic cell-based vaccines | |
| CN117797250A (zh) | 个体化mRNA组合物、载体、mRNA疫苗及其应用 | |
| Dawson et al. | Surface-Presentation of CpG and Protein–Antigen on Pathogen-Like Polymer Particles Generate Strong Prophylactic and Therapeutic Antitumor Protection | |
| US20250144231A1 (en) | Compositions and methods for localized delivery of cytokines for adoptive cell therapy | |
| CN117320717A (zh) | 包含与高亲和力il-2受体激动剂组合的免疫抑制剂以增强免疫耐受性的合成纳米载体 |