JP2018510139A5 - - Google Patents
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- Publication number
- JP2018510139A5 JP2018510139A5 JP2017544035A JP2017544035A JP2018510139A5 JP 2018510139 A5 JP2018510139 A5 JP 2018510139A5 JP 2017544035 A JP2017544035 A JP 2017544035A JP 2017544035 A JP2017544035 A JP 2017544035A JP 2018510139 A5 JP2018510139 A5 JP 2018510139A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- compound
- substituted
- fluorine atoms
- chf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims description 91
- 125000001153 fluoro group Chemical group F* 0.000 claims description 35
- 229910052731 fluorine Inorganic materials 0.000 claims description 32
- 239000008194 pharmaceutical composition Substances 0.000 claims description 32
- 150000003839 salts Chemical class 0.000 claims description 15
- 239000012453 solvate Substances 0.000 claims description 15
- 206010016654 Fibrosis Diseases 0.000 claims description 6
- 230000004761 fibrosis Effects 0.000 claims description 6
- 102000006495 integrins Human genes 0.000 claims description 6
- 108010044426 integrins Proteins 0.000 claims description 6
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
- 201000010099 disease Diseases 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 210000002216 heart Anatomy 0.000 claims description 2
- 210000000936 intestine Anatomy 0.000 claims description 2
- 210000003734 kidney Anatomy 0.000 claims description 2
- 210000004185 liver Anatomy 0.000 claims description 2
- 210000004072 lung Anatomy 0.000 claims description 2
- 230000001404 mediated effect Effects 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 description 8
- 125000000217 alkyl group Chemical group 0.000 description 8
- 0 CN(CCN1C)C1=* Chemical compound CN(CCN1C)C1=* 0.000 description 5
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562118303P | 2015-02-19 | 2015-02-19 | |
| US62/118,303 | 2015-02-19 | ||
| PCT/US2016/018612 WO2016134223A2 (en) | 2015-02-19 | 2016-02-19 | Fluorinated tetrahydronaphthyridinyl nonanoic acid derivatives and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020171641A Division JP7191299B2 (ja) | 2015-02-19 | 2020-10-12 | フッ化テトラヒドロナフチリジニルノナン酸誘導体およびその使用法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018510139A JP2018510139A (ja) | 2018-04-12 |
| JP2018510139A5 true JP2018510139A5 (OSRAM) | 2019-03-14 |
Family
ID=56689184
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017544035A Pending JP2018510139A (ja) | 2015-02-19 | 2016-02-19 | フッ化テトラヒドロナフチリジニルノナン酸誘導体およびその使用法 |
| JP2020171641A Active JP7191299B2 (ja) | 2015-02-19 | 2020-10-12 | フッ化テトラヒドロナフチリジニルノナン酸誘導体およびその使用法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020171641A Active JP7191299B2 (ja) | 2015-02-19 | 2020-10-12 | フッ化テトラヒドロナフチリジニルノナン酸誘導体およびその使用法 |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US9790222B2 (OSRAM) |
| EP (2) | EP3259271B1 (OSRAM) |
| JP (2) | JP2018510139A (OSRAM) |
| KR (1) | KR102647026B1 (OSRAM) |
| CN (2) | CN114805342A (OSRAM) |
| AU (1) | AU2016219906B2 (OSRAM) |
| BR (1) | BR112017017888A2 (OSRAM) |
| CA (1) | CA2976634C (OSRAM) |
| ES (1) | ES2892954T3 (OSRAM) |
| IL (1) | IL253873A0 (OSRAM) |
| RU (1) | RU2017132433A (OSRAM) |
| TW (1) | TWI736529B (OSRAM) |
| WO (1) | WO2016134223A2 (OSRAM) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2953948T3 (en) | 2013-02-07 | 2017-12-18 | Scifluor Life Sciences Inc | FLUORINATED INTEGRIN ANTAGONISTS |
| US8901144B2 (en) * | 2013-02-07 | 2014-12-02 | Scifluor Life Sciences, Llc | Fluorinated 3-(2-oxo-3-(3-arylpropyl)imidazolidin-1-yl)-3-arylpropanoic acid derivatives |
| GB201305668D0 (en) | 2013-03-28 | 2013-05-15 | Glaxosmithkline Ip Dev Ltd | Avs6 Integrin Antagonists |
| GB201417002D0 (en) | 2014-09-26 | 2014-11-12 | Glaxosmithkline Ip Dev Ltd | Novel compound |
| GB201417094D0 (en) | 2014-09-26 | 2014-11-12 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| GB201417018D0 (en) | 2014-09-26 | 2014-11-12 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| GB201417011D0 (en) | 2014-09-26 | 2014-11-12 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| CN114805342A (zh) * | 2015-02-19 | 2022-07-29 | 赛弗卢尔生命科学公司 | 氟化四氢萘啶基壬酸衍生物及其用途 |
| WO2016154369A1 (en) * | 2015-03-26 | 2016-09-29 | Merck Sharp & Dohme Corp. | Composition and methods for treating chronic kidney disease |
| AU2016255494A1 (en) * | 2015-04-30 | 2017-11-02 | Scifluor Life Sciences, Inc. | Tetrahydronaphthyridinyl propionic acid derivatives and uses thereof |
| GB201604680D0 (en) | 2016-03-21 | 2016-05-04 | Glaxosmithkline Ip Dev Ltd | Chemical Compounds |
| WO2017189828A1 (en) | 2016-04-27 | 2017-11-02 | Scifluor Life Sciences, Inc. | Nonanoic and decanoic acid derivatives and uses thereof |
| WO2018049068A1 (en) | 2016-09-07 | 2018-03-15 | Pliant Therapeutics, Inc. | N-acyl amino acid compounds and methods of use |
| ES2886650T3 (es) | 2016-11-08 | 2021-12-20 | Bristol Myers Squibb Co | Derivados de indazol como antagonistas de integrina alfaV |
| WO2018089360A1 (en) | 2016-11-08 | 2018-05-17 | Bristol-Myers Squibb Company | Pyrrole amides as alpha v integrin inhibitors |
| EP3538527B1 (en) | 2016-11-08 | 2021-10-13 | Bristol-Myers Squibb Company | Azole amides and amines as alpha v integrin inhibitors |
| TW201819378A (zh) * | 2016-11-08 | 2018-06-01 | 美商必治妥美雅史谷比公司 | 作為αｖ整合素抑制劑之含環丁烷及氮雜環丁烷之單及螺環化合物 |
| EP3538525B1 (en) | 2016-11-08 | 2022-06-22 | Bristol-Myers Squibb Company | 3-substituted propionic acids as alpha v integrin inhibitors |
| MA52117A (fr) | 2017-02-28 | 2022-04-06 | Morphic Therapeutic Inc | Inhibiteurs de l'intégrine (alpha-v) (bêta-6) |
| TW201835078A (zh) | 2017-02-28 | 2018-10-01 | 美商萊築理公司 | αvβ6整合蛋白之抑制劑 |
| WO2018183795A1 (en) | 2017-03-30 | 2018-10-04 | Scifluor Life Sciences, Inc. | Method of making tetrahydronaphthyridinyl nonanoic acid compounds |
| SG11202004077WA (en) | 2017-11-07 | 2020-05-28 | Bristol Myers Squibb Co | Pyrrolopyrazine derivatives as alpha v integrin inhibitors |
| AU2019260738B2 (en) * | 2018-04-27 | 2025-01-30 | Arrowhead Pharmaceuticals, Inc. | Integrin targeting ligands and uses thereof |
| MX2021002181A (es) | 2018-08-29 | 2021-07-15 | Morphic Therapeutic Inc | Inhibicion de la integrina alfa v beta 6. |
| TWI835840B (zh) * | 2018-08-29 | 2024-03-21 | 美商莫菲克醫療股份有限公司 | αvβ6整合素之抑制劑 |
| MX2022013753A (es) * | 2020-05-07 | 2023-01-30 | Pliant Therapeutics Inc | Tratamiento de enfermedades respiratorias con compuestos de aminoacidos. |
| WO2021231581A1 (en) | 2020-05-12 | 2021-11-18 | Scifluor Life Sciences, Inc. | METHODS OF TREATING OR PREVENTING VIRAL INFECTION WITH FLUORINATED α V INTEGRIN ANTAGONISTS |
| EP4232079A4 (en) * | 2020-10-20 | 2024-10-23 | The Board Of Trustees Of The Leland Stanford Junior University | INJECTABLE HYDROGELS FOR ADOPTIVE CELL THERAPY |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0307483A4 (en) | 1987-03-30 | 1990-02-06 | Anritsu Corp | LIGHT SIGNAL GENERATOR AND CALIBRATION METHOD OF A LIGHT POWER MEASURING DEVICE WITH THIS LIGHT SIGNAL GENERATOR. |
| CA1318254C (en) | 1988-01-06 | 1993-05-25 | Munehiro Tomikawa | Inhibitory agent of hepatic fibrosis containing pantethine |
| EP0581904B1 (en) | 1991-04-01 | 1997-05-28 | Duke University | Method of inhibiting fibrosis |
| US5501969A (en) | 1994-03-08 | 1996-03-26 | Human Genome Sciences, Inc. | Human osteoclast-derived cathepsin |
| JP3818322B2 (ja) | 1994-04-28 | 2006-09-06 | 敏一 中村 | コラーゲン分解促進剤 |
| US5736357A (en) | 1994-10-27 | 1998-04-07 | Arris Pharmaceutical | Cathespin O protease |
| US6544767B1 (en) | 1994-10-27 | 2003-04-08 | Axys Pharmaceuticals, Inc. | Cathespin O2 protease |
| US5645839A (en) | 1995-06-07 | 1997-07-08 | Trustees Of Boston University | Combined use of angiotensin inhibitors and nitric oxide stimulators to treat fibrosis |
| US6664227B1 (en) | 1996-03-01 | 2003-12-16 | Genetics Institute, Llc | Treatment of fibrosis by antagonism of IL-13 and IL-13 receptor chains |
| US6211184B1 (en) | 1996-08-29 | 2001-04-03 | Merck & Co., Inc. | Integrin antagonists |
| WO1998008528A1 (en) | 1996-08-30 | 1998-03-05 | Biomeasure Incorporated | Method of inhibiting fibrosis with a somatostatin agonist |
| EA002822B1 (ru) | 1997-12-17 | 2002-10-31 | Мерк Энд Ко., Инк. | Антагонисты рецептора интегрина |
| US6017926A (en) | 1997-12-17 | 2000-01-25 | Merck & Co., Inc. | Integrin receptor antagonists |
| KR20030048081A (ko) * | 1997-12-17 | 2003-06-18 | 머크 앤드 캄파니 인코포레이티드 | 인테그린 수용체 길항제를 포함하는 약제학적 조성물 |
| US6066648A (en) | 1997-12-17 | 2000-05-23 | Merck & Co., Inc. | Integrin receptor antagonists |
| WO1999030709A1 (en) | 1997-12-17 | 1999-06-24 | Merck & Co., Inc. | Integrin receptor antagonists |
| CN1284955A (zh) | 1997-12-17 | 2001-02-21 | 麦克公司 | 整联蛋白受体拮抗剂 |
| US6048861A (en) | 1997-12-17 | 2000-04-11 | Merck & Co., Inc. | Integrin receptor antagonists |
| US6117445A (en) | 1998-01-28 | 2000-09-12 | Link Technology Inc. | Methods for the prevention and treatment of fibrosis and sclerosis |
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| US6420396B1 (en) * | 1998-12-16 | 2002-07-16 | Beiersdorf Ag | Biphenyl and biphenyl-analogous compounds as integrin antagonists |
| US6291503B1 (en) | 1999-01-15 | 2001-09-18 | Bayer Aktiengesellschaft | β-phenylalanine derivatives as integrin antagonists |
| IL146378A0 (en) * | 1999-06-02 | 2002-07-25 | Merck & Co Inc | Alpha v integrin receptor antagonists |
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| US6455539B2 (en) | 1999-12-23 | 2002-09-24 | Celltech R&D Limited | Squaric acid derivates |
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| CA2397665A1 (en) | 2000-01-24 | 2001-07-26 | Merck & Co., Inc. | Alpha v integrin receptor antagonists |
| WO2001062292A1 (en) | 2000-02-22 | 2001-08-30 | Suntory Limited | Preventive or therapeutic drugs for fibrosis containing chymase inhibitors as the active ingredient |
| GB0011817D0 (en) * | 2000-05-16 | 2000-07-05 | Pharmacia & Upjohn Spa | Antagonists of integrin receptors |
| ATE353219T1 (de) | 2000-07-26 | 2007-02-15 | Merck & Co Inc | Alpha v integrin-rezeptor-antagonisten |
| JP2004509123A (ja) | 2000-09-14 | 2004-03-25 | メルク エンド カムパニー インコーポレーテッド | アルファνインテグリン受容体アンタゴニスト |
| AU2001290772A1 (en) | 2000-09-14 | 2002-03-26 | Merck And Co., Inc. | Alpha v integrin receptor antagonists |
| JP2004508401A (ja) * | 2000-09-18 | 2004-03-18 | メルク エンド カムパニー インコーポレーテッド | シクロオキシゲナーゼ−２阻害剤およびインテグリンアルファ−ｖアンタゴニストの組合せを用いる炎症の治療 |
| CA2465416A1 (en) | 2001-11-06 | 2003-05-15 | Merck & Co., Inc. | Amine salts of an integrin receptor antagonist |
| US20040053968A1 (en) | 2001-12-28 | 2004-03-18 | Hartman George D. | Methods and compositions for treating peridontal disease |
| WO2004026233A2 (en) | 2002-09-20 | 2004-04-01 | Merck & Co., Inc. | Mannitol formulation for integrin receptor antagonist |
| CA2507699A1 (en) | 2002-12-20 | 2004-07-15 | Pharmacia Corporation | Heteroarylalkanoic acids as integrin receptor antagonists |
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| EP3673922A1 (en) * | 2008-03-14 | 2020-07-01 | VisEn Medical, Inc. | Integrin targeting agents and methods of using same |
| WO2011060395A1 (en) | 2009-11-16 | 2011-05-19 | Schering Corporation | Cyclic ureas useful as hiv inhibitors |
| NZ603789A (en) | 2010-05-26 | 2015-03-27 | Sunovion Pharmaceuticals Inc | Heteroaryl compounds and methods of use thereof |
| ES2820855T3 (es) | 2011-05-09 | 2021-04-22 | Allegro Pharmaceuticals Llc | Antagonistas del receptor de integrina y sus métodos de uso |
| CN103764118A (zh) | 2011-06-28 | 2014-04-30 | 拜尔健康护理有限责任公司 | 含有索拉非尼的局部眼用药用组合物 |
| DK2953948T3 (en) * | 2013-02-07 | 2017-12-18 | Scifluor Life Sciences Inc | FLUORINATED INTEGRIN ANTAGONISTS |
| US8901144B2 (en) | 2013-02-07 | 2014-12-02 | Scifluor Life Sciences, Llc | Fluorinated 3-(2-oxo-3-(3-arylpropyl)imidazolidin-1-yl)-3-arylpropanoic acid derivatives |
| CN114805342A (zh) | 2015-02-19 | 2022-07-29 | 赛弗卢尔生命科学公司 | 氟化四氢萘啶基壬酸衍生物及其用途 |
| AU2016255494A1 (en) | 2015-04-30 | 2017-11-02 | Scifluor Life Sciences, Inc. | Tetrahydronaphthyridinyl propionic acid derivatives and uses thereof |
| WO2018183795A1 (en) | 2017-03-30 | 2018-10-04 | Scifluor Life Sciences, Inc. | Method of making tetrahydronaphthyridinyl nonanoic acid compounds |
-
2016
- 2016-02-19 CN CN202210129062.7A patent/CN114805342A/zh active Pending
- 2016-02-19 EP EP16753120.1A patent/EP3259271B1/en active Active
- 2016-02-19 CN CN201680022826.5A patent/CN107531699A/zh active Pending
- 2016-02-19 ES ES16753120T patent/ES2892954T3/es active Active
- 2016-02-19 TW TW105104964A patent/TWI736529B/zh not_active IP Right Cessation
- 2016-02-19 EP EP21171386.2A patent/EP3925959A1/en active Pending
- 2016-02-19 BR BR112017017888A patent/BR112017017888A2/pt not_active Application Discontinuation
- 2016-02-19 CA CA2976634A patent/CA2976634C/en active Active
- 2016-02-19 AU AU2016219906A patent/AU2016219906B2/en not_active Ceased
- 2016-02-19 JP JP2017544035A patent/JP2018510139A/ja active Pending
- 2016-02-19 WO PCT/US2016/018612 patent/WO2016134223A2/en not_active Ceased
- 2016-02-19 RU RU2017132433A patent/RU2017132433A/ru not_active Application Discontinuation
- 2016-02-19 KR KR1020177026258A patent/KR102647026B1/ko active Active
- 2016-02-19 US US15/047,717 patent/US9790222B2/en not_active Expired - Fee Related
-
2017
- 2017-08-07 IL IL253873A patent/IL253873A0/en active IP Right Grant
- 2017-09-11 US US15/700,351 patent/US10301307B2/en active Active
-
2019
- 2019-04-03 US US16/373,780 patent/US20190225609A1/en not_active Abandoned
-
2020
- 2020-10-12 JP JP2020171641A patent/JP7191299B2/ja active Active
- 2020-10-22 US US17/076,891 patent/US11685738B2/en active Active
-
2023
- 2023-05-31 US US18/203,776 patent/US12286432B2/en active Active
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