JP2018509424A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018509424A5 JP2018509424A5 JP2017548170A JP2017548170A JP2018509424A5 JP 2018509424 A5 JP2018509424 A5 JP 2018509424A5 JP 2017548170 A JP2017548170 A JP 2017548170A JP 2017548170 A JP2017548170 A JP 2017548170A JP 2018509424 A5 JP2018509424 A5 JP 2018509424A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkenyl
- alkynyl
- cycloalkyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *CC[C@](C(N[C@@](CCC(NCC[C@](C[C@@](CO)O)O)=O)C(N[C@](CC***)C(N[C@@](CCC(NCCCC[C@](CO)O)=O)C(N[C@@](*)CSSCCOC=O)=O)=O)=O)=O)NC(C*)=O Chemical compound *CC[C@](C(N[C@@](CCC(NCC[C@](C[C@@](CO)O)O)=O)C(N[C@](CC***)C(N[C@@](CCC(NCCCC[C@](CO)O)=O)C(N[C@@](*)CSSCCOC=O)=O)=O)=O)=O)NC(C*)=O 0.000 description 3
- OZGOWPGCMDMDDG-BDAKNGLRSA-N CCCC(NCC[C@H](C[C@@H](CO)O)O)=O Chemical compound CCCC(NCC[C@H](C[C@@H](CO)O)O)=O OZGOWPGCMDMDDG-BDAKNGLRSA-N 0.000 description 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2015/020397 WO2016148674A1 (en) | 2015-03-13 | 2015-03-13 | Conjugates for treating diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020043256A Division JP2020117509A (ja) | 2020-03-12 | 2020-03-12 | 疾患を処置するためのコンジュゲート |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018509424A JP2018509424A (ja) | 2018-04-05 |
| JP2018509424A5 true JP2018509424A5 (enExample) | 2018-05-24 |
| JP6676650B2 JP6676650B2 (ja) | 2020-04-08 |
Family
ID=56920017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017548170A Active JP6676650B2 (ja) | 2015-03-13 | 2015-03-13 | 疾患を処置するためのコンジュゲート |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10624972B2 (enExample) |
| EP (1) | EP3268046A4 (enExample) |
| JP (1) | JP6676650B2 (enExample) |
| CN (1) | CN107847609A (enExample) |
| CA (1) | CA2979527A1 (enExample) |
| WO (1) | WO2016148674A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20170266303A1 (en) * | 2014-11-25 | 2017-09-21 | Endocyte, Inc. | Methods of treating cancer by targeting tumor-associated macrophages |
| WO2016148674A1 (en) | 2015-03-13 | 2016-09-22 | Endocyte, Inc. | Conjugates for treating diseases |
| US20200323991A1 (en) * | 2016-03-29 | 2020-10-15 | Endocyte, Inc. | Pbd conjugates for treating diseases |
| CN109475558A (zh) * | 2016-05-25 | 2019-03-15 | 普渡研究基金会 | 通过靶向骨髓衍生的抑制细胞而治疗癌症的方法 |
| US11135307B2 (en) | 2016-11-23 | 2021-10-05 | Mersana Therapeutics, Inc. | Peptide-containing linkers for antibody-drug conjugates |
| EP4086268A4 (en) | 2019-12-31 | 2024-08-21 | LegoChem Biosciences, Inc. | PYRROLOBENZODIAZEPINE DERIVATIVE AND LIGAND-LINKER CONJUGATE THEREOF |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60255789A (ja) | 1984-06-01 | 1985-12-17 | Kyowa Hakko Kogyo Co Ltd | マイトマイシン誘導体，その製造法および抗腫瘍剤 |
| JPH03206886A (ja) | 1989-11-13 | 1991-09-10 | Green Cross Corp:The | ヒト腫瘍細胞抗原に対し特異性を持つマウス―ヒトキメラａ１０抗体 |
| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| JPH06502301A (ja) | 1990-08-29 | 1994-03-17 | サントル オスピタリエ レジオナル デ ナント | 安定タンパク質コアに結合されたタンパク質ポリリガンド |
| AUPN449295A0 (en) | 1995-07-28 | 1995-08-24 | Inner And Eastern Health Care Network, The | Radioprotectors |
| GB9518953D0 (en) | 1995-09-15 | 1995-11-15 | Pfizer Ltd | Pharmaceutical formulations |
| WO2000035298A1 (en) | 1996-11-27 | 2000-06-22 | Wm. Wrigley Jr. Company | Chewing gum containing medicament active agents |
| GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
| GB9818731D0 (en) | 1998-08-27 | 1998-10-21 | Univ Portsmouth | Compounds |
| WO2001010468A2 (en) * | 1999-08-09 | 2001-02-15 | The General Hospital Corporation | Drug-carrier complexes and methods of use thereof |
| US6822086B1 (en) * | 1999-08-09 | 2004-11-23 | The General Hospital Corporation | Drug-carrier complexes and methods of use thereof |
| JP5576007B2 (ja) | 2003-01-27 | 2014-08-20 | エンドサイト・インコーポレイテッド | ビタミン受容体結合性薬剤送達結合体 |
| EP2374480A3 (en) * | 2005-08-19 | 2013-05-01 | Endocyte, Inc. | Mutli-drug ligand conjugates |
| CN101287500A (zh) * | 2005-08-19 | 2008-10-15 | 恩多塞特公司 | 多药物配体缀合物 |
| EP2125870A4 (en) | 2007-02-16 | 2011-04-06 | Boehringer Ingelheim Int | INHIBITORS OF HEPATITIS C NS3 PROTEASE |
| CN104383553A (zh) * | 2007-06-25 | 2015-03-04 | 恩多塞特公司 | 含有亲水性间隔区接头的共轭物 |
| US20100074863A1 (en) * | 2008-09-17 | 2010-03-25 | Yat Sun Or | Anti-infective pyrrolidine derivatives and analogs |
| US8546425B2 (en) | 2008-09-17 | 2013-10-01 | Purdue Research Foundation | Folate receptor binding conjugates of antifolates |
| WO2011130598A1 (en) * | 2010-04-15 | 2011-10-20 | Spirogen Limited | Pyrrolobenzodiazepines and conjugates thereof |
| CA2799391A1 (en) | 2010-05-19 | 2011-12-04 | Endocyte, Inc. | Improved process for a folate-targeted agent |
| KR20140010076A (ko) * | 2011-02-15 | 2014-01-23 | 이뮤노젠 아이엔씨 | 세포독성 벤조다이아제핀 유도체 |
| US20130267522A1 (en) * | 2012-03-01 | 2013-10-10 | Endocyte, Inc. | Methods for treating cancer |
| JP2015536323A (ja) * | 2012-10-16 | 2015-12-21 | エンドサイト・インコーポレイテッドＥｎｄｏｃｙｔｅ， Ｉｎｃ． | 非天然アミノ酸を含む薬物送達結合体および使用方法 |
| AU2013344778C1 (en) * | 2012-11-15 | 2024-06-27 | Endocyte, Inc. | Conjugates for treating diseases caused by PSMA expressing cells |
| AU2012395148B2 (en) * | 2012-11-24 | 2016-10-27 | Hangzhou Dac Biotech Co., Ltd. | Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules |
| HK1216176A1 (zh) | 2012-12-21 | 2016-10-21 | Medlmmune Limited | 用於治疗增殖性和自身免疫疾病的非对称吡咯并苯并二氮杂卓二聚物 |
| MY186334A (en) | 2014-09-12 | 2021-07-12 | Genentech Inc | Anti-her2 antibodies and immunoconjugates |
| US20170266303A1 (en) | 2014-11-25 | 2017-09-21 | Endocyte, Inc. | Methods of treating cancer by targeting tumor-associated macrophages |
| WO2016148674A1 (en) | 2015-03-13 | 2016-09-22 | Endocyte, Inc. | Conjugates for treating diseases |
| US20200323991A1 (en) | 2016-03-29 | 2020-10-15 | Endocyte, Inc. | Pbd conjugates for treating diseases |
-
2015
- 2015-03-13 WO PCT/US2015/020397 patent/WO2016148674A1/en not_active Ceased
- 2015-03-13 EP EP15885705.2A patent/EP3268046A4/en not_active Withdrawn
- 2015-03-13 CA CA2979527A patent/CA2979527A1/en active Pending
- 2015-03-13 CN CN201580079950.0A patent/CN107847609A/zh active Pending
- 2015-03-13 JP JP2017548170A patent/JP6676650B2/ja active Active
- 2015-03-13 US US15/557,703 patent/US10624972B2/en active Active
-
2020
- 2020-03-20 US US16/825,566 patent/US20200289659A1/en not_active Abandoned