JP2018509424A5 - - Google Patents
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- Publication number
- JP2018509424A5 JP2018509424A5 JP2017548170A JP2017548170A JP2018509424A5 JP 2018509424 A5 JP2018509424 A5 JP 2018509424A5 JP 2017548170 A JP2017548170 A JP 2017548170A JP 2017548170 A JP2017548170 A JP 2017548170A JP 2018509424 A5 JP2018509424 A5 JP 2018509424A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkenyl
- alkynyl
- cycloalkyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *CC[C@](C(N[C@@](CCC(NCC[C@](C[C@@](CO)O)O)=O)C(N[C@](CC***)C(N[C@@](CCC(NCCCC[C@](CO)O)=O)C(N[C@@](*)CSSCCOC=O)=O)=O)=O)=O)NC(C*)=O Chemical compound *CC[C@](C(N[C@@](CCC(NCC[C@](C[C@@](CO)O)O)=O)C(N[C@](CC***)C(N[C@@](CCC(NCCCC[C@](CO)O)=O)C(N[C@@](*)CSSCCOC=O)=O)=O)=O)=O)NC(C*)=O 0.000 description 3
- OZGOWPGCMDMDDG-BDAKNGLRSA-N CCCC(NCC[C@H](C[C@@H](CO)O)O)=O Chemical compound CCCC(NCC[C@H](C[C@@H](CO)O)O)=O OZGOWPGCMDMDDG-BDAKNGLRSA-N 0.000 description 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2015/020397 WO2016148674A1 (en) | 2015-03-13 | 2015-03-13 | Conjugates for treating diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020043256A Division JP2020117509A (ja) | 2020-03-12 | 2020-03-12 | 疾患を処置するためのコンジュゲート |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018509424A JP2018509424A (ja) | 2018-04-05 |
| JP2018509424A5 true JP2018509424A5 (enExample) | 2018-05-24 |
| JP6676650B2 JP6676650B2 (ja) | 2020-04-08 |
Family
ID=56920017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017548170A Active JP6676650B2 (ja) | 2015-03-13 | 2015-03-13 | 疾患を処置するためのコンジュゲート |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10624972B2 (enExample) |
| EP (1) | EP3268046A4 (enExample) |
| JP (1) | JP6676650B2 (enExample) |
| CN (1) | CN107847609A (enExample) |
| CA (1) | CA2979527A1 (enExample) |
| WO (1) | WO2016148674A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3223860A4 (en) * | 2014-11-25 | 2018-08-01 | Endocyte, Inc. | Methods of treating cancer by targeting tumor-associated macrophages |
| CN107847609A (zh) | 2015-03-13 | 2018-03-27 | 恩多塞特公司 | 用于治疗疾病的缀合物 |
| WO2017172930A1 (en) * | 2016-03-29 | 2017-10-05 | Endocyte, Inc. | Pbd conjugates for treating diseases |
| CN109475558A (zh) * | 2016-05-25 | 2019-03-15 | 普渡研究基金会 | 通过靶向骨髓衍生的抑制细胞而治疗癌症的方法 |
| US11135307B2 (en) | 2016-11-23 | 2021-10-05 | Mersana Therapeutics, Inc. | Peptide-containing linkers for antibody-drug conjugates |
| BR112022013008A2 (pt) | 2019-12-31 | 2022-09-06 | Legochem Biosciences Inc | Composto derivado de pirrolobenzodiazepina, conjugado de derivado-ligante de pirrolobenzodiazepina, e, composição farmacêutica e método para prevenção ou tratamento de doença proliferativa |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60255789A (ja) | 1984-06-01 | 1985-12-17 | Kyowa Hakko Kogyo Co Ltd | マイトマイシン誘導体，その製造法および抗腫瘍剤 |
| EP0457875A4 (en) | 1989-11-13 | 1993-03-03 | Xoma Corporation | Chimeric mouse-human a10 antibody with specificity to a human tumor cell antigen |
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| EP0547163B1 (en) | 1990-08-29 | 2002-02-06 | Centre Hospitalier Regional De Nantes | Protein polyligands joined to a stable protein core |
| AUPN449295A0 (en) * | 1995-07-28 | 1995-08-24 | Inner And Eastern Health Care Network, The | Radioprotectors |
| GB9518953D0 (en) | 1995-09-15 | 1995-11-15 | Pfizer Ltd | Pharmaceutical formulations |
| WO2000035298A1 (en) | 1996-11-27 | 2000-06-22 | Wm. Wrigley Jr. Company | Chewing gum containing medicament active agents |
| GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
| GB9818731D0 (en) | 1998-08-27 | 1998-10-21 | Univ Portsmouth | Compounds |
| US6822086B1 (en) | 1999-08-09 | 2004-11-23 | The General Hospital Corporation | Drug-carrier complexes and methods of use thereof |
| JP4813712B2 (ja) * | 1999-08-09 | 2011-11-09 | ザ ジェネラル ホスピタル コーポレーション | 薬物−担体複合体およびその使用方法 |
| US7601332B2 (en) | 2003-01-27 | 2009-10-13 | Endocyte, Inc. | Vitamin receptor binding drug delivery conjugates |
| RU2470668C2 (ru) * | 2005-08-19 | 2012-12-27 | Эндосайт, Инк. | Конъюгаты лиганда с несколькими лекарственными средствами |
| CN101287500A (zh) * | 2005-08-19 | 2008-10-15 | 恩多塞特公司 | 多药物配体缀合物 |
| JP2010518128A (ja) | 2007-02-16 | 2010-05-27 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃ型肝炎ｎｓ３プロテアーゼのインヒビター |
| BRPI0812970A2 (pt) * | 2007-06-25 | 2019-09-24 | Endocyte Inc | conjugados contendo espaçadores hidrofílicos |
| JP5675619B2 (ja) | 2008-09-17 | 2015-02-25 | エンドサイト, インク.Endocyte, Inc. | 葉酸拮抗薬の葉酸受容体結合性コンジュゲート |
| US20100074863A1 (en) * | 2008-09-17 | 2010-03-25 | Yat Sun Or | Anti-infective pyrrolidine derivatives and analogs |
| PT2528625E (pt) * | 2010-04-15 | 2013-10-17 | Spirogen Sarl | Pirrolobenzodiazepinas e conjugados das mesmas |
| RU2012154914A (ru) | 2010-05-19 | 2014-06-27 | Эндосайт, Инк. | Улучшенный способ получения нацеленного на фолат средства |
| SI2675480T1 (sl) | 2011-02-15 | 2019-05-31 | Immunogen, Inc. | Metode priprave konjugatov |
| CA2807712A1 (en) * | 2012-03-01 | 2013-09-01 | Purdue Research Foundation | Methods for treating cancer |
| EA201590622A1 (ru) * | 2012-10-16 | 2015-10-30 | Эндосайт, Инк. | Конъюгаты для доставки лекарственного средства, содержащие не встречающиеся в природе аминокислоты, и способы применения |
| KR102318999B1 (ko) * | 2012-11-15 | 2021-10-29 | 엔도사이트, 인코포레이티드 | Psma 발현 세포에 의해 야기되는 질병을 치료하기 위한 컨쥬게이트 |
| US10131682B2 (en) * | 2012-11-24 | 2018-11-20 | Hangzhou Dac Biotech Co., Ltd. | Hydrophilic linkers and their uses for conjugation of drugs to a cell binding molecules |
| US9567340B2 (en) | 2012-12-21 | 2017-02-14 | Medimmune Limited | Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases |
| SI3191135T1 (sl) | 2014-09-12 | 2021-01-29 | Genentech, Inc. | Anti-HER2 protitelesa in imunokonjugati |
| EP3223860A4 (en) | 2014-11-25 | 2018-08-01 | Endocyte, Inc. | Methods of treating cancer by targeting tumor-associated macrophages |
| CN107847609A (zh) | 2015-03-13 | 2018-03-27 | 恩多塞特公司 | 用于治疗疾病的缀合物 |
| WO2017172930A1 (en) | 2016-03-29 | 2017-10-05 | Endocyte, Inc. | Pbd conjugates for treating diseases |
-
2015
- 2015-03-13 CN CN201580079950.0A patent/CN107847609A/zh active Pending
- 2015-03-13 EP EP15885705.2A patent/EP3268046A4/en not_active Withdrawn
- 2015-03-13 US US15/557,703 patent/US10624972B2/en active Active
- 2015-03-13 WO PCT/US2015/020397 patent/WO2016148674A1/en not_active Ceased
- 2015-03-13 JP JP2017548170A patent/JP6676650B2/ja active Active
- 2015-03-13 CA CA2979527A patent/CA2979527A1/en active Pending
-
2020
- 2020-03-20 US US16/825,566 patent/US20200289659A1/en not_active Abandoned