JP2018525399A5 - - Google Patents
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- JP2018525399A5 JP2018525399A5 JP2018507646A JP2018507646A JP2018525399A5 JP 2018525399 A5 JP2018525399 A5 JP 2018525399A5 JP 2018507646 A JP2018507646 A JP 2018507646A JP 2018507646 A JP2018507646 A JP 2018507646A JP 2018525399 A5 JP2018525399 A5 JP 2018525399A5
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- Prior art keywords
- alkyl
- cancer
- alkenyl
- alkynyl
- cycloalkyl
- Prior art date
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- 238000000034 method Methods 0.000 claims 1
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- 229920000570 polyether Polymers 0.000 claims 1
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
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| PCT/US2016/046292 WO2017030859A1 (en) | 2015-08-14 | 2016-08-10 | Cck2r-drug conjugates |
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| US11229708B2 (en) | 2015-12-04 | 2022-01-25 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
| US11793880B2 (en) | 2015-12-04 | 2023-10-24 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
| KR20230158005A (ko) | 2021-03-18 | 2023-11-17 | 씨젠 인크. | 생물학적 활성 화합물의 내재화된 접합체로부터의 선택적 약물 방출 |
| AU2021466987B2 (en) * | 2021-09-28 | 2025-11-20 | Paul Scherrer Institut | Method for predicting the response of a patient diagnosed with cancer to treatment and/or imaging with a compound targeting cck2-r, and compound for use in methods of selectively treating and/or imaging cancer |
| CN120554245A (zh) * | 2025-07-30 | 2025-08-29 | 辽宁众辉生物科技有限公司 | 一种氟吡菌酰胺中间体n-乙酰氧基甲基-2-三氟甲基苯甲酰胺的合成方法 |
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| US7776814B2 (en) * | 2002-07-09 | 2010-08-17 | R&D-Biopharmaceuticals Gmbh | Tubulysin conjugates |
| US8431714B2 (en) * | 2007-04-16 | 2013-04-30 | University Of Southern California | Synthesis of drug conjugates via reaction with epoxide-containing linkers |
| WO2013126797A1 (en) | 2012-02-24 | 2013-08-29 | Purdue Research Foundation | Cholecystokinin b receptor targeting for imaging and therapy |
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