JP2018507890A5 - - Google Patents
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- JP2018507890A5 JP2018507890A5 JP2017547558A JP2017547558A JP2018507890A5 JP 2018507890 A5 JP2018507890 A5 JP 2018507890A5 JP 2017547558 A JP2017547558 A JP 2017547558A JP 2017547558 A JP2017547558 A JP 2017547558A JP 2018507890 A5 JP2018507890 A5 JP 2018507890A5
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- JP
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- Prior art keywords
- alkyl
- cycloalkyl
- compound according
- amino
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 59
- 125000000217 alkyl group Chemical group 0.000 claims 55
- 125000000753 cycloalkyl group Chemical group 0.000 claims 35
- 125000001072 heteroaryl group Chemical group 0.000 claims 28
- 125000000623 heterocyclic group Chemical group 0.000 claims 27
- 125000003118 aryl group Chemical group 0.000 claims 25
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 23
- 125000001424 substituent group Chemical group 0.000 claims 21
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 20
- 150000003839 salts Chemical class 0.000 claims 19
- 229910052739 hydrogen Inorganic materials 0.000 claims 14
- 239000001257 hydrogen Substances 0.000 claims 14
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 12
- 125000004442 acylamino group Chemical group 0.000 claims 11
- 150000001735 carboxylic acids Chemical class 0.000 claims 11
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 claims 11
- 125000004093 cyano group Chemical group *C#N 0.000 claims 10
- 125000005843 halogen group Chemical group 0.000 claims 9
- 125000000304 alkynyl group Chemical group 0.000 claims 8
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- 125000003545 alkoxy group Chemical group 0.000 claims 7
- 125000003282 alkyl amino group Chemical group 0.000 claims 7
- 125000000539 amino acid group Chemical group 0.000 claims 7
- 125000003710 aryl alkyl group Chemical group 0.000 claims 7
- 150000007942 carboxylates Chemical class 0.000 claims 7
- 150000002431 hydrogen Chemical class 0.000 claims 7
- -1 -COO-alkyl Chemical group 0.000 claims 6
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 6
- 125000003342 alkenyl group Chemical group 0.000 claims 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 5
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 4
- 125000002252 acyl group Chemical group 0.000 claims 4
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 3
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 125000004103 aminoalkyl group Chemical group 0.000 claims 3
- 210000004899 c-terminal region Anatomy 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 3
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 3
- NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Chemical group C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 3
- 125000001960 7 membered carbocyclic group Chemical group 0.000 claims 2
- 208000035143 Bacterial infection Diseases 0.000 claims 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical group C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims 2
- 206010017533 Fungal infection Diseases 0.000 claims 2
- 208000031888 Mycoses Diseases 0.000 claims 2
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 2
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 2
- 208000036142 Viral infection Diseases 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 208000022362 bacterial infectious disease Diseases 0.000 claims 2
- 150000001733 carboxylic acid esters Chemical class 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 208000026278 immune system disease Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 230000009385 viral infection Effects 0.000 claims 2
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 101100407308 Mus musculus Pdcd1lg2 gene Proteins 0.000 claims 1
- 108700030875 Programmed Cell Death 1 Ligand 2 Proteins 0.000 claims 1
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 1
- 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 125000003368 amide group Chemical group 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000005244 familial abdominal 2 aortic aneurysm Diseases 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 201000008968 osteosarcoma Diseases 0.000 claims 1
- 125000000466 oxiranyl group Chemical group 0.000 claims 1
- 230000037361 pathway Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- SBMSLRMNBSMKQC-UHFFFAOYSA-N pyrrolidin-1-amine Chemical group NN1CCCC1 SBMSLRMNBSMKQC-UHFFFAOYSA-N 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020128394A JP6937090B2 (ja) | 2015-03-10 | 2020-07-29 | 免疫調節剤としての１，２，４−オキサジアゾールおよびチアジアゾール化合物 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1180/CHE/2015 | 2015-03-10 | ||
| IN1178CH2015 | 2015-03-10 | ||
| IN1180CH2015 | 2015-03-10 | ||
| IN1178/CHE/2015 | 2015-03-10 | ||
| PCT/IB2016/051266 WO2016142833A1 (en) | 2015-03-10 | 2016-03-07 | 1,2,4-oxadiazole and thiadiazole compounds as immunomodulators |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020128394A Division JP6937090B2 (ja) | 2015-03-10 | 2020-07-29 | 免疫調節剤としての１，２，４−オキサジアゾールおよびチアジアゾール化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018507890A JP2018507890A (ja) | 2018-03-22 |
| JP2018507890A5 true JP2018507890A5 (https=) | 2019-05-09 |
| JP6815686B2 JP6815686B2 (ja) | 2021-01-20 |
Family
ID=56879282
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017547558A Active JP6815686B2 (ja) | 2015-03-10 | 2016-03-07 | 免疫調節剤としての１，２，４−オキサジアゾールおよびチアジアゾール化合物 |
| JP2020128394A Active JP6937090B2 (ja) | 2015-03-10 | 2020-07-29 | 免疫調節剤としての１，２，４−オキサジアゾールおよびチアジアゾール化合物 |
| JP2021139182A Active JP7325483B6 (ja) | 2015-03-10 | 2021-08-27 | 免疫調節剤としての１，２，４－オキサジアゾールおよびチアジアゾール化合物 |
| JP2023125731A Active JP7659015B2 (ja) | 2015-03-10 | 2023-08-01 | 免疫調節剤としての１，２，４－オキサジアゾールおよびチアジアゾール化合物 |
| JP2025052596A Pending JP2025114536A (ja) | 2015-03-10 | 2025-03-26 | 免疫調節剤としての１，２，４－オキサジアゾールおよびチアジアゾール化合物 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020128394A Active JP6937090B2 (ja) | 2015-03-10 | 2020-07-29 | 免疫調節剤としての１，２，４−オキサジアゾールおよびチアジアゾール化合物 |
| JP2021139182A Active JP7325483B6 (ja) | 2015-03-10 | 2021-08-27 | 免疫調節剤としての１，２，４－オキサジアゾールおよびチアジアゾール化合物 |
| JP2023125731A Active JP7659015B2 (ja) | 2015-03-10 | 2023-08-01 | 免疫調節剤としての１，２，４－オキサジアゾールおよびチアジアゾール化合物 |
| JP2025052596A Pending JP2025114536A (ja) | 2015-03-10 | 2025-03-26 | 免疫調節剤としての１，２，４－オキサジアゾールおよびチアジアゾール化合物 |
Country Status (27)
| Country | Link |
|---|---|
| US (4) | US10781189B2 (https=) |
| EP (2) | EP4023645A1 (https=) |
| JP (5) | JP6815686B2 (https=) |
| KR (3) | KR102894264B1 (https=) |
| CN (4) | CN114213356A (https=) |
| AU (3) | AU2016230793B2 (https=) |
| CA (2) | CA2979137C (https=) |
| CU (1) | CU24509B1 (https=) |
| CY (1) | CY1125161T1 (https=) |
| DK (1) | DK3267984T3 (https=) |
| EA (1) | EA034708B1 (https=) |
| ES (1) | ES2907988T3 (https=) |
| HR (1) | HRP20220258T1 (https=) |
| HU (1) | HUE058274T2 (https=) |
| IL (3) | IL254040B2 (https=) |
| LT (1) | LT3267984T (https=) |
| MX (2) | MX384444B (https=) |
| MY (1) | MY196130A (https=) |
| NZ (1) | NZ734650A (https=) |
| PH (1) | PH12017501454A1 (https=) |
| PL (1) | PL3267984T3 (https=) |
| PT (1) | PT3267984T (https=) |
| RS (1) | RS62960B1 (https=) |
| SG (2) | SG10202108921VA (https=) |
| SI (1) | SI3267984T1 (https=) |
| SM (1) | SMT202200163T1 (https=) |
| WO (1) | WO2016142833A1 (https=) |
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