JP2018528261A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018528261A5 JP2018528261A5 JP2018525526A JP2018525526A JP2018528261A5 JP 2018528261 A5 JP2018528261 A5 JP 2018528261A5 JP 2018525526 A JP2018525526 A JP 2018525526A JP 2018525526 A JP2018525526 A JP 2018525526A JP 2018528261 A5 JP2018528261 A5 JP 2018528261A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- group
- compound
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562199566P | 2015-07-31 | 2015-07-31 | |
| US62/199,566 | 2015-07-31 | ||
| PCT/US2016/044767 WO2017023774A1 (en) | 2015-07-31 | 2016-07-29 | Prodrugs of glutamine analogs |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018528261A JP2018528261A (ja) | 2018-09-27 |
| JP2018528261A5 true JP2018528261A5 (https=) | 2019-09-05 |
| JP6863981B2 JP6863981B2 (ja) | 2021-04-21 |
Family
ID=57943518
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018525526A Active JP6863981B2 (ja) | 2015-07-31 | 2016-07-29 | グルタミン類似体のプロドラッグ |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US10336778B2 (https=) |
| EP (1) | EP3328827B1 (https=) |
| JP (1) | JP6863981B2 (https=) |
| KR (1) | KR102666477B1 (https=) |
| CN (2) | CN108290827B (https=) |
| AU (1) | AU2016302940B2 (https=) |
| CA (1) | CA2994258C (https=) |
| DK (1) | DK3328827T3 (https=) |
| EA (1) | EA034571B1 (https=) |
| ES (1) | ES2957583T3 (https=) |
| FI (1) | FI3328827T3 (https=) |
| HR (1) | HRP20231163T1 (https=) |
| HU (1) | HUE063399T2 (https=) |
| IL (1) | IL257219B (https=) |
| LT (1) | LT3328827T (https=) |
| MX (1) | MX384906B (https=) |
| PL (1) | PL3328827T3 (https=) |
| PT (1) | PT3328827T (https=) |
| RS (1) | RS64597B1 (https=) |
| SI (1) | SI3328827T1 (https=) |
| SM (1) | SMT202300320T1 (https=) |
| WO (1) | WO2017023774A1 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2994165A1 (en) | 2015-07-31 | 2017-02-09 | The Johns Hopkins University | Methods for cancer and immunotherapy using glutamine analogues, including don |
| AU2016302940B2 (en) | 2015-07-31 | 2021-02-04 | The Johns Hopkins University | Prodrugs of glutamine analogs |
| EP3328374A4 (en) * | 2015-07-31 | 2019-03-13 | The Johns Hopkins University | GLUTAMINANTAGONISTS FOR THE TREATMENT OF COGNITIVE DEFICITES |
| US10842763B2 (en) | 2015-07-31 | 2020-11-24 | The Johns Hopkins University | Methods for cancer and immunotherapy using prodrugs of glutamine analogs |
| CA3052283A1 (en) | 2017-02-01 | 2018-08-09 | The Johns Hopkins University | Prodrugs of glutamine analogs |
| CN111566083A (zh) * | 2017-10-06 | 2020-08-21 | 约翰·霍普金斯大学 | 新的谷氨酰胺拮抗剂及其用途 |
| SG11202107317WA (en) * | 2019-01-18 | 2021-08-30 | Dracen Pharmaceuticals Inc | Combinaton therapy with a don prodrug and an immune checkpoint inhibitor |
| JP2022519574A (ja) * | 2019-02-11 | 2022-03-24 | ドラセン ファーマシューティカルズ インコーポレイテッド | L-グルタミン酸からdonプロドラッグを調製する方法 |
| US11760723B2 (en) | 2019-02-11 | 2023-09-19 | Dracen Pharmaceuticals, Inc. | Method of preparing a DON prodrug from L-pyroglutamic acid |
| CA3153424A1 (en) * | 2019-10-03 | 2021-04-08 | Dracen Pharmaceuticals, Inc. | Lyophilized composition comprising (s)-isopropyl 2-((s)-2-acetamido-3-(1h-indol-3-yl)propanamido)-6-diazo-5-oxohexanoate for intravenous administration and the use thereof |
| CN110763792A (zh) * | 2019-10-24 | 2020-02-07 | 湖北省宏源药业科技股份有限公司 | 一种鸟嘌呤有关物质检测方法 |
| WO2021239049A1 (en) * | 2020-05-27 | 2021-12-02 | Jacobio Pharmaceuticals Co., Ltd. | Novel glutamine analogs |
| WO2022022612A1 (en) * | 2020-07-29 | 2022-02-03 | Jacobio Pharmaceuticals Co., Ltd. | Novel glutamine analogs |
| JP7846686B2 (ja) * | 2020-10-02 | 2026-04-15 | ドラセン ファーマシューティカルズ インコーポレイテッド | 皮下投与のための(s)-イソプロピル2-((s)-2-アセトアミド-3-(1h-インドール-3-イル)プロパンアミド)-6-ジアゾ-5-オキソヘキサノエートを含む凍結乾燥組成物およびその使用 |
| WO2022078462A1 (en) * | 2020-10-15 | 2022-04-21 | Jacobio Pharmaceuticals Co., Ltd. | Novel glutamine analogs |
| EP4229029B1 (en) * | 2020-10-15 | 2026-02-25 | Jacobio Pharmaceuticals Co., Ltd. | Novel glutamine analogs |
| CN114621120B (zh) * | 2020-12-10 | 2023-11-03 | 深圳先进技术研究院 | 一种don前药分子、前药激活化合物和前药激活体系 |
| US20240246902A1 (en) * | 2021-04-29 | 2024-07-25 | The Johns Hopkins University | Prodrugs of 6-diazo-5-oxo-l-norleucine |
| WO2022261117A1 (en) * | 2021-06-07 | 2022-12-15 | Dracen Pharmaceuticals, Inc. | Combination therapy with a don prodrug and a tigit inhibitor |
| CN113461563B (zh) * | 2021-07-27 | 2022-05-10 | 中国药科大学 | Nqo1激活型6-重氮基-5-氧代-l-正亮氨酸前药及其制备方法和应用 |
| CN114306620A (zh) * | 2021-12-07 | 2022-04-12 | 深圳先进技术研究院 | 基于代谢检查点的人血清白蛋白纳米药物及其制备方法和应用 |
| JP2025078888A (ja) * | 2022-01-28 | 2025-05-21 | 国立大学法人富山大学 | グルタミナーゼ阻害剤 |
| CN114917230B (zh) * | 2022-03-09 | 2023-03-24 | 山东第一医科大学附属眼科研究所(山东省眼科研究所、山东第一医科大学附属青岛眼科医院) | Cb-839在制备抑制角膜新生血管生成的药物中的应用 |
| TW202406539A (zh) * | 2022-04-21 | 2024-02-16 | 大陸商北京加科思新藥研發有限公司 | 藥物組合及其用途 |
| TW202404938A (zh) * | 2022-04-21 | 2024-02-01 | 大陸商北京加科思新藥研發有限公司 | 麩醯胺酸拮抗劑的多晶型及其用途 |
| CN114805138B (zh) * | 2022-05-12 | 2023-10-10 | 中国科学院长春应用化学研究所 | 6-重氮-5-氧代-l-正亮氨酸的前药、其制备方法及应用 |
| WO2024094526A1 (en) | 2022-11-02 | 2024-05-10 | Ecole Polytechnique Federale De Lausanne (Epfl) | 6-diazo-5-oxo-l-norleucine prodrugs |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US121179A (en) * | 1871-11-21 | Improvement in brick-kilns | ||
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| EP0102324A3 (de) | 1982-07-29 | 1984-11-07 | Ciba-Geigy Ag | Lipide und Tenside in wässriger Phase |
| US4503044A (en) * | 1983-04-25 | 1985-03-05 | American Cyanamid Company | Antibiotic LL-D05139 β |
| US4568646A (en) * | 1983-04-25 | 1986-02-04 | American Cyanamid Company | Preparation of antibiotic LL-D05139β from cultures of Glycomyces harbinensis, gen. nov., sp. nov. |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
| US5328470A (en) | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
| SK285353B6 (sk) * | 1996-04-12 | 2006-11-03 | G. D. Searle & Co. | Substituované benzénsulfónamidy ako proliečivá COX-2 inhibítorov, farmaceutická kompozícia a spôsobich prípravy a použitia |
| WO2001041707A2 (en) | 1999-12-08 | 2001-06-14 | Vanderbilt University | Modulation of in vivo glutamine and glycine levels in the treatment of autism |
| US7419670B2 (en) | 2000-09-29 | 2008-09-02 | Viron Therapeutics, Inc. | Method of treating arthritis with SERP-1 and an immunosuppressant |
| US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US7605150B2 (en) | 2002-05-14 | 2009-10-20 | The Board Of Trustees Of The Leland Stanford Junior University | Drug therapy for Celiac Sprue |
| AU2003294221A1 (en) * | 2002-09-13 | 2004-04-19 | Kenneth E. Miller | Method of alleviating pain via inhibition of neurotransmitter synthesis |
| GB0314262D0 (en) * | 2003-06-19 | 2003-07-23 | Univ Nottingham Trent | Novel compounds and methods of using the same |
| KR20110097942A (ko) | 2003-08-20 | 2011-08-31 | 제노포트 인코포레이티드 | 아실옥시알킬 카르바메이트 프로드러그, 합성 및 사용 방법 |
| US7579313B2 (en) | 2003-11-18 | 2009-08-25 | The Board Of Trustees Of The Leland Stanford Junior University | Transglutaminase inhibitors and methods of use thereof |
| BRPI0506939A (pt) | 2004-01-19 | 2007-06-12 | Novartis Ag | derivados de indolilmaleimida como inibidores de pkc |
| JP2007532506A (ja) | 2004-04-08 | 2007-11-15 | ノバルティス アクチエンゲゼルシャフト | 自己免疫疾患および拒絶反応の処置のためのタンパク質キナーゼc阻害剤 |
| US20060276438A1 (en) | 2004-10-04 | 2006-12-07 | Natarajan Sethuraman | Prevention and treatment of influenza with glutamine antagonist agents |
| EP1874342B1 (en) | 2005-04-26 | 2018-06-06 | Eisai R&D Management Co., Ltd. | Compositions and methods for cancer immunotherapy |
| BRPI0708615A2 (pt) | 2006-03-07 | 2011-06-07 | Array Biopharma Inc | compostos de pirazol heterobicìclicos e métodos de uso |
| US8465736B2 (en) | 2006-05-10 | 2013-06-18 | New Medical Enzymes Ag | Glutadon |
| WO2008033572A1 (en) | 2006-09-15 | 2008-03-20 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use |
| US8343477B2 (en) | 2006-11-01 | 2013-01-01 | Bristol-Myers Squibb Company | Inhibitors of hepatitis C virus |
| US20080107623A1 (en) | 2006-11-01 | 2008-05-08 | Bristol-Myers Squibb Company | Inhibitors of Hepatitis C Virus |
| US20080160024A1 (en) | 2006-12-07 | 2008-07-03 | Board Of Trustees Of The University Of Arkansas | Inhibition of cancer metastasis |
| WO2009029729A1 (en) | 2007-08-31 | 2009-03-05 | Genelabs Technologies, Inc. | Amino tricyclic-nucleoside compounds, compositions, and methods of use |
| US8580312B2 (en) | 2010-02-17 | 2013-11-12 | National University Corporation Kobe University | Radiation therapy agent |
| AU2011270701B2 (en) | 2010-06-24 | 2015-05-14 | Alkermes Pharma Ireland Limited | Prodrugs of NH-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives |
| JP6130307B2 (ja) | 2011-03-17 | 2017-05-17 | ザ ユニバーシティ オブ バーミンガム | 再指向性免疫療法 |
| KR101900478B1 (ko) | 2011-08-04 | 2018-09-20 | 한올바이오파마주식회사 | 암의 재발 또는 전이의 억제용 약제학적 조성물 |
| US20160008380A1 (en) * | 2013-03-06 | 2016-01-14 | The Johns Hopkins University | Targeting glutamine metabolism in brain tumors |
| US20160022708A1 (en) | 2013-03-14 | 2016-01-28 | St. Jude Children's Research Hospital | Methods and compositions for the treatment of glutamine-addicted cancers |
| WO2015035112A1 (en) | 2013-09-05 | 2015-03-12 | The Johns Hopkins University | Cancer therapy via a combination of epigenetic modulation and immune modulation |
| KR20160093012A (ko) | 2013-11-05 | 2016-08-05 | 코그네이트 바이오서비시즈, 인코포레이티드 | 암 치료를 위한 체크포인트 억제제 및 치료제의 배합물 |
| JP2017500313A (ja) * | 2013-12-09 | 2017-01-05 | ブレット バイオテクノロジー, インコーポレーテッドBullet Biotechnology, Inc. | 特異的ウイルス様粒子−CpGオリゴヌクレオチドワクチンおよびその使用 |
| CA2934700A1 (en) | 2014-01-06 | 2015-07-09 | Rhizen Pharmaceuticals Sa | Glutaminase inhibitors |
| EP3116872A4 (en) | 2014-03-14 | 2017-08-30 | Calithera Biosciences, Inc. | Combination therapy with glutaminase inhibitors |
| KR20170012562A (ko) | 2014-06-13 | 2017-02-02 | 칼리테라 바이오사이언시즈 인코포레이티드 | 글루타미나제 억제제를 사용하는 병용 요법 |
| US10864180B2 (en) | 2015-04-23 | 2020-12-15 | The Johns Hopkins University | Combination of immunotherapy with local chemotherapy for the treatment of malignancies |
| US10842763B2 (en) | 2015-07-31 | 2020-11-24 | The Johns Hopkins University | Methods for cancer and immunotherapy using prodrugs of glutamine analogs |
| EP3328374A4 (en) | 2015-07-31 | 2019-03-13 | The Johns Hopkins University | GLUTAMINANTAGONISTS FOR THE TREATMENT OF COGNITIVE DEFICITES |
| CA2994165A1 (en) | 2015-07-31 | 2017-02-09 | The Johns Hopkins University | Methods for cancer and immunotherapy using glutamine analogues, including don |
| AU2016302940B2 (en) | 2015-07-31 | 2021-02-04 | The Johns Hopkins University | Prodrugs of glutamine analogs |
-
2016
- 2016-07-29 AU AU2016302940A patent/AU2016302940B2/en active Active
- 2016-07-29 JP JP2018525526A patent/JP6863981B2/ja active Active
- 2016-07-29 CN CN201680057659.8A patent/CN108290827B/zh active Active
- 2016-07-29 CN CN202011474256.8A patent/CN112920092B/zh active Active
- 2016-07-29 DK DK16833623.8T patent/DK3328827T3/da active
- 2016-07-29 ES ES16833623T patent/ES2957583T3/es active Active
- 2016-07-29 KR KR1020187006078A patent/KR102666477B1/ko active Active
- 2016-07-29 EA EA201890395A patent/EA034571B1/ru unknown
- 2016-07-29 PT PT168336238T patent/PT3328827T/pt unknown
- 2016-07-29 PL PL16833623.8T patent/PL3328827T3/pl unknown
- 2016-07-29 LT LTEPPCT/US2016/044767T patent/LT3328827T/lt unknown
- 2016-07-29 CA CA2994258A patent/CA2994258C/en active Active
- 2016-07-29 RS RS20230850A patent/RS64597B1/sr unknown
- 2016-07-29 HR HRP20231163TT patent/HRP20231163T1/hr unknown
- 2016-07-29 EP EP16833623.8A patent/EP3328827B1/en active Active
- 2016-07-29 FI FIEP16833623.8T patent/FI3328827T3/fi active
- 2016-07-29 WO PCT/US2016/044767 patent/WO2017023774A1/en not_active Ceased
- 2016-07-29 SM SM20230320T patent/SMT202300320T1/it unknown
- 2016-07-29 SI SI201631748T patent/SI3328827T1/sl unknown
- 2016-07-29 HU HUE16833623A patent/HUE063399T2/hu unknown
- 2016-07-29 MX MX2018001300A patent/MX384906B/es unknown
-
2018
- 2018-01-29 IL IL257219A patent/IL257219B/en active IP Right Grant
- 2018-01-31 US US15/885,258 patent/US10336778B2/en active Active
-
2019
- 2019-06-27 US US16/454,880 patent/US10738066B2/en active Active
- 2019-06-27 US US16/454,853 patent/US10954257B2/en active Active
-
2021
- 2021-03-19 US US17/207,388 patent/US11926640B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018528261A5 (https=) | ||
| JP2021513534A5 (https=) | ||
| JP2011219498A5 (https=) | ||
| IL276322B2 (en) | Lipid-like nanocomplexes and uses thereof | |
| JP2020169171A5 (https=) | ||
| JP2021532162A5 (https=) | ||
| JP2014503574A5 (https=) | ||
| JP2015522650A5 (https=) | ||
| JP2019512478A5 (https=) | ||
| JP2017509586A5 (https=) | ||
| RU2015118647A (ru) | Аминопиримидиновые соединения в качестве ингибиторов содержащих т790м мутантных egfr | |
| JP2014503567A5 (https=) | ||
| JP2014532716A5 (https=) | ||
| JP2019524883A5 (https=) | ||
| JP2016053042A5 (https=) | ||
| JP2010527913A5 (https=) | ||
| JP2006505543A5 (https=) | ||
| JP2008510828A5 (https=) | ||
| JP2008509166A5 (https=) | ||
| JP2016519072A5 (https=) | ||
| RU2018127728A (ru) | Слитые трициклические гетероциклические соединения в качестве ингибиторов интегразы вич | |
| JP2019510810A5 (https=) | ||
| JP2010511721A5 (https=) | ||
| JP2019500387A5 (https=) | ||
| JP2017511321A5 (https=) |