JP2018505700A5 - - Google Patents
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- Publication number
- JP2018505700A5 JP2018505700A5 JP2017562972A JP2017562972A JP2018505700A5 JP 2018505700 A5 JP2018505700 A5 JP 2018505700A5 JP 2017562972 A JP2017562972 A JP 2017562972A JP 2017562972 A JP2017562972 A JP 2017562972A JP 2018505700 A5 JP2018505700 A5 JP 2018505700A5
- Authority
- JP
- Japan
- Prior art keywords
- microparticle
- solid support
- ligand
- linker
- domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000011859 microparticle Substances 0.000 claims 57
- 239000003446 ligand Substances 0.000 claims 44
- 239000007787 solid Substances 0.000 claims 36
- 238000000034 method Methods 0.000 claims 29
- 150000007523 nucleic acids Chemical group 0.000 claims 27
- 108020004707 nucleic acids Proteins 0.000 claims 24
- 102000039446 nucleic acids Human genes 0.000 claims 24
- 239000011230 binding agent Substances 0.000 claims 20
- 239000010419 fine particle Substances 0.000 claims 8
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 7
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 claims 6
- 230000000295 complement effect Effects 0.000 claims 6
- 239000011325 microbead Substances 0.000 claims 6
- 239000002245 particle Substances 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 150000003384 small molecules Chemical class 0.000 claims 4
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 125000002252 acyl group Chemical group 0.000 claims 3
- 239000000908 ammonium hydroxide Substances 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 125000000565 sulfonamide group Chemical group 0.000 claims 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 239000003513 alkali Substances 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 238000012163 sequencing technique Methods 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 229910021529 ammonia Inorganic materials 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- -1 carboxybenzyl Chemical group 0.000 claims 1
- 150000001735 carboxylic acids Chemical class 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000000412 dendrimer Substances 0.000 claims 1
- 229920000736 dendritic polymer Polymers 0.000 claims 1
- 125000005519 fluorenylmethyloxycarbonyl group Chemical group 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 230000001788 irregular Effects 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 239000000377 silicon dioxide Substances 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 150000003573 thiols Chemical class 0.000 claims 1
- 238000009281 ultraviolet germicidal irradiation Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021068860A JP7109618B6 (ja) | 2015-02-24 | 2021-04-15 | 化学的にコードされ空間的にアドレスされたライブラリースクリーニングプラットフォーム |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562120262P | 2015-02-24 | 2015-02-24 | |
| US62/120,262 | 2015-02-24 | ||
| PCT/US2016/019426 WO2016138184A1 (en) | 2015-02-24 | 2016-02-24 | Chemically encoded spatially addressed library screening platforms |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021068860A Division JP7109618B6 (ja) | 2015-02-24 | 2021-04-15 | 化学的にコードされ空間的にアドレスされたライブラリースクリーニングプラットフォーム |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018505700A JP2018505700A (ja) | 2018-03-01 |
| JP2018505700A5 true JP2018505700A5 (enExample) | 2019-09-12 |
| JP6872501B2 JP6872501B2 (ja) | 2021-05-19 |
Family
ID=56789474
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017562972A Active JP6872501B2 (ja) | 2015-02-24 | 2016-02-24 | 化学的にコードされ空間的にアドレスされたライブラリースクリーニングプラットフォーム |
| JP2021068860A Active JP7109618B6 (ja) | 2015-02-24 | 2021-04-15 | 化学的にコードされ空間的にアドレスされたライブラリースクリーニングプラットフォーム |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021068860A Active JP7109618B6 (ja) | 2015-02-24 | 2021-04-15 | 化学的にコードされ空間的にアドレスされたライブラリースクリーニングプラットフォーム |
Country Status (19)
| Country | Link |
|---|---|
| US (6) | US10760181B2 (enExample) |
| EP (4) | EP4276059A3 (enExample) |
| JP (2) | JP6872501B2 (enExample) |
| AU (2) | AU2016222755B2 (enExample) |
| CA (1) | CA2976946C (enExample) |
| CY (1) | CY1124954T1 (enExample) |
| DK (3) | DK3650458T5 (enExample) |
| ES (3) | ES2954467T3 (enExample) |
| FI (2) | FI3650459T3 (enExample) |
| HR (3) | HRP20231536T1 (enExample) |
| HU (3) | HUE063406T2 (enExample) |
| LT (3) | LT3650459T (enExample) |
| NZ (1) | NZ734644A (enExample) |
| PL (3) | PL3650458T3 (enExample) |
| PT (3) | PT3650458T (enExample) |
| RS (3) | RS62847B1 (enExample) |
| SI (3) | SI3650459T1 (enExample) |
| SM (3) | SMT202300430T1 (enExample) |
| WO (1) | WO2016138184A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2622112B2 (ja) | 1986-09-26 | 1997-06-18 | キヤノン株式会社 | 画像処理システム |
| WO2009069203A1 (ja) * | 2007-11-28 | 2009-06-04 | Glory Ltd. | チケット処理装置、チケット処理システム及びチケット処理方法 |
| PL3650458T3 (pl) | 2015-02-24 | 2023-11-06 | City Of Hope | Platformy do analiz przesiewowych bibliotek kodowanych chemicznie i adresowanych przestrzennie |
| WO2016165621A1 (zh) * | 2015-04-14 | 2016-10-20 | 成都先导药物开发有限公司 | 一种固相合成dna编码化合物库的方法 |
| CN110249050B (zh) * | 2016-11-08 | 2023-08-18 | 南纳治疗有限公司 | 无标签编码化合物文库 |
| US11084037B2 (en) | 2017-09-25 | 2021-08-10 | Plexium, Inc. | Oligonucleotide encoded chemical libraries |
| SG11202003923PA (en) | 2017-10-31 | 2020-05-28 | Encodia Inc | Methods and kits using nucleic acid encoding and/or label |
| CN114829626A (zh) | 2019-10-10 | 2022-07-29 | 1859公司 | 用于微流体筛选的方法和系统 |
| WO2022170034A1 (en) * | 2021-02-05 | 2022-08-11 | Affinergy, Llc | Rapid assay for apol1 g0 protein |
| WO2023027184A1 (ja) * | 2021-08-27 | 2023-03-02 | 国立大学法人神戸大学 | 基材上に収率よく空孔を形成する技術のためのコアシェル鋳型分子・粒子 |
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| US4672040A (en) | 1983-05-12 | 1987-06-09 | Advanced Magnetics, Inc. | Magnetic particles for use in separations |
| US5235033A (en) | 1985-03-15 | 1993-08-10 | Anti-Gene Development Group | Alpha-morpholino ribonucleoside derivatives and polymers thereof |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| CA2118806A1 (en) * | 1991-09-18 | 1993-04-01 | William J. Dower | Method of synthesizing diverse collections of oligomers |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| US5565324A (en) | 1992-10-01 | 1996-10-15 | The Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
| EP0675873A4 (en) * | 1992-12-11 | 2000-03-29 | Chiron Corp | PRODUCTION OF CODED POLYMERS |
| DK0705279T3 (da) * | 1993-05-27 | 2003-06-10 | Selectide Corp | Topologisk adskilte, kodende fastfase-biblioteker |
| DE69429542T2 (de) * | 1993-06-21 | 2002-08-08 | Selectide Corp., Tucson | Selektiv spaltbare verbindungen, die auf iminodiessigsäure-ester-bindungen basieren |
| US6087186A (en) | 1993-07-16 | 2000-07-11 | Irori | Methods and apparatus for synthesizing labeled combinatorial chemistry libraries |
| NZ276860A (en) | 1993-11-02 | 1997-09-22 | Affymax Tech Nv | Apparatus and its use for synthesising diverse molecular products on substrates |
| US6936477B2 (en) | 1994-04-13 | 2005-08-30 | The Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
| US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
| US7615368B1 (en) | 1994-06-17 | 2009-11-10 | The Board Of Trustees Of The Leland Stanford Junior University | Microarrays of polypeptides |
| US5830645A (en) | 1994-12-09 | 1998-11-03 | The Regents Of The University Of California | Comparative fluorescence hybridization to nucleic acid arrays |
| US5846839A (en) | 1995-12-22 | 1998-12-08 | Glaxo Group Limited | Methods for hard-tagging an encoded synthetic library |
| ES2288760T3 (es) * | 1996-04-25 | 2008-01-16 | Bioarray Solutions Ltd. | Ensamblaje electrocinetico controlado por luz de particulas proximas a superficies. |
| IL127938A (en) | 1996-07-08 | 2002-09-12 | Burstein Lab Inc | A device with a main signal fixed for diagnostic applications and a test method |
| DE19782097T1 (de) | 1996-11-06 | 1999-10-14 | Sequenom Inc | Zusammensetzungen und Verfahren zur Immobilisierung von Nucleinsäuren an feste Träger |
| WO1999067641A2 (en) | 1998-06-24 | 1999-12-29 | Illumina, Inc. | Decoding of array sensors with microspheres |
| US6429027B1 (en) * | 1998-12-28 | 2002-08-06 | Illumina, Inc. | Composite arrays utilizing microspheres |
| US20020150909A1 (en) * | 1999-02-09 | 2002-10-17 | Stuelpnagel John R. | Automated information processing in randomly ordered arrays |
| US6824987B1 (en) | 1999-05-11 | 2004-11-30 | President And Fellows Of Harvard College | Small molecule printing |
| US7932213B2 (en) | 1999-05-11 | 2011-04-26 | President And Fellows Of Harvard College | Small molecule printing |
| US6544732B1 (en) * | 1999-05-20 | 2003-04-08 | Illumina, Inc. | Encoding and decoding of array sensors utilizing nanocrystals |
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| PL3650458T3 (pl) | 2015-02-24 | 2023-11-06 | City Of Hope | Platformy do analiz przesiewowych bibliotek kodowanych chemicznie i adresowanych przestrzennie |
-
2016
- 2016-02-24 PL PL19196007.9T patent/PL3650458T3/pl unknown
- 2016-02-24 CA CA2976946A patent/CA2976946C/en active Active
- 2016-02-24 JP JP2017562972A patent/JP6872501B2/ja active Active
- 2016-02-24 DK DK19196007.9T patent/DK3650458T5/da active
- 2016-02-24 SM SM20230430T patent/SMT202300430T1/it unknown
- 2016-02-24 PL PL19196019.4T patent/PL3650459T3/pl unknown
- 2016-02-24 RS RS20220051A patent/RS62847B1/sr unknown
- 2016-02-24 RS RS20231135A patent/RS64899B1/sr unknown
- 2016-02-24 EP EP23195322.5A patent/EP4276059A3/en active Pending
- 2016-02-24 SI SI201631770T patent/SI3650459T1/sl unknown
- 2016-02-24 RS RS20230660A patent/RS64567B1/sr unknown
- 2016-02-24 ES ES19196007T patent/ES2954467T3/es active Active
- 2016-02-24 SI SI201631737T patent/SI3650458T1/sl unknown
- 2016-02-24 NZ NZ734644A patent/NZ734644A/en unknown
- 2016-02-24 HU HUE19196007A patent/HUE063406T2/hu unknown
- 2016-02-24 PL PL16756316T patent/PL3262059T3/pl unknown
- 2016-02-24 FI FIEP19196019.4T patent/FI3650459T3/fi active
- 2016-02-24 SM SM20230275T patent/SMT202300275T1/it unknown
- 2016-02-24 ES ES16756316T patent/ES2904997T3/es active Active
- 2016-02-24 EP EP16756316.2A patent/EP3262059B1/en active Active
- 2016-02-24 HR HRP20231536TT patent/HRP20231536T1/hr unknown
- 2016-02-24 AU AU2016222755A patent/AU2016222755B2/en active Active
- 2016-02-24 SM SM20220039T patent/SMT202200039T1/it unknown
- 2016-02-24 ES ES19196019T patent/ES2965764T3/es active Active
- 2016-02-24 HR HRP20220093TT patent/HRP20220093T1/hr unknown
- 2016-02-24 HR HRP20230928TT patent/HRP20230928T1/hr unknown
- 2016-02-24 DK DK16756316.2T patent/DK3262059T3/da active
- 2016-02-24 HU HUE19196019A patent/HUE064689T2/hu unknown
- 2016-02-24 EP EP19196019.4A patent/EP3650459B1/en active Active
- 2016-02-24 PT PT191960079T patent/PT3650458T/pt unknown
- 2016-02-24 DK DK19196019.4T patent/DK3650459T5/da active
- 2016-02-24 HU HUE16756316A patent/HUE058813T2/hu unknown
- 2016-02-24 EP EP19196007.9A patent/EP3650458B1/en active Active
- 2016-02-24 US US15/553,140 patent/US10760181B2/en active Active
- 2016-02-24 FI FIEP19196007.9T patent/FI3650458T3/fi active
- 2016-02-24 LT LTEP19196019.4T patent/LT3650459T/lt unknown
- 2016-02-24 PT PT167563162T patent/PT3262059T/pt unknown
- 2016-02-24 PT PT191960194T patent/PT3650459T/pt unknown
- 2016-02-24 SI SI201631454T patent/SI3262059T1/sl unknown
- 2016-02-24 WO PCT/US2016/019426 patent/WO2016138184A1/en not_active Ceased
- 2016-02-24 LT LTEP19196007.9T patent/LT3650458T/lt unknown
- 2016-02-24 LT LTEPPCT/US2016/019426T patent/LT3262059T/lt unknown
-
2019
- 2019-08-29 US US16/555,531 patent/US10767278B2/en active Active
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2020
- 2020-07-28 US US16/940,499 patent/US11015265B2/en active Active
- 2020-07-30 US US16/943,630 patent/US11015266B2/en active Active
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2021
- 2021-01-21 AU AU2021200399A patent/AU2021200399B2/en active Active
- 2021-04-15 JP JP2021068860A patent/JP7109618B6/ja active Active
- 2021-04-22 US US17/238,150 patent/US20210324538A1/en active Pending
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2022
- 2022-01-21 CY CY20221100054T patent/CY1124954T1/el unknown
- 2022-06-21 US US17/845,949 patent/US20220341059A1/en active Pending
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