JP2018505700A5 - - Google Patents
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- Publication number
- JP2018505700A5 JP2018505700A5 JP2017562972A JP2017562972A JP2018505700A5 JP 2018505700 A5 JP2018505700 A5 JP 2018505700A5 JP 2017562972 A JP2017562972 A JP 2017562972A JP 2017562972 A JP2017562972 A JP 2017562972A JP 2018505700 A5 JP2018505700 A5 JP 2018505700A5
- Authority
- JP
- Japan
- Prior art keywords
- microparticle
- solid support
- ligand
- linker
- domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000011859 microparticle Substances 0.000 claims 57
- 239000003446 ligand Substances 0.000 claims 44
- 239000007787 solid Substances 0.000 claims 36
- 238000000034 method Methods 0.000 claims 29
- 150000007523 nucleic acids Chemical group 0.000 claims 27
- 108020004707 nucleic acids Proteins 0.000 claims 24
- 102000039446 nucleic acids Human genes 0.000 claims 24
- 239000011230 binding agent Substances 0.000 claims 20
- 239000010419 fine particle Substances 0.000 claims 8
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 7
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 claims 6
- 230000000295 complement effect Effects 0.000 claims 6
- 239000011325 microbead Substances 0.000 claims 6
- 239000002245 particle Substances 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 150000003384 small molecules Chemical class 0.000 claims 4
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 125000002252 acyl group Chemical group 0.000 claims 3
- 239000000908 ammonium hydroxide Substances 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 125000000565 sulfonamide group Chemical group 0.000 claims 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 239000003513 alkali Substances 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 238000012163 sequencing technique Methods 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 229910021529 ammonia Inorganic materials 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- -1 carboxybenzyl Chemical group 0.000 claims 1
- 150000001735 carboxylic acids Chemical class 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000000412 dendrimer Substances 0.000 claims 1
- 229920000736 dendritic polymer Polymers 0.000 claims 1
- 125000005519 fluorenylmethyloxycarbonyl group Chemical group 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 230000001788 irregular Effects 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 239000000377 silicon dioxide Substances 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 150000003573 thiols Chemical class 0.000 claims 1
- 238000009281 ultraviolet germicidal irradiation Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021068860A JP7109618B6 (ja) | 2015-02-24 | 2021-04-15 | 化学的にコードされ空間的にアドレスされたライブラリースクリーニングプラットフォーム |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562120262P | 2015-02-24 | 2015-02-24 | |
| US62/120,262 | 2015-02-24 | ||
| PCT/US2016/019426 WO2016138184A1 (en) | 2015-02-24 | 2016-02-24 | Chemically encoded spatially addressed library screening platforms |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021068860A Division JP7109618B6 (ja) | 2015-02-24 | 2021-04-15 | 化学的にコードされ空間的にアドレスされたライブラリースクリーニングプラットフォーム |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018505700A JP2018505700A (ja) | 2018-03-01 |
| JP2018505700A5 true JP2018505700A5 (enExample) | 2019-09-12 |
| JP6872501B2 JP6872501B2 (ja) | 2021-05-19 |
Family
ID=56789474
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017562972A Active JP6872501B2 (ja) | 2015-02-24 | 2016-02-24 | 化学的にコードされ空間的にアドレスされたライブラリースクリーニングプラットフォーム |
| JP2021068860A Active JP7109618B6 (ja) | 2015-02-24 | 2021-04-15 | 化学的にコードされ空間的にアドレスされたライブラリースクリーニングプラットフォーム |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021068860A Active JP7109618B6 (ja) | 2015-02-24 | 2021-04-15 | 化学的にコードされ空間的にアドレスされたライブラリースクリーニングプラットフォーム |
Country Status (19)
| Country | Link |
|---|---|
| US (6) | US10760181B2 (enExample) |
| EP (4) | EP3262059B1 (enExample) |
| JP (2) | JP6872501B2 (enExample) |
| AU (2) | AU2016222755B2 (enExample) |
| CA (1) | CA2976946C (enExample) |
| CY (1) | CY1124954T1 (enExample) |
| DK (3) | DK3262059T3 (enExample) |
| ES (3) | ES2954467T3 (enExample) |
| FI (2) | FI3650458T3 (enExample) |
| HR (3) | HRP20231536T1 (enExample) |
| HU (3) | HUE063406T2 (enExample) |
| LT (3) | LT3650458T (enExample) |
| NZ (1) | NZ734644A (enExample) |
| PL (3) | PL3262059T3 (enExample) |
| PT (3) | PT3650459T (enExample) |
| RS (3) | RS62847B1 (enExample) |
| SI (3) | SI3650458T1 (enExample) |
| SM (3) | SMT202300430T1 (enExample) |
| WO (1) | WO2016138184A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2622112B2 (ja) | 1986-09-26 | 1997-06-18 | キヤノン株式会社 | 画像処理システム |
| WO2009069203A1 (ja) * | 2007-11-28 | 2009-06-04 | Glory Ltd. | チケット処理装置、チケット処理システム及びチケット処理方法 |
| US10760181B2 (en) * | 2015-02-24 | 2020-09-01 | City Of Hope | Chemically encoded spatially addressed library screening platforms |
| EP3284851B1 (en) * | 2015-04-14 | 2020-12-23 | Hitgen Inc. | Method for solid-phase synthesis of dna-encoded chemical library |
| CN110249050B (zh) * | 2016-11-08 | 2023-08-18 | 南纳治疗有限公司 | 无标签编码化合物文库 |
| US11084037B2 (en) | 2017-09-25 | 2021-08-10 | Plexium, Inc. | Oligonucleotide encoded chemical libraries |
| US20210355483A1 (en) | 2017-10-31 | 2021-11-18 | Encodia, Inc. | Methods and kits using nucleic acid encoding and/or label |
| AU2020361681A1 (en) | 2019-10-10 | 2022-05-05 | 1859, Inc. | Methods and systems for microfluidic screening |
| US12577702B2 (en) | 2020-01-28 | 2026-03-17 | Plexium, Inc. | Oligonucleotide encoded chemical libraries, related systems, devices, and methods for detecting, analyzing, quantifying, and testing biologics/genetics |
| WO2022170034A1 (en) * | 2021-02-05 | 2022-08-11 | Affinergy, Llc | Rapid assay for apol1 g0 protein |
| US20250368840A1 (en) * | 2021-08-27 | 2025-12-04 | National University Corporation Kobe University | Core-shell template molecule/particle for technique for high-yield formation of pores on substrate |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4672040A (en) * | 1983-05-12 | 1987-06-09 | Advanced Magnetics, Inc. | Magnetic particles for use in separations |
| US5235033A (en) | 1985-03-15 | 1993-08-10 | Anti-Gene Development Group | Alpha-morpholino ribonucleoside derivatives and polymers thereof |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| EP0604552B1 (en) | 1991-09-18 | 1997-02-12 | Affymax Technologies N.V. | Method of synthesizing diverse collections of oligomers |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| US5565324A (en) | 1992-10-01 | 1996-10-15 | The Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
| WO1994013623A1 (en) | 1992-12-11 | 1994-06-23 | Chiron Corporation | Synthesis of encoded polymers |
| CA2163637C (en) * | 1993-05-27 | 2008-05-06 | Michal Lebl | Topologically segregated, encoded solid phase libraries |
| NZ268292A (en) * | 1993-06-21 | 1997-09-22 | Selectide Corp | Solid phase peptide synthesis and supports therefor |
| US6087186A (en) | 1993-07-16 | 2000-07-11 | Irori | Methods and apparatus for synthesizing labeled combinatorial chemistry libraries |
| JPH09508353A (ja) * | 1993-11-02 | 1997-08-26 | アフィマックス テクノロジーズ ナムローゼ フェンノートシャップ | 分子多様性の合成及びスクリーニング |
| US6936477B2 (en) | 1994-04-13 | 2005-08-30 | The Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
| US7615368B1 (en) | 1994-06-17 | 2009-11-10 | The Board Of Trustees Of The Leland Stanford Junior University | Microarrays of polypeptides |
| US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
| US5830645A (en) | 1994-12-09 | 1998-11-03 | The Regents Of The University Of California | Comparative fluorescence hybridization to nucleic acid arrays |
| US5846839A (en) | 1995-12-22 | 1998-12-08 | Glaxo Group Limited | Methods for hard-tagging an encoded synthetic library |
| US6251691B1 (en) | 1996-04-25 | 2001-06-26 | Bioarray Solutions, Llc | Light-controlled electrokinetic assembly of particles near surfaces |
| IL127938A (en) * | 1996-07-08 | 2002-09-12 | Burstein Lab Inc | A device with a main signal fixed for diagnostic applications and a test method |
| DE69706187T2 (de) * | 1996-11-06 | 2002-04-11 | Sequenom, Inc. | Zusammensetzungen und verfahren zur immobilisierung von nukleinsäure auf festträgern |
| US7060431B2 (en) | 1998-06-24 | 2006-06-13 | Illumina, Inc. | Method of making and decoding of array sensors with microspheres |
| US6429027B1 (en) * | 1998-12-28 | 2002-08-06 | Illumina, Inc. | Composite arrays utilizing microspheres |
| US20020150909A1 (en) * | 1999-02-09 | 2002-10-17 | Stuelpnagel John R. | Automated information processing in randomly ordered arrays |
| US6824987B1 (en) | 1999-05-11 | 2004-11-30 | President And Fellows Of Harvard College | Small molecule printing |
| US7932213B2 (en) | 1999-05-11 | 2011-04-26 | President And Fellows Of Harvard College | Small molecule printing |
| US6544732B1 (en) * | 1999-05-20 | 2003-04-08 | Illumina, Inc. | Encoding and decoding of array sensors utilizing nanocrystals |
| US7160735B2 (en) | 2000-04-28 | 2007-01-09 | Monogram Biosciences, Inc. | Tagged microparticle compositions and methods |
| JP3899831B2 (ja) | 2001-03-02 | 2007-03-28 | 株式会社日立製作所 | 生化学センサ及びこれを用いた生化学検査装置 |
| US20060040286A1 (en) | 2001-03-28 | 2006-02-23 | Nanosphere, Inc. | Bio-barcode based detection of target analytes |
| US20030027221A1 (en) | 2001-04-06 | 2003-02-06 | Scott Melissa E. | High-throughput screening assays by encapsulation |
| US20030228619A1 (en) | 2002-06-10 | 2003-12-11 | Xenoport, Inc. | Peptide nucleic acids as tags in encoded libraries |
| CA2565967A1 (en) | 2004-06-10 | 2005-12-29 | Perkinelmer Las, Inc. | Multiplexing assays for analyte detection |
| US20060134697A1 (en) * | 2004-10-28 | 2006-06-22 | The Regents Of The University Of California | Method of preparing coded compound libraries |
| AU2006336290A1 (en) * | 2005-09-16 | 2007-07-26 | The Regents Of The University Of California | A colorimetric bio-barcode amplification assay for analyte detection |
| EP2396409A2 (en) | 2009-02-10 | 2011-12-21 | Idera Pharmaceuticals, Inc. | Synthetic rna-based agonists of tlr7 |
| US9172561B2 (en) | 2009-07-29 | 2015-10-27 | Qualcomm Incorporated | Adaptive transmissions in coordinated multiple point communications |
| WO2011014879A2 (en) | 2009-07-31 | 2011-02-03 | Prognosys Biosciences, Inc. | Assay tools and methods of use |
| WO2011143583A1 (en) * | 2010-05-13 | 2011-11-17 | Illumina, Inc. | Binding assays for markers |
| CN104781276A (zh) | 2012-08-14 | 2015-07-15 | 安吉奥开米公司 | 肽-树枝状聚合物结合物及其用途 |
| CN104620093B (zh) * | 2012-08-23 | 2018-04-20 | 干细胞技术公司 | 用于快速可逆生物分子标记的组合物和方法 |
| US10760181B2 (en) | 2015-02-24 | 2020-09-01 | City Of Hope | Chemically encoded spatially addressed library screening platforms |
-
2016
- 2016-02-24 US US15/553,140 patent/US10760181B2/en active Active
- 2016-02-24 HR HRP20231536TT patent/HRP20231536T1/hr unknown
- 2016-02-24 PT PT191960194T patent/PT3650459T/pt unknown
- 2016-02-24 RS RS20220051A patent/RS62847B1/sr unknown
- 2016-02-24 LT LTEP19196007.9T patent/LT3650458T/lt unknown
- 2016-02-24 LT LTEP19196019.4T patent/LT3650459T/lt unknown
- 2016-02-24 DK DK16756316.2T patent/DK3262059T3/da active
- 2016-02-24 SM SM20230430T patent/SMT202300430T1/it unknown
- 2016-02-24 PL PL16756316T patent/PL3262059T3/pl unknown
- 2016-02-24 AU AU2016222755A patent/AU2016222755B2/en active Active
- 2016-02-24 SM SM20220039T patent/SMT202200039T1/it unknown
- 2016-02-24 RS RS20230660A patent/RS64567B1/sr unknown
- 2016-02-24 NZ NZ734644A patent/NZ734644A/en unknown
- 2016-02-24 RS RS20231135A patent/RS64899B1/sr unknown
- 2016-02-24 SM SM20230275T patent/SMT202300275T1/it unknown
- 2016-02-24 LT LTEPPCT/US2016/019426T patent/LT3262059T/lt unknown
- 2016-02-24 ES ES19196007T patent/ES2954467T3/es active Active
- 2016-02-24 EP EP16756316.2A patent/EP3262059B1/en active Active
- 2016-02-24 HU HUE19196007A patent/HUE063406T2/hu unknown
- 2016-02-24 HR HRP20220093TT patent/HRP20220093T1/hr unknown
- 2016-02-24 CA CA2976946A patent/CA2976946C/en active Active
- 2016-02-24 SI SI201631737T patent/SI3650458T1/sl unknown
- 2016-02-24 SI SI201631454T patent/SI3262059T1/sl unknown
- 2016-02-24 EP EP23195322.5A patent/EP4276059A3/en not_active Withdrawn
- 2016-02-24 FI FIEP19196007.9T patent/FI3650458T3/fi active
- 2016-02-24 PT PT167563162T patent/PT3262059T/pt unknown
- 2016-02-24 WO PCT/US2016/019426 patent/WO2016138184A1/en not_active Ceased
- 2016-02-24 PL PL19196019.4T patent/PL3650459T3/pl unknown
- 2016-02-24 ES ES16756316T patent/ES2904997T3/es active Active
- 2016-02-24 ES ES19196019T patent/ES2965764T3/es active Active
- 2016-02-24 HU HUE19196019A patent/HUE064689T2/hu unknown
- 2016-02-24 DK DK19196019.4T patent/DK3650459T5/da active
- 2016-02-24 DK DK19196007.9T patent/DK3650458T5/da active
- 2016-02-24 HR HRP20230928TT patent/HRP20230928T1/hr unknown
- 2016-02-24 JP JP2017562972A patent/JP6872501B2/ja active Active
- 2016-02-24 SI SI201631770T patent/SI3650459T1/sl unknown
- 2016-02-24 HU HUE16756316A patent/HUE058813T2/hu unknown
- 2016-02-24 EP EP19196019.4A patent/EP3650459B1/en active Active
- 2016-02-24 PL PL19196007.9T patent/PL3650458T3/pl unknown
- 2016-02-24 EP EP19196007.9A patent/EP3650458B1/en active Active
- 2016-02-24 FI FIEP19196019.4T patent/FI3650459T3/fi active
- 2016-02-24 PT PT191960079T patent/PT3650458T/pt unknown
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2019
- 2019-08-29 US US16/555,531 patent/US10767278B2/en active Active
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2020
- 2020-07-28 US US16/940,499 patent/US11015265B2/en active Active
- 2020-07-30 US US16/943,630 patent/US11015266B2/en active Active
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2021
- 2021-01-21 AU AU2021200399A patent/AU2021200399B2/en active Active
- 2021-04-15 JP JP2021068860A patent/JP7109618B6/ja active Active
- 2021-04-22 US US17/238,150 patent/US12624476B2/en active Active
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2022
- 2022-01-21 CY CY20221100054T patent/CY1124954T1/el unknown
- 2022-06-21 US US17/845,949 patent/US20220341059A1/en active Pending
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