JP6872501B2 - 化学的にコードされ空間的にアドレスされたライブラリースクリーニングプラットフォーム - Google Patents

化学的にコードされ空間的にアドレスされたライブラリースクリーニングプラットフォーム Download PDF

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JP6872501B2
JP6872501B2 JP2017562972A JP2017562972A JP6872501B2 JP 6872501 B2 JP6872501 B2 JP 6872501B2 JP 2017562972 A JP2017562972 A JP 2017562972A JP 2017562972 A JP2017562972 A JP 2017562972A JP 6872501 B2 JP6872501 B2 JP 6872501B2
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fine particles
ligand
linker
nucleic acid
solid support
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JP2018505700A5 (enExample
JP2018505700A (ja
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ベルリン，ジェイコブ
コープランド，グレゴリー
エリソン，キャスリーン
ムラディアン，ヒュリック
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City of Hope
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City of Hope
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    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C40B50/16—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support involving encoding steps
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Plant Pathology (AREA)
  • Structural Engineering (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Signal Processing For Digital Recording And Reproducing (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
JP2017562972A 2015-02-24 2016-02-24 化学的にコードされ空間的にアドレスされたライブラリースクリーニングプラットフォーム Active JP6872501B2 (ja)

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JP2021068860A JP7109618B6 (ja) 2015-02-24 2021-04-15 化学的にコードされ空間的にアドレスされたライブラリースクリーニングプラットフォーム

Applications Claiming Priority (3)

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US201562120262P 2015-02-24 2015-02-24
US62/120,262 2015-02-24
PCT/US2016/019426 WO2016138184A1 (en) 2015-02-24 2016-02-24 Chemically encoded spatially addressed library screening platforms

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JP2021068860A Active JP7109618B6 (ja) 2015-02-24 2021-04-15 化学的にコードされ空間的にアドレスされたライブラリースクリーニングプラットフォーム

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US (6) US10760181B2 (enExample)
EP (4) EP4276059A3 (enExample)
JP (2) JP6872501B2 (enExample)
AU (2) AU2016222755B2 (enExample)
CA (1) CA2976946C (enExample)
CY (1) CY1124954T1 (enExample)
DK (3) DK3650458T5 (enExample)
ES (3) ES2954467T3 (enExample)
FI (2) FI3650459T3 (enExample)
HR (3) HRP20231536T1 (enExample)
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NZ (1) NZ734644A (enExample)
PL (3) PL3650458T3 (enExample)
PT (3) PT3650458T (enExample)
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SI (3) SI3650459T1 (enExample)
SM (3) SMT202300430T1 (enExample)
WO (1) WO2016138184A1 (enExample)

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EP3650458A1 (en) 2020-05-13
DK3262059T3 (da) 2022-01-31
RS64567B1 (sr) 2023-10-31
PT3650458T (pt) 2023-08-31
SMT202300275T1 (it) 2023-11-13
US11015266B2 (en) 2021-05-25
SMT202300430T1 (it) 2024-01-10
US20210324538A1 (en) 2021-10-21
ES2904997T3 (es) 2022-04-06
AU2021200399A1 (en) 2021-03-18
ES2965764T3 (es) 2024-04-16
CA2976946A1 (en) 2016-09-01
US20200378032A1 (en) 2020-12-03
DK3650459T3 (da) 2023-12-11
HRP20231536T1 (hr) 2024-03-15
FI3650458T3 (fi) 2023-08-21
LT3650458T (lt) 2023-10-10
LT3262059T (lt) 2022-02-25
HUE064689T2 (hu) 2024-04-28
NZ734644A (en) 2023-02-24
HRP20230928T1 (hr) 2023-11-24
NZ772386A (en) 2024-10-25
JP2021106607A (ja) 2021-07-29
WO2016138184A1 (en) 2016-09-01
DK3650458T3 (da) 2023-09-04
EP3650459A1 (en) 2020-05-13
PL3650459T3 (pl) 2024-02-26
CA2976946C (en) 2023-09-19
AU2016222755A1 (en) 2017-08-31
HUE063406T2 (hu) 2024-01-28
HUE058813T2 (hu) 2022-09-28
RS62847B1 (sr) 2022-02-28
EP3262059B1 (en) 2022-01-05
FI3650459T3 (fi) 2023-11-28
SMT202200039T1 (it) 2022-03-21
DK3650459T5 (da) 2024-08-26
SI3262059T1 (sl) 2022-04-29
PL3650458T3 (pl) 2023-11-06
US10760181B2 (en) 2020-09-01
EP3262059A1 (en) 2018-01-03
AU2021200399B2 (en) 2023-04-20
PT3262059T (pt) 2022-01-27
LT3650459T (lt) 2023-12-27
HRP20220093T1 (hr) 2022-04-15
SI3650458T1 (sl) 2023-11-30
DK3650458T5 (da) 2024-08-26
SI3650459T1 (sl) 2024-04-30
US20220341059A1 (en) 2022-10-27
EP4276059A3 (en) 2024-05-01
EP3650458B1 (en) 2023-08-09
ES2954467T3 (es) 2023-11-22
US10767278B2 (en) 2020-09-08
EP4276059A2 (en) 2023-11-15
JP7109618B2 (ja) 2022-07-29
AU2016222755B2 (en) 2021-02-18
US20200378031A1 (en) 2020-12-03
JP7109618B6 (ja) 2022-08-22
EP3650459B1 (en) 2023-09-06
EP3262059A4 (en) 2018-12-05
US20180245241A1 (en) 2018-08-30
PT3650459T (pt) 2023-12-06
US20190390367A1 (en) 2019-12-26
CY1124954T1 (el) 2023-01-05
JP2018505700A (ja) 2018-03-01
RS64899B1 (sr) 2023-12-29
US11015265B2 (en) 2021-05-25
PL3262059T3 (pl) 2022-02-21

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