HRP20220093T1 - Platforme za provjeravanje kemijski kodiranih prostorno adresiranih biblioteka - Google Patents
Platforme za provjeravanje kemijski kodiranih prostorno adresiranih biblioteka Download PDFInfo
- Publication number
- HRP20220093T1 HRP20220093T1 HRP20220093TT HRP20220093T HRP20220093T1 HR P20220093 T1 HRP20220093 T1 HR P20220093T1 HR P20220093T T HRP20220093T T HR P20220093TT HR P20220093 T HRP20220093 T HR P20220093T HR P20220093 T1 HRP20220093 T1 HR P20220093T1
- Authority
- HR
- Croatia
- Prior art keywords
- linker
- microparticle
- domain
- nucleic acid
- ligand
- Prior art date
Links
- 238000012216 screening Methods 0.000 title 1
- 239000003446 ligand Substances 0.000 claims 15
- 239000011859 microparticle Substances 0.000 claims 15
- 150000007523 nucleic acids Chemical class 0.000 claims 9
- 239000007787 solid Substances 0.000 claims 8
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 7
- 239000011325 microbead Substances 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 150000003384 small molecules Chemical class 0.000 claims 4
- 239000011230 binding agent Substances 0.000 claims 3
- 239000000758 substrate Substances 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 230000001681 protective effect Effects 0.000 claims 2
- 229920001059 synthetic polymer Polymers 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 239000013592 cell lysate Substances 0.000 claims 1
- 239000000412 dendrimer Substances 0.000 claims 1
- 229920000736 dendritic polymer Polymers 0.000 claims 1
- 239000002223 garnet Substances 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 235000012239 silicon dioxide Nutrition 0.000 claims 1
- 239000000377 silicon dioxide Substances 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
- C40B50/16—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support involving encoding steps
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54346—Nanoparticles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Nanotechnology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Structural Engineering (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Signal Processing For Digital Recording And Reproducing (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
Claims (14)
1. Mikročestica imobilizirana na čvrstoj podlozi, naznačena time, što je navedena mikročestica kovalentno prikačena još i za:
(i) domenu liganda preko prvog linkera; i
(ii) domenu nukleinske kiseline preko drugog linkera;
pri čemu je navedena domena nukleinske kiseline kodirajuća oznaka koja identificira navedenu domenu liganda;
pri čemu je navedeni drugi linker cjepljiv i navedeni prvi linker nije cjepljiv pod uvjetima pod kojima je navedeni drugi linker cjepljiv; i navedeni prvi linker uključuje -C(O)NH- ili -NHC(O)-, i navedeni drugi linker uključuje -C(O)O- ili -OC(O)-.
2. Mikročestica iz patentnog zahtjeva 1, naznačena time, što je navedena mikročestica mikroperlica, funkcionalizirana mikroperlica, magnetna mikroperlica, metalna mikroperlica, mikroperlica od silicij-dioksida, polimerna mikroperlica, dendrimer ili granati polimer.
3. Mikročestica iz patentnog zahtjeva 1 ili patentnog zahtjeva 2, naznačena time, što je navedena domena liganda mala molekula.
4. Mikročestica iz patentnog zahtjeva 1 ili patentnog zahtjeva 2, naznačena time, što je navedena domena liganda peptid ili protein.
5. Mikročestica iz bilo kojeg od patentnih zahtjeva 1-4, naznačena time, što navedena domena liganda uključuje reaktivnu komponentu kovalentno prikačenu za uklonjivu zaštitnu komponentu.
6. Mikročestica iz patentnog zahtjeva 5, naznačena time, što se navedena reaktivna komponenta bira između aminokiselinskog bočnog lanca, amino-terminusa, ili karboksi-terminusa.
7. Mikročestica iz bilo kojeg od patentnih zahtjeva 1 do 6, naznačena time, što je navedena domena nukleinske kiseline vezana za komplementarnu sekvencu nukleinske kiseline, pri čemu navedena sekvenca nukleinske kiseline uključuje komponentu koja se može detektirati.
8. Mikročestica iz bilo kojeg od patentnih zahtjeva 1 do 7, naznačena time, što se navedena domena liganda veže sa vezivom liganda.
9. Čvrsta podloga, naznačena time, što uključuje veliki broj bunarčića, pri čemu svaki od navedenog velikog broja bunarčića uključuje imobiliziranu mikročesticu, pri čemu je navedena mikročestica kovalentno prikačena za:
(i) domenu liganda preko prvog linkera; i
(ii) domenu nukleinske kiseline preko drugog linkera;
pri čemu je navedena domena nukleinske kiseline kodirajuća oznaka koja identificira navedenu domenu liganda;
pri čemu je navedeni drugi linker cjepljiv i navedeni prvi linker nije cjepljiv pod uvjetima pod kojima je navedeni drugi linker cjepljiv; i navedeni prvi linker uključuje -C(O)NH- ili -NHC(O)-, i navedeni drugi linker uključuje -C(O)O- ili -OC(O)-;
i
pri čemu se navedena domena liganda može vezati za vezivo liganda koje se bira između proteina, mješavine proteina, male molekule, mješavine malih molekula, elementa, mješavine elemenata, sintetskog polimera, mješavine sintetskih polimera, ili staničnog lizata.
10. Čvrsta podloga iz patentnog zahtjeva 9, naznačena time, što je domena liganda peptid, mala molekula ili protein.
11. Čvrsta podloga iz patentnog zahtjeva 9 ili patentnog zahtjeva 10, naznačena time, što navedena domena liganda uključuje reaktivnu komponentu kovalentno prikačenu za uklonjivu zaštitnu komponentu.
12. Čvrsta podloga iz bilo kojeg od patentnih zahtjeva 9 do 11, naznačena time, što je navedena domena nukleinske kiseline vezana za komplementarnu nukleinsku kiselinu koja uključuje komponentu koja se može detektirati.
13. Čvrsta podloga iz bilo kojeg od patentnih zahtjeva 9 do 12, naznačena time, što se navedena domena liganda veže sa navedenim vezivom liganda.
14. Čvrsta podloga iz bilo kojeg od patentnih zahtjeva 9 do 13, naznačena time, što su mikročestice, uključujući navedenu mikročesticu, sastavljene na čvrstoj podlozi da bi formirale uređeni niz koji uključuje najmanje 10,000 mikročestica po kvadratnom milimetru.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562120262P | 2015-02-24 | 2015-02-24 | |
| EP16756316.2A EP3262059B1 (en) | 2015-02-24 | 2016-02-24 | Chemically encoded spatially addressed library screening platforms |
| PCT/US2016/019426 WO2016138184A1 (en) | 2015-02-24 | 2016-02-24 | Chemically encoded spatially addressed library screening platforms |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20220093T1 true HRP20220093T1 (hr) | 2022-04-15 |
Family
ID=56789474
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20231536TT HRP20231536T1 (hr) | 2015-02-24 | 2016-02-24 | Platforme za pregled kemijski kodiranih prostorno adresiranih biblioteka |
| HRP20230928TT HRP20230928T1 (hr) | 2015-02-24 | 2016-02-24 | Platforme za skrining kemijski kodiranih prostorno adresiranih biblioteka |
| HRP20220093TT HRP20220093T1 (hr) | 2015-02-24 | 2016-02-24 | Platforme za provjeravanje kemijski kodiranih prostorno adresiranih biblioteka |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20231536TT HRP20231536T1 (hr) | 2015-02-24 | 2016-02-24 | Platforme za pregled kemijski kodiranih prostorno adresiranih biblioteka |
| HRP20230928TT HRP20230928T1 (hr) | 2015-02-24 | 2016-02-24 | Platforme za skrining kemijski kodiranih prostorno adresiranih biblioteka |
Country Status (18)
| Country | Link |
|---|---|
| US (6) | US10760181B2 (hr) |
| EP (4) | EP4276059A3 (hr) |
| JP (2) | JP6872501B2 (hr) |
| AU (2) | AU2016222755B2 (hr) |
| CA (1) | CA2976946C (hr) |
| CY (1) | CY1124954T1 (hr) |
| DK (3) | DK3262059T3 (hr) |
| ES (3) | ES2954467T3 (hr) |
| FI (2) | FI3650459T3 (hr) |
| HR (3) | HRP20231536T1 (hr) |
| HU (3) | HUE058813T2 (hr) |
| LT (3) | LT3650458T (hr) |
| NZ (1) | NZ734644A (hr) |
| PL (3) | PL3650458T3 (hr) |
| PT (3) | PT3650459T (hr) |
| RS (3) | RS64567B1 (hr) |
| SI (3) | SI3650459T1 (hr) |
| WO (1) | WO2016138184A1 (hr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009069203A1 (ja) * | 2007-11-28 | 2009-06-04 | Glory Ltd. | チケット処理装置、チケット処理システム及びチケット処理方法 |
| PL3650458T3 (pl) | 2015-02-24 | 2023-11-06 | City Of Hope | Platformy do analiz przesiewowych bibliotek kodowanych chemicznie i adresowanych przestrzennie |
| JP6554180B6 (ja) * | 2015-04-14 | 2019-09-11 | 成都先導薬物開発股▲フン▼有限公司 | Ｄｎａコード化化合物ライブラリーの固相合成方法 |
| IL266318B2 (en) * | 2016-11-08 | 2023-10-01 | Nanna Therapeutics Ltd | A chemical library without coded labeling |
| CN111971124B (zh) | 2017-09-25 | 2022-08-23 | 普莱克斯姆公司 | 寡核苷酸编码的化学文库 |
| WO2019089851A1 (en) * | 2017-10-31 | 2019-05-09 | Encodia, Inc. | Methods and kits using nucleic acid encoding and/or label |
| KR20220097404A (ko) | 2019-10-10 | 2022-07-07 | 1859, 인크. | 미세유체 스크리닝을 위한 방법 및 시스템 |
| WO2022170034A1 (en) * | 2021-02-05 | 2022-08-11 | Affinergy, Llc | Rapid assay for apol1 g0 protein |
| TW202337974A (zh) * | 2021-08-27 | 2023-10-01 | 國立大學法人神戶大學 | 用於於基材上產率良好地形成空孔之技術之核殼模板分子、粒子 |
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| US4672040A (en) * | 1983-05-12 | 1987-06-09 | Advanced Magnetics, Inc. | Magnetic particles for use in separations |
| US5235033A (en) | 1985-03-15 | 1993-08-10 | Anti-Gene Development Group | Alpha-morpholino ribonucleoside derivatives and polymers thereof |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| AU669489B2 (en) | 1991-09-18 | 1996-06-13 | Affymax Technologies N.V. | Method of synthesizing diverse collections of oligomers |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| US5565324A (en) | 1992-10-01 | 1996-10-15 | The Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
| JPH08504444A (ja) * | 1992-12-11 | 1996-05-14 | カイロン コーポレイション | コードされるポリマーの合成 |
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| AU703472B2 (en) * | 1993-11-02 | 1999-03-25 | Affymax Technologies N.V. | Synthesizing and screening molecular diversity |
| US6936477B2 (en) | 1994-04-13 | 2005-08-30 | The Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
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| US7615368B1 (en) | 1994-06-17 | 2009-11-10 | The Board Of Trustees Of The Leland Stanford Junior University | Microarrays of polypeptides |
| US5830645A (en) | 1994-12-09 | 1998-11-03 | The Regents Of The University Of California | Comparative fluorescence hybridization to nucleic acid arrays |
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-
2016
- 2016-02-24 PL PL19196007.9T patent/PL3650458T3/pl unknown
- 2016-02-24 PL PL16756316T patent/PL3262059T3/pl unknown
- 2016-02-24 LT LTEP19196007.9T patent/LT3650458T/lt unknown
- 2016-02-24 EP EP23195322.5A patent/EP4276059A3/en active Pending
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