JP2018504890A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018504890A5 JP2018504890A5 JP2017529742A JP2017529742A JP2018504890A5 JP 2018504890 A5 JP2018504890 A5 JP 2018504890A5 JP 2017529742 A JP2017529742 A JP 2017529742A JP 2017529742 A JP2017529742 A JP 2017529742A JP 2018504890 A5 JP2018504890 A5 JP 2018504890A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- chain variable
- variable region
- sequence represented
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001413 amino acids Chemical class 0.000 claims description 1694
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims description 394
- 238000012986 modification Methods 0.000 claims description 389
- 230000004048 modification Effects 0.000 claims description 389
- 239000000427 antigen Substances 0.000 claims description 130
- 102000036639 antigens Human genes 0.000 claims description 130
- 108091007433 antigens Proteins 0.000 claims description 130
- 239000012634 fragment Substances 0.000 claims description 110
- 101001040713 Homo sapiens G-protein coupled receptor family C group 5 member D Proteins 0.000 claims description 38
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 32
- 206010028980 Neoplasm Diseases 0.000 claims description 24
- 102000044456 human GPRC5D Human genes 0.000 claims description 22
- 102100021197 G-protein coupled receptor family C group 5 member D Human genes 0.000 claims description 16
- 208000034578 Multiple myelomas Diseases 0.000 claims description 12
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 12
- 210000004027 cell Anatomy 0.000 claims description 12
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 8
- 208000016025 Waldenstroem macroglobulinemia Diseases 0.000 claims description 6
- 208000033559 Waldenström macroglobulinemia Diseases 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 6
- 239000003937 drug carrier Substances 0.000 claims description 6
- 229940127121 immunoconjugate Drugs 0.000 claims description 6
- HVLSXIKZNLPZJJ-TXZCQADKSA-N HA peptide Chemical compound C([C@@H](C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](C)C(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 HVLSXIKZNLPZJJ-TXZCQADKSA-N 0.000 claims description 4
- 239000013604 expression vector Substances 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 150000007523 nucleic acids Chemical class 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 238000006467 substitution reaction Methods 0.000 claims description 4
- 229940124597 therapeutic agent Drugs 0.000 claims description 4
- 101710112752 Cytotoxin Proteins 0.000 claims description 2
- 101100225046 Schizosaccharomyces pombe (strain 972 / ATCC 24843) ecl2 gene Proteins 0.000 claims description 2
- 101100225047 Schizosaccharomyces pombe (strain 972 / ATCC 24843) ecl3 gene Proteins 0.000 claims description 2
- 231100000599 cytotoxic agent Toxicity 0.000 claims description 2
- 239000002619 cytotoxin Substances 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 101150058725 ecl1 gene Proteins 0.000 claims description 2
- 210000002865 immune cell Anatomy 0.000 claims description 2
- 238000002955 isolation Methods 0.000 claims description 2
- 210000004897 n-terminal region Anatomy 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
- 210000004881 tumor cell Anatomy 0.000 claims description 2
- 238000000034 method Methods 0.000 description 10
- 230000001939 inductive effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462088228P | 2014-12-05 | 2014-12-05 | |
| US62/088,228 | 2014-12-05 | ||
| PCT/US2015/064122 WO2016090329A2 (en) | 2014-12-05 | 2015-12-04 | Antibodies targeting g-protein coupled receptor and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020081773A Division JP7027482B2 (ja) | 2014-12-05 | 2020-05-07 | Ｇタンパク質共役受容体を標的化する抗体および使用の方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018504890A JP2018504890A (ja) | 2018-02-22 |
| JP2018504890A5 true JP2018504890A5 (OSRAM) | 2019-01-17 |
| JP6753851B2 JP6753851B2 (ja) | 2020-09-09 |
Family
ID=56092679
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017529742A Active JP6753851B2 (ja) | 2014-12-05 | 2015-12-04 | Ｇタンパク質共役受容体を標的化する抗体および使用の方法 |
| JP2020081773A Active JP7027482B2 (ja) | 2014-12-05 | 2020-05-07 | Ｇタンパク質共役受容体を標的化する抗体および使用の方法 |
| JP2020140643A Withdrawn JP2020191900A (ja) | 2014-12-05 | 2020-08-24 | Ｇタンパク質共役受容体を標的化する抗体および使用の方法 |
| JP2022002183A Withdrawn JP2022044638A (ja) | 2014-12-05 | 2022-01-11 | Ｇタンパク質共役受容体を標的化する抗体および使用の方法 |
| JP2022082303A Withdrawn JP2022103382A (ja) | 2014-12-05 | 2022-05-19 | Ｇタンパク質共役受容体を標的化する抗体および使用の方法 |
| JP2024033776A Pending JP2024053016A (ja) | 2014-12-05 | 2024-03-06 | Ｇタンパク質共役受容体を標的化する抗体および使用の方法 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020081773A Active JP7027482B2 (ja) | 2014-12-05 | 2020-05-07 | Ｇタンパク質共役受容体を標的化する抗体および使用の方法 |
| JP2020140643A Withdrawn JP2020191900A (ja) | 2014-12-05 | 2020-08-24 | Ｇタンパク質共役受容体を標的化する抗体および使用の方法 |
| JP2022002183A Withdrawn JP2022044638A (ja) | 2014-12-05 | 2022-01-11 | Ｇタンパク質共役受容体を標的化する抗体および使用の方法 |
| JP2022082303A Withdrawn JP2022103382A (ja) | 2014-12-05 | 2022-05-19 | Ｇタンパク質共役受容体を標的化する抗体および使用の方法 |
| JP2024033776A Pending JP2024053016A (ja) | 2014-12-05 | 2024-03-06 | Ｇタンパク質共役受容体を標的化する抗体および使用の方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US10590196B2 (OSRAM) |
| EP (1) | EP3227324A4 (OSRAM) |
| JP (6) | JP6753851B2 (OSRAM) |
| KR (2) | KR102602417B1 (OSRAM) |
| CN (3) | CN113429484A (OSRAM) |
| AU (3) | AU2015357535B2 (OSRAM) |
| BR (1) | BR112017011932A8 (OSRAM) |
| CA (1) | CA2969886A1 (OSRAM) |
| IL (3) | IL307767A (OSRAM) |
| MX (3) | MX2017007247A (OSRAM) |
| MY (1) | MY195115A (OSRAM) |
| PH (1) | PH12017501039A1 (OSRAM) |
| RU (2) | RU2725819C2 (OSRAM) |
| SA (1) | SA517381664B1 (OSRAM) |
| SG (2) | SG10201913937QA (OSRAM) |
| WO (1) | WO2016090329A2 (OSRAM) |
Families Citing this family (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113429484A (zh) * | 2014-12-05 | 2021-09-24 | 纪念斯隆-凯特琳癌症中心 | 靶向g-蛋白偶联受体的抗体和使用方法 |
| CN113683711A (zh) | 2014-12-05 | 2021-11-23 | 纪念斯隆-凯特琳癌症中心 | 靶向g-蛋白偶联受体的嵌合抗原受体及其用途 |
| MX2018004721A (es) | 2015-10-23 | 2018-07-06 | Eureka Therapeutics Inc | Construcciones quimericas anticuerpo/receptor de celulas t y usos de las mismas. |
| TWI781108B (zh) * | 2016-07-20 | 2022-10-21 | 比利時商健生藥品公司 | 抗ｇｐｒｃ５ｄ抗體、結合ｇｐｒｃ５ｄ與ｃｄ３之雙特異性抗原結合分子及其用途 |
| US12269859B2 (en) | 2016-12-02 | 2025-04-08 | Angeles Therapeutics, Inc. | Synthetic immune receptors and methods of use thereof |
| SG11201907321TA (en) * | 2017-02-07 | 2019-09-27 | Daiichi Sankyo Co Ltd | Anti-gprc5d antibody and molecule comprising the antibody |
| AU2018258045B2 (en) | 2017-04-26 | 2024-02-29 | Eureka Therapeutics, Inc. | Chimeric antibody/T-cell receptor constructs and uses thereof |
| MX2020001491A (es) | 2017-08-09 | 2020-08-06 | Juno Therapeutics Inc | Metodos y composiciones para preparar celulas geneticamente modificadas. |
| ES2959953T3 (es) | 2017-08-09 | 2024-02-29 | Juno Therapeutics Inc | Métodos para producir composiciones celulares genéticamente modificadas y composiciones relacionadas |
| EP3679370A1 (en) | 2017-09-07 | 2020-07-15 | Juno Therapeutics, Inc. | Methods of identifying cellular attributes related to outcomes associated with cell therapy |
| CN111447952A (zh) | 2017-10-05 | 2020-07-24 | 第一三共株式会社 | 用于细胞毒性t细胞耗竭的组合物 |
| EP3704229B1 (en) | 2017-11-01 | 2023-12-20 | Juno Therapeutics, Inc. | Process for producing a t cell composition |
| US11564946B2 (en) | 2017-11-01 | 2023-01-31 | Juno Therapeutics, Inc. | Methods associated with tumor burden for assessing response to a cell therapy |
| US12031975B2 (en) | 2017-11-01 | 2024-07-09 | Juno Therapeutics, Inc. | Methods of assessing or monitoring a response to a cell therapy |
| PL3703750T3 (pl) | 2017-11-01 | 2025-04-07 | Juno Therapeutics, Inc. | Chimeryczne receptory antygenowe specyficzne dla antygenu dojrzewania komórek b i kodujące polinukleotydy |
| SG11202003688PA (en) | 2017-11-01 | 2020-05-28 | Juno Therapeutics Inc | Process for generating therapeutic compositions of engineered cells |
| EP3716980A1 (en) | 2017-12-01 | 2020-10-07 | Juno Therapeutics, Inc. | Methods for dosing and for modulation of genetically engineered cells |
| KR102853341B1 (ko) | 2017-12-08 | 2025-09-02 | 주노 쎄러퓨티크스 인코퍼레이티드 | 조작된 ｔ 세포의 조성물을 제조하는 방법 |
| CA3084446A1 (en) | 2017-12-08 | 2019-06-13 | Juno Therapeutics, Inc. | Phenotypic markers for cell therapy and related methods |
| SG11202005228YA (en) | 2017-12-08 | 2020-07-29 | Juno Therapeutics Inc | Serum-free media formulation for culturing cells and methods of use thereof |
| TWI829667B (zh) * | 2018-02-09 | 2024-01-21 | 瑞士商赫孚孟拉羅股份公司 | 結合gprc5d之抗體 |
| EP3774919A4 (en) * | 2018-03-30 | 2021-12-29 | Eureka Therapeutics, Inc. | Constructs targeting cd22 and uses thereof |
| US12473342B2 (en) | 2018-04-27 | 2025-11-18 | The Trustees Of The University Of Pennsylvania | Chimeric antigen receptor T regulatory cells for the treatment of atherosclerosis |
| CA3100118A1 (en) * | 2018-05-16 | 2019-11-21 | Janssen Biotech, Inc. | Bcma/cd3 and gprdc5d/cd3 bispecific antibodies for use in cancer therapy |
| KR20210059715A (ko) | 2018-08-09 | 2021-05-25 | 주노 쎄러퓨티크스 인코퍼레이티드 | 통합된 핵산 평가 방법 |
| SG11202101204TA (en) | 2018-08-09 | 2021-03-30 | Juno Therapeutics Inc | Processes for generating engineered cells and compositions thereof |
| AU2019370705A1 (en) | 2018-10-31 | 2021-05-27 | Juno Therapeutics Gmbh | Methods for selection and stimulation of cells and apparatus for same |
| CA3117419A1 (en) | 2018-11-01 | 2020-05-07 | Juno Therapeutics, Inc. | Methods for treatment using chimeric antigen receptors specific for b-cell maturation antigen |
| PE20211058A1 (es) | 2018-11-01 | 2021-06-07 | Juno Therapeutics Inc | Receptores de antigenos quimericos especificos para el miembro d del grupo 5 de la clase c del receptor acoplado a proteina g (gprc5d) |
| WO2020113194A2 (en) | 2018-11-30 | 2020-06-04 | Juno Therapeutics, Inc. | Methods for treatment using adoptive cell therapy |
| MX2021013223A (es) | 2019-05-01 | 2022-02-17 | Juno Therapeutics Inc | Celulas que expresan un receptor quimerico de un locus cd247 modificado, polinucleotidos relacionados y metodos. |
| CN114025788A (zh) | 2019-05-01 | 2022-02-08 | 朱诺治疗学股份有限公司 | 从经修饰的tgfbr2基因座表达重组受体的细胞、相关多核苷酸和方法 |
| KR20220034782A (ko) | 2019-06-12 | 2022-03-18 | 주노 쎄러퓨티크스 인코퍼레이티드 | 세포 매개 세포 독성 요법 및 친생존 ｂｃｌ2 패밀리 단백질 억제제의 병용 요법 |
| EP3983447A4 (en) | 2019-06-14 | 2023-06-28 | Dana-Farber Cancer Institute, Inc. | Antibodies against muc1 and methods of use thereof |
| KR20220038362A (ko) | 2019-07-02 | 2022-03-28 | 프레드 헛친슨 켄서 리서치 센터 | 재조합 ad35 벡터 및 관련 유전자 요법 개선 |
| JP2022543551A (ja) | 2019-07-31 | 2022-10-13 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | Ｇｐｒｃ５ｄに結合する抗体 |
| PE20220394A1 (es) * | 2019-07-31 | 2022-03-18 | Hoffmann La Roche | Anticuerpos que se fijan a gprc5d |
| US20220298222A1 (en) | 2019-08-22 | 2022-09-22 | Juno Therapeutics, Inc. | Combination therapy of a t cell therapy and an enhancer of zeste homolog 2 (ezh2) inhibitor and related methods |
| AU2020377043A1 (en) | 2019-10-30 | 2022-06-02 | Juno Therapeutics Gmbh | Cell selection and/or stimulation devices and methods of use |
| US20230192869A1 (en) * | 2019-12-06 | 2023-06-22 | Juno Therapeutics, Inc. | Anti-idiotypic antibodies to gprc5d-targeted binding domains and related compositions and methods |
| EP4097218A1 (en) | 2020-01-28 | 2022-12-07 | Juno Therapeutics, Inc. | Methods for t cell transduction |
| KR20230005234A (ko) * | 2020-04-17 | 2023-01-09 | 얀센 바이오테크 인코포레이티드 | 생합성 당단백질 집단 |
| KR20230024283A (ko) | 2020-05-13 | 2023-02-20 | 주노 쎄러퓨티크스 인코퍼레이티드 | 임상 반응과 관련된 특징을 식별하는 방법 및 이의 용도 |
| US20240216508A1 (en) | 2020-06-26 | 2024-07-04 | Juno Therapeutics Gmbh | Engineered t cells conditionally expressing a recombinant receptor, related polynucleotides and methods |
| EP4240756A1 (en) | 2020-11-04 | 2023-09-13 | Juno Therapeutics, Inc. | Cells expressing a chimeric receptor from a modified invariant cd3 immunoglobulin superfamily chain locus and related polynucleotides and methods |
| EP4274851B1 (en) | 2021-01-05 | 2025-11-26 | Lanova Medicines Development Co., Ltd. | Anti-gprc5d monoclonal antibodies and uses thereof |
| WO2022148370A1 (en) * | 2021-01-05 | 2022-07-14 | Lanova Medicines Development Co., Ltd. | Anti-gprc5d monoclonal antibodies and uses thereof |
| CR20230398A (es) | 2021-02-16 | 2023-11-15 | Janssen Pharmaceutica Nv | Anticuerpo triespecífico dirigido a bcma, gprc5d, y cd3 |
| WO2022187406A1 (en) | 2021-03-03 | 2022-09-09 | Juno Therapeutics, Inc. | Combination of a t cell therapy and a dgk inhibitor |
| AU2022244229A1 (en) | 2021-03-22 | 2023-09-14 | Juno Therapeutics, Inc. | Method to assess potency of viral vector particles |
| JP2024511418A (ja) | 2021-03-22 | 2024-03-13 | ジュノー セラピューティクス インコーポレイテッド | 治療用細胞組成物の効力を決定する方法 |
| CN117916256A (zh) | 2021-05-06 | 2024-04-19 | 朱诺治疗学有限公司 | 用于刺激和转导t细胞的方法 |
| WO2022247804A1 (zh) * | 2021-05-23 | 2022-12-01 | 上海祥耀生物科技有限责任公司 | 抗gprc5d抗体、其制备方法与用途 |
| KR20240099351A (ko) * | 2021-11-05 | 2024-06-28 | 치아타이 티안큉 파마수티컬 그룹 주식회사 | Gprc5d에 결합하는 항체 및 그 용도 |
| EP4442828A4 (en) | 2021-11-30 | 2025-11-12 | Daiichi Sankyo Co Ltd | Masked antibodies cleavable by protease |
| EP4458851A1 (en) * | 2021-12-31 | 2024-11-06 | Kyinno Biotechnology Co., Ltd. | Anti-gprc5d antibody and use thereof |
| EP4464722A1 (en) * | 2022-01-10 | 2024-11-20 | Nanjing Leads Biolabs Co., Ltd. | Antibody and use thereof |
| JP2025504002A (ja) | 2022-01-28 | 2025-02-06 | ジュノー セラピューティクス インコーポレイテッド | 細胞組成物を製造する方法 |
| US20250170255A1 (en) | 2022-02-09 | 2025-05-29 | Daiichi Sankyo Company, Limited | Environmentally-responsive masked antibody and use thereof |
| WO2023213969A1 (en) | 2022-05-05 | 2023-11-09 | Juno Therapeutics Gmbh | Viral-binding protein and related reagents, articles, and methods of use |
| US20250302954A1 (en) | 2022-05-11 | 2025-10-02 | Celgene Corporation | Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy |
| WO2023230581A1 (en) | 2022-05-25 | 2023-11-30 | Celgene Corporation | Methods of manufacturing t cell therapies |
| CA3257679A1 (en) * | 2022-05-27 | 2023-11-30 | Antengene Biologics Limited | NEW ANTI-GPRC5D ANTIBODIES, BISPECIFIC ANTIGEN-BINDING MOLECULES THAT BIND TO GPRC5D AND CD3, AND THEIR USES |
| CA3259982A1 (en) | 2022-06-30 | 2024-01-04 | Indapta Therapeutics, Inc. | COMBINATION OF MODIFIED NATURAL KILLER (NK) CELLS AND ANTIBODY THERAPY AND ASSOCIATED METHODS |
| CN119698434A (zh) * | 2022-07-21 | 2025-03-25 | 山东先声生物制药有限公司 | 抗gprc5d纳米抗体及其应用 |
| WO2024031091A2 (en) | 2022-08-05 | 2024-02-08 | Juno Therapeutics, Inc. | Chimeric antigen receptors specific for gprc5d and bcma |
| JP2025531850A (ja) | 2022-09-08 | 2025-09-25 | ジュノー セラピューティクス インコーポレイテッド | Ｔ細胞療法および継続的または間欠的ｄｇｋ阻害剤投薬の組合せ |
| WO2024100604A1 (en) | 2022-11-09 | 2024-05-16 | Juno Therapeutics Gmbh | Methods for manufacturing engineered immune cells |
| WO2024102954A1 (en) | 2022-11-10 | 2024-05-16 | Massachusetts Institute Of Technology | Activation induced clipping system (aics) |
| CN121002052A (zh) | 2023-02-03 | 2025-11-21 | C3S2 有限公司 | 用于非病毒生产工程化免疫细胞的方法 |
| WO2024220588A1 (en) | 2023-04-18 | 2024-10-24 | Juno Therapeutics, Inc. | Cytotoxicity assay for assessing potency of therapeutic cell compositions |
| WO2024243365A2 (en) | 2023-05-23 | 2024-11-28 | Juno Therapeutics, Inc. | Activation markers of t cells and method for assessing t cell activation |
| AR133427A1 (es) * | 2023-07-31 | 2025-09-24 | Sanofi Sa | Anticuerpos anti-gprc5d y composiciones |
| WO2025059362A1 (en) | 2023-09-13 | 2025-03-20 | Juno Therapeutics, Inc. | Combination therapies with a cell therapy expressing a gprc5d-targeting car and related methods and uses |
| WO2025076113A1 (en) | 2023-10-05 | 2025-04-10 | Capstan Therapeutics, Inc. | Ionizable cationic lipids with conserved spacing and lipid nanoparticles |
| US20250127728A1 (en) | 2023-10-05 | 2025-04-24 | Capstan Therapeutics, Inc. | Constrained Ionizable Cationic Lipids and Lipid Nanoparticles |
| WO2025076472A1 (en) | 2023-10-06 | 2025-04-10 | Juno Therapeutics, Inc. | Combination therapies with a cell therapy expressing a gprc5d-targeting car and related methods and uses |
| WO2025134050A1 (en) | 2023-12-21 | 2025-06-26 | Janssen Biotech, Inc | Trispecific antibody targeting bcma, gprc5d and cd3 for the treatment of multiple myeloma |
| WO2025134049A1 (en) | 2023-12-21 | 2025-06-26 | Janssen Biotech, Inc | Trispecific antibody targeting bcma, gprc5d and cd3 for the treatment of al amyloidosis |
| WO2025147545A1 (en) | 2024-01-03 | 2025-07-10 | Juno Therapeutics, Inc. | Lipid nanoparticles for delivery of nucleic acids and related methods and uses |
| WO2025217452A1 (en) | 2024-04-11 | 2025-10-16 | Capstan Therapeutics, Inc. | Constrained ionizable cationic lipids and lipid nanoparticles |
| WO2025217454A2 (en) | 2024-04-11 | 2025-10-16 | Capstan Therapeutics, Inc. | Ionizable cationic lipids and lipid nanoparticles |
| WO2025231372A2 (en) | 2024-05-03 | 2025-11-06 | Janssen Biotech, Inc. | Methods for treating multiple myeloma with car-t cells and bispecific antibodies |
| WO2025231408A2 (en) | 2024-05-03 | 2025-11-06 | Janssen Biotech, Inc. | Methods for treating multiple myeloma with car-t cells and bispecific antibodies |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5132405A (en) | 1987-05-21 | 1992-07-21 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| JPS6412935A (en) | 1987-07-02 | 1989-01-17 | Mitsubishi Electric Corp | Constant-speed travel device for vehicle |
| US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
| WO1996005302A1 (en) * | 1994-08-11 | 1996-02-22 | Takeda Chemical Industries, Ltd. | G protein coupled receptor protein, production, and use thereof |
| CN1824777A (zh) * | 1999-09-24 | 2006-08-30 | 索尔瓦药物有限公司 | 新的人g蛋白偶联受体 |
| US6436703B1 (en) | 2000-03-31 | 2002-08-20 | Hyseq, Inc. | Nucleic acids and polypeptides |
| WO2003016553A2 (en) * | 2001-08-20 | 2003-02-27 | Genentech, Inc. | Gpcr-like retinoic acid-induced gene 1 protein and nucleic acid |
| AU2002367145A1 (en) * | 2001-12-27 | 2003-07-15 | Sumitomo Pharmaceuticals Co., Ltd. | Remedies for anorexia or lifestyle-related diseases and method of screening the same |
| US7446190B2 (en) | 2002-05-28 | 2008-11-04 | Sloan-Kettering Institute For Cancer Research | Nucleic acids encoding chimeric T cell receptors |
| US7276372B2 (en) * | 2002-12-20 | 2007-10-02 | Pdl Biopharma, Inc. | Antibodies against GPR64 and uses thereof |
| EP1592713A2 (en) * | 2003-02-13 | 2005-11-09 | Pharmacia Corporation | Antibodies to c-met for the treatment of cancers |
| WO2005019258A2 (en) * | 2003-08-11 | 2005-03-03 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| JP5362563B2 (ja) * | 2006-08-03 | 2013-12-11 | アストラゼネカ・アクチエボラーグ | αＶβ６に対する抗体およびその使用 |
| US9512236B2 (en) * | 2006-12-19 | 2016-12-06 | Ablynx N.V. | Amino acid sequences directed against GPCRS and polypeptides comprising the same for the treatment of GPCR-related diseases and disorders |
| DK2856876T3 (en) | 2007-03-30 | 2018-04-03 | Memorial Sloan Kettering Cancer Center | Constitutive expression of co-stimulatory ligands on adoptively transmitted T lymphocytes |
| CA2699394C (en) * | 2007-09-17 | 2020-03-24 | The Regents Of The University Of California | Internalizing human monoclonal antibodies targeting prostate cancer cells in situ |
| US7947807B2 (en) * | 2007-10-15 | 2011-05-24 | The Board Of Trustees Of The Leland Stanford Junior University | Method for obtaining G protein-coupled receptor (GPCR) diffraction-quality crystals employing a monoclonal antibody that binds to the third intracellular loop (IL3) |
| CN101808663B (zh) | 2007-10-25 | 2015-09-30 | 特雷利斯生物科学股份有限公司 | 抗rsv g蛋白抗体 |
| RU2531758C2 (ru) | 2008-02-11 | 2014-10-27 | Куретек Лтд. | Моноклональные антитела для лечения опухолей |
| US9217032B2 (en) * | 2010-01-08 | 2015-12-22 | Les Laboratoires Servier | Methods for treating colorectal cancer |
| AU2011282423B2 (en) * | 2010-07-22 | 2015-05-14 | Schrader, Sabariah | Cross-protective pathogen protection, methods and compositions thereof |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| WO2013033626A2 (en) | 2011-08-31 | 2013-03-07 | Trustees Of Dartmouth College | Nkp30 receptor targeted therapeutics |
| CN103483452B (zh) | 2012-06-12 | 2021-08-13 | 上海细胞治疗集团有限公司 | 双信号独立的嵌合抗原受体及其用途 |
| WO2014087010A1 (en) | 2012-12-07 | 2014-06-12 | Ablynx N.V. | IMPROVED POLYPEPTIDES DIRECTED AGAINST IgE |
| JO3519B1 (ar) * | 2013-01-25 | 2020-07-05 | Amgen Inc | تركيبات أجسام مضادة لأجل cdh19 و cd3 |
| KR102064230B1 (ko) | 2013-02-15 | 2020-01-13 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 키메라 항원 수용체 및 이의 이용 방법 |
| US9745368B2 (en) | 2013-03-15 | 2017-08-29 | The Trustees Of The University Of Pennsylvania | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
| AU2014273490B2 (en) | 2013-05-29 | 2019-05-09 | Cellectis | Methods for engineering T cells for immunotherapy by using RNA-guided Cas nuclease system |
| ES2939760T3 (es) | 2014-03-15 | 2023-04-26 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico para antígenos |
| SG11201609707WA (en) * | 2014-07-01 | 2017-01-27 | Pfizer | Bispecific heterodimeric diabodies and uses thereof |
| JP2017528433A (ja) | 2014-07-21 | 2017-09-28 | ノバルティス アーゲー | 低い免疫増強用量のｍＴＯＲ阻害剤とＣＡＲの組み合わせ |
| CN113429484A (zh) * | 2014-12-05 | 2021-09-24 | 纪念斯隆-凯特琳癌症中心 | 靶向g-蛋白偶联受体的抗体和使用方法 |
| CN113683711A (zh) * | 2014-12-05 | 2021-11-23 | 纪念斯隆-凯特琳癌症中心 | 靶向g-蛋白偶联受体的嵌合抗原受体及其用途 |
| MX2018004721A (es) * | 2015-10-23 | 2018-07-06 | Eureka Therapeutics Inc | Construcciones quimericas anticuerpo/receptor de celulas t y usos de las mismas. |
| KR20230148844A (ko) | 2016-03-29 | 2023-10-25 | 유니버시티 오브 써던 캘리포니아 | 암을 표적하는 키메라 항원 수용체 |
| CA3018253A1 (en) * | 2016-03-31 | 2017-10-05 | University Of Southern California | A highly sensitive and specific luciferase based reporter assay for antigen detection |
| PE20211058A1 (es) * | 2018-11-01 | 2021-06-07 | Juno Therapeutics Inc | Receptores de antigenos quimericos especificos para el miembro d del grupo 5 de la clase c del receptor acoplado a proteina g (gprc5d) |
-
2015
- 2015-12-04 CN CN202110535457.2A patent/CN113429484A/zh active Pending
- 2015-12-04 SG SG10201913937QA patent/SG10201913937QA/en unknown
- 2015-12-04 RU RU2017123545A patent/RU2725819C2/ru active
- 2015-12-04 MY MYPI2017000851A patent/MY195115A/en unknown
- 2015-12-04 KR KR1020177018387A patent/KR102602417B1/ko active Active
- 2015-12-04 JP JP2017529742A patent/JP6753851B2/ja active Active
- 2015-12-04 MX MX2017007247A patent/MX2017007247A/es unknown
- 2015-12-04 IL IL307767A patent/IL307767A/en unknown
- 2015-12-04 WO PCT/US2015/064122 patent/WO2016090329A2/en not_active Ceased
- 2015-12-04 AU AU2015357535A patent/AU2015357535B2/en active Active
- 2015-12-04 IL IL285101A patent/IL285101B2/en unknown
- 2015-12-04 CN CN202110535420.XA patent/CN113429482A/zh active Pending
- 2015-12-04 CA CA2969886A patent/CA2969886A1/en active Pending
- 2015-12-04 RU RU2020120613A patent/RU2020120613A/ru unknown
- 2015-12-04 KR KR1020237038827A patent/KR20230159637A/ko not_active Ceased
- 2015-12-04 SG SG11201704552TA patent/SG11201704552TA/en unknown
- 2015-12-04 CN CN201580075556.XA patent/CN107206077B/zh active Active
- 2015-12-04 BR BR112017011932A patent/BR112017011932A8/pt active Search and Examination
- 2015-12-04 EP EP15865989.6A patent/EP3227324A4/en active Pending
-
2017
- 2017-06-04 IL IL252646A patent/IL252646B/en unknown
- 2017-06-05 US US15/614,290 patent/US10590196B2/en active Active
- 2017-06-05 SA SA517381664A patent/SA517381664B1/ar unknown
- 2017-06-05 MX MX2022001878A patent/MX2022001878A/es unknown
- 2017-06-05 MX MX2022009463A patent/MX2022009463A/es unknown
- 2017-06-05 PH PH12017501039A patent/PH12017501039A1/en unknown
-
2019
- 2019-12-31 US US16/732,022 patent/US11566071B2/en active Active
- 2019-12-31 US US16/731,973 patent/US20200123249A1/en not_active Abandoned
-
2020
- 2020-05-07 JP JP2020081773A patent/JP7027482B2/ja active Active
- 2020-08-10 AU AU2020217320A patent/AU2020217320A1/en not_active Abandoned
- 2020-08-24 JP JP2020140643A patent/JP2020191900A/ja not_active Withdrawn
-
2022
- 2022-01-11 JP JP2022002183A patent/JP2022044638A/ja not_active Withdrawn
- 2022-05-19 JP JP2022082303A patent/JP2022103382A/ja not_active Withdrawn
- 2022-12-22 US US18/145,254 patent/US20240076370A1/en active Pending
-
2023
- 2023-11-21 AU AU2023270242A patent/AU2023270242A1/en not_active Abandoned
-
2024
- 2024-03-06 JP JP2024033776A patent/JP2024053016A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018504890A5 (OSRAM) | ||
| US20240076370A1 (en) | Antibodies targeting g-protein coupled receptor and methods of use | |
| JP2018500014A5 (OSRAM) | ||
| CA2956471C (en) | OPTIMIZED CONSTRUCTIONS OF SINGLE-CATENAL, BI-SPECIFIC, AND CROSS-SPECIFIC ANTIBODY | |
| KR102022734B1 (ko) | 신규 조절제 및 용법 | |
| IL295295A (en) | Antibodies against fcrl5 and methods of their use | |
| RU2017123549A (ru) | Антитела, нацеленные на антиген созревания в-клеток, и способы их применения | |
| JP7257971B6 (ja) | 抗ｃｄ４０抗体、その抗原結合フラグメント、およびその医学的使用 | |
| JP2018527919A5 (OSRAM) | ||
| KR20210099027A (ko) | 항-cd40 항체, 이의 항원-결합 단편 및 약학적 용도 | |
| JP2013535191A5 (OSRAM) | ||
| WO2019091449A1 (zh) | Cd96抗体、其抗原结合片段及医药用途 | |
| JP2019505166A5 (OSRAM) | ||
| HRP20160702T1 (hr) | Protutijela protiv proliferirajućeg inducirajućeg liganda (april) | |
| JP2020515277A5 (OSRAM) | ||
| JP2019507580A5 (OSRAM) | ||
| JP2019504615A5 (OSRAM) | ||
| JP2021512159A5 (OSRAM) | ||
| JP2017537082A5 (OSRAM) | ||
| HK1208053A1 (en) | Antibody against transporter and use thereof | |
| JP2016529213A5 (OSRAM) | ||
| JP2012523221A5 (OSRAM) | ||
| JPWO2020227457A5 (OSRAM) | ||
| JP2020533955A5 (OSRAM) | ||
| AU2022293634A1 (en) | Anti-her3 antibody, antibody drug conjugate containing the same, and use thereof |