JP2018504890A5 - - Google Patents
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- JP2018504890A5 JP2018504890A5 JP2017529742A JP2017529742A JP2018504890A5 JP 2018504890 A5 JP2018504890 A5 JP 2018504890A5 JP 2017529742 A JP2017529742 A JP 2017529742A JP 2017529742 A JP2017529742 A JP 2017529742A JP 2018504890 A5 JP2018504890 A5 JP 2018504890A5
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- 150000001413 amino acids Chemical class 0.000 claims description 1694
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims description 394
- 238000012986 modification Methods 0.000 claims description 389
- 230000004048 modification Effects 0.000 claims description 389
- 239000000427 antigen Substances 0.000 claims description 130
- 102000036639 antigens Human genes 0.000 claims description 130
- 108091007433 antigens Proteins 0.000 claims description 130
- 239000012634 fragment Substances 0.000 claims description 110
- 101001040713 Homo sapiens G-protein coupled receptor family C group 5 member D Proteins 0.000 claims description 38
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 32
- 206010028980 Neoplasm Diseases 0.000 claims description 24
- 102000044456 human GPRC5D Human genes 0.000 claims description 22
- 102100021197 G-protein coupled receptor family C group 5 member D Human genes 0.000 claims description 16
- 208000034578 Multiple myelomas Diseases 0.000 claims description 12
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 12
- 210000004027 cell Anatomy 0.000 claims description 12
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 8
- 208000016025 Waldenstroem macroglobulinemia Diseases 0.000 claims description 6
- 208000033559 Waldenström macroglobulinemia Diseases 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 6
- 239000003937 drug carrier Substances 0.000 claims description 6
- 229940127121 immunoconjugate Drugs 0.000 claims description 6
- HVLSXIKZNLPZJJ-TXZCQADKSA-N HA peptide Chemical compound C([C@@H](C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](C)C(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 HVLSXIKZNLPZJJ-TXZCQADKSA-N 0.000 claims description 4
- 239000013604 expression vector Substances 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 150000007523 nucleic acids Chemical class 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 238000006467 substitution reaction Methods 0.000 claims description 4
- 229940124597 therapeutic agent Drugs 0.000 claims description 4
- 101710112752 Cytotoxin Proteins 0.000 claims description 2
- 101100225046 Schizosaccharomyces pombe (strain 972 / ATCC 24843) ecl2 gene Proteins 0.000 claims description 2
- 101100225047 Schizosaccharomyces pombe (strain 972 / ATCC 24843) ecl3 gene Proteins 0.000 claims description 2
- 231100000599 cytotoxic agent Toxicity 0.000 claims description 2
- 239000002619 cytotoxin Substances 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 101150058725 ecl1 gene Proteins 0.000 claims description 2
- 210000002865 immune cell Anatomy 0.000 claims description 2
- 238000002955 isolation Methods 0.000 claims description 2
- 210000004897 n-terminal region Anatomy 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
- 210000004881 tumor cell Anatomy 0.000 claims description 2
- 238000000034 method Methods 0.000 description 10
- 230000001939 inductive effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462088228P | 2014-12-05 | 2014-12-05 | |
| US62/088,228 | 2014-12-05 | ||
| PCT/US2015/064122 WO2016090329A2 (en) | 2014-12-05 | 2015-12-04 | Antibodies targeting g-protein coupled receptor and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020081773A Division JP7027482B2 (ja) | 2014-12-05 | 2020-05-07 | Ｇタンパク質共役受容体を標的化する抗体および使用の方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018504890A JP2018504890A (ja) | 2018-02-22 |
| JP2018504890A5 true JP2018504890A5 (OSRAM) | 2019-01-17 |
| JP6753851B2 JP6753851B2 (ja) | 2020-09-09 |
Family
ID=56092679
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017529742A Active JP6753851B2 (ja) | 2014-12-05 | 2015-12-04 | Ｇタンパク質共役受容体を標的化する抗体および使用の方法 |
| JP2020081773A Active JP7027482B2 (ja) | 2014-12-05 | 2020-05-07 | Ｇタンパク質共役受容体を標的化する抗体および使用の方法 |
| JP2020140643A Withdrawn JP2020191900A (ja) | 2014-12-05 | 2020-08-24 | Ｇタンパク質共役受容体を標的化する抗体および使用の方法 |
| JP2022002183A Withdrawn JP2022044638A (ja) | 2014-12-05 | 2022-01-11 | Ｇタンパク質共役受容体を標的化する抗体および使用の方法 |
| JP2022082303A Withdrawn JP2022103382A (ja) | 2014-12-05 | 2022-05-19 | Ｇタンパク質共役受容体を標的化する抗体および使用の方法 |
| JP2024033776A Pending JP2024053016A (ja) | 2014-12-05 | 2024-03-06 | Ｇタンパク質共役受容体を標的化する抗体および使用の方法 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020081773A Active JP7027482B2 (ja) | 2014-12-05 | 2020-05-07 | Ｇタンパク質共役受容体を標的化する抗体および使用の方法 |
| JP2020140643A Withdrawn JP2020191900A (ja) | 2014-12-05 | 2020-08-24 | Ｇタンパク質共役受容体を標的化する抗体および使用の方法 |
| JP2022002183A Withdrawn JP2022044638A (ja) | 2014-12-05 | 2022-01-11 | Ｇタンパク質共役受容体を標的化する抗体および使用の方法 |
| JP2022082303A Withdrawn JP2022103382A (ja) | 2014-12-05 | 2022-05-19 | Ｇタンパク質共役受容体を標的化する抗体および使用の方法 |
| JP2024033776A Pending JP2024053016A (ja) | 2014-12-05 | 2024-03-06 | Ｇタンパク質共役受容体を標的化する抗体および使用の方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US10590196B2 (OSRAM) |
| EP (1) | EP3227324A4 (OSRAM) |
| JP (6) | JP6753851B2 (OSRAM) |
| KR (2) | KR20230159637A (OSRAM) |
| CN (3) | CN107206077B (OSRAM) |
| AU (3) | AU2015357535B2 (OSRAM) |
| BR (1) | BR112017011932A8 (OSRAM) |
| CA (1) | CA2969886A1 (OSRAM) |
| IL (3) | IL307767A (OSRAM) |
| MX (3) | MX2017007247A (OSRAM) |
| MY (1) | MY195115A (OSRAM) |
| PH (1) | PH12017501039A1 (OSRAM) |
| RU (2) | RU2020120613A (OSRAM) |
| SA (1) | SA517381664B1 (OSRAM) |
| SG (2) | SG10201913937QA (OSRAM) |
| WO (1) | WO2016090329A2 (OSRAM) |
Families Citing this family (84)
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| ES2899779T3 (es) | 2014-12-05 | 2022-03-14 | Memorial Sloan Kettering Cancer Center | Receptores antigénicos quiméricos dirigidos a receptor acoplado a proteína G y usos de los mismos |
| JP6753851B2 (ja) * | 2014-12-05 | 2020-09-09 | メモリアル スローン ケタリング キャンサー センター | Ｇタンパク質共役受容体を標的化する抗体および使用の方法 |
| IL295398B2 (en) | 2015-10-23 | 2025-01-01 | Eureka Therapeutics Inc | Antibody/T-cell receptor chimeric constructs and their uses |
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| AU2017366739B2 (en) | 2016-12-02 | 2023-11-23 | Angeles Therapeutics, Inc. | Synthetic immune receptors and methods of use thereof |
| JPWO2018147245A1 (ja) | 2017-02-07 | 2019-11-21 | 第一三共株式会社 | 抗ｇｐｒｃ５ｄ抗体及び該抗体を含む分子 |
| CN110741016A (zh) | 2017-04-26 | 2020-01-31 | 优瑞科生物技术公司 | 嵌合抗体/t-细胞受体构筑体及其用途 |
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