JP2018503399A - 多特異性免疫調節抗原結合構築物 - Google Patents

多特異性免疫調節抗原結合構築物 Download PDF

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JP2018503399A
JP2018503399A JP2017556515A JP2017556515A JP2018503399A JP 2018503399 A JP2018503399 A JP 2018503399A JP 2017556515 A JP2017556515 A JP 2017556515A JP 2017556515 A JP2017556515 A JP 2017556515A JP 2018503399 A JP2018503399 A JP 2018503399A
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cancer
cell
abm2
abm3
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JP2018503399A5 (enExample
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トーマス ジョセフ シュッツ
トーマス ジョセフ シュッツ
ピオトロ ボブロウィック
ピオトロ ボブロウィック
ヘレン サブゼバリ
ヘレン サブゼバリ
マイケル マーチ シュミット
マイケル マーチ シュミット
ロバート ブイ ザ サード タイ
ロバート ブイ ザ サード タイ
サイモン メテノウ
サイモン メテノウ
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コンパス セラピューティクス リミテッド ライアビリティ カンパニー
コンパス セラピューティクス リミテッド ライアビリティ カンパニー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • A—HUMAN NECESSITIES
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    • C07K16/2851—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
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    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
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JP2017556515A 2015-01-14 2016-01-13 多特異性免疫調節抗原結合構築物 Withdrawn JP2018503399A (ja)

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US201562103402P 2015-01-14 2015-01-14
US62/103,402 2015-01-14
PCT/US2016/013291 WO2016115274A1 (en) 2015-01-14 2016-01-13 Multispecific immunomodulatory antigen-binding constructs

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CN (1) CN107614522A (enExample)
AU (1) AU2016206707A1 (enExample)
BR (1) BR112017015136A2 (enExample)
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Cited By (6)

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JP2021519072A (ja) * 2018-03-27 2021-08-10 システィミューン， インク．Ｓｙｓｔｉｍｍｕｎｅ， Ｉｎｃ． ガイダンス及びナビゲーションコントロール蛋白質並びにその生産及び使用方法
JP2021521275A (ja) * 2018-04-13 2021-08-26 アフィメド ゲーエムベーハー Ｎｋ細胞結合抗体融合構築物
JP2021523140A (ja) * 2018-05-07 2021-09-02 ドラゴンフライ セラピューティクス， インコーポレイテッド Ｎｋｇ２ｄ、ｃｄ１６、及び腫瘍関連抗原に結合するタンパク質
JP2021533161A (ja) * 2018-08-08 2021-12-02 ドラゴンフライ セラピューティクス， インコーポレイテッド Ｈｅｒ２、ｎｋｇ２ｄおよびｃｄ１６に結合する多重特異性結合タンパク質ならびに使用方法
JP2022539527A (ja) * 2019-06-26 2022-09-12 エーピー バイオサイエンシーズ， インコーポレイテッド Ｔ細胞活性化のための抗体
JP2024023438A (ja) * 2018-05-28 2024-02-21 ドラゴンフライ セラピューティクス， インコーポレイテッド 多重特異性結合タンパク質及びその改善

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