JP2018199694A - バイオアベイラビリティが高いアルボシジブプロドラッグ - Google Patents
バイオアベイラビリティが高いアルボシジブプロドラッグ Download PDFInfo
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- JP2018199694A JP2018199694A JP2018153504A JP2018153504A JP2018199694A JP 2018199694 A JP2018199694 A JP 2018199694A JP 2018153504 A JP2018153504 A JP 2018153504A JP 2018153504 A JP2018153504 A JP 2018153504A JP 2018199694 A JP2018199694 A JP 2018199694A
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Abstract
Description
技術分野
本発明は、一般に、アルボシジブのホスフェートプロドラッグおよびがん処置のためのその使用に関する。
サイクリン依存性キナーゼ(CDK)は、細胞周期のタイミングおよび協調を調節する重要な制御因子である。CDKは、その必須のサイクリンパートナーと可逆的な複合体を形成して、細胞周期における重大な時点からの移行を調節する。例えば、活性化されたCDK4−サイクリンD1複合体は細胞周期のG1期の通過を調節し、CDK1−サイクリンB1複合体は細胞周期の分裂期に入るのを調節する。内因性サイクリン依存性キナーゼ阻害タンパク質(CDKI)は、CDK成分またはサイクリン成分のいずれかに結合し、複合体のキナーゼ活性を阻害することが公知である。黒色腫、膵臓がん、および食道がんなどの多くの腫瘍において、これらの天然CDKIは存在しないか変異している。したがって、選択的CDKインヒビターは、有効な化学治療剤である可能性がある。
簡単には、本発明の実施形態は、アルボシジブ親化合物と比較してバイオアベイラビリティが高いアルボシジブのホスフェートプロドラッグを提供する。したがって、一実施形態では、下記の構造(I):
一実施形態において、例えば、以下の項目が提供される。
(項目1)
下記の構造(I):
R1、R2、またはR3のうちの1つは−P(=O)(OH)2であり、R1、R2、およびR3のうちの他の2つはそれぞれHである、化合物またはその立体異性体、互変異性体、もしくは薬学的に許容され得る塩。
(項目2)
下記の構造(I’):
(項目3)
下記の構造(IA):
(項目4)
下記の構造(IA’):
(項目5)
下記の構造(IB):
(項目6)
下記の構造(IB’):
(項目7)
下記の構造(IC):
(項目8)
下記の構造(IC’):
(項目9)
項目1〜8のいずれか1項に記載の化合物の薬学的に許容され得る塩。
(項目10)
前記薬学的に許容され得る塩が塩基付加塩である、項目9に記載の薬学的に許容され得る塩。
(項目11)
前記薬学的に許容され得る塩がナトリウム塩である、項目10に記載の薬学的に許容され得る塩。
(項目12)
前記薬学的に許容され得る塩が酸付加塩である、項目9に記載の薬学的に許容され得る塩。
(項目13)
前記薬学的に許容され得る塩が塩酸塩である、項目12に記載の薬学的に許容され得る塩。
(項目14)
薬学的に許容され得る担体または賦形剤および項目1〜13のいずれか1項に記載の化合物を含む医薬組成物。
(項目15)
前記医薬組成物が経口送達のために製剤化されている、項目14に記載の医薬組成物。
(項目16)
サイクリン依存性キナーゼ(CDK)の過剰発現に関連する疾患の処置を、それを必要とする哺乳動物において行う方法であって、治療有効量の項目1〜13のいずれか1項に記載の化合物または項目14もしくは15のいずれか1項に記載の組成物を前記哺乳動物に投与する工程を含む、方法。
(項目17)
前記疾患ががんである、項目16に記載の方法。
(項目18)
前記がんが血液学的がんである、項目17に記載の方法。
(項目19)
前記血液学的がんが、急性骨髄白血病(AML)、多発性骨髄腫、濾胞性リンパ腫、急性リンパ芽球性白血病(ALL)、慢性リンパ性白血病(CLL)、および非ホジキンリンパ腫から選択される、項目18に記載の方法。
(項目20)
前記血液がんが急性骨髄白血病(AML)である、項目19に記載の方法。
(項目21)
前記血液学的がんが慢性リンパ性白血病(CLL)である、項目19に記載の方法。
(項目22)
前記血液学的がんが骨髄異形成症候群(MDS)である、項目18に記載の方法。
(項目23)
前記方法が、項目1〜13のいずれか1項に記載の化合物または項目14もしくは15のいずれか1項に記載の組成物を前記哺乳動物に経口投与する工程を含む、項目16〜22のいずれか1項に記載の方法。
以下の説明において、本発明の種々の実施形態の充分な理解をもたらすために特定の具体的な詳細な説明を示す。しかしながら、当業者には、本発明がこれらの詳細な説明なしに実施され得ることが理解されよう。
(Elsevier,Amsterdam)を参照)。プロドラッグの考察は、Higuchi, T.ら, "Pro-drugs as NovelDelivery Systems," A.C.S. Symposium Series, Vol. 14, and in Bioreversible Carriers in Drug Design, Ed. Edward B. Roche, American Pharmaceutical Association and Pergamon Press,1987に示されている。これらの両方ともが、参考により本明細書中に全体が援用される。
(i)哺乳動物において、該疾患または状態が発生するのを予防すること(特に、このような哺乳動物が該状態に罹りやすいが、該状態を有するとは未だ診断されていない場合);
(ii)該疾患または状態を抑制すること、すなわち、その発症を止めること;
(iii)該疾患または状態を軽減すること、すなわち、該疾患または状態の後退をもたらすこと;あるいは
(iv)該疾患または状態に起因する症状を軽減すること、すなわち、根源的な疾患または状態に取り組まずに痛みを軽減することを含む。本明細書において使用される場合、用語「疾患」および「状態」は互換的に使用され得るか、あるいは、具体的な疾病または状態が既知の原因因子を有していなくともよく(その結果、病因がまだ解明されていない)、したがって、それはまだ疾患と認識されていないが単に望ましくない状態または症候群とだけ認識されており、臨床医によって多かれ少なかれ具体的な1セットの症状が確認されているという点で異なり得る。
I.化合物
R1、R2、またはR3のうちの1つは−P(=O)(OH)2であり、R1、R2、およびR3のうちの他の2つはそれぞれHである、化合物、またはその立体異性体、互変異性体、もしくは薬学的に許容され得る塩を提供する。
方法
代表的なホスフェートプロドラッグ(IB’)の調製
アルボシジブプロドラッグの薬物動態学的プロフィール
n.e.=未評価
実施例3
動力学的溶解度プロフィール
血漿安定性プロフィール
化合物IB’の血漿安定性を、4種由来の血漿を使用して決定した。マウス、ラット、イヌ、およびヒトの結果を、表5、6、7、および8にそれぞれ示す。アルボシジブおよびフルマゼニルをコントロールとして使用した。マウス、ラット、およびヒトの血漿では、化合物IB’は、5時間のインキュベーション後に安定性が100%維持された。イヌ血漿では、5時間後におよそ90%の化合物IB’が残存した。比較すると、アルボシジブは、5時間後に4種全てにわたって100%安定性を維持し、フルマゼニルはマウスおよびラットの血漿で不安定であった。
スプレーグ・ドーリーラットにおける薬物動態学
マウスにおける最大忍容急性用量
SCIDマウスを処置群あたり3匹使用して行った。動物を、45、30、15、または7.5mg/kgの単一用量の化合物IB’を使用して処置した。比較のために、さらなる動物を同一の用量レベルのアルボシジブで処置した。経口投与後(図2A〜B)および静脈内(IV)投与後(図2C〜D)の体重測定を死亡率および臨床所見と共に使用して、最大忍容急性用量(MTDacute)を決定した。
実施例7
マウスにおける最大忍容反復用量スケジュール
ラットにおける最大忍容急性用量
マウス異種移植片有効性研究
マウス異種移植片薬力学研究
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- 本明細書に記載の発明。
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