JP2018162250A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018162250A5 JP2018162250A5 JP2018094605A JP2018094605A JP2018162250A5 JP 2018162250 A5 JP2018162250 A5 JP 2018162250A5 JP 2018094605 A JP2018094605 A JP 2018094605A JP 2018094605 A JP2018094605 A JP 2018094605A JP 2018162250 A5 JP2018162250 A5 JP 2018162250A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- organic solvent
- alkyl
- producing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 0 **(*)CCCCC#C[C@@](c1c(CC=C)c(O*)ccc1)O Chemical compound **(*)CCCCC#C[C@@](c1c(CC=C)c(O*)ccc1)O 0.000 description 3
- PAJMKGZZBBTTOY-ZUQLYSRVSA-N CCCCC[C@@H](CC[C@@H]([C@@H](C1)O)[C@@H](C2)C1Cc1c2cccc1OCC(O)=O)O Chemical compound CCCCC[C@@H](CC[C@@H]([C@@H](C1)O)[C@@H](C2)C1Cc1c2cccc1OCC(O)=O)O PAJMKGZZBBTTOY-ZUQLYSRVSA-N 0.000 description 2
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261734672P | 2012-12-07 | 2012-12-07 | |
| US61/734,672 | 2012-12-07 | ||
| US201361777882P | 2013-03-12 | 2013-03-12 | |
| US61/777,882 | 2013-03-12 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015545860A Division JP6342414B2 (ja) | 2012-12-07 | 2013-12-06 | プロスタサイクリン類似体を合成する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018162250A JP2018162250A (ja) | 2018-10-18 |
| JP2018162250A5 true JP2018162250A5 (enExample) | 2019-02-14 |
Family
ID=49881039
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015545860A Expired - Fee Related JP6342414B2 (ja) | 2012-12-07 | 2013-12-06 | プロスタサイクリン類似体を合成する方法 |
| JP2018094605A Ceased JP2018162250A (ja) | 2012-12-07 | 2018-05-16 | プロスタサイクリン類似体を合成する方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015545860A Expired - Fee Related JP6342414B2 (ja) | 2012-12-07 | 2013-12-06 | プロスタサイクリン類似体を合成する方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US20150315114A1 (enExample) |
| EP (2) | EP3398931B1 (enExample) |
| JP (2) | JP6342414B2 (enExample) |
| KR (1) | KR20150091170A (enExample) |
| CN (3) | CN104837806A (enExample) |
| AU (2) | AU2013355130B2 (enExample) |
| BR (1) | BR112015013085A2 (enExample) |
| CA (1) | CA2893604A1 (enExample) |
| CL (1) | CL2015001535A1 (enExample) |
| DK (1) | DK2928858T3 (enExample) |
| EA (1) | EA034309B1 (enExample) |
| ES (1) | ES2664026T3 (enExample) |
| IL (1) | IL239172B (enExample) |
| MX (2) | MX369094B (enExample) |
| NZ (1) | NZ708130A (enExample) |
| PE (1) | PE20160090A1 (enExample) |
| PH (2) | PH12015501258B1 (enExample) |
| SG (2) | SG10201600303WA (enExample) |
| TW (1) | TWI634104B (enExample) |
| WO (1) | WO2014089385A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104837806A (zh) * | 2012-12-07 | 2015-08-12 | 开曼化学股份有限公司 | 前列环素类似物的合成方法 |
| US9505737B2 (en) | 2013-01-11 | 2016-11-29 | Corsair Pharma, Inc. | Treprostinil derivative compounds and methods of using same |
| EP3712142B1 (en) | 2013-01-11 | 2022-07-06 | Corsair Pharma, Inc. | Prodrugs of treprostinil |
| CN105722812B (zh) * | 2013-11-13 | 2018-11-16 | 开曼化学股份有限公司 | 前列环素类似物的胺盐 |
| HU231186B1 (hu) * | 2014-10-08 | 2021-06-28 | CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. | Új eljárás treprostinil és sói előállítására |
| US9643911B2 (en) | 2015-06-17 | 2017-05-09 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| US9394227B1 (en) | 2015-06-17 | 2016-07-19 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| JP7220650B2 (ja) | 2016-09-26 | 2023-02-10 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニルプロドラッグ |
| EP3498283A1 (en) | 2017-12-14 | 2019-06-19 | Ipsol AG | Glycosidic derivatives of treprostinil |
| HU231296B1 (hu) * | 2018-03-09 | 2022-09-28 | Chinoin Zrt | Eljárás treprostinil-dietanol-amin só B polimorf formájának előállítására |
| JP6503508B2 (ja) * | 2018-08-03 | 2019-04-17 | Ｊｘｔｇエネルギー株式会社 | テトラカルボン酸二無水物、ポリイミド前駆体樹脂、ポリイミド、ポリイミド前駆体樹脂溶液、ポリイミド溶液及びポリイミドフィルム |
| EP4017588A1 (en) | 2019-08-23 | 2022-06-29 | United Therapeutics Corporation | Treprostinil prodrugs |
| JP2023523557A (ja) | 2020-04-17 | 2023-06-06 | ユナイテッド セラピューティクス コーポレイション | 間質性肺疾患の治療における使用のためのトレプロスチニル |
| IL298591A (en) | 2020-06-09 | 2023-01-01 | United Therapeutics Corp | Pomeryl dictopiperidine prodrugs of treprostinil |
| KR20220030006A (ko) | 2020-09-02 | 2022-03-10 | 바이오플러스 주식회사 | 미용 조성물을 포함하는 마스크 및 그 제조 방법 |
| KR20250133451A (ko) | 2020-12-14 | 2025-09-05 | 유나이티드 쎄러퓨틱스 코포레이션 | 트레프로스티닐 프로드러그로 질환을 치료하는 방법 |
| JP2024510930A (ja) | 2021-03-03 | 2024-03-12 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニル及びそのプロドラッグの乾燥粉末組成物、及び、さらに（ｅ）－３，６－ビス［４－（ｎ－カルボニル－２－プロペニル）アミドブチル］－２，５－ジケトピペラジン（ｆｄｋｐ）を含む乾燥粉末組成物 |
| US11884640B2 (en) * | 2021-06-02 | 2024-01-30 | Chirogate International Inc. | Processes and intermediates for the preparations of benzoprostacyclin analogues and benzoprostacyclin analogues prepared therefrom |
| US11884613B2 (en) * | 2022-05-05 | 2024-01-30 | Chirogate International Inc. | Processes and intermediates for the preparation of carbaprostacyclin analogues |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4306075A (en) | 1980-03-28 | 1981-12-15 | The Upjohn Company | Composition and process |
| CA2039857A1 (en) * | 1990-04-26 | 1991-10-27 | Wilfred Po-Sum Shum | Process for producing epoxyalcohols of high optical purity |
| US6441245B1 (en) | 1997-10-24 | 2002-08-27 | United Therapeutics Corporation | Process for stereoselective synthesis of prostacyclin derivatives |
| US6700025B2 (en) | 2001-01-05 | 2004-03-02 | United Therapeutics Corporation | Process for stereoselective synthesis of prostacyclin derivatives |
| ES2622471T5 (es) * | 2003-05-22 | 2020-07-23 | United Therapeutics Corp | Compuestos y procedimientos para la administración de análogos de prostaciclina |
| JPWO2009019868A1 (ja) * | 2007-08-06 | 2010-10-28 | 大正製薬株式会社 | １０ａ、１２位架橋型１０ａ−アザライド化合物 |
| CN101903324B (zh) | 2007-12-17 | 2013-07-03 | 联合治疗公司 | 一种制备Remodulin中的活性成分曲前列素的改良方法 |
| WO2009158010A1 (en) * | 2008-06-27 | 2009-12-30 | Concert Pharmaceuticals, Inc. | Prostacyclin analogs |
| WO2010039531A1 (en) * | 2008-09-23 | 2010-04-08 | Resolvyx Pharmaceuticals, Inc. | Therapeutic compounds |
| CN101891596B (zh) * | 2009-05-22 | 2013-12-11 | 上海天伟生物制药有限公司 | 一种化合物及其制备方法和用途 |
| JP6046034B2 (ja) * | 2010-06-03 | 2016-12-14 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニルの製造 |
| CA2710726C (en) * | 2010-07-22 | 2016-02-23 | Alphora Research Inc. | Synthesis of treprostinil and intermediates useful therein |
| KR20140025303A (ko) | 2010-10-01 | 2014-03-04 | 릭스하스피탈렛 | 급성 외상성 응고장애 및 소생된 심박 정지의 예방 또는 치료에 사용되는 내피 무결성을 조절／보존할 수 있는 화합물 |
| US8865898B2 (en) * | 2010-11-30 | 2014-10-21 | Japan Science And Technology Agency | Nucleoside analog or salt thereof, oligonucleotide analog, gene expression inhibitor, and nucleic-acid probe for detecting gene |
| US8524939B2 (en) | 2011-08-24 | 2013-09-03 | Chirogate International Inc. | Intermediates for the synthesis of benzindene prostaglandins and preparations thereof |
| CN102796134B (zh) * | 2012-08-31 | 2015-07-01 | 甘肃皓天化学科技有限公司 | 一种马沙骨化醇中间体的制备方法 |
| CN104837806A (zh) * | 2012-12-07 | 2015-08-12 | 开曼化学股份有限公司 | 前列环素类似物的合成方法 |
| CN105722812B (zh) * | 2013-11-13 | 2018-11-16 | 开曼化学股份有限公司 | 前列环素类似物的胺盐 |
-
2013
- 2013-12-06 CN CN201380064046.3A patent/CN104837806A/zh active Pending
- 2013-12-06 AU AU2013355130A patent/AU2013355130B2/en not_active Ceased
- 2013-12-06 BR BR112015013085A patent/BR112015013085A2/pt not_active Application Discontinuation
- 2013-12-06 KR KR1020157018095A patent/KR20150091170A/ko not_active Ceased
- 2013-12-06 CN CN201710389417.5A patent/CN107098925B/zh not_active Expired - Fee Related
- 2013-12-06 JP JP2015545860A patent/JP6342414B2/ja not_active Expired - Fee Related
- 2013-12-06 TW TW102144990A patent/TWI634104B/zh not_active IP Right Cessation
- 2013-12-06 SG SG10201600303WA patent/SG10201600303WA/en unknown
- 2013-12-06 DK DK13812336.9T patent/DK2928858T3/en active
- 2013-12-06 CN CN201910784017.3A patent/CN110590547A/zh active Pending
- 2013-12-06 US US14/650,234 patent/US20150315114A1/en not_active Abandoned
- 2013-12-06 CA CA2893604A patent/CA2893604A1/en not_active Abandoned
- 2013-12-06 NZ NZ708130A patent/NZ708130A/en not_active IP Right Cessation
- 2013-12-06 MX MX2015006972A patent/MX369094B/es active IP Right Grant
- 2013-12-06 SG SG11201504430TA patent/SG11201504430TA/en unknown
- 2013-12-06 EP EP18154039.4A patent/EP3398931B1/en active Active
- 2013-12-06 ES ES13812336.9T patent/ES2664026T3/es active Active
- 2013-12-06 WO PCT/US2013/073474 patent/WO2014089385A2/en not_active Ceased
- 2013-12-06 PE PE2015000742A patent/PE20160090A1/es unknown
- 2013-12-06 EP EP13812336.9A patent/EP2928858B1/en active Active
- 2013-12-06 EA EA201591093A patent/EA034309B1/ru not_active IP Right Cessation
-
2015
- 2015-06-02 MX MX2019009102A patent/MX2019009102A/es unknown
- 2015-06-03 IL IL239172A patent/IL239172B/en not_active IP Right Cessation
- 2015-06-03 PH PH12015501258A patent/PH12015501258B1/en unknown
- 2015-06-05 CL CL2015001535A patent/CL2015001535A1/es unknown
-
2017
- 2017-05-01 US US15/583,457 patent/US9908834B2/en not_active Expired - Fee Related
-
2018
- 2018-01-18 US US15/874,093 patent/US10450257B2/en not_active Expired - Fee Related
- 2018-03-15 PH PH12018500562A patent/PH12018500562A1/en unknown
- 2018-05-16 JP JP2018094605A patent/JP2018162250A/ja not_active Ceased
- 2018-09-21 AU AU2018233009A patent/AU2018233009B2/en not_active Expired - Fee Related
-
2019
- 2019-09-11 US US16/567,471 patent/US20200002261A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018162250A5 (enExample) | ||
| JP2016537363A5 (enExample) | ||
| JP2016504303A5 (enExample) | ||
| JP2013520495A5 (enExample) | ||
| WO2005049592A1 (en) | A novel process for ezetimibe intermediate | |
| Quattropani et al. | Enantioselective deprotonation/electrophile addition reactions of tricarbonyl (phenyl carbamate) chromium complexes | |
| JP2671962B2 (ja) | キラルチアゾリジン−２，４−ジオン誘導体の合成における中間体の製造方法 | |
| US7439400B2 (en) | Amino alcohol ligand and its use in preparation of chiral proparglic tertiary alcohols and tertiary amines via enantioselective addition reaction | |
| CN114031487B (zh) | 一种2-芳基苯乙酮类化合物的合成方法 | |
| JP3905340B2 (ja) | 有機金属化合物の新規調製法 | |
| JP5437671B2 (ja) | グリニヤール試薬の製造方法 | |
| JP2917552B2 (ja) | α−メチレンシクロペンタノン誘導体の製造法 | |
| JP5063044B2 (ja) | α−トリフルオロメチルケトン化合物の製造法 | |
| JP4807549B2 (ja) | シロキサン類，シラノール類及びシラン類，並びにその製造方法 | |
| CN120817878A (zh) | 一种氮氟试剂介导的硫氟化合物的合成方法 | |
| FI103891B (fi) | Uudet organoboorireagenssit substituoimattomien propargyylialkoholien valmistamiseksi | |
| JP3907733B2 (ja) | フッ化アリールマグネシウム誘導体の製造方法 | |
| JP4057271B2 (ja) | イノラートアニオンの新規合成法 | |
| CN1129567C (zh) | 环丙基乙炔衍生物的制备方法 | |
| JP2004018503A (ja) | ３，３，３−トリフルオロ−２−ヒドロキシプロピオン酸およびその誘導体の製造方法 | |
| JP3762994B2 (ja) | アルキニルｓ，ｎ−アセタール誘導体及びその製造方法 | |
| JP5177346B2 (ja) | α−トリフルオロメチルケトン化合物の製造方法 | |
| JP6954615B2 (ja) | ヒドロシランの製造方法 | |
| JP3650156B2 (ja) | トリアルキルシリルトリアルキルシロキシメチレン化合物の製造方法 | |
| JP4794186B2 (ja) | テトラキスフェノール化合物の製造方法及びその中間体 |