JP2018162250A5 - - Google Patents
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- Publication number
- JP2018162250A5 JP2018162250A5 JP2018094605A JP2018094605A JP2018162250A5 JP 2018162250 A5 JP2018162250 A5 JP 2018162250A5 JP 2018094605 A JP2018094605 A JP 2018094605A JP 2018094605 A JP2018094605 A JP 2018094605A JP 2018162250 A5 JP2018162250 A5 JP 2018162250A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- organic solvent
- alkyl
- producing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 0 **(*)CCCCC#C[C@@](c1c(CC=C)c(O*)ccc1)O Chemical compound **(*)CCCCC#C[C@@](c1c(CC=C)c(O*)ccc1)O 0.000 description 3
- PAJMKGZZBBTTOY-ZUQLYSRVSA-N CCCCC[C@@H](CC[C@@H]([C@@H](C1)O)[C@@H](C2)C1Cc1c2cccc1OCC(O)=O)O Chemical compound CCCCC[C@@H](CC[C@@H]([C@@H](C1)O)[C@@H](C2)C1Cc1c2cccc1OCC(O)=O)O PAJMKGZZBBTTOY-ZUQLYSRVSA-N 0.000 description 2
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261734672P | 2012-12-07 | 2012-12-07 | |
| US61/734,672 | 2012-12-07 | ||
| US201361777882P | 2013-03-12 | 2013-03-12 | |
| US61/777,882 | 2013-03-12 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015545860A Division JP6342414B2 (ja) | 2012-12-07 | 2013-12-06 | プロスタサイクリン類似体を合成する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018162250A JP2018162250A (ja) | 2018-10-18 |
| JP2018162250A5 true JP2018162250A5 (enExample) | 2019-02-14 |
Family
ID=49881039
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015545860A Expired - Fee Related JP6342414B2 (ja) | 2012-12-07 | 2013-12-06 | プロスタサイクリン類似体を合成する方法 |
| JP2018094605A Ceased JP2018162250A (ja) | 2012-12-07 | 2018-05-16 | プロスタサイクリン類似体を合成する方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015545860A Expired - Fee Related JP6342414B2 (ja) | 2012-12-07 | 2013-12-06 | プロスタサイクリン類似体を合成する方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US20150315114A1 (enExample) |
| EP (2) | EP3398931B1 (enExample) |
| JP (2) | JP6342414B2 (enExample) |
| KR (1) | KR20150091170A (enExample) |
| CN (3) | CN104837806A (enExample) |
| AU (2) | AU2013355130B2 (enExample) |
| BR (1) | BR112015013085A2 (enExample) |
| CA (1) | CA2893604A1 (enExample) |
| CL (1) | CL2015001535A1 (enExample) |
| DK (1) | DK2928858T3 (enExample) |
| EA (1) | EA034309B1 (enExample) |
| ES (1) | ES2664026T3 (enExample) |
| IL (1) | IL239172B (enExample) |
| MX (2) | MX369094B (enExample) |
| NZ (1) | NZ708130A (enExample) |
| PE (1) | PE20160090A1 (enExample) |
| PH (2) | PH12015501258B1 (enExample) |
| SG (2) | SG10201600303WA (enExample) |
| TW (1) | TWI634104B (enExample) |
| WO (1) | WO2014089385A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX369094B (es) * | 2012-12-07 | 2019-10-29 | Cayman Chemical Co Inc | Metodos para sintetizar un analogo de prostaciclina. |
| JP6542128B2 (ja) | 2013-01-11 | 2019-07-10 | コルセア ファーマ インコーポレイテッド | トレプロスチニルのプロドラッグ |
| US9505737B2 (en) | 2013-01-11 | 2016-11-29 | Corsair Pharma, Inc. | Treprostinil derivative compounds and methods of using same |
| CA2930574A1 (en) * | 2013-11-13 | 2015-05-21 | Cayman Chemical Company Incorporated | Amine salts of a prostacyclin analog |
| HU231184B1 (hu) * | 2014-10-08 | 2021-07-28 | CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. | Treprostinil-nátrium-monohidrát és eljárás ennek előállítására |
| US9643911B2 (en) | 2015-06-17 | 2017-05-09 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| US9394227B1 (en) | 2015-06-17 | 2016-07-19 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| CA3038276A1 (en) | 2016-09-26 | 2018-03-29 | United Therapeutics Corporation | Treprostinil prodrugs |
| EP3498283A1 (en) | 2017-12-14 | 2019-06-19 | Ipsol AG | Glycosidic derivatives of treprostinil |
| HU231296B1 (hu) * | 2018-03-09 | 2022-09-28 | Chinoin Zrt | Eljárás treprostinil-dietanol-amin só B polimorf formájának előállítására |
| JP6503508B2 (ja) * | 2018-08-03 | 2019-04-17 | Ｊｘｔｇエネルギー株式会社 | テトラカルボン酸二無水物、ポリイミド前駆体樹脂、ポリイミド、ポリイミド前駆体樹脂溶液、ポリイミド溶液及びポリイミドフィルム |
| CN114616225A (zh) | 2019-08-23 | 2022-06-10 | 联合治疗公司 | 曲前列环素前药 |
| WO2021211916A1 (en) | 2020-04-17 | 2021-10-21 | United Therapeutics Corporation | Treprostinil for use in the treatment of intersitial lung disease |
| US11793780B2 (en) | 2020-06-09 | 2023-10-24 | United Therapeutics Corporation | Prodrugs of treprosiinil |
| KR20220030006A (ko) | 2020-09-02 | 2022-03-10 | 바이오플러스 주식회사 | 미용 조성물을 포함하는 마스크 및 그 제조 방법 |
| WO2022132655A1 (en) | 2020-12-14 | 2022-06-23 | United Therapeutics Corporation | Methods of treating disease with treprostinil prodrugs |
| EP4301372A1 (en) | 2021-03-03 | 2024-01-10 | United Therapeutics Corporation | A dry powder composition of trestinil and its prodrug thereof and further comprising comprising (e)-3,6-bis[4-(n-carbonyl-2-propenyl)amidobutyl]-2,5-diketopiperazine (fdkp) |
| US11884640B2 (en) * | 2021-06-02 | 2024-01-30 | Chirogate International Inc. | Processes and intermediates for the preparations of benzoprostacyclin analogues and benzoprostacyclin analogues prepared therefrom |
| US11884613B2 (en) * | 2022-05-05 | 2024-01-30 | Chirogate International Inc. | Processes and intermediates for the preparation of carbaprostacyclin analogues |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4306075A (en) * | 1980-03-28 | 1981-12-15 | The Upjohn Company | Composition and process |
| CA2039857A1 (en) * | 1990-04-26 | 1991-10-27 | Wilfred Po-Sum Shum | Process for producing epoxyalcohols of high optical purity |
| US6441245B1 (en) * | 1997-10-24 | 2002-08-27 | United Therapeutics Corporation | Process for stereoselective synthesis of prostacyclin derivatives |
| US6700025B2 (en) * | 2001-01-05 | 2004-03-02 | United Therapeutics Corporation | Process for stereoselective synthesis of prostacyclin derivatives |
| ES2622471T5 (es) * | 2003-05-22 | 2020-07-23 | United Therapeutics Corp | Compuestos y procedimientos para la administración de análogos de prostaciclina |
| JPWO2009019868A1 (ja) * | 2007-08-06 | 2010-10-28 | 大正製薬株式会社 | １０ａ、１２位架橋型１０ａ−アザライド化合物 |
| CA2710205C (en) | 2007-12-17 | 2016-04-26 | United Therapeutics Corporation | An improved process to prepare treprostinil, the active ingredient in remodulin |
| WO2009158010A1 (en) * | 2008-06-27 | 2009-12-30 | Concert Pharmaceuticals, Inc. | Prostacyclin analogs |
| WO2010039531A1 (en) * | 2008-09-23 | 2010-04-08 | Resolvyx Pharmaceuticals, Inc. | Therapeutic compounds |
| CN101891596B (zh) * | 2009-05-22 | 2013-12-11 | 上海天伟生物制药有限公司 | 一种化合物及其制备方法和用途 |
| CN103261142B (zh) | 2010-06-03 | 2014-12-10 | 联合治疗公司 | 曲前列环素的制备 |
| CA2710726C (en) | 2010-07-22 | 2016-02-23 | Alphora Research Inc. | Synthesis of treprostinil and intermediates useful therein |
| CN103238070B (zh) | 2010-10-01 | 2016-06-29 | 丹麦国家医院 | 能够调节/保护内皮完整性的用于预防或治疗急性创伤性凝血病和心脏骤停复苏的化合物 |
| US8865898B2 (en) * | 2010-11-30 | 2014-10-21 | Japan Science And Technology Agency | Nucleoside analog or salt thereof, oligonucleotide analog, gene expression inhibitor, and nucleic-acid probe for detecting gene |
| US8524939B2 (en) | 2011-08-24 | 2013-09-03 | Chirogate International Inc. | Intermediates for the synthesis of benzindene prostaglandins and preparations thereof |
| CN102796134B (zh) * | 2012-08-31 | 2015-07-01 | 甘肃皓天化学科技有限公司 | 一种马沙骨化醇中间体的制备方法 |
| MX369094B (es) * | 2012-12-07 | 2019-10-29 | Cayman Chemical Co Inc | Metodos para sintetizar un analogo de prostaciclina. |
| CA2930574A1 (en) * | 2013-11-13 | 2015-05-21 | Cayman Chemical Company Incorporated | Amine salts of a prostacyclin analog |
-
2013
- 2013-12-06 MX MX2015006972A patent/MX369094B/es active IP Right Grant
- 2013-12-06 SG SG10201600303WA patent/SG10201600303WA/en unknown
- 2013-12-06 KR KR1020157018095A patent/KR20150091170A/ko not_active Ceased
- 2013-12-06 BR BR112015013085A patent/BR112015013085A2/pt not_active Application Discontinuation
- 2013-12-06 US US14/650,234 patent/US20150315114A1/en not_active Abandoned
- 2013-12-06 CA CA2893604A patent/CA2893604A1/en not_active Abandoned
- 2013-12-06 AU AU2013355130A patent/AU2013355130B2/en not_active Ceased
- 2013-12-06 EP EP18154039.4A patent/EP3398931B1/en active Active
- 2013-12-06 DK DK13812336.9T patent/DK2928858T3/en active
- 2013-12-06 EP EP13812336.9A patent/EP2928858B1/en active Active
- 2013-12-06 ES ES13812336.9T patent/ES2664026T3/es active Active
- 2013-12-06 SG SG11201504430TA patent/SG11201504430TA/en unknown
- 2013-12-06 EA EA201591093A patent/EA034309B1/ru not_active IP Right Cessation
- 2013-12-06 CN CN201380064046.3A patent/CN104837806A/zh active Pending
- 2013-12-06 CN CN201910784017.3A patent/CN110590547A/zh active Pending
- 2013-12-06 JP JP2015545860A patent/JP6342414B2/ja not_active Expired - Fee Related
- 2013-12-06 NZ NZ708130A patent/NZ708130A/en not_active IP Right Cessation
- 2013-12-06 CN CN201710389417.5A patent/CN107098925B/zh not_active Expired - Fee Related
- 2013-12-06 PE PE2015000742A patent/PE20160090A1/es unknown
- 2013-12-06 WO PCT/US2013/073474 patent/WO2014089385A2/en not_active Ceased
- 2013-12-06 TW TW102144990A patent/TWI634104B/zh not_active IP Right Cessation
-
2015
- 2015-06-02 MX MX2019009102A patent/MX2019009102A/es unknown
- 2015-06-03 IL IL239172A patent/IL239172B/en not_active IP Right Cessation
- 2015-06-03 PH PH12015501258A patent/PH12015501258B1/en unknown
- 2015-06-05 CL CL2015001535A patent/CL2015001535A1/es unknown
-
2017
- 2017-05-01 US US15/583,457 patent/US9908834B2/en not_active Expired - Fee Related
-
2018
- 2018-01-18 US US15/874,093 patent/US10450257B2/en not_active Expired - Fee Related
- 2018-03-15 PH PH12018500562A patent/PH12018500562A1/en unknown
- 2018-05-16 JP JP2018094605A patent/JP2018162250A/ja not_active Ceased
- 2018-09-21 AU AU2018233009A patent/AU2018233009B2/en not_active Expired - Fee Related
-
2019
- 2019-09-11 US US16/567,471 patent/US20200002261A1/en not_active Abandoned
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