JP2016504303A5 - - Google Patents
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- Publication number
- JP2016504303A5 JP2016504303A5 JP2015545860A JP2015545860A JP2016504303A5 JP 2016504303 A5 JP2016504303 A5 JP 2016504303A5 JP 2015545860 A JP2015545860 A JP 2015545860A JP 2015545860 A JP2015545860 A JP 2015545860A JP 2016504303 A5 JP2016504303 A5 JP 2016504303A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- item
- reacting
- produce
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261734672P | 2012-12-07 | 2012-12-07 | |
| US61/734,672 | 2012-12-07 | ||
| US201361777882P | 2013-03-12 | 2013-03-12 | |
| US61/777,882 | 2013-03-12 | ||
| PCT/US2013/073474 WO2014089385A2 (en) | 2012-12-07 | 2013-12-06 | Methods of synthesizing a prostacyclin analog |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018094605A Division JP2018162250A (ja) | 2012-12-07 | 2018-05-16 | プロスタサイクリン類似体を合成する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016504303A JP2016504303A (ja) | 2016-02-12 |
| JP2016504303A5 true JP2016504303A5 (enExample) | 2017-01-26 |
| JP6342414B2 JP6342414B2 (ja) | 2018-06-13 |
Family
ID=49881039
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015545860A Expired - Fee Related JP6342414B2 (ja) | 2012-12-07 | 2013-12-06 | プロスタサイクリン類似体を合成する方法 |
| JP2018094605A Ceased JP2018162250A (ja) | 2012-12-07 | 2018-05-16 | プロスタサイクリン類似体を合成する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018094605A Ceased JP2018162250A (ja) | 2012-12-07 | 2018-05-16 | プロスタサイクリン類似体を合成する方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US20150315114A1 (enExample) |
| EP (2) | EP2928858B1 (enExample) |
| JP (2) | JP6342414B2 (enExample) |
| KR (1) | KR20150091170A (enExample) |
| CN (3) | CN110590547A (enExample) |
| AU (2) | AU2013355130B2 (enExample) |
| BR (1) | BR112015013085A2 (enExample) |
| CA (1) | CA2893604A1 (enExample) |
| CL (1) | CL2015001535A1 (enExample) |
| DK (1) | DK2928858T3 (enExample) |
| EA (1) | EA034309B1 (enExample) |
| ES (1) | ES2664026T3 (enExample) |
| IL (1) | IL239172B (enExample) |
| MX (2) | MX369094B (enExample) |
| NZ (1) | NZ708130A (enExample) |
| PE (1) | PE20160090A1 (enExample) |
| PH (2) | PH12015501258A1 (enExample) |
| SG (2) | SG10201600303WA (enExample) |
| TW (1) | TWI634104B (enExample) |
| WO (1) | WO2014089385A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20160090A1 (es) * | 2012-12-07 | 2016-02-20 | Cayman Chemical Co Inc | Metodos para sintetizar un analogo de la prostaciclina |
| US9505737B2 (en) | 2013-01-11 | 2016-11-29 | Corsair Pharma, Inc. | Treprostinil derivative compounds and methods of using same |
| US9371264B2 (en) | 2013-01-11 | 2016-06-21 | Corsair Pharma, Inc. | Treprostinil derivative compounds and methods of using same |
| WO2015073314A1 (en) * | 2013-11-13 | 2015-05-21 | Cayman Chemical Company Incorporated | Amine salts of a prostacyclin analog |
| HU231186B1 (hu) | 2014-10-08 | 2021-06-28 | CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. | Új eljárás treprostinil és sói előállítására |
| US9394227B1 (en) | 2015-06-17 | 2016-07-19 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| US9643911B2 (en) | 2015-06-17 | 2017-05-09 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| EP3515430A1 (en) | 2016-09-26 | 2019-07-31 | United Therapeutics Corporation | Treprostinil prodrugs |
| EP3498283A1 (en) | 2017-12-14 | 2019-06-19 | Ipsol AG | Glycosidic derivatives of treprostinil |
| HU231296B1 (hu) * | 2018-03-09 | 2022-09-28 | Chinoin Zrt | Eljárás treprostinil-dietanol-amin só B polimorf formájának előállítására |
| JP6503508B2 (ja) * | 2018-08-03 | 2019-04-17 | Ｊｘｔｇエネルギー株式会社 | テトラカルボン酸二無水物、ポリイミド前駆体樹脂、ポリイミド、ポリイミド前駆体樹脂溶液、ポリイミド溶液及びポリイミドフィルム |
| JP2022546314A (ja) | 2019-08-23 | 2022-11-04 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニルプロドラッグ |
| US11826327B2 (en) | 2020-04-17 | 2023-11-28 | United Therapeutics Corporation | Treatment for interstitial lung disease |
| KR20250057075A (ko) | 2020-06-09 | 2025-04-28 | 유나이티드 쎄러퓨틱스 코포레이션 | 트레프로스티닐의 푸마릴 디케토피페리딘 프로드러그 |
| KR20220030006A (ko) | 2020-09-02 | 2022-03-10 | 바이오플러스 주식회사 | 미용 조성물을 포함하는 마스크 및 그 제조 방법 |
| JP7826317B2 (ja) | 2020-12-14 | 2026-03-09 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニルプロドラッグで疾患を治療する方法 |
| EP4301372A1 (en) | 2021-03-03 | 2024-01-10 | United Therapeutics Corporation | A dry powder composition of trestinil and its prodrug thereof and further comprising comprising (e)-3,6-bis[4-(n-carbonyl-2-propenyl)amidobutyl]-2,5-diketopiperazine (fdkp) |
| US11884640B2 (en) * | 2021-06-02 | 2024-01-30 | Chirogate International Inc. | Processes and intermediates for the preparations of benzoprostacyclin analogues and benzoprostacyclin analogues prepared therefrom |
| US11884613B2 (en) * | 2022-05-05 | 2024-01-30 | Chirogate International Inc. | Processes and intermediates for the preparation of carbaprostacyclin analogues |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4306075A (en) * | 1980-03-28 | 1981-12-15 | The Upjohn Company | Composition and process |
| CA2039857A1 (en) * | 1990-04-26 | 1991-10-27 | Wilfred Po-Sum Shum | Process for producing epoxyalcohols of high optical purity |
| US6441245B1 (en) | 1997-10-24 | 2002-08-27 | United Therapeutics Corporation | Process for stereoselective synthesis of prostacyclin derivatives |
| US6700025B2 (en) | 2001-01-05 | 2004-03-02 | United Therapeutics Corporation | Process for stereoselective synthesis of prostacyclin derivatives |
| WO2005007081A2 (en) * | 2003-05-22 | 2005-01-27 | United Therapeutics Corporation | Compounds and methods for delivery of prostacyclin analogs |
| US8293715B2 (en) * | 2007-08-06 | 2012-10-23 | Taisho Pharmaceutical Co., Ltd. | 10a-Azalide compound crosslinked at 10a- and 12-positions |
| EP2252570B1 (en) | 2007-12-17 | 2017-04-05 | United Therapeutics Corporation | An improved process to prepare treprostinil, the active ingredient in remodulin ® |
| WO2009158010A1 (en) * | 2008-06-27 | 2009-12-30 | Concert Pharmaceuticals, Inc. | Prostacyclin analogs |
| WO2010039531A1 (en) * | 2008-09-23 | 2010-04-08 | Resolvyx Pharmaceuticals, Inc. | Therapeutic compounds |
| CN101891596B (zh) * | 2009-05-22 | 2013-12-11 | 上海天伟生物制药有限公司 | 一种化合物及其制备方法和用途 |
| EP2576492B1 (en) * | 2010-06-03 | 2017-09-20 | United Therapeutics Corporation | Treprostinil production |
| CA2710726C (en) * | 2010-07-22 | 2016-02-23 | Alphora Research Inc. | Synthesis of treprostinil and intermediates useful therein |
| CN103238070B (zh) | 2010-10-01 | 2016-06-29 | 丹麦国家医院 | 能够调节/保护内皮完整性的用于预防或治疗急性创伤性凝血病和心脏骤停复苏的化合物 |
| US8865898B2 (en) * | 2010-11-30 | 2014-10-21 | Japan Science And Technology Agency | Nucleoside analog or salt thereof, oligonucleotide analog, gene expression inhibitor, and nucleic-acid probe for detecting gene |
| US8524939B2 (en) | 2011-08-24 | 2013-09-03 | Chirogate International Inc. | Intermediates for the synthesis of benzindene prostaglandins and preparations thereof |
| CN102796134B (zh) * | 2012-08-31 | 2015-07-01 | 甘肃皓天化学科技有限公司 | 一种马沙骨化醇中间体的制备方法 |
| PE20160090A1 (es) * | 2012-12-07 | 2016-02-20 | Cayman Chemical Co Inc | Metodos para sintetizar un analogo de la prostaciclina |
| WO2015073314A1 (en) * | 2013-11-13 | 2015-05-21 | Cayman Chemical Company Incorporated | Amine salts of a prostacyclin analog |
-
2013
- 2013-12-06 PE PE2015000742A patent/PE20160090A1/es unknown
- 2013-12-06 CA CA2893604A patent/CA2893604A1/en not_active Abandoned
- 2013-12-06 US US14/650,234 patent/US20150315114A1/en not_active Abandoned
- 2013-12-06 WO PCT/US2013/073474 patent/WO2014089385A2/en not_active Ceased
- 2013-12-06 EP EP13812336.9A patent/EP2928858B1/en active Active
- 2013-12-06 NZ NZ708130A patent/NZ708130A/en not_active IP Right Cessation
- 2013-12-06 DK DK13812336.9T patent/DK2928858T3/en active
- 2013-12-06 SG SG10201600303WA patent/SG10201600303WA/en unknown
- 2013-12-06 EP EP18154039.4A patent/EP3398931B1/en active Active
- 2013-12-06 CN CN201910784017.3A patent/CN110590547A/zh active Pending
- 2013-12-06 CN CN201380064046.3A patent/CN104837806A/zh active Pending
- 2013-12-06 CN CN201710389417.5A patent/CN107098925B/zh not_active Expired - Fee Related
- 2013-12-06 TW TW102144990A patent/TWI634104B/zh not_active IP Right Cessation
- 2013-12-06 MX MX2015006972A patent/MX369094B/es active IP Right Grant
- 2013-12-06 KR KR1020157018095A patent/KR20150091170A/ko not_active Ceased
- 2013-12-06 JP JP2015545860A patent/JP6342414B2/ja not_active Expired - Fee Related
- 2013-12-06 SG SG11201504430TA patent/SG11201504430TA/en unknown
- 2013-12-06 ES ES13812336.9T patent/ES2664026T3/es active Active
- 2013-12-06 EA EA201591093A patent/EA034309B1/ru not_active IP Right Cessation
- 2013-12-06 BR BR112015013085A patent/BR112015013085A2/pt not_active Application Discontinuation
- 2013-12-06 AU AU2013355130A patent/AU2013355130B2/en not_active Ceased
-
2015
- 2015-06-02 MX MX2019009102A patent/MX2019009102A/es unknown
- 2015-06-03 PH PH12015501258A patent/PH12015501258A1/en unknown
- 2015-06-03 IL IL239172A patent/IL239172B/en not_active IP Right Cessation
- 2015-06-05 CL CL2015001535A patent/CL2015001535A1/es unknown
-
2017
- 2017-05-01 US US15/583,457 patent/US9908834B2/en not_active Expired - Fee Related
-
2018
- 2018-01-18 US US15/874,093 patent/US10450257B2/en not_active Expired - Fee Related
- 2018-03-15 PH PH12018500562A patent/PH12018500562A1/en unknown
- 2018-05-16 JP JP2018094605A patent/JP2018162250A/ja not_active Ceased
- 2018-09-21 AU AU2018233009A patent/AU2018233009B2/en not_active Expired - Fee Related
-
2019
- 2019-09-11 US US16/567,471 patent/US20200002261A1/en not_active Abandoned
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