CL2015001535A1 - Métodos para sintetizar un análogo de la prostaciclina - Google Patents

Métodos para sintetizar un análogo de la prostaciclina

Info

Publication number
CL2015001535A1
CL2015001535A1 CL2015001535A CL2015001535A CL2015001535A1 CL 2015001535 A1 CL2015001535 A1 CL 2015001535A1 CL 2015001535 A CL2015001535 A CL 2015001535A CL 2015001535 A CL2015001535 A CL 2015001535A CL 2015001535 A1 CL2015001535 A1 CL 2015001535A1
Authority
CL
Chile
Prior art keywords
synthesize
methods
prostacyclin analog
intermediate compounds
purifying
Prior art date
Application number
CL2015001535A
Other languages
English (en)
Inventor
Kirk William Hering
Gilles Chambournier
Gregory William Endres
Victor Fedu
Thomas James Ii Krell
Hussein Mahmound Mahmoud
Original Assignee
Cayman Chemical Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cayman Chemical Co Inc filed Critical Cayman Chemical Co Inc
Publication of CL2015001535A1 publication Critical patent/CL2015001535A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/34—Separation; Purification; Stabilisation; Use of additives
    • C07C41/44—Separation; Purification; Stabilisation; Use of additives by treatments giving rise to a chemical modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/32—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/14—Benz[f]indenes; Hydrogenated benz[f]indenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

METODO PARA GENERAR ACIDO (1R,2R,3AS,9AS)-[[2,3,3A,4,9,9A- HEXAHIDRO-2-HIDROXI-1- [(3S) -3-HIDROXIOCTIL] -1H-BENZ [F] INDEN-5- IL]OXI]ACETICO (TREPROSTINIL); METODO PARA PURIFICAR ESTE COMPUESTO; METODO PARA GENERAR COMPUESTOS INTERMEDIARIOS; METODO PARA PURIFICAR LOS COMPUESTOS INTERMEDIARIOS; Y COMPUESTOS INTERMEDIARIOS.
CL2015001535A 2012-12-07 2015-06-05 Métodos para sintetizar un análogo de la prostaciclina CL2015001535A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261734672P 2012-12-07 2012-12-07
US201361777882P 2013-03-12 2013-03-12

Publications (1)

Publication Number Publication Date
CL2015001535A1 true CL2015001535A1 (es) 2016-01-15

Family

ID=49881039

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2015001535A CL2015001535A1 (es) 2012-12-07 2015-06-05 Métodos para sintetizar un análogo de la prostaciclina

Country Status (21)

Country Link
US (4) US20150315114A1 (es)
EP (2) EP3398931B1 (es)
JP (2) JP6342414B2 (es)
KR (1) KR20150091170A (es)
CN (3) CN110590547A (es)
AU (2) AU2013355130B2 (es)
BR (1) BR112015013085A2 (es)
CA (1) CA2893604A1 (es)
CL (1) CL2015001535A1 (es)
DK (1) DK2928858T3 (es)
EA (1) EA034309B1 (es)
ES (1) ES2664026T3 (es)
HK (1) HK1212323A1 (es)
IL (1) IL239172B (es)
MX (2) MX369094B (es)
NZ (1) NZ708130A (es)
PE (1) PE20160090A1 (es)
PH (2) PH12015501258B1 (es)
SG (2) SG10201600303WA (es)
TW (1) TWI634104B (es)
WO (1) WO2014089385A2 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11427609B2 (en) 2017-12-14 2022-08-30 Aop Orphan Ip Ag Glycosidic derivatives of treprostinil

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110590547A (zh) * 2012-12-07 2019-12-20 开曼化学股份有限公司 前列环素衍生物的合成方法
WO2014110491A1 (en) 2013-01-11 2014-07-17 Theratrophix Llc Prodrugs of treprostinil
US9505737B2 (en) 2013-01-11 2016-11-29 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
EP3068752A1 (en) * 2013-11-13 2016-09-21 Cayman Chemical Company Incorporated Amine salts of a prostacyclin analog
HU231184B1 (hu) 2014-10-08 2021-07-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Treprostinil-nátrium-monohidrát és eljárás ennek előállítására
US9394227B1 (en) 2015-06-17 2016-07-19 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US9643911B2 (en) 2015-06-17 2017-05-09 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
KR102541885B1 (ko) 2016-09-26 2023-06-12 유나이티드 쎄러퓨틱스 코포레이션 트레프로스티닐 프로드럭
HU231296B1 (hu) 2018-03-09 2022-09-28 Chinoin Zrt Eljárás treprostinil-dietanol-amin só B polimorf formájának előállítására
EP4017588A1 (en) 2019-08-23 2022-06-29 United Therapeutics Corporation Treprostinil prodrugs
IL296567A (en) 2020-04-17 2022-11-01 United Therapeutics Corp Terfostinil for use in the treatment of interstitial lung disease
WO2021252446A1 (en) 2020-06-09 2021-12-16 United Therapeutics Corporation Fumaryl diketopiperidine prodrugs of treprostinil
KR20220030006A (ko) 2020-09-02 2022-03-10 바이오플러스 주식회사 미용 조성물을 포함하는 마스크 및 그 제조 방법
WO2022132655A1 (en) 2020-12-14 2022-06-23 United Therapeutics Corporation Methods of treating disease with treprostinil prodrugs
US11884640B2 (en) * 2021-06-02 2024-01-30 Chirogate International Inc. Processes and intermediates for the preparations of benzoprostacyclin analogues and benzoprostacyclin analogues prepared therefrom

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4306075A (en) 1980-03-28 1981-12-15 The Upjohn Company Composition and process
CA2039857A1 (en) * 1990-04-26 1991-10-27 Wilfred Po-Sum Shum Process for producing epoxyalcohols of high optical purity
US6441245B1 (en) 1997-10-24 2002-08-27 United Therapeutics Corporation Process for stereoselective synthesis of prostacyclin derivatives
US6700025B2 (en) 2001-01-05 2004-03-02 United Therapeutics Corporation Process for stereoselective synthesis of prostacyclin derivatives
EP2792353B1 (en) * 2003-05-22 2018-02-28 United Therapeutics Corporation Polymorph of Treprostinil diethanolamine salt
US8293715B2 (en) * 2007-08-06 2012-10-23 Taisho Pharmaceutical Co., Ltd. 10a-Azalide compound crosslinked at 10a- and 12-positions
KR20160048222A (ko) 2007-12-17 2016-05-03 유나이티드 세러퓨틱스 코오포레이션 레모둘린?의 활성 성분인 트레프로스티닐의 개선된 제조 방법
WO2010039531A1 (en) * 2008-09-23 2010-04-08 Resolvyx Pharmaceuticals, Inc. Therapeutic compounds
CN101891596B (zh) * 2009-05-22 2013-12-11 上海天伟生物制药有限公司 一种化合物及其制备方法和用途
WO2011153363A1 (en) * 2010-06-03 2011-12-08 United Therapeutics Corporation Treprostinil production
CA2710726C (en) 2010-07-22 2016-02-23 Alphora Research Inc. Synthesis of treprostinil and intermediates useful therein
CN103238070B (zh) 2010-10-01 2016-06-29 丹麦国家医院 能够调节/保护内皮完整性的用于预防或治疗急性创伤性凝血病和心脏骤停复苏的化合物
JP5199519B2 (ja) * 2010-11-30 2013-05-15 独立行政法人科学技術振興機構 ヌクレオシド類縁体又はその塩、オリゴヌクレオチド類縁体、遺伝子発現抑制剤、及び遺伝子検出用核酸プローブ
US8524939B2 (en) 2011-08-24 2013-09-03 Chirogate International Inc. Intermediates for the synthesis of benzindene prostaglandins and preparations thereof
CN102796134B (zh) * 2012-08-31 2015-07-01 甘肃皓天化学科技有限公司 一种马沙骨化醇中间体的制备方法
CN110590547A (zh) * 2012-12-07 2019-12-20 开曼化学股份有限公司 前列环素衍生物的合成方法
EP3068752A1 (en) * 2013-11-13 2016-09-21 Cayman Chemical Company Incorporated Amine salts of a prostacyclin analog

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11427609B2 (en) 2017-12-14 2022-08-30 Aop Orphan Ip Ag Glycosidic derivatives of treprostinil

Also Published As

Publication number Publication date
JP2016504303A (ja) 2016-02-12
US9908834B2 (en) 2018-03-06
EP2928858B1 (en) 2018-01-31
TWI634104B (zh) 2018-09-01
WO2014089385A3 (en) 2014-08-28
EA034309B1 (ru) 2020-01-27
PH12015501258A1 (en) 2015-08-17
US10450257B2 (en) 2019-10-22
CN104837806A (zh) 2015-08-12
SG10201600303WA (en) 2016-02-26
US20180141889A1 (en) 2018-05-24
AU2018233009B2 (en) 2020-01-23
JP6342414B2 (ja) 2018-06-13
MX2015006972A (es) 2016-02-11
ES2664026T3 (es) 2018-04-18
IL239172B (en) 2020-01-30
SG11201504430TA (en) 2015-07-30
HK1212323A1 (en) 2016-06-10
KR20150091170A (ko) 2015-08-07
TW201422577A (zh) 2014-06-16
AU2018233009A1 (en) 2018-10-18
PE20160090A1 (es) 2016-02-20
US20170297995A1 (en) 2017-10-19
IL239172A0 (en) 2015-07-30
CA2893604A1 (en) 2014-06-12
WO2014089385A2 (en) 2014-06-12
MX369094B (es) 2019-10-29
US20150315114A1 (en) 2015-11-05
NZ708130A (en) 2020-01-31
EA201591093A1 (ru) 2015-09-30
AU2013355130A1 (en) 2015-06-11
PH12018500562A1 (en) 2019-03-04
MX2019009102A (es) 2019-09-16
JP2018162250A (ja) 2018-10-18
AU2013355130B2 (en) 2018-06-21
CN107098925A (zh) 2017-08-29
CN110590547A (zh) 2019-12-20
US20200002261A1 (en) 2020-01-02
DK2928858T3 (en) 2018-02-19
EP2928858A2 (en) 2015-10-14
CN107098925B (zh) 2019-09-13
EP3398931A1 (en) 2018-11-07
BR112015013085A2 (pt) 2017-07-11
PH12015501258B1 (en) 2015-08-17
EP3398931B1 (en) 2020-04-08

Similar Documents

Publication Publication Date Title
CL2015001535A1 (es) Métodos para sintetizar un análogo de la prostaciclina
WO2015100213A3 (en) Process-scale synthesis of urolithins
EP2681204A4 (en) SYNTHESIS OF INTERMEDIATE PRODUCTS FOR TREPROSTINE PRODUCTION
CL2012003629A1 (es) Molecula de acido nucleico aislada que comprende el precursor mir166; constructo de expresion vegetal que comprende dicha molécula; metodo de modulacion en comparacion con una respectiva planta de referencia.
UY33325A (es) Purificación mediante adsorción de colorante caramelo
MX2013011257A (es) Proceso para la preparacion de dronedarona por n-butilacion.
WO2014203278A3 (en) NOVEL PROCESS FOR THE PREPARATION OF (1R,2R,3aS,9aS)-[[2,3,3a,4,9,9a-HEXAHYDRO-2-HYDROXY-1-[(3S)-3-HYDROXYOCTYL]-1H-BENZ[f]INDEN-5-YL]OXY]ACETIC ACID
IN2014MN01521A (es)
CL2011002657A1 (es) Proceso para preparar una mezcla racemica de acidos cis- y trans-octahidro ciclopenta[c]pirrol-1-carboxilicos; compuestos intermediarios.
MX2013000295A (es) Procedimiento de preparacion de un inhibidor especifico de la trombina.
MY164954A (en) Method for purifying organic diphosphite compounds
AR080656A1 (es) Sintesis de magnolol y sus compuestos analogos, y composicion farmaceutica
WO2011126245A3 (en) Novel method of preparing vanadosilicate molecular sieve and novel vanadosilicate molecular sieve
EP2611764A4 (en) FERMENTATION ROUTE FOR THE PRODUCTION OF LÉVULINIC ACID, LEVULINATE ESTERS, VALÉROLACTONE, AND CERTAIN OF THEIR DERIVATIVES
CY1117233T1 (el) Διεργασια για την παρασκευη νεμπιβολολης
MX2014004083A (es) Metodo para aislar ingenol.
NZ577081A (en) Synthesis of compounds useful as modulators of amyloid-beta production
RU2015118163A (ru) Новое алициклическое диольное соединение и способ его получения
MY170265A (en) Polythiols as cis/trans isomerization catalysts for unsaturated compounds
EA201590116A1 (ru) Способ получения замещенных триазолопиридинов
MY164880A (en) Process for the preparation of isoxazolyl-methoxy-nicotinic acids
EP4282973A3 (en) Processes for the preparation of pyrimidinylcyclopentane compounds
CO7030967A2 (es) Método para preparar un compuesto mediante la reacción de adición de michael novedosa usando agua o varios ácidos como aditivo
MY170264A (en) Nitrogen monoxide as cis/trans isomerization catalysts for unsaturated compounds
AR082166A1 (es) USO DE a-AMINO ETERES PARA ELIMINAR MERCAPTANOS DE HIDROCARBUROS