|
US4683202A
(en)
|
1985-03-28 |
1987-07-28 |
Cetus Corporation |
Process for amplifying nucleic acid sequences
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US5324731A
(en)
|
1989-02-14 |
1994-06-28 |
Amira, Inc. |
Method of inhibiting transformation of cells in which purine metabolic enzyme activity is elevated
|
|
US5676978A
(en)
|
1989-02-14 |
1997-10-14 |
Amira, Inc. |
Methods of inhibiting undesirable cell growth using a combination of a cyclocreatine compound and a hyperplastic inhibitory agent
|
|
US6040138A
(en)
|
1995-09-15 |
2000-03-21 |
Affymetrix, Inc. |
Expression monitoring by hybridization to high density oligonucleotide arrays
|
|
US5215882A
(en)
|
1989-11-30 |
1993-06-01 |
Ortho Diagnostic Systems, Inc. |
Method of immobilizing nucleic acid on a solid surface for use in nucleic acid hybridization assays
|
|
EP0519596B1
(en)
|
1991-05-17 |
2005-02-23 |
Merck & Co. Inc. |
A method for reducing the immunogenicity of antibody variable domains
|
|
US5565332A
(en)
|
1991-09-23 |
1996-10-15 |
Medical Research Council |
Production of chimeric antibodies - a combinatorial approach
|
|
US5639641A
(en)
|
1992-09-09 |
1997-06-17 |
Immunogen Inc. |
Resurfacing of rodent antibodies
|
|
US5837832A
(en)
|
1993-06-25 |
1998-11-17 |
Affymetrix, Inc. |
Arrays of nucleic acid probes on biological chips
|
|
US5807522A
(en)
|
1994-06-17 |
1998-09-15 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods for fabricating microarrays of biological samples
|
|
DE69621507T2
(de)
|
1995-03-28 |
2003-01-09 |
Japan Science And Technology Corp., Kawaguchi |
Verfahren zur molekularen Indexierung von Genen unter Verwendung von Restriktionsenzymen
|
|
US5843974A
(en)
*
|
1995-06-06 |
1998-12-01 |
Eli Lilly And Company |
Methods of inhibiting melanoma using Benzothiophenes as cytotoxic agents per se
|
|
US5958342A
(en)
|
1996-05-17 |
1999-09-28 |
Incyte Pharmaceuticals, Inc. |
Jet droplet device
|
|
US6060240A
(en)
|
1996-12-13 |
2000-05-09 |
Arcaris, Inc. |
Methods for measuring relative amounts of nucleic acids in a complex mixture and retrieval of specific sequences therefrom
|
|
US6090556A
(en)
|
1997-04-07 |
2000-07-18 |
Japan Science & Technology Corporation |
Method for quantitatively determining the expression of a gene
|
|
US5994076A
(en)
|
1997-05-21 |
1999-11-30 |
Clontech Laboratories, Inc. |
Methods of assaying differential expression
|
|
ATE338118T1
(de)
|
1997-12-12 |
2006-09-15 |
Univ Western Ontario |
Neues peptid, apoep1.b, zusammensetzungen und verwendungen davon
|
|
US6004755A
(en)
|
1998-04-07 |
1999-12-21 |
Incyte Pharmaceuticals, Inc. |
Quantitative microarray hybridizaton assays
|
|
US6048695A
(en)
|
1998-05-04 |
2000-04-11 |
Baylor College Of Medicine |
Chemically modified nucleic acids and methods for coupling nucleic acids to solid support
|
|
US6087112A
(en)
|
1998-12-30 |
2000-07-11 |
Oligos Etc. Inc. |
Arrays with modified oligonucleotide and polynucleotide compositions
|
|
US6316503B1
(en)
|
1999-03-15 |
2001-11-13 |
Tularik Inc. |
LXR modulators
|
|
US8257750B2
(en)
|
1999-04-30 |
2012-09-04 |
Kibow Biotech, Inc. |
Calcium carbonate compositions for preventing or treating hyperphosphatemia
|
|
US6716622B2
(en)
|
2000-07-18 |
2004-04-06 |
Uab Research Foundation |
Tissue-specific self-inactivating gene therapy vector
|
|
US20030027335A1
(en)
|
2000-09-07 |
2003-02-06 |
Ruley H. Earl |
Genome engineering by cell-permeable DNA site-specific recombinases
|
|
WO2002024632A2
(en)
|
2000-09-18 |
2002-03-28 |
Glaxo Group Limited |
Substituted aminopropoxyaryl derivatives useful as agonists for lxr
|
|
AU2002219718A1
(en)
|
2000-12-13 |
2002-06-24 |
Sca Hygiene Products Zeist B.V. |
Process for oxidising primary alcohols
|
|
JP2003033179A
(ja)
|
2001-07-05 |
2003-02-04 |
Asahi Kasei Corp |
可逆的遺伝子導入ベクター
|
|
EP1575495A4
(en)
|
2002-03-27 |
2009-12-02 |
Smithkline Beecham Corp |
COMPOUNDS AND METHODS
|
|
AU2003220558A1
(en)
|
2002-03-27 |
2004-06-03 |
Smithkline Beecham Corporation |
Amide compounds and methods of using the same
|
|
US7560586B2
(en)
|
2002-03-27 |
2009-07-14 |
Smithkline Beecham Corporation |
Acid and ester compounds and methods of using the same
|
|
ATE470722T1
(de)
|
2002-07-19 |
2010-06-15 |
Althea Technologies Inc |
Strategien zur genexpressionsanalyse
|
|
US7135575B2
(en)
*
|
2003-03-03 |
2006-11-14 |
Array Biopharma, Inc. |
P38 inhibitors and methods of use thereof
|
|
US20040216178A1
(en)
|
2003-03-03 |
2004-10-28 |
Jones Stephen N |
Regulation of mdm2 function
|
|
WO2005007877A2
(en)
|
2003-07-18 |
2005-01-27 |
University Of Massachusetts |
Regulatable promoters for synthesis of small hairpin rna
|
|
BRPI0415563A
(pt)
|
2003-10-20 |
2007-01-02 |
Nsgene As |
método para o tratamento do mal de parkinson, uso de um vetor viral, vetor de expressão viral, composição farmacêutica, célula hospedeira isolada, linhagem de células de empacotamento, mamìfero não humano quimérico, dispositivo de cultura celular implantável, cápsula biocompatìvel, método para tratamento de uma doença do sistema nervoso, célula de mamìfero, e, método para produzir neurturin ou um seu equivalente funcional
|
|
AU2004298486A1
(en)
|
2003-12-12 |
2005-06-30 |
Wyeth |
Quinolines useful in treating cardiovascular disease
|
|
FR2865736B1
(fr)
|
2004-02-02 |
2006-07-14 |
Synt Em |
Inhibiteurs de l'angiogenese, compositions les contenant et leur utilisation pour le traitement des maladies liees a une deregulation de l'angiogenese
|
|
WO2005112620A2
(en)
|
2004-05-18 |
2005-12-01 |
Massachusetts Institute Of Technology |
A cre-lox based method for conditional rna interference
|
|
WO2006004030A1
(ja)
*
|
2004-07-02 |
2006-01-12 |
Sankyo Company, Limited |
組織因子産生抑制剤
|
|
CN1980665A
(zh)
|
2004-07-07 |
2007-06-13 |
默克公司 |
吡唑酰胺衍生物,包含这些化合物的组合物和使用方法
|
|
US20060058311A1
(en)
|
2004-08-14 |
2006-03-16 |
Boehringer Ingelheim International Gmbh |
Combinations for the treatment of diseases involving cell proliferation
|
|
ATE415385T1
(de)
|
2004-10-01 |
2008-12-15 |
Hoffmann La Roche |
Hexafluorisopropanolsubstituierte etherderivate
|
|
WO2006066779A1
(en)
|
2004-12-22 |
2006-06-29 |
F.Hoffmann-La Roche Ag |
Novel cyclohexane derivatives
|
|
US20090029945A2
(en)
|
2005-01-10 |
2009-01-29 |
Astrazeneca Ab |
Non-Anilinic Derivatives of Isothiazol-3(2H)-Thione 1,1-Dioxides As Liver X Receptor Modulators
|
|
JP2008526841A
(ja)
|
2005-01-10 |
2008-07-24 |
アストラゼネカ アクチボラグ |
肝臓x受容体調節因子としてのイソチアゾール−3(2h)−オン1,1−ジオキシドのアニリン系誘導体
|
|
SE0500056D0
(sv)
|
2005-01-10 |
2005-01-10 |
Astrazeneca Ab |
Therapeutic agents 4
|
|
SE0500058D0
(sv)
|
2005-01-10 |
2005-01-10 |
Astrazeneca Ab |
Therapeutic agents 5
|
|
SE0500055D0
(sv)
|
2005-01-10 |
2005-01-10 |
Astrazeneca Ab |
Therapeutic agents 3
|
|
RU2007131400A
(ru)
|
2005-03-01 |
2009-04-10 |
Вайет (Us) |
Соединения циннолина и их применение в качестве модуляторов х-рецепторов печени
|
|
US8318760B2
(en)
|
2005-03-21 |
2012-11-27 |
Merck Sharp & Dohme Corp. |
Substituted aryl and heteroaryl derivatives, compositions containing such compounds and methods of use
|
|
BRPI0612287A8
(pt)
|
2005-06-27 |
2019-01-22 |
Exelixis Inc |
composição para uso farmacêutico no tratamento de doenças através da medicina nuclear e métodos de uso e para modulação de atividade de receptor nuclear
|
|
SI1934174T1
(sl)
|
2005-10-07 |
2011-08-31 |
Exelixis Inc |
Inhibitorji MEK in postopki za njihovo uporabo
|
|
US7741317B2
(en)
|
2005-10-21 |
2010-06-22 |
Bristol-Myers Squibb Company |
LXR modulators
|
|
US7790745B2
(en)
|
2005-10-21 |
2010-09-07 |
Bristol-Myers Squibb Company |
Tetrahydroisoquinoline LXR Modulators
|
|
CN101309915A
(zh)
|
2005-11-14 |
2008-11-19 |
Irm责任有限公司 |
作为lxr调节剂的化合物和组合物
|
|
WO2007081335A1
(en)
|
2006-01-12 |
2007-07-19 |
Merck & Co., Inc. |
Therapeutic compounds for treating dyslipidemic conditions
|
|
ATE495197T1
(de)
|
2006-03-20 |
2011-01-15 |
Cepep Iii Ab |
Chimäre konstrukte zwischen auf krebs zielenden peptiden und zellpenetrierenden peptiden gekoppelt an antikrebsmittel und/oder diagnostische mittel
|
|
WO2008011071A2
(en)
*
|
2006-07-19 |
2008-01-24 |
The Regents Of The University Of California |
Interactions of hedgehog and liver x receptor signaling pathways
|
|
TW200825054A
(en)
|
2006-10-18 |
2008-06-16 |
Wyeth Corp |
Quinoline compounds
|
|
US8324367B2
(en)
|
2006-11-03 |
2012-12-04 |
Medtronic, Inc. |
Compositions and methods for making therapies delivered by viral vectors reversible for safety and allele-specificity
|
|
KR20090086084A
(ko)
|
2006-11-30 |
2009-08-10 |
코와 가부시키가이샤 |
치환 카르비놀 화합물
|
|
KR20090094125A
(ko)
|
2006-12-08 |
2009-09-03 |
엑셀리시스, 인코포레이티드 |
Lxr 및 fxr 조절자
|
|
JP2008179562A
(ja)
|
2007-01-24 |
2008-08-07 |
Kowa Co |
Lxrアゴニスト
|
|
US8993628B2
(en)
|
2007-02-23 |
2015-03-31 |
City Of Hope |
Synthetic ligands selective for LXRβ over LXRα, identification and methods of use thereof
|
|
EP2142517A2
(en)
|
2007-05-18 |
2010-01-13 |
Wyeth |
Quinazoline compounds
|
|
WO2009005793A2
(en)
|
2007-06-29 |
2009-01-08 |
Avi Biopharma, Inc. |
Tissue specific peptide conjugates and methods
|
|
JP5220858B2
(ja)
|
2007-08-13 |
2013-06-26 |
エフ.ホフマン−ラ ロシュ アーゲー |
新規ピペラジンアミド誘導体
|
|
TW200922582A
(en)
|
2007-08-20 |
2009-06-01 |
Organon Nv |
N-benzyl, N'-arylcarbonylpiperazine derivatives
|
|
US8039493B2
(en)
|
2007-09-27 |
2011-10-18 |
Hoffmann-La Roche Inc. |
Biaryl sulfonamide derivatives
|
|
EP2623599B1
(en)
*
|
2007-10-04 |
2019-01-02 |
Roche Innovation Center Copenhagen A/S |
Micromirs
|
|
CA2705152C
(en)
|
2007-11-09 |
2016-10-11 |
Peregrine Pharmaceuticals, Inc. |
Anti-vegf antibody compositions and methods
|
|
WO2009075836A2
(en)
*
|
2007-12-10 |
2009-06-18 |
The Brigham And Women's Hospital, Inc. |
Rap variants for drug delivery
|
|
JP2011507905A
(ja)
|
2007-12-21 |
2011-03-10 |
ワイス・エルエルシー |
ベンズイミダゾール化合物
|
|
EP2231660A1
(en)
|
2007-12-21 |
2010-09-29 |
Wyeth LLC |
Imidazo [1,2-a] pyridine compounds
|
|
WO2009086130A1
(en)
|
2007-12-21 |
2009-07-09 |
Wyeth |
Imidazo [1,2-b] pyridazine compounds as modulators of liver x receptors
|
|
US20100324073A1
(en)
|
2007-12-21 |
2010-12-23 |
Wyeth Llc |
Pyrazolo [1,5-A] Pyrimidine Compounds
|
|
US7919509B2
(en)
|
2008-02-29 |
2011-04-05 |
Kowa Company, Ltd. |
2-oxochromene derivatives
|
|
US20090311187A1
(en)
*
|
2008-05-29 |
2009-12-17 |
Bristol-Myers Squibb Company |
Methods for predicting patient response to modulation of the Co-stimulatory pathway
|
|
WO2010002982A1
(en)
*
|
2008-07-01 |
2010-01-07 |
Cognosci, Inc. |
Methods of treating cancer with apoe peptides
|
|
US8552154B2
(en)
|
2008-09-26 |
2013-10-08 |
Emory University |
Anti-PD-L1 antibodies and uses therefor
|
|
WO2010101888A2
(en)
*
|
2009-03-02 |
2010-09-10 |
Biocure Pharma, Llc |
Methods and compositions for treatment of tumor metastasis
|
|
KR101676704B1
(ko)
*
|
2009-05-28 |
2016-11-16 |
엑셀리시스 페이턴트 컴퍼니 엘엘씨 |
Lxr 조절자
|
|
WO2011115892A1
(en)
*
|
2010-03-15 |
2011-09-22 |
Griffin Patrick R |
Modulators of the retinoic acid receptor-related orphan receptors
|
|
US9421218B2
(en)
*
|
2010-04-13 |
2016-08-23 |
New York University |
Compositions and methods for treatment of melanoma
|
|
US20130090258A1
(en)
|
2010-06-16 |
2013-04-11 |
National University Corporation Hamamatsu University School Of Medicines |
Method for detecting colorectal tumor
|
|
EP2474617A1
(en)
*
|
2011-01-11 |
2012-07-11 |
InteRNA Technologies BV |
Mir for treating neo-angiogenesis
|
|
US20130004481A1
(en)
*
|
2011-01-12 |
2013-01-03 |
Boehringer Ingelheim International Gmbh |
Anticancer therapy
|
|
AR088728A1
(es)
|
2011-03-25 |
2014-07-02 |
Bristol Myers Squibb Co |
Moduladores de lxr como prodroga de imidazol
|
|
WO2013043569A1
(en)
*
|
2011-09-20 |
2013-03-28 |
Vical Incorporated |
Synergistic anti-tumor efficacy using alloantigen combination immunotherapy
|
|
AU2013302861A1
(en)
*
|
2012-08-13 |
2015-03-05 |
The Rockefeller University |
Treatment and diagnosis of melanoma
|