JP2019523214A5 - - Google Patents
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- Publication number
- JP2019523214A5 JP2019523214A5 JP2018557405A JP2018557405A JP2019523214A5 JP 2019523214 A5 JP2019523214 A5 JP 2019523214A5 JP 2018557405 A JP2018557405 A JP 2018557405A JP 2018557405 A JP2018557405 A JP 2018557405A JP 2019523214 A5 JP2019523214 A5 JP 2019523214A5
- Authority
- JP
- Japan
- Prior art keywords
- ala
- drug conjugate
- iii
- edfyd
- bt17bdc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1607827.1A GB201607827D0 (en) | 2016-05-04 | 2016-05-04 | Bicyclic peptide-toxin conjugates specific for MT1-MMP |
| GB1607827.1 | 2016-05-04 | ||
| PCT/GB2017/051250 WO2017191460A1 (en) | 2016-05-04 | 2017-05-04 | Bicyclic peptide-toxin conjugates specific for mt1-mmp |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019523214A JP2019523214A (ja) | 2019-08-22 |
| JP2019523214A5 true JP2019523214A5 (https=) | 2020-06-18 |
| JP6942147B2 JP6942147B2 (ja) | 2021-09-29 |
Family
ID=56234400
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018557405A Active JP6942147B2 (ja) | 2016-05-04 | 2017-05-04 | Ｍｔ１−ｍｍｐに対して特異的な二環式ペプチド−毒素コンジュゲート |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10994019B2 (https=) |
| EP (1) | EP3452096B1 (https=) |
| JP (1) | JP6942147B2 (https=) |
| CN (1) | CN109414510B (https=) |
| DK (1) | DK3452096T3 (https=) |
| ES (1) | ES3010545T3 (https=) |
| GB (1) | GB201607827D0 (https=) |
| WO (1) | WO2017191460A1 (https=) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107148425B (zh) | 2014-10-29 | 2021-08-03 | 拜斯科阿迪有限公司 | 对mt1-mmp特异性的双环肽配体 |
| GB201607827D0 (en) | 2016-05-04 | 2016-06-15 | Bicycle Therapeutics Ltd | Bicyclic peptide-toxin conjugates specific for MT1-MMP |
| EP3544621A1 (en) | 2016-11-27 | 2019-10-02 | BicycleRD Limited | Methods for treating cancer |
| WO2018115203A1 (en) | 2016-12-23 | 2018-06-28 | Bicyclerd Limited | Peptide derivatives having novel linkage structures |
| US10624968B2 (en) | 2017-01-06 | 2020-04-21 | Bicyclerd Limited | Compounds for treating cancer |
| US12410143B2 (en) | 2017-01-17 | 2025-09-09 | Michael David FORREST | Therapeutic inhibitors of the reverse mode of ATP synthase |
| KR20190125310A (ko) | 2017-03-10 | 2019-11-06 | 퀴아펙 파마슈티칼스 에이비 | 방출가능한 접합체 |
| US10857196B2 (en) | 2017-04-27 | 2020-12-08 | Bicycletx Limited | Bicyclic peptide ligands and uses thereof |
| EP3645549A1 (en) | 2017-06-26 | 2020-05-06 | BicycleRD Limited | Bicyclic peptide ligands with detectable moieties and uses thereof |
| BR112019028172A2 (pt) | 2017-07-13 | 2020-10-06 | Michael David Forrest | moduladores terapêuticos do modo reverso da atp sintase |
| JP7670481B2 (ja) | 2017-08-04 | 2025-04-30 | バイスクルテクス・リミテッド | Ｃｄ１３７に対して特異的な二環式ペプチドリガンド |
| WO2019034868A1 (en) * | 2017-08-14 | 2019-02-21 | Bicyclerd Limited | CONJUGATES PEPTIDE BICYCLIC-LIGAND PPR-A AND USES THEREOF |
| GB201721265D0 (en) | 2017-12-19 | 2018-01-31 | Bicyclerd Ltd | Bicyclic peptide ligands specific for EphA2 |
| TWI825046B (zh) * | 2017-12-19 | 2023-12-11 | 英商拜西可泰克斯有限公司 | Epha2特用之雙環胜肽配位基 |
| CN111902429A (zh) | 2018-02-23 | 2020-11-06 | 拜斯科技术开发有限公司 | 多聚体双环肽配体 |
| KR20220127380A (ko) | 2018-03-09 | 2022-09-19 | 퀴아펙 파마슈티칼스 에이비 | 방출가능한 항체 접합체 |
| GB201810320D0 (en) | 2018-06-22 | 2018-08-08 | Bicycletx Ltd | Peptide ligands for binding to CD38 |
| GB201810316D0 (en) | 2018-06-22 | 2018-08-08 | Bicyclerd Ltd | Peptide ligands for binding to EphA2 |
| GB201810329D0 (en) | 2018-06-22 | 2018-08-08 | Bicycletx Ltd | Peptide ligands for binding to integrin avB3 |
| IL279489B2 (en) | 2018-06-22 | 2025-10-01 | Bicycletx Ltd | Bicyclic peptide ligands specific for nectin-4, a drug conjugate containing the peptide ligands and a pharmaceutical composition containing the drug conjugate |
| GB201810327D0 (en) | 2018-06-22 | 2018-08-08 | Bicycletx Ltd | Peptide ligands for binding to IL-17 |
| CA3112473A1 (en) | 2018-09-12 | 2020-03-19 | Quiapeg Pharmaceuticals Ab | Releasable glp-1 conjugates |
| WO2020084305A1 (en) | 2018-10-23 | 2020-04-30 | Bicycletx Limited | Bicyclic peptide ligands and uses thereof |
| WO2020120984A1 (en) * | 2018-12-13 | 2020-06-18 | Bicycletx Limited | Bicyclic peptide ligands specific for mt1-mmp |
| GB201820295D0 (en) | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for MT1-MMP |
| GB201820288D0 (en) | 2018-12-13 | 2019-01-30 | Bicycle Tx Ltd | Bicycle peptide ligaands specific for MT1-MMP |
| GB201820325D0 (en) | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for psma |
| WO2020128527A1 (en) * | 2018-12-21 | 2020-06-25 | Bicyclerd Limited | Bicyclic peptide ligands specific for pd-l1 |
| US12492224B2 (en) | 2018-12-21 | 2025-12-09 | Bicycletx Limited | Bicyclic peptide ligands specific for PD-L1 |
| GB201900526D0 (en) * | 2019-01-15 | 2019-03-06 | Bicyclerd Ltd | Bicyclic peptide ligands specific for caix |
| GB201900529D0 (en) | 2019-01-15 | 2019-03-06 | Bicycletx Ltd | Bicyclic peptide ligands specific for CD38 |
| WO2020225577A1 (en) * | 2019-05-09 | 2020-11-12 | Bicycletx Limited | Bicyclic peptide ligands specific for ox40 |
| TWI869398B (zh) | 2019-05-10 | 2025-01-11 | 英商拜西克爾德有限公司 | 治療癌症之方法 |
| CN112048013B (zh) * | 2019-06-05 | 2021-11-05 | 深圳先进技术研究院 | 靶向脑胶质瘤的多肽化合物及其合成方法与应用 |
| TWI860386B (zh) | 2019-07-30 | 2024-11-01 | 英商拜西可泰克斯有限公司 | 異質雙環肽複合物 |
| SMT202500247T1 (it) | 2019-10-03 | 2025-09-12 | Bicycletx Ltd | Complessi peptidici eterotandem biciclici |
| AU2021322934A1 (en) | 2020-08-03 | 2023-03-30 | Bicycletx Limited | Peptide-based linkers |
| US20250186539A2 (en) | 2021-01-11 | 2025-06-12 | Bicycletx Limited | Methods for treating cancer |
| MX2023007788A (es) | 2021-01-24 | 2023-11-17 | Michael David Forrest | Inhibidores de la atp sintasa, usos cosmeticos y terapeuticos. |
| GB202114282D0 (en) | 2021-10-06 | 2021-11-17 | Bicyclerd Ltd | Bicyclic peptide ligand drug conjugates |
| CN118103388A (zh) * | 2021-10-14 | 2024-05-28 | 西藏海思科制药有限公司 | EphA2的双环肽配体及其缀合物 |
| WO2023088236A1 (zh) * | 2021-11-16 | 2023-05-25 | 海思科医药集团股份有限公司 | Mt1-mmp的双环肽配体及其缀合物 |
| GB202214528D0 (en) | 2022-10-03 | 2022-11-16 | Owlstone Med Ltd | A compound |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60336149D1 (de) * | 2002-08-16 | 2011-04-07 | Immunogen Inc | Vernetzer mit hoher reaktivität und löslichkeit und ihre verwendung bei der herstellung von konjugaten für die gezielte abgabe von kleinmolekularen arzneimitteln |
| EP1452868A2 (en) | 2003-02-27 | 2004-09-01 | Pepscan Systems B.V. | Method for selecting a candidate drug compound |
| EP1618897A4 (en) * | 2003-04-04 | 2010-09-29 | Eisai R&D Man Co Ltd | LIPID MEMBRANE STRUCTURE COMPRISING AN ANTI-MT-MMP MONOCLONAL ANTIBODY |
| WO2006078161A1 (en) | 2005-01-24 | 2006-07-27 | Pepscan Systems B.V. | Binding compounds, immunogenic compounds and peptidomimetics |
| EP2653545A1 (en) | 2008-02-05 | 2013-10-23 | Bicycle Therapeutics Limited | Methods and compositions |
| GB0913775D0 (en) | 2009-08-06 | 2009-09-16 | Medical Res Council | Multispecific peptides |
| GB0914110D0 (en) | 2009-08-12 | 2009-09-16 | Medical Res Council | Peptide libraries |
| JP2013518558A (ja) * | 2010-02-04 | 2013-05-23 | メディカル リサーチ カウンシル | 構造化されたペプチドプロセシング |
| PL2764140T3 (pl) * | 2011-10-07 | 2018-04-30 | Bicyclerd Limited | Modulacja specyficzności polipeptydów ustrukturyzowanych |
| US20140274759A1 (en) | 2013-03-15 | 2014-09-18 | Bicycle Therapeutics Limited | Modification of polypeptides |
| GB201306623D0 (en) | 2013-04-11 | 2013-05-29 | Bicycle Therapeutics Ltd | Modulation of structured polypeptide specificity |
| ES2715379T3 (es) | 2013-10-28 | 2019-06-04 | Bicyclerd Ltd | Novedosos polipéptidos |
| CN107148425B (zh) | 2014-10-29 | 2021-08-03 | 拜斯科阿迪有限公司 | 对mt1-mmp特异性的双环肽配体 |
| GB201600911D0 (en) * | 2016-01-18 | 2016-03-02 | Bicycle Therapeutics Ltd | Stabilized peptide derivatives |
| GB201607827D0 (en) | 2016-05-04 | 2016-06-15 | Bicycle Therapeutics Ltd | Bicyclic peptide-toxin conjugates specific for MT1-MMP |
| EP3544621A1 (en) | 2016-11-27 | 2019-10-02 | BicycleRD Limited | Methods for treating cancer |
| WO2018115203A1 (en) | 2016-12-23 | 2018-06-28 | Bicyclerd Limited | Peptide derivatives having novel linkage structures |
| US20190389907A1 (en) | 2016-12-23 | 2019-12-26 | Bicycletx Limited | Peptide ligands for binding to mt1-mmp |
| US10624968B2 (en) | 2017-01-06 | 2020-04-21 | Bicyclerd Limited | Compounds for treating cancer |
| GB201706477D0 (en) | 2017-04-24 | 2017-06-07 | Bicycle Therapeutics Ltd | Modification of polypeptides |
| US10857196B2 (en) | 2017-04-27 | 2020-12-08 | Bicycletx Limited | Bicyclic peptide ligands and uses thereof |
| EP3645549A1 (en) | 2017-06-26 | 2020-05-06 | BicycleRD Limited | Bicyclic peptide ligands with detectable moieties and uses thereof |
| TWI825046B (zh) | 2017-12-19 | 2023-12-11 | 英商拜西可泰克斯有限公司 | Epha2特用之雙環胜肽配位基 |
| CN111902429A (zh) | 2018-02-23 | 2020-11-06 | 拜斯科技术开发有限公司 | 多聚体双环肽配体 |
| EP3774851A1 (en) | 2018-04-04 | 2021-02-17 | BicycleTX Limited | Heterotandem bicyclic peptide complexes |
| WO2020084305A1 (en) | 2018-10-23 | 2020-04-30 | Bicycletx Limited | Bicyclic peptide ligands and uses thereof |
| SG11202104356VA (en) | 2018-10-30 | 2021-05-28 | Bicyclerd Ltd | Bt1718 for use in treating cancer |
-
2016
- 2016-05-04 GB GBGB1607827.1A patent/GB201607827D0/en not_active Ceased
-
2017
- 2017-05-04 US US16/097,305 patent/US10994019B2/en active Active
- 2017-05-04 CN CN201780031804.XA patent/CN109414510B/zh active Active
- 2017-05-04 DK DK17723745.0T patent/DK3452096T3/da active
- 2017-05-04 ES ES17723745T patent/ES3010545T3/es active Active
- 2017-05-04 WO PCT/GB2017/051250 patent/WO2017191460A1/en not_active Ceased
- 2017-05-04 EP EP17723745.0A patent/EP3452096B1/en active Active
- 2017-05-04 JP JP2018557405A patent/JP6942147B2/ja active Active
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