JP2018127458A5 - - Google Patents
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- JP2018127458A5 JP2018127458A5 JP2018039593A JP2018039593A JP2018127458A5 JP 2018127458 A5 JP2018127458 A5 JP 2018127458A5 JP 2018039593 A JP2018039593 A JP 2018039593A JP 2018039593 A JP2018039593 A JP 2018039593A JP 2018127458 A5 JP2018127458 A5 JP 2018127458A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- composition
- fragment
- protein
- self
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000427 antigen Substances 0.000 claims 50
- 102000036639 antigens Human genes 0.000 claims 43
- 108091007433 antigens Proteins 0.000 claims 43
- 239000000203 mixture Substances 0.000 claims 33
- 239000012634 fragment Substances 0.000 claims 24
- 210000003743 erythrocyte Anatomy 0.000 claims 14
- 230000002163 immunogen Effects 0.000 claims 14
- 102000004169 proteins and genes Human genes 0.000 claims 8
- 108090000623 proteins and genes Proteins 0.000 claims 8
- 230000028993 immune response Effects 0.000 claims 7
- KISWVXRQTGLFGD-UHFFFAOYSA-N 2-[[2-[[6-amino-2-[[2-[[2-[[5-amino-2-[[2-[[1-[2-[[6-amino-2-[(2,5-diamino-5-oxopentanoyl)amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-(diaminomethylideneamino)p Chemical compound C1CCN(C(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)NC(=O)C(N)CCC(N)=O)C1C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(CC(C)C)C(O)=O)CC1=CC=C(O)C=C1 KISWVXRQTGLFGD-UHFFFAOYSA-N 0.000 claims 6
- 108010061711 Gliadin Proteins 0.000 claims 6
- 102000047918 Myelin Basic Human genes 0.000 claims 6
- 101710107068 Myelin basic protein Proteins 0.000 claims 6
- 230000003614 tolerogenic effect Effects 0.000 claims 6
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 5
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 5
- 102000016202 Proteolipids Human genes 0.000 claims 5
- 108010010974 Proteolipids Proteins 0.000 claims 5
- 108010076181 Proinsulin Proteins 0.000 claims 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 4
- 206010022498 insulinoma Diseases 0.000 claims 4
- 208000021255 pancreatic insulinoma Diseases 0.000 claims 4
- 102000006386 Myelin Proteins Human genes 0.000 claims 3
- 108010083674 Myelin Proteins Proteins 0.000 claims 3
- 102000002233 Myelin-Oligodendrocyte Glycoprotein Human genes 0.000 claims 3
- 108010000123 Myelin-Oligodendrocyte Glycoprotein Proteins 0.000 claims 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 210000005012 myelin Anatomy 0.000 claims 3
- 210000004248 oligodendroglia Anatomy 0.000 claims 3
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 102100035902 Glutamate decarboxylase 1 Human genes 0.000 claims 2
- 108010068370 Glutens Proteins 0.000 claims 2
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 2
- 108090001061 Insulin Proteins 0.000 claims 2
- 102000004877 Insulin Human genes 0.000 claims 2
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 108010024847 glutamate decarboxylase 1 Proteins 0.000 claims 2
- 108010050792 glutenin Proteins 0.000 claims 2
- 208000026278 immune system disease Diseases 0.000 claims 2
- 238000011065 in-situ storage Methods 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 229940125396 insulin Drugs 0.000 claims 2
- 108010066381 preproinsulin Proteins 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 208000015943 Coeliac disease Diseases 0.000 claims 1
- 101710087459 Gamma-gliadin Proteins 0.000 claims 1
- 102000003638 Glucose-6-Phosphatase Human genes 0.000 claims 1
- 108010086800 Glucose-6-Phosphatase Proteins 0.000 claims 1
- 102100036255 Glucose-6-phosphatase 2 Human genes 0.000 claims 1
- 101710172364 Glucose-6-phosphatase 2 Proteins 0.000 claims 1
- 102000028180 Glycophorins Human genes 0.000 claims 1
- 108091005250 Glycophorins Proteins 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
- 102000055324 Myelin Proteolipid Human genes 0.000 claims 1
- 101710094913 Myelin proteolipid protein Proteins 0.000 claims 1
- 108020004511 Recombinant DNA Proteins 0.000 claims 1
- 239000003054 catalyst Substances 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 229930195712 glutamate Natural products 0.000 claims 1
- 230000002519 immonomodulatory effect Effects 0.000 claims 1
- 230000006058 immune tolerance Effects 0.000 claims 1
- 230000028709 inflammatory response Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 108060006613 prolamin Proteins 0.000 claims 1
- XXRYFVCIMARHRS-UHFFFAOYSA-N propan-2-yl n-dimethoxyphosphorylcarbamate Chemical compound COP(=O)(OC)NC(=O)OC(C)C XXRYFVCIMARHRS-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/397,202 | 2012-02-15 | ||
| US13/397,202 US9517257B2 (en) | 2010-08-10 | 2012-02-15 | Erythrocyte-binding therapeutics |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014557135A Division JP6692602B2 (ja) | 2012-02-15 | 2013-02-15 | 赤血球結合治療剤 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020100620A Division JP2020147591A (ja) | 2012-02-15 | 2020-06-10 | 赤血球結合治療剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018127458A JP2018127458A (ja) | 2018-08-16 |
| JP2018127458A5 true JP2018127458A5 (enExample) | 2018-11-22 |
| JP6716619B2 JP6716619B2 (ja) | 2020-07-01 |
Family
ID=48326347
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014557135A Active JP6692602B2 (ja) | 2012-02-15 | 2013-02-15 | 赤血球結合治療剤 |
| JP2018039593A Active JP6716619B2 (ja) | 2012-02-15 | 2018-03-06 | 赤血球結合治療剤 |
| JP2020100620A Pending JP2020147591A (ja) | 2012-02-15 | 2020-06-10 | 赤血球結合治療剤 |
| JP2022147649A Pending JP2022184955A (ja) | 2012-02-15 | 2022-09-16 | 赤血球結合治療剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014557135A Active JP6692602B2 (ja) | 2012-02-15 | 2013-02-15 | 赤血球結合治療剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020100620A Pending JP2020147591A (ja) | 2012-02-15 | 2020-06-10 | 赤血球結合治療剤 |
| JP2022147649A Pending JP2022184955A (ja) | 2012-02-15 | 2022-09-16 | 赤血球結合治療剤 |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP2814500B1 (enExample) |
| JP (4) | JP6692602B2 (enExample) |
| KR (1) | KR20150010699A (enExample) |
| CN (3) | CN104271148A (enExample) |
| AU (2) | AU2013220079B2 (enExample) |
| BR (1) | BR112014020304A8 (enExample) |
| CA (1) | CA2864432A1 (enExample) |
| EA (2) | EA028087B1 (enExample) |
| ES (1) | ES2781773T3 (enExample) |
| HK (1) | HK1202051A1 (enExample) |
| IL (1) | IL234056B (enExample) |
| MX (1) | MX2014009900A (enExample) |
| NZ (2) | NZ722352A (enExample) |
| SG (2) | SG10201609500QA (enExample) |
| WO (1) | WO2013121296A1 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2476435T (pt) | 2006-08-11 | 2018-03-05 | Life Sciences Res Partners Vzw | Péptidos imunogénicos e a sua utilização em distúrbios imunitários |
| CA2715611C (en) | 2008-02-14 | 2018-03-13 | Life Sciences Research Partners Vzw | Immunotherapy targeting intracellular pathogens |
| US8999346B2 (en) | 2008-02-14 | 2015-04-07 | Life Sciences Research Partners Vzw | Immunogenic control of tumours and tumour cells |
| US9850296B2 (en) | 2010-08-10 | 2017-12-26 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| US9517257B2 (en) | 2010-08-10 | 2016-12-13 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| AU2011289579B2 (en) | 2010-08-10 | 2016-11-17 | Ecole Polytechnique Federale De Lausanne | Erythrocyte-binding therapeutics |
| RU2615460C2 (ru) | 2010-11-25 | 2017-04-04 | Имнейт Сарл | Иммуногенные пептиды для применения в профилактике и/или лечении инфекционных заболеваний, аутоиммунных заболеваний, иммунных ответов на аллогенные факторы, аллергических заболеваний, опухолей, отторжения трансплантата и иммунных ответов против вирусных векторов. используемых для генной терапии или генной вакцинации |
| EP2945964A2 (en) * | 2013-01-18 | 2015-11-25 | Glycotope GmbH | Fusion peptides for enhancing protein expression |
| GB201309469D0 (en) | 2013-05-28 | 2013-07-10 | Imcyse Sa | Detection of CD4+ T lymphocytes |
| JP6702866B2 (ja) | 2013-11-18 | 2020-06-03 | ルビウス セラピューティクス， インコーポレイテッド | 合成膜−レシーバー複合体 |
| US10046056B2 (en) | 2014-02-21 | 2018-08-14 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
| LT3107563T (lt) * | 2014-02-21 | 2021-07-12 | Ecole Polytechnique Fédérale De Lausanne (Epfl) Epfl-Tto | Gliko-nukreipiantys terapiniai agenai |
| US10946079B2 (en) | 2014-02-21 | 2021-03-16 | Ecole Polytechnique Federale De Lausanne | Glycotargeting therapeutics |
| US10953101B2 (en) | 2014-02-21 | 2021-03-23 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
| WO2015153102A1 (en) | 2014-04-01 | 2015-10-08 | Rubius Therapeutics, Inc. | Methods and compositions for immunomodulation |
| GB201418433D0 (en) | 2014-10-17 | 2014-12-03 | Imcyse Sa | Novel immunogenic peptides |
| US10729791B2 (en) | 2015-05-18 | 2020-08-04 | Imcyse Sa | Animal models for evaluating pharmaceutical compounds |
| IL317262A (en) * | 2015-09-19 | 2025-01-01 | Ecole Polytechnique Fed Lausanne Epfl | Glyco-directed therapy |
| EP3352782B1 (en) | 2015-09-25 | 2021-03-31 | ImCyse SA | Improved methods and compounds for eliminating immune responses to therapeutic agents |
| CA3002766A1 (en) * | 2015-10-23 | 2017-04-27 | Immix Biopharma, Inc. | Methods and related compositions for the treatment of cancer |
| CN108778318B (zh) * | 2016-01-14 | 2022-05-03 | 北卡罗莱纳州立大学 | 葡萄糖响应性胰岛素递送组合物和方法 |
| KR20240015731A (ko) | 2016-04-19 | 2024-02-05 | 임시스 에스에이 | 신규 면역원성 CD1d 결합 펩티드 |
| KR102430856B1 (ko) * | 2016-05-03 | 2022-08-08 | 에스큐지 바이오테크놀로지스 컴퍼니 | 관용을 유도하는 생체분자의 세포내 전달 |
| CN109562185A (zh) | 2016-06-02 | 2019-04-02 | 赛诺菲 | 药剂与能够结合葡萄糖感应蛋白的部分的新颖缀合物 |
| US11253579B2 (en) | 2017-06-16 | 2022-02-22 | The University Of Chicago | Compositions and methods for inducing immune tolerance |
| CN111247170B (zh) * | 2017-10-20 | 2024-07-16 | 杰特有限公司 | 一种方法 |
| KR20200095507A (ko) | 2017-12-01 | 2020-08-10 | 사노피 | 글루코오스 감지 단백질에 결합할 수 있는 모이어티 및 약제의 신규 접합체 |
| US20220153859A1 (en) * | 2018-05-07 | 2022-05-19 | Anokion Sa | Glycophorin a antigen-binding proteins |
| EA202092723A1 (ru) | 2018-05-09 | 2021-04-09 | Зе Юниверсити Оф Чикаго | Композиции и способы, касающиеся иммунной толерантности |
| EP4058049A1 (en) | 2019-11-11 | 2022-09-21 | CSL Behring Lengnau AG | Polypeptides for inducing tolerance to factor viii |
| US20230184766A1 (en) * | 2020-05-01 | 2023-06-15 | The Johns Hopkins University | Compositions and methods for coronavirus detection |
| JP2023545520A (ja) | 2020-10-14 | 2023-10-30 | ビリジアン セラピューティクス， インコーポレイテッド | 甲状腺眼疾患を治療するための組成物及び方法 |
| US20240277768A1 (en) * | 2021-06-17 | 2024-08-22 | Tihamer Orban | Individualized Cell Therapy Using Patient-Derived Antigen-Specific Regulatory T Cells |
| WO2023019171A1 (en) | 2021-08-10 | 2023-02-16 | Viridian Therapeutics, Inc. | Compositions, doses, and methods for treatment of thyroid eye disease |
| CN116731962B (zh) * | 2023-08-14 | 2023-11-03 | 天津中新科炬生物制药股份有限公司 | 全血中分离红细胞的试剂盒及方法 |
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| PL2493487T3 (pl) | 2009-10-27 | 2017-02-28 | Erytech Pharma | Kompozycja do indukowania swoistej tolerancji immunologicznej |
| AU2011289579B2 (en) * | 2010-08-10 | 2016-11-17 | Ecole Polytechnique Federale De Lausanne | Erythrocyte-binding therapeutics |
| US9517257B2 (en) * | 2010-08-10 | 2016-12-13 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
-
2013
- 2013-02-15 CN CN201380019578.5A patent/CN104271148A/zh active Pending
- 2013-02-15 BR BR112014020304A patent/BR112014020304A8/pt not_active Application Discontinuation
- 2013-02-15 KR KR20147025631A patent/KR20150010699A/ko not_active Ceased
- 2013-02-15 CN CN201811569705.XA patent/CN110075283A/zh active Pending
- 2013-02-15 SG SG10201609500QA patent/SG10201609500QA/en unknown
- 2013-02-15 HK HK15102492.2A patent/HK1202051A1/xx unknown
- 2013-02-15 CA CA2864432A patent/CA2864432A1/en not_active Abandoned
- 2013-02-15 EA EA201491524A patent/EA028087B1/ru unknown
- 2013-02-15 SG SG11201404943PA patent/SG11201404943PA/en unknown
- 2013-02-15 MX MX2014009900A patent/MX2014009900A/es unknown
- 2013-02-15 EP EP13721386.4A patent/EP2814500B1/en active Active
- 2013-02-15 NZ NZ722352A patent/NZ722352A/en unknown
- 2013-02-15 JP JP2014557135A patent/JP6692602B2/ja active Active
- 2013-02-15 NZ NZ628851A patent/NZ628851A/en unknown
- 2013-02-15 CN CN201811569743.5A patent/CN110075284A/zh active Pending
- 2013-02-15 AU AU2013220079A patent/AU2013220079B2/en active Active
- 2013-02-15 ES ES13721386T patent/ES2781773T3/es active Active
- 2013-02-15 EA EA201790862A patent/EA035931B1/ru unknown
- 2013-02-15 WO PCT/IB2013/000684 patent/WO2013121296A1/en not_active Ceased
-
2014
- 2014-08-11 IL IL234056A patent/IL234056B/en active IP Right Grant
-
2017
- 2017-12-13 AU AU2017276218A patent/AU2017276218B2/en active Active
-
2018
- 2018-03-06 JP JP2018039593A patent/JP6716619B2/ja active Active
-
2020
- 2020-06-10 JP JP2020100620A patent/JP2020147591A/ja active Pending
-
2022
- 2022-09-16 JP JP2022147649A patent/JP2022184955A/ja active Pending