JP2018109022A5 - - Google Patents
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- Publication number
- JP2018109022A5 JP2018109022A5 JP2018022248A JP2018022248A JP2018109022A5 JP 2018109022 A5 JP2018109022 A5 JP 2018109022A5 JP 2018022248 A JP2018022248 A JP 2018022248A JP 2018022248 A JP2018022248 A JP 2018022248A JP 2018109022 A5 JP2018109022 A5 JP 2018109022A5
- Authority
- JP
- Japan
- Prior art keywords
- combination
- inhibitor
- medicament
- mutation
- raf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims 9
- 201000010099 disease Diseases 0.000 claims 8
- 230000002062 proliferating Effects 0.000 claims 8
- 101700004551 BRAF Proteins 0.000 claims 6
- 230000035772 mutation Effects 0.000 claims 6
- 229940121647 EGFR inhibitors Drugs 0.000 claims 4
- 239000003112 inhibitor Substances 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000011780 sodium chloride Substances 0.000 claims 4
- 108010022830 Cetuximab Proteins 0.000 claims 2
- AAKJLRGGTJKAMG-UHFFFAOYSA-N Erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 claims 2
- 229960001433 Erlotinib Drugs 0.000 claims 2
- 239000005551 L01XE03 - Erlotinib Substances 0.000 claims 2
- 229960005395 cetuximab Drugs 0.000 claims 2
- 201000011231 colorectal cancer Diseases 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229940000425 combination drugs Drugs 0.000 claims 1
Claims (12)
- 同時投与、個別投与又は逐次投与のための、
（ａ）式
のＢ−Ｒａｆ阻害薬又は医薬として許容されるその塩、
（ｂ）セツキシマブ又はエルロチニブであるＥＧＦＲ阻害薬、及び場合によっては
（ｃ）化合物Ｂ：
（Ｂ）
又は医薬として許容されるその塩であるＰＩ３Ｋ−α阻害薬
を含む組合せ医薬。 - ＥＧＦＲ阻害薬が、エルロチニブである、請求項１に記載の組合せ医薬。
- ＥＧＦＲ阻害薬が、セツキシマブである、請求項１に記載の組合せ医薬。
- それを必要とする対象における増殖性疾患の治療に使用するための、請求項１に記載の組合せ医薬。
- 増殖性疾患の治療用の医薬品の調製に使用するための、請求項１に記載の組合せ医薬。
- 増殖性疾患がＢ−Ｒａｆ変異を特徴とする、請求項５に記載の組合せ医薬。
- Ｂ−Ｒａｆ変異がＶ６００変異である、請求項６に記載の組合せ医薬。
- 増殖性疾患が結腸直腸がんである、請求項７に記載の組合せ医薬。
- 増殖性疾患の治療用の医薬品の製造のための、請求項１に記載の組合せ医薬の使用。
- ヒト患者における増殖性疾患の治療用の医薬品の製造のための、
（ａ）式
のＢ−Ｒａｆ阻害薬又は医薬として許容されるその塩、
（ｂ）セツキシマブ又はエルロチニブであるＥＧＦＲ阻害薬、及び場合によっては
（ｃ）化合物Ｂ：
（Ｂ）
又は医薬として許容されるその塩であるＰＩ３Ｋ−α阻害薬
の使用であって、前記増殖性疾患がＢ−Ｒａｆ変異を特徴とする、使用。 - Ｂ−Ｒａｆ変異がＶ６００変異である、請求項１０に記載の使用。
- 増殖性疾患が結腸直腸がんである、請求項１１に記載の使用。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019174353A JP6974669B2 (ja) | 2012-08-07 | 2019-09-25 | Ｂ−Ｒａｆ阻害薬、ＥＧＦＲ阻害薬及び場合によってはＰＩ３Ｋ−α阻害薬を含む組合せ医薬 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261680473P | 2012-08-07 | 2012-08-07 | |
| US61/680,473 | 2012-08-07 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015526606A Division JP6342396B2 (ja) | 2012-08-07 | 2013-08-05 | Ｂ−Ｒａｆ阻害薬、ＥＧＦＲ阻害薬及び場合によってはＰＩ３Ｋ−α阻害薬を含む組合せ医薬 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019174353A Division JP6974669B2 (ja) | 2012-08-07 | 2019-09-25 | Ｂ−Ｒａｆ阻害薬、ＥＧＦＲ阻害薬及び場合によってはＰＩ３Ｋ−α阻害薬を含む組合せ医薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018109022A JP2018109022A (ja) | 2018-07-12 |
| JP2018109022A5 true JP2018109022A5 (ja) | 2018-10-25 |
| JP6595024B2 JP6595024B2 (ja) | 2019-10-23 |
Family
ID=48980368
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015526606A Active JP6342396B2 (ja) | 2012-08-07 | 2013-08-05 | Ｂ−Ｒａｆ阻害薬、ＥＧＦＲ阻害薬及び場合によってはＰＩ３Ｋ−α阻害薬を含む組合せ医薬 |
| JP2018022248A Active JP6595024B2 (ja) | 2012-08-07 | 2018-02-09 | Ｂ−Ｒａｆ阻害薬、ＥＧＦＲ阻害薬及び場合によってはＰＩ３Ｋ−α阻害薬を含む組合せ医薬 |
| JP2019174353A Active JP6974669B2 (ja) | 2012-08-07 | 2019-09-25 | Ｂ−Ｒａｆ阻害薬、ＥＧＦＲ阻害薬及び場合によってはＰＩ３Ｋ−α阻害薬を含む組合せ医薬 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015526606A Active JP6342396B2 (ja) | 2012-08-07 | 2013-08-05 | Ｂ−Ｒａｆ阻害薬、ＥＧＦＲ阻害薬及び場合によってはＰＩ３Ｋ−α阻害薬を含む組合せ医薬 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019174353A Active JP6974669B2 (ja) | 2012-08-07 | 2019-09-25 | Ｂ−Ｒａｆ阻害薬、ＥＧＦＲ阻害薬及び場合によってはＰＩ３Ｋ−α阻害薬を含む組合せ医薬 |
Country Status (39)
| Country | Link |
|---|---|
| US (1) | US9474754B2 (ja) |
| EP (2) | EP3574904A1 (ja) |
| JP (3) | JP6342396B2 (ja) |
| KR (1) | KR102112885B1 (ja) |
| CN (1) | CN104519887B (ja) |
| AR (1) | AR092045A1 (ja) |
| AU (1) | AU2013299841B8 (ja) |
| CA (1) | CA2879548C (ja) |
| CL (1) | CL2015000294A1 (ja) |
| CO (1) | CO7200273A2 (ja) |
| CY (1) | CY1122143T1 (ja) |
| DK (1) | DK2882440T3 (ja) |
| EA (1) | EA028420B1 (ja) |
| EC (1) | ECSP15008695A (ja) |
| ES (1) | ES2717911T3 (ja) |
| GT (1) | GT201500025A (ja) |
| HK (2) | HK1204976A1 (ja) |
| HR (1) | HRP20190537T1 (ja) |
| HU (1) | HUE042877T2 (ja) |
| IL (1) | IL236934B (ja) |
| IN (1) | IN2015DN00450A (ja) |
| JO (1) | JOP20130236B1 (ja) |
| LT (1) | LT2882440T (ja) |
| MA (1) | MA37829A1 (ja) |
| MX (1) | MX359403B (ja) |
| MY (1) | MY176031A (ja) |
| NZ (1) | NZ703940A (ja) |
| PE (2) | PE20191655A1 (ja) |
| PH (1) | PH12015500246A1 (ja) |
| PL (1) | PL2882440T3 (ja) |
| PT (1) | PT2882440T (ja) |
| RS (1) | RS58734B1 (ja) |
| SG (1) | SG11201500321YA (ja) |
| SI (1) | SI2882440T1 (ja) |
| TN (1) | TN2015000027A1 (ja) |
| TR (1) | TR201904980T4 (ja) |
| TW (1) | TWI607754B (ja) |
| UA (1) | UA115786C2 (ja) |
| WO (1) | WO2014025688A1 (ja) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ703940A (en) * | 2012-08-07 | 2018-04-27 | Novartis Ag | Pharmaceutical combinations comprising a b-raf inhibitor, an egfr inhibitor and optionally a pi3k-alpha inhibitor |
| CN105209073A (zh) | 2013-03-21 | 2015-12-30 | 诺华股份有限公司 | 包含B-Raf抑制剂和第二抑制剂的组合疗法 |
| WO2015145388A2 (en) * | 2014-03-27 | 2015-10-01 | Novartis Ag | Methods of treating colorectal cancers harboring upstream wnt pathway mutations |
| JP6704861B2 (ja) * | 2014-06-16 | 2020-06-03 | ワールドワイド・イノベイティブ・ネットワークＷｏｒｌｄｗｉｄｅ Ｉｎｎｏｖａｔｉｖｅ Ｎｅｔｗｏｒｋ | 癌処置のための個別化三剤治療を選択するための方法 |
| WO2016193955A1 (en) * | 2015-06-04 | 2016-12-08 | Giorgio Stassi | Combinations of kinase inhibitors for treating colorectal cancer |
| JP2018525402A (ja) * | 2015-08-28 | 2018-09-06 | ノバルティス アーゲー | Ｐｉ３ｋ阻害剤のアルペリシブおよびｂ−ｒａｆ阻害剤のダブラフェニブを含む組合せ医薬、がんの治療または予防におけるそのような組合せの使用 |
| EP3380097A2 (en) * | 2015-08-28 | 2018-10-03 | Novartis AG | Pharmaceutical combination comprising (a) the alpha-isoform specific pi3k inhibitor alpelisib (byl719) and (b) an akt inhibitor, preferably mk-2206, afuresertib or uprosertib, and the use thereof in the treatment/prevention of cancer |
| WO2017066664A1 (en) * | 2015-10-16 | 2017-04-20 | Millennium Pharmaceuticals, Inc. | Combination therapy including a raf inhibitor for the treatment of colorectal cancer |
| SG11201810793XA (en) * | 2016-06-03 | 2018-12-28 | Giordano Caponigro | Pharmaceutical combinations |
| CN109715163B (zh) * | 2016-09-19 | 2022-11-22 | 诺华股份有限公司 | 包含raf抑制剂和erk抑制剂的治疗组合 |
| CA3069564A1 (en) * | 2017-08-03 | 2019-02-07 | Novartis Ag | Therapeutic combination of a third-generation egfr tyrosine kinase inhibitor and a raf inhibitor |
| CN113490668A (zh) | 2018-10-05 | 2021-10-08 | 安娜普尔纳生物股份有限公司 | 用于治疗与apj受体活性有关的疾病的化合物和组合物 |
| TW202043225A (zh) * | 2019-01-25 | 2020-12-01 | 英屬開曼群島商百濟神州有限公司 | B-raf激酶二聚體抑制劑之穩定固體分散體、製備方法及其用途 |
| WO2020164997A1 (en) * | 2019-02-12 | 2020-08-20 | Bayer Aktiengesellschaft | Combination of pi3k-inhibitors |
| WO2023145530A1 (ja) * | 2022-01-27 | 2023-08-03 | 国立大学法人東北大学 | 癌治療剤 |
| WO2023230554A1 (en) | 2022-05-25 | 2023-11-30 | Pfizer Inc. | Combination of a braf inhibitor, an egfr inhibitor, and a pd-1 antagonist for the treatment of braf v600e-mutant, msi-h/dmmr colorectal cancer |
| WO2024073364A1 (en) * | 2022-09-26 | 2024-04-04 | Beigene, Ltd. | Combinations of a b-raf inhibitor, and an anti-egfr antibody for the treatment of cancer |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4128089A (en) | 1988-09-15 | 1990-03-22 | Rorer International (Overseas) Inc. | Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same |
| US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| EP2139484B9 (en) | 2007-04-10 | 2014-06-11 | Exelixis, Inc. | Methods of treating cancer using pyridopyrimidinone inhibitors of pi3k alpha |
| UA104147C2 (uk) | 2008-09-10 | 2014-01-10 | Новартис Аг | Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань |
| WO2011028540A1 (en) | 2009-08-24 | 2011-03-10 | Genentech, Inc. | Determining sensitivity of cells to b-raf inhibitor treatment by detecting kras mutation and rtk expression levels |
| JO3002B1 (ar) * | 2009-08-28 | 2016-09-05 | Irm Llc | مركبات و تركيبات كمثبطات كيناز بروتين |
| MX2012004259A (es) * | 2009-10-12 | 2012-05-29 | Glaxosmithkline Llc | Combinacion. |
| US20120045433A1 (en) | 2010-08-17 | 2012-02-23 | Kapil Dhingra | Combination therapy |
| BR112013009624A2 (pt) * | 2010-11-08 | 2016-07-12 | Novartis Ag | uso de derivados de 2-carboxamida cicloamino ureia no tratamento de doenças dependemtes de egfr pu doenças que tenham adquirido resistência a agentes que tenham como alvo membros da família egfr |
| AU2012335665A1 (en) | 2011-11-10 | 2014-07-03 | Memorial Sloan-Kettering Cancer Center | Treatment of ovarian cancer with 2-amino-4H-naphtho[1,2-B]pyran-3-carbonitriles |
| CA2855243C (en) * | 2011-11-11 | 2020-04-14 | Novartis Ag | Method of treating a proliferative disease |
| NZ703940A (en) * | 2012-08-07 | 2018-04-27 | Novartis Ag | Pharmaceutical combinations comprising a b-raf inhibitor, an egfr inhibitor and optionally a pi3k-alpha inhibitor |
-
2013
- 2013-08-05 NZ NZ703940A patent/NZ703940A/en unknown
- 2013-08-05 DK DK13748243.6T patent/DK2882440T3/da active
- 2013-08-05 TR TR2019/04980T patent/TR201904980T4/tr unknown
- 2013-08-05 EA EA201590332A patent/EA028420B1/ru not_active IP Right Cessation
- 2013-08-05 US US14/419,256 patent/US9474754B2/en active Active
- 2013-08-05 PE PE2019001539A patent/PE20191655A1/es unknown
- 2013-08-05 PE PE2015000130A patent/PE20150673A1/es not_active Application Discontinuation
- 2013-08-05 RS RS20190351A patent/RS58734B1/sr unknown
- 2013-08-05 AR ARP130102776A patent/AR092045A1/es not_active Application Discontinuation
- 2013-08-05 MY MYPI2015000102A patent/MY176031A/en unknown
- 2013-08-05 EP EP19159506.5A patent/EP3574904A1/en active Pending
- 2013-08-05 EP EP13748243.6A patent/EP2882440B1/en active Active
- 2013-08-05 PT PT13748243T patent/PT2882440T/pt unknown
- 2013-08-05 HU HUE13748243A patent/HUE042877T2/hu unknown
- 2013-08-05 JP JP2015526606A patent/JP6342396B2/ja active Active
- 2013-08-05 KR KR1020157002982A patent/KR102112885B1/ko active IP Right Grant
- 2013-08-05 CN CN201380042229.5A patent/CN104519887B/zh active Active
- 2013-08-05 SG SG11201500321YA patent/SG11201500321YA/en unknown
- 2013-08-05 IN IN450DEN2015 patent/IN2015DN00450A/en unknown
- 2013-08-05 CA CA2879548A patent/CA2879548C/en active Active
- 2013-08-05 ES ES13748243T patent/ES2717911T3/es active Active
- 2013-08-05 UA UAA201500424A patent/UA115786C2/uk unknown
- 2013-08-05 PL PL13748243T patent/PL2882440T3/pl unknown
- 2013-08-05 WO PCT/US2013/053619 patent/WO2014025688A1/en active Application Filing
- 2013-08-05 LT LTEP13748243.6T patent/LT2882440T/lt unknown
- 2013-08-05 SI SI201331387T patent/SI2882440T1/sl unknown
- 2013-08-05 AU AU2013299841A patent/AU2013299841B8/en active Active
- 2013-08-05 MX MX2015001732A patent/MX359403B/es active IP Right Grant
- 2013-08-06 TW TW102128165A patent/TWI607754B/zh active
- 2013-08-06 JO JOP/2013/0236A patent/JOP20130236B1/ar active
-
2015
- 2015-01-19 TN TNP2015000027A patent/TN2015000027A1/fr unknown
- 2015-01-26 IL IL236934A patent/IL236934B/en active IP Right Grant
- 2015-02-04 MA MA37829A patent/MA37829A1/fr unknown
- 2015-02-04 PH PH12015500246A patent/PH12015500246A1/en unknown
- 2015-02-06 CO CO15024921A patent/CO7200273A2/es unknown
- 2015-02-06 CL CL2015000294A patent/CL2015000294A1/es unknown
- 2015-02-06 GT GT201500025A patent/GT201500025A/es unknown
- 2015-03-06 EC ECIEPI20158695A patent/ECSP15008695A/es unknown
- 2015-06-18 HK HK15105815.5A patent/HK1204976A1/xx unknown
- 2015-11-03 HK HK15110834.2A patent/HK1211831A1/xx unknown
-
2018
- 2018-02-09 JP JP2018022248A patent/JP6595024B2/ja active Active
-
2019
- 2019-03-19 HR HRP20190537TT patent/HRP20190537T1/hr unknown
- 2019-04-30 CY CY20191100461T patent/CY1122143T1/el unknown
- 2019-09-25 JP JP2019174353A patent/JP6974669B2/ja active Active
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