CY1117916T1 - Θεραπεια διαταραχων που σχετιζονται me bdnf χρησιμοποιωντας laquinimod - Google Patents
Θεραπεια διαταραχων που σχετιζονται me bdnf χρησιμοποιωντας laquinimodInfo
- Publication number
- CY1117916T1 CY1117916T1 CY20161100805T CY161100805T CY1117916T1 CY 1117916 T1 CY1117916 T1 CY 1117916T1 CY 20161100805 T CY20161100805 T CY 20161100805T CY 161100805 T CY161100805 T CY 161100805T CY 1117916 T1 CY1117916 T1 CY 1117916T1
- Authority
- CY
- Cyprus
- Prior art keywords
- bdnf
- laquinimod
- treatment
- amount
- human subject
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Μία μέθοδος αύξησης του επιπέδου ορού του νεύρο-τροφικού παράγοντα που παράγεται από τον εγκέφαλο (BDNF) σε ένα ανθρώπινο άτομο που περιλαμβάνει χορήγηση στο άτομο μιας ποσότητας laquinimod ή φαρμακευτικά αποδεκτού άλατος αυτού. Η μέθοδος μπορεί να περιλαμβάνει περαιτέρω περιοδική χορήγηση στο άτομο μιας ποσότητας ενός δεύτερου παράγοντα αύξησης του BDNF. Μία μέθοδος για την θεραπεία ενός ανθρώπινου ατόμου που υποφέρει από μία ασθένεια που σχετίζεται με BDNF που περιλαμβάνει περιοδική χορήγηση laquinimod ή ενός φαρμακευτικά αποδεκτού άλατος αυτού για την θεραπεία του ανθρώπινου ατόμου. Χρήση του laquimmod στην κατασκευή ενός φαρμάκου αύξησης του επιπέδου ορού του BDNF σε ένα ανθρώπινο άτομο. Ένα φαρμακευτικό παρασκεύασμα που περιλαμβάνει μία ποσότητα laquinimod και μία ποσότητα ενός δεύτερου παράγοντα αύξησης του BDNF αποτελεσματικού για χρήση στην αύξηση του επιπέδου ορού του BDNF σε ένα ανθρώπινο άτομο.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27392009P | 2009-08-10 | 2009-08-10 | |
PCT/US2010/002194 WO2011019375A1 (en) | 2009-08-10 | 2010-08-09 | Treatment of bdnf-related disorders using laquinimod |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1117916T1 true CY1117916T1 (el) | 2017-05-17 |
Family
ID=43535297
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20161100805T CY1117916T1 (el) | 2009-08-10 | 2016-08-16 | Θεραπεια διαταραχων που σχετιζονται me bdnf χρησιμοποιωντας laquinimod |
Country Status (19)
Country | Link |
---|---|
US (3) | US9585878B2 (el) |
EP (2) | EP2467372B1 (el) |
JP (1) | JP5859438B2 (el) |
AU (2) | AU2010282948C1 (el) |
CA (1) | CA2771203C (el) |
CY (1) | CY1117916T1 (el) |
DK (1) | DK2467372T3 (el) |
ES (2) | ES2731052T3 (el) |
HK (1) | HK1225970A1 (el) |
HR (1) | HRP20160997T1 (el) |
HU (1) | HUE029983T2 (el) |
IL (1) | IL217901B (el) |
ME (1) | ME02495B (el) |
PL (2) | PL3064206T3 (el) |
PT (1) | PT2467372T (el) |
RS (1) | RS55071B1 (el) |
SI (1) | SI2467372T1 (el) |
SM (1) | SMT201600281B (el) |
WO (1) | WO2011019375A1 (el) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007047863A2 (en) * | 2005-10-19 | 2007-04-26 | Teva Pharmaceutical Industries, Ltd. | Crystals of laquinimod sodium, and process for the manufacture thereof |
KR101495327B1 (ko) | 2006-06-12 | 2015-02-24 | 테바 파마슈티컬 인더스트리즈 리미티드 | 안정한 라퀴니모드 제제 |
WO2009082471A1 (en) | 2007-12-20 | 2009-07-02 | Teva Pharmaceutical Industries, Ltd. | Stable laquinimod preparations |
CA2736091A1 (en) * | 2008-09-03 | 2010-03-11 | Teva Pharmaceutical Industries Ltd. | 2-oxo-1,2-dihydro-quinoline modulators of immune function |
SI2458992T1 (sl) * | 2009-07-30 | 2016-03-31 | Teva Pharmaceutical Industries Ltd. | Zdravljenje Crohnove bolezni z lakvinimodom |
JP5859438B2 (ja) * | 2009-08-10 | 2016-02-10 | テバ ファーマシューティカル インダストリーズ リミティド | ラキニモドを用いたbdnf関連疾患の治療 |
BR112012022187A2 (pt) * | 2010-03-03 | 2015-09-22 | Teva Pharma | tratamento de artrite reumatóide com a combinação de laquinimod e metotrexato |
ES2558556T3 (es) * | 2010-03-03 | 2016-02-05 | Teva Pharmaceutical Industries Ltd. | Tratamiento de nefritis lúpica usando laquinimod |
BR112012022064A2 (pt) * | 2010-03-03 | 2015-09-08 | Teva Pharma | tratamento de artrite lúpica usando laquinimod |
SG186948A1 (en) | 2010-07-09 | 2013-02-28 | Teva Pharma | Deuterated n-ethyl-n-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide, salts and uses thereof |
CN105944081A (zh) * | 2011-07-28 | 2016-09-21 | 泰华制药工业有限公司 | 用拉喹莫德与醋酸格拉替雷的组合治疗多发性硬化症 |
EP2766020A4 (en) | 2011-10-12 | 2015-04-01 | Teva Pharma | TREATMENT OF MULTIPLE SCLEROSIS BY COMBINING LAQUINIMOD AND FINGOLIMOD |
KR20140138694A (ko) | 2012-02-03 | 2014-12-04 | 테바 파마슈티컬 인더스트리즈 리미티드 | 최선의 항-TNFα 요법에 실패한 크론병 환자를 치료하기 위한 라퀴니모드의 용도 |
JP6215238B2 (ja) | 2012-02-16 | 2017-10-18 | テバ ファーマシューティカル インダストリーズ リミティド | N−エチル−n−フェニル−1,2−ジヒドロ−4,5−ジ−ヒドロキシ−1−メチル−2−オキソ−3−キノリンカルボキサミド、その製剤、および使用 |
TW201350467A (zh) | 2012-05-08 | 2013-12-16 | Teva Pharma | N-乙基-4-羥基-1-甲基-5-(甲基(2,3,4,5,6-五羥基己基)胺基)-2-側氧-n-苯基-1,2-二氫喹啉-3-甲醯胺 |
TW201400117A (zh) * | 2012-06-05 | 2014-01-01 | Teva Pharma | 使用拉喹莫德治療眼發炎疾病 |
TW201410244A (zh) | 2012-08-13 | 2014-03-16 | Teva Pharma | 用於治療gaba媒介之疾病之拉喹莫德(laquinimod) |
TW201410243A (zh) * | 2012-08-13 | 2014-03-16 | Teva Pharma | 用於治療大麻素受體型1(cb1)媒介之疾病之拉喹莫德(laquinimod) |
MX2015003608A (es) * | 2012-09-27 | 2015-06-05 | Teva Pharma | Combinacion de laquinimod y pridopidina para tratar trastornos neurodegenerativos. |
JP2015533163A (ja) * | 2012-10-12 | 2015-11-19 | テバ ファーマシューティカル インダストリーズ リミティド | 多発性硬化症における視床損傷を低減するためのラキニモド |
MX2015005632A (es) | 2012-11-07 | 2016-02-05 | Teva Pharma | Sales de amina de laquinimod. |
MX2015010967A (es) | 2013-03-14 | 2015-10-26 | Teva Pharma | Formulaciones transdermicas de laquinimod. |
BR112015021602A2 (pt) | 2013-03-14 | 2017-07-18 | Teva Pharma | cristais de laquinimod de sódio e processo melhorado para a fabricação dos mesmos |
US20150141458A1 (en) * | 2013-11-15 | 2015-05-21 | Teva Pharmaceutical Industries, Ltd. | Treatment of Glaucoma Using Laquinimod |
CA2933380A1 (en) * | 2013-12-20 | 2015-06-25 | Esther Lukasiewicz Hagai | Use of laquinimod to delay huntington's disease progression |
AU2015253330A1 (en) | 2014-04-29 | 2016-12-01 | Teva Pharmaceutical Industries Ltd. | Laquinimod for the treatment of relapsing-remitting multiple sclerosis (RRMS) patients with a high disability status |
CA2961187A1 (en) * | 2014-09-16 | 2016-03-24 | Teva Pharmaceuticals Industries Ltd. | Treatment of neurodegenerative diseases with combination of laquinimod and fingolimod |
CA3109769A1 (en) * | 2018-08-16 | 2020-02-20 | Biohaven Therapeutics Ltd. | Use of riluzole oral disintigrating tablets for treating diseases |
Family Cites Families (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3024257A (en) | 1961-04-10 | 1962-03-06 | Frosst & Co Charles E | Stable preparations of alkali metal salts of estrone sulfate |
FR2340735A1 (fr) | 1976-02-11 | 1977-09-09 | Roussel Uclaf | Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament |
IE52670B1 (en) | 1981-03-03 | 1988-01-20 | Leo Ab | Heterocyclic carboxamides,compositions containing such compounds,and processes for their preparation |
DE3437232A1 (de) | 1984-10-10 | 1986-04-17 | Mack Chem Pharm | Stabilisierte injektionsloesungen von piroxicam |
US4737971A (en) * | 1986-04-07 | 1988-04-12 | American Telephone And Telegraph Company | Synchronization detection circuit |
US5540934A (en) | 1994-06-22 | 1996-07-30 | Touitou; Elka | Compositions for applying active substances to or through the skin |
US5912349A (en) | 1997-01-31 | 1999-06-15 | Pharmacia & Upjohn Company | Process for the preparation of roquinimex |
US20030124187A1 (en) | 1997-02-14 | 2003-07-03 | Smithkline Beecham Laboratoires Pharmaceutiques, | Pharmaceutical formulations comprising amoxycillin and clavulanate |
US6696407B1 (en) * | 1997-03-21 | 2004-02-24 | The Regents Of The University Of California | Huntington's disease treatment comprising administering aldose reductase inhibitors to increase striatal CNTF |
SE9801474D0 (sv) | 1998-04-27 | 1998-04-27 | Active Biotech Ab | Quinoline Derivatives |
US6077851A (en) * | 1998-04-27 | 2000-06-20 | Active Biotech Ab | Quinoline derivatives |
SE9802550D0 (sv) | 1998-07-15 | 1998-07-15 | Active Biotech Ab | Quinoline derivatives |
SE9802549D0 (sv) | 1998-07-15 | 1998-07-15 | Active Biotech Ab | Quinoline derivatives |
US6121287A (en) | 1998-07-15 | 2000-09-19 | Active Biotech Ab | Quinoline derivatives |
US6133285A (en) | 1998-07-15 | 2000-10-17 | Active Biotech Ab | Quinoline derivatives |
RS51019B (sr) | 1999-10-25 | 2010-10-31 | Active Biotech Ab. | Lekovi za lečenje malignih tumora |
JP2002003401A (ja) * | 2000-06-27 | 2002-01-09 | Japan Science & Technology Corp | 脳由来神経栄養因子誘導剤 |
AU2001278981A1 (en) | 2000-07-21 | 2002-02-05 | Tom F Lue | Prevention and treatment of sexual arousal disorders |
US6307050B1 (en) | 2000-08-29 | 2001-10-23 | R. T. Alamo Venture I Llc | Method of synthesizing flosequinan from 4-fluoroanthranilic acid |
US6802422B2 (en) | 2000-12-12 | 2004-10-12 | Multi-Comp, Inc. | Sealed blister assembly |
US6706733B2 (en) | 2001-05-08 | 2004-03-16 | Dainippon Ink And Chemicals, Inc. | Quinolinone derivative formulation and its production method |
US20030119826A1 (en) | 2001-09-24 | 2003-06-26 | Pharmacia Corporation | Neuroprotective treatment methods using selective iNOS inhibitors |
SE0201778D0 (sv) | 2002-06-12 | 2002-06-12 | Active Biotech Ab | Process for the manufacture of quinoline derivatives |
US7560557B2 (en) | 2002-06-12 | 2009-07-14 | Active Biotech Ag | Process for the manufacture of quinoline derivatives |
US6875869B2 (en) | 2002-06-12 | 2005-04-05 | Active Biotech Ab | Process for the manufacture of quinoline derivatives |
US7820145B2 (en) | 2003-08-04 | 2010-10-26 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
US20070292461A1 (en) | 2003-08-04 | 2007-12-20 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
US7790197B2 (en) | 2003-06-09 | 2010-09-07 | Warner-Lambert Company Llc | Pharmaceutical compositions of atorvastatin |
US20050271717A1 (en) | 2003-06-12 | 2005-12-08 | Alfred Berchielli | Pharmaceutical compositions of atorvastatin |
AU2004251750A1 (en) | 2003-06-25 | 2005-01-06 | Elan Pharmaceuticals, Inc. | Methods and compositions for treating rheumatoid arthritis |
SE0400235D0 (sv) | 2004-02-06 | 2004-02-06 | Active Biotech Ab | New composition containing quinoline compounds |
US8314124B2 (en) | 2004-02-06 | 2012-11-20 | Active Biotech Ab | Crystalline salts of quinoline compounds and methods for preparing them |
EP1763361A2 (en) | 2004-04-01 | 2007-03-21 | Elan Pharmaceuticals, Inc. | Steroid sparing agents and their use |
US20090048181A1 (en) | 2004-09-02 | 2009-02-19 | Schipper Hyman M | Combination therapy with glatiramer acetate and n-acetylcysteine for the treatment of multiple sclerosis |
HUE028833T2 (en) * | 2004-09-09 | 2017-01-30 | Yeda Res & Dev | Polypeptide mixtures, compositions containing them, process for their preparation, and applications |
US20060205822A1 (en) | 2004-12-22 | 2006-09-14 | Forest Laboratories, Inc. | 1-Aminocyclohexane derivatives for the treatment of multiple sclerosis, emotional lability and pseudobulbar affect |
US9168286B2 (en) | 2005-10-13 | 2015-10-27 | Human Genome Sciences, Inc. | Methods and compositions for use in treatment of patients with autoantibody positive disease |
EA015860B1 (ru) | 2005-10-13 | 2011-12-30 | Хьюман Дженом Сайенсиз, Инк. | Способы лечения аутоиммунных заболеваний при использовании антагониста нейтрокина-альфа |
WO2007047863A2 (en) | 2005-10-19 | 2007-04-26 | Teva Pharmaceutical Industries, Ltd. | Crystals of laquinimod sodium, and process for the manufacture thereof |
CA2623879C (en) | 2005-10-26 | 2014-03-25 | Laboratoires Serono S.A. | Sulfonamide derivatives and use thereof for the modulation of metalloproteinases |
US8367629B2 (en) | 2006-02-14 | 2013-02-05 | Noxxon Pharma Ag | MCP-1 binding nucleic acids and use thereof |
US8410115B2 (en) | 2006-02-28 | 2013-04-02 | Elan Pharmaceuticals, Inc. | Methods of treating inflammatory and autoimmune diseases with alpha-4 inhibitory compounds |
LT2676967T (lt) | 2006-02-28 | 2019-09-10 | Biogen Ma Inc. | Uždegiminių ir autoimuninių ligų gydymo būdai su natalizumabu |
ES2663377T3 (es) | 2006-03-03 | 2018-04-12 | Biogen Ma Inc. | Métodos para el tratamiento de enfermedades inflamatorias y autoinmunes con natalizumab |
US9399061B2 (en) | 2006-04-10 | 2016-07-26 | Abbvie Biotechnology Ltd | Methods for determining efficacy of TNF-α inhibitors for treatment of rheumatoid arthritis |
WO2007139887A2 (en) | 2006-05-22 | 2007-12-06 | Cargill, Incorporated | Methods for treating bone or joint inflammation |
KR101495327B1 (ko) | 2006-06-12 | 2015-02-24 | 테바 파마슈티컬 인더스트리즈 리미티드 | 안정한 라퀴니모드 제제 |
US20080118553A1 (en) * | 2006-06-12 | 2008-05-22 | Anton Frenkel | Tannate salt form of polypeptide mixtures, their preparation and use |
US20080090897A1 (en) * | 2006-08-11 | 2008-04-17 | The Johns Hopkins University | Compositions and methods for neuroprotectin |
PT2056807E (pt) | 2006-08-17 | 2012-12-21 | Univ Chicago | Tratamento de doenças inflamatórias |
AU2007338771A1 (en) * | 2006-12-19 | 2008-07-03 | Merrimack Pharmaceuticals, Inc. | Coadministration of alpha-fetoprotein and an immunomodulatory agent to treat multiple sclerosis |
AU2008275148A1 (en) * | 2007-07-11 | 2009-01-15 | Medicinova, Inc. | Treatment of progressive neurodegenerative disease with ibudilast |
JP2009084271A (ja) * | 2007-09-07 | 2009-04-23 | Toyama Univ | 脳由来神経栄養因子の発現誘導剤および発現誘導方法 |
WO2009053070A1 (en) | 2007-10-23 | 2009-04-30 | Schwarz Pharma Ag | Compounds for treating demyelination conditions |
WO2009082471A1 (en) | 2007-12-20 | 2009-07-02 | Teva Pharmaceutical Industries, Ltd. | Stable laquinimod preparations |
CA2736091A1 (en) | 2008-09-03 | 2010-03-11 | Teva Pharmaceutical Industries Ltd. | 2-oxo-1,2-dihydro-quinoline modulators of immune function |
AR073295A1 (es) | 2008-09-16 | 2010-10-28 | Genentech Inc | Metodos para tratar la esclerosis multiple progresiva. articulo de fabricacion. |
CA2743717A1 (en) * | 2008-11-13 | 2010-05-20 | Link Medicine Corporation | Azaquinolinone derivatives and uses thereof |
AU2010260455A1 (en) | 2009-06-19 | 2012-02-02 | Teva Pharmaceutical Industries Ltd. | Treatment of multiple sclerosis with laquinimod |
JP5859438B2 (ja) * | 2009-08-10 | 2016-02-10 | テバ ファーマシューティカル インダストリーズ リミティド | ラキニモドを用いたbdnf関連疾患の治療 |
BR112012022187A2 (pt) | 2010-03-03 | 2015-09-22 | Teva Pharma | tratamento de artrite reumatóide com a combinação de laquinimod e metotrexato |
ES2558556T3 (es) | 2010-03-03 | 2016-02-05 | Teva Pharmaceutical Industries Ltd. | Tratamiento de nefritis lúpica usando laquinimod |
BR112012022064A2 (pt) | 2010-03-03 | 2015-09-08 | Teva Pharma | tratamento de artrite lúpica usando laquinimod |
KR20130041193A (ko) | 2010-07-09 | 2013-04-24 | 테바 파마슈티컬 인더스트리즈 리미티드 | 5-클로로-4-하이드록시-1-메틸-2-옥소-n-페닐-1,2-다이하이드로퀴놀린-3-카복스아마이드, 염 및 그의 용도 |
SG186948A1 (en) | 2010-07-09 | 2013-02-28 | Teva Pharma | Deuterated n-ethyl-n-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide, salts and uses thereof |
BR112013014061A2 (pt) | 2010-12-07 | 2016-09-13 | Teva Pharma | uso de laquinimod para redução da fadiga, melhorando o estado fundicional e melhorando a qualidade de vida nos pacientes com esclerose múltipla |
EP2766020A4 (en) | 2011-10-12 | 2015-04-01 | Teva Pharma | TREATMENT OF MULTIPLE SCLEROSIS BY COMBINING LAQUINIMOD AND FINGOLIMOD |
-
2010
- 2010-08-09 JP JP2012524692A patent/JP5859438B2/ja active Active
- 2010-08-09 PL PL16160522T patent/PL3064206T3/pl unknown
- 2010-08-09 SI SI201031245A patent/SI2467372T1/sl unknown
- 2010-08-09 RS RS20160664A patent/RS55071B1/sr unknown
- 2010-08-09 WO PCT/US2010/002194 patent/WO2011019375A1/en active Application Filing
- 2010-08-09 ME MEP-2016-162A patent/ME02495B/me unknown
- 2010-08-09 US US12/806,275 patent/US9585878B2/en active Active
- 2010-08-09 PL PL10808442T patent/PL2467372T3/pl unknown
- 2010-08-09 PT PT108084427T patent/PT2467372T/pt unknown
- 2010-08-09 AU AU2010282948A patent/AU2010282948C1/en active Active
- 2010-08-09 EP EP10808442.7A patent/EP2467372B1/en active Active
- 2010-08-09 CA CA2771203A patent/CA2771203C/en active Active
- 2010-08-09 ES ES16160522T patent/ES2731052T3/es active Active
- 2010-08-09 EP EP16160522.5A patent/EP3064206B1/en active Active
- 2010-08-09 DK DK10808442.7T patent/DK2467372T3/en active
- 2010-08-09 ES ES10808442.7T patent/ES2586843T3/es active Active
- 2010-08-09 HU HUE10808442A patent/HUE029983T2/en unknown
-
2012
- 2012-02-02 IL IL217901A patent/IL217901B/en active IP Right Grant
-
2016
- 2016-02-22 US US15/049,942 patent/US20160243103A1/en not_active Abandoned
- 2016-08-09 HR HRP20160997TT patent/HRP20160997T1/hr unknown
- 2016-08-16 CY CY20161100805T patent/CY1117916T1/el unknown
- 2016-08-18 SM SM201600281T patent/SMT201600281B/it unknown
- 2016-12-16 HK HK16114333A patent/HK1225970A1/zh unknown
- 2016-12-21 AU AU2016277618A patent/AU2016277618A1/en not_active Abandoned
-
2017
- 2017-02-07 US US15/426,626 patent/US20170239234A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP3064206B1 (en) | 2019-03-20 |
JP2013501784A (ja) | 2013-01-17 |
CA2771203A1 (en) | 2011-02-17 |
PT2467372T (pt) | 2016-08-23 |
ES2731052T3 (es) | 2019-11-13 |
US20160243103A1 (en) | 2016-08-25 |
US9585878B2 (en) | 2017-03-07 |
IL217901B (en) | 2018-12-31 |
WO2011019375A1 (en) | 2011-02-17 |
HUE029983T2 (en) | 2017-04-28 |
IL217901A0 (en) | 2012-03-29 |
ME02495B (me) | 2017-02-20 |
US20170239234A1 (en) | 2017-08-24 |
HK1225970A1 (zh) | 2017-09-22 |
SMT201600281B (it) | 2016-11-10 |
AU2016277618A1 (en) | 2017-01-19 |
EP3064206A1 (en) | 2016-09-07 |
EP2467372A1 (en) | 2012-06-27 |
AU2010282948C1 (en) | 2017-03-02 |
AU2010282948B2 (en) | 2016-09-29 |
PL2467372T3 (pl) | 2017-04-28 |
CA2771203C (en) | 2019-04-09 |
AU2010282948A1 (en) | 2012-04-05 |
ES2586843T3 (es) | 2016-10-19 |
EP2467372A4 (en) | 2013-01-09 |
PL3064206T3 (pl) | 2020-02-28 |
HRP20160997T1 (hr) | 2016-10-07 |
SI2467372T1 (sl) | 2016-09-30 |
JP5859438B2 (ja) | 2016-02-10 |
US20110034508A1 (en) | 2011-02-10 |
EP2467372B1 (en) | 2016-05-18 |
DK2467372T3 (en) | 2016-08-22 |
RS55071B1 (sr) | 2016-12-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1117916T1 (el) | Θεραπεια διαταραχων που σχετιζονται me bdnf χρησιμοποιωντας laquinimod | |
CY1116727T1 (el) | Θεραπεια πολλαπλης σκληρυνσης me laquinimod | |
CY1120964T1 (el) | Ετερογενη εμφυτευσιμα προϊοντα για χορηγηση φαρμακων | |
CY1122628T1 (el) | Χρηση αιθυλεστερα εικοσαπενταενοϊκου οξεος για θεραπεια υπερτριγλυκεριδαιμιας | |
CY1114139T1 (el) | Πλακιδιο βουπρενορφινης για τη θεραπεια υποκαταστασης ναρκωτικων | |
CY1119074T1 (el) | Αγωγη για αλλεργια σε φιστικια | |
EA201690069A1 (ru) | Применение высоких доз придопидина для лечения болезни хантингтона | |
JP2018109022A5 (el) | ||
EA201101704A1 (ru) | ПРОИЗВОДНЫЕ 1H-ИМИДАЗО[4,5-c]ХИНОЛИНОНА | |
CY1113253T1 (el) | Δοσολογικο σχημα για τη θεραπευτικη αντιμετωπιση μιας τραυματικης εγκεφαλικης βλαβης με προγεστερονη | |
CY1110495T1 (el) | Χρηση ενος αγωνιστη υποδοχεα nmda για τη θεραπεια εμβοης που προκαλειται απο κοχλιακη διεγερτοτοξικοτητα | |
DE60323090D1 (de) | 1h-imidazoä4,5-cüchinolinderivate zur behandlung von protein kinase-abhängigen krankheiten | |
UA107578C2 (uk) | Комбінована терапія при лікуванні діабету | |
MX2014013039A (es) | Uso de laquinimod de dosis alta para el tratamiento de esclerosis multiple. | |
CY1115269T1 (el) | Χρηση ανταγωνιστων οπιοειδων για την παρασκευη ενος φαρμακου στη θεραπευτικη αγωγη εκφυλιστικων ασθενειων του αμφιβληστροειδους | |
CY1123583T1 (el) | Ανοσογονος συνθεση για χρηση στη θεραπεια | |
EA202090242A1 (ru) | Лечение болезни фабри у фзт-наивных и фзт-леченных пациентов | |
EA200800075A1 (ru) | Схема дозирования для празугреля | |
CY1118486T1 (el) | Λαπατινιμπη για τη θεραπεια του καρκινου | |
WO2012044783A3 (en) | Method of achieving a thymosin beta 4 concentration in a human patient | |
MX341660B (es) | Agonista del receptor de ghrelina para el tratamiento de caquexia. | |
EA202090416A1 (ru) | Способы лечения симптомов гастропареза с использованием велусетрага | |
CY1117605T1 (el) | Θεραπεια της ασθενειας crohn me laquinimod | |
TH93888A (el) | ||
CY1114276T1 (el) | Χρηση αιθυλεστερα εικοσαπενταενοϊκου οξεος για θεραπεια υπερτριγλυκεριδαιμιας |