MX2015010967A - Formulaciones transdermicas de laquinimod. - Google Patents
Formulaciones transdermicas de laquinimod.Info
- Publication number
- MX2015010967A MX2015010967A MX2015010967A MX2015010967A MX2015010967A MX 2015010967 A MX2015010967 A MX 2015010967A MX 2015010967 A MX2015010967 A MX 2015010967A MX 2015010967 A MX2015010967 A MX 2015010967A MX 2015010967 A MX2015010967 A MX 2015010967A
- Authority
- MX
- Mexico
- Prior art keywords
- pharmaceutical composition
- laquinimod
- optionally
- transdermal patch
- provides
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Esta invención proporciona un parche transdérmico que comprende: a) una capa de respaldo; b) un revestimiento; c) opcionalmente, una membrana altamente porosa; y d) una composición farmacéutica que comprende: (i) opcionalmente, un adhesivo sensible a la presión en una cantidad de hasta aproximadamente 95% de peso de la composición farmacéutica, (ii) el laquinimod en una cantidad de aproximadamente 0.1-20% de peso de la composición farmacéutica, y (iii) opcionalmente, uno o más potenciadores de permeación en una cantidad total de hasta aproximadamente 70% de peso de la composición farmacéutica. Esta invención también proporciona un método para suministrar el laquinimod a través de la piel de un sujeto y para tratar a un sujeto humano afligido con una forma de esclerosis múltiple que comprende la administración de un parche transdérmico a la piel del sujeto como se describe en la presente. Esta invención además proporciona un parche transdérmico como se describe en la presente para usarse en un tratamiento de un sujeto humano afligido con una forma de esclerosis múltiple.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361781585P | 2013-03-14 | 2013-03-14 | |
PCT/US2014/026807 WO2014152009A1 (en) | 2013-03-14 | 2014-03-13 | Transdermal formulations of laquinimod |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2015010967A true MX2015010967A (es) | 2015-10-26 |
Family
ID=50729775
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015010967A MX2015010967A (es) | 2013-03-14 | 2014-03-13 | Formulaciones transdermicas de laquinimod. |
Country Status (8)
Country | Link |
---|---|
US (1) | US20160038435A1 (es) |
EP (1) | EP2968203A1 (es) |
JP (1) | JP2016513665A (es) |
CA (1) | CA2900977A1 (es) |
HK (1) | HK1220125A1 (es) |
IL (1) | IL240557A0 (es) |
MX (1) | MX2015010967A (es) |
WO (1) | WO2014152009A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104093310A (zh) | 2012-02-03 | 2014-10-08 | 泰华制药工业有限公司 | 拉喹莫德用于治疗一线抗TNFα疗法失败的克罗恩氏病患者的用途 |
TW201410244A (zh) | 2012-08-13 | 2014-03-16 | Teva Pharma | 用於治療gaba媒介之疾病之拉喹莫德(laquinimod) |
WO2015138887A1 (en) * | 2014-03-14 | 2015-09-17 | Teva Pharmaceutical Industries Ltd. | Transmucosal delivery of laquinimod by oral patches |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6077851A (en) | 1998-04-27 | 2000-06-20 | Active Biotech Ab | Quinoline derivatives |
US20040033253A1 (en) * | 2002-02-19 | 2004-02-19 | Ihor Shevchuk | Acyl opioid antagonists |
SE0400235D0 (sv) | 2004-02-06 | 2004-02-06 | Active Biotech Ab | New composition containing quinoline compounds |
BRPI0617477A2 (pt) | 2005-10-19 | 2011-07-26 | Teva Pharma | mistura de partÍculas cristalinas de laquinimod sàdica, composiÇço, processo de cristalizaÇço de laquinimod sàdica, laquinimod sàdica, e, processo para produzir uma composiÇço farmacÊutica |
EP2035001B1 (en) | 2006-06-12 | 2011-11-09 | Teva Pharmaceutical Industries Limited | Stable laquinimod preparations |
PL2682120T3 (pl) | 2007-12-20 | 2017-02-28 | Teva Pharmaceutical Industries, Ltd. | Stabilne preparaty lakwinimodu |
BRPI0913518A2 (pt) | 2008-09-03 | 2016-07-26 | Teva Pharma | composto, composição farmacêutica, e, método de tratamento de um distúrbio mediado por função imune |
MX2011013902A (es) | 2009-06-19 | 2012-02-23 | Teva Pharma | Tratamiento de esclerosis multiple con laquinimod. |
ME02414B (me) | 2009-07-30 | 2016-09-20 | Teva Pharma | Tretman kronove bolesti lakvinimodom |
EP3064206B1 (en) | 2009-08-10 | 2019-03-20 | Active Biotech AB | Treatment of huntington's disease using laquinimod |
DE102010026879A1 (de) * | 2010-02-11 | 2011-08-11 | AMW GmbH, 83627 | Transdermales System mit Immunmodulator |
BR112012021905A2 (pt) | 2010-03-03 | 2015-09-29 | Teva Pharma | tratamento de nefrite lúpica usando laquinimod |
JP5819328B2 (ja) | 2010-03-03 | 2015-11-24 | テバ ファーマシューティカル インダストリーズ リミティド | ラキニモドとメトトレキセートとの組合せによる関節リウマチの治療 |
PT2542080T (pt) | 2010-03-03 | 2016-11-16 | Teva Pharma | Tratamento de artrite causada por lúpus usando laquinimod |
US8252993B1 (en) | 2010-05-25 | 2012-08-28 | Pioneer Hi-Bred International, Inc. | Inbred maize variety PH18FN |
AU2011274502A1 (en) | 2010-07-09 | 2013-02-28 | Teva Pharmaceutical Industries Ltd. | 5-chloro-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide, salts and uses thereof |
SG10201505236YA (en) | 2010-07-09 | 2015-08-28 | Teva Pharma | Deuterated n-ethyl-n-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide, salts and uses thereof |
WO2012078591A1 (en) | 2010-12-07 | 2012-06-14 | Teva Pharmaceutical Industries Ltd. | Use of laquinimod for reducing fatigue, improving functional status, and improving quality of life in multiple sclerosis patients |
-
2014
- 2014-03-13 EP EP14724199.6A patent/EP2968203A1/en not_active Withdrawn
- 2014-03-13 MX MX2015010967A patent/MX2015010967A/es unknown
- 2014-03-13 US US14/773,658 patent/US20160038435A1/en not_active Abandoned
- 2014-03-13 CA CA2900977A patent/CA2900977A1/en not_active Abandoned
- 2014-03-13 JP JP2016502251A patent/JP2016513665A/ja not_active Withdrawn
- 2014-03-13 WO PCT/US2014/026807 patent/WO2014152009A1/en active Application Filing
-
2015
- 2015-08-13 IL IL240557A patent/IL240557A0/en unknown
-
2016
- 2016-07-13 HK HK16108223.4A patent/HK1220125A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
IL240557A0 (en) | 2015-10-29 |
US20160038435A1 (en) | 2016-02-11 |
CA2900977A1 (en) | 2014-09-25 |
WO2014152009A1 (en) | 2014-09-25 |
HK1220125A1 (zh) | 2017-04-28 |
JP2016513665A (ja) | 2016-05-16 |
EP2968203A1 (en) | 2016-01-20 |
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