JP2018052903A - 皮膚バリア機能増強剤 - Google Patents
皮膚バリア機能増強剤 Download PDFInfo
- Publication number
- JP2018052903A JP2018052903A JP2016194598A JP2016194598A JP2018052903A JP 2018052903 A JP2018052903 A JP 2018052903A JP 2016194598 A JP2016194598 A JP 2016194598A JP 2016194598 A JP2016194598 A JP 2016194598A JP 2018052903 A JP2018052903 A JP 2018052903A
- Authority
- JP
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- Prior art keywords
- barrier function
- skin barrier
- fatty acid
- extract
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Landscapes
- Cosmetics (AREA)
Abstract
Description
(I−1)高級脂肪酸、高級脂肪酸塩、及び高級アルコールを含有する皮膚バリア機能増強剤。
(I−2)高級脂肪酸の含有量が5〜25重量%、高級脂肪酸塩の含有量が2〜10重量%、及び高級アルコールの含有量が0.5〜8重量%である、(I−1)記載の皮膚バリア機能増強剤。
(I−3)前記高級脂肪酸及び前記高級脂肪酸塩の高級脂肪酸が、それぞれ同一又は異なって、炭素数14〜18の飽和又は不飽和脂肪酸である(I−1)または(I−2)に記載する皮膚バリア機能増強剤。
(I−4)前記高級アルコールが炭素数14〜18の飽和または不飽和の一価のアルコールである(I−1)〜(I−3)のいずれかに記載する皮膚バリア機能増強剤。
(I−5)鹸化率が20〜40%、好ましくは30%程度である、(I−1)〜(I−4)のいずれかに記載する皮膚バリア機能増強剤。
(I−6)さらに液体飽和グリコールを含有する(I−1)〜(I−5)のいずれかに記載する皮膚バリア機能増強剤。
(I−7)液体飽和グリコールの含有量が0.5〜60重量%である(I−6)に記載する皮膚バリア機能増強剤。
(I−8)液体飽和グリコールがプロピレングリコール、ジプロピレングリコール、1,3−ブチレングリコール、及びポリエチレングリコールからなる群から選択される少なくとも1種である、(I−6)または(I−7)のいずれかに記載する皮膚バリア機能増強剤。
(I−9)O/W型乳化組成物である、(I−1)〜(I−8)のいずれかに記載する皮膚バリア機能増強剤。
(I−10)皮膚外用剤である(I−1)〜(I−9)のいずれかに記載する皮膚バリア機能増強剤。
(II−1)原料として少なくとも高級脂肪酸、アルカリ、及び高級アルコールを用いて、これらを混合する工程を有する、(I−1)〜(I−10)のいずれかに記載する皮膚バリア機能増強剤の製造方法。
(II−2)高級脂肪酸の配合量が8〜30重量%、アルカリの配合量が0.2〜5重量%、及び高級アルコールの含有量が0.5〜8重量%である、(II−1)記載の製造方法。
(II−3)高級脂肪酸の配合量100重量部に対するアルカリの配合量が4〜8重量部である(II−1)または(II−2)に記載する製造方法。
(II−4)前記高級脂肪酸及び前記高級脂肪酸塩の高級脂肪酸が、それぞれ同一又は異なって、炭素数14〜18の飽和又は不飽和の脂肪酸である(II−1)〜(II−3)のいずれかに記載する製造方法。
(II−5)前記高級アルコールが炭素数14〜18の飽和又は不飽和の一価のアルコールである(II−1)〜(II−4)のいずれかに記載する製造方法。
(II−6)鹸化率20〜40%、好ましくは30%程度の皮膚バリア機能増強剤を製造する方法である(II−1)〜(II−5)のいずれかに記載する製造方法。
(II−7)さらに液体飽和グリコールを配合する工程を有する(II−1)〜(II−6)のいずれかに記載する製造方法。
(II−8)液体飽和グリコールの配合量が0.5〜60重量%である(II−7)に記載する製造方法。
(II−9)液体飽和グリコールがプロピレングリコール、ジプロピレングリコール、1,3−ブチレングリコール、及びポリエチレングリコールからなる群から選択される少なくとも1種である、(II−7)または(II−8)のいずれかに記載する製造方法。
(II−10)皮膚バリア機能増強剤がO/W型乳化組成物であって、乳化工程を有する、(II−1)〜(II−9)のいずれかに記載する製造方法。
(II−11)皮膚バリア機能増強剤が皮膚外用剤であり、外用形態に調製する工程を有する(II−1)〜(II−10)のいずれかに記載する製造方法。
(III−1)上記(I−1)〜(I−10)のいずれかに記載する皮膚バリア機能増強剤を、被験者の皮膚に適用する工程を有する、皮膚バリア機能を増強する美容方法。
(III−2)上記美容方法が皮膚バリア機能低下に起因する皮膚症状を改善する方法である、(III−1)に記載する美容方法。
(III−3)上記美容方法が肌荒れ、しみ、シワ、ハリの低下、及び肌のたるみからなる群から選択される、皮膚バリア機能低下に起因する皮膚症状を改善する美容方法である、(III−1)または(III−2)に記載する美容方法。
本発明の皮膚バリア機能増強剤は、高級脂肪酸、高級脂肪酸塩、及び高級アルコールを含有することを特徴とする。
本発明において、高級脂肪酸は、制限されないものの、炭素数が14〜18の飽和または不飽和脂肪酸であることが好ましい。かかる脂肪酸としては、ミリスチン酸(14:0)、ペンタデシル酸(15:0)、パルミチン酸(16:0)、パルミトレイン酸(16:1)、マルガリン酸(17:0)、ステアリン酸(18:0)、オレイン酸(18:1)、バクセン酸(18:1)、リノール酸(18:2)、リノレン酸(18:3)、及びエレオステアリン酸(18:3)を挙げることができる。なお、上記化学名の後ろの括弧内の数字は前者が脂肪酸の炭素数、後者が二重結合の数を示す。皮膚バリア機能増強作用に加えて、使用感の良さという観点から、より好ましくは炭素数が16〜18の飽和脂肪酸であり、特に好ましくはパルミチン酸、ステアリン酸、マルガリン酸である。
高級脂肪酸塩は、後述するように、製造工程において、原料として使用する高級脂肪酸にアルカリが反応することによって生成されるが、これに限らず、別途添加配合されたものであってもよく、その由来は特に制限されるものではない。
本発明において、高級アルコールは、制限されないものの、炭素数が14〜18の飽和または不飽和の一価のアルコールであることが好ましい。かかる高級アルコールとしては、ミリスチルアルコール、ペンタデシルアルコール、セタノール、セトスアリルアルコール、パルミトレイルアルコール、1−ヘプタデカノール、ステアリルアルコール、イソステアリルアルコール、エライジルアルコール、オレイルアルコール、リノレイルアルコール、リシノレイルアルコール等の脂肪アルコールまたは合成アルコールを挙げることができる。皮膚バリア機能増強作用に加えて、使用感の良さという観点から、好ましくは炭素数が16〜18の飽和の一価アルコールであり、特に好ましくはセタノール、セトスアリルアルコール、パルミトレイルアルコール、1−ヘプタデカノール、ステアリルアルコール、イソステアリルアルコール、オレイルアルコールである。
本発明の皮膚バリア機能増強剤は、液体飽和グリコールを含有するものであってもよい。当該液体飽和グリコールは、皮膚に対して保湿剤または柔軟剤として作用する。かかる液体飽和グリコールとして、制限されないが、具体的には、プロピレングリコール、ジプロピレングリコール、1,3−ブチレングリコール、及びポリエチレングリコールからなる群から選択される少なくとも1種を挙げることができる。好ましくはプロピレングリコール、ジプロピレングリコール及びポリエチレングリコールであり、より好ましくはプロピレングリコール、ポリエチレングリコールである。本発明の皮膚バリア機能増強剤における液体飽和グリコールの含有割合として、制限されないものの0.5〜60重量%の範囲を挙げることができる。好ましくは1〜60重量%、より好ましくは5〜60重量%を挙げることができる。
本発明の皮膚バリア機能増強剤は、皮膚バリア機能増強作用を発揮するという本発明の効果を妨げないことを限度として、上記(A)〜(C)成分、または上記(A)〜(D)成分に加えて、他の成分が含まれていてもよい。かかる成分としては、保湿剤、増粘剤、界面活性剤、油性成分、抗酸化剤、防腐・殺菌剤、粉体成分、香料、顔料、水等を例示することができる。
前述する少なくとも(A)〜(C)成分を含有する本発明の皮膚バリア機能増強剤は、原料として少なくとも高級脂肪酸、アルカリ、及び高級アルコールを用いて、これらを混合する工程を経て調製することができる。
本発明は、皮膚バリア機能が低下した被験者に対して、前述する本発明の皮膚バリア機能増強剤を適用し、当該被験者の皮膚バリア機能を増強し改善する美容方法に関する。なお、本発明が対象とする方法は、美容方法であり、ヒトに対する治療方法ではない。
表2に示す組成からなる皮膚外用組成物(クリーム剤)(実施例1〜4、比較例1)をヒトの皮膚に適用して経上皮水分蒸散量を測定し、皮膚バリア機能増強作用を評価した。
表2に記載する組成について、実施例1〜4については、まず表1記載のA相の成分を表1記載の割合でとり80℃に加熱する。次いでB相の成分を表1記載の割合でとり80℃に加熱する。次いでA相成分の混合物にB相成分の混合物を加えて攪拌する。次いでこれを30℃まで冷却(自然放冷)しながら攪拌して表2に記載の組成からなる乳化物(クリーム状)(被験試料(皮膚外用組成物))を調製した。
下記の手順に従って、被験試料(実施例1〜4、比較例1)の塗布前後で、皮膚被験部位の経上皮水分蒸散量(TEWL)を測定し、上記被験試料の皮膚バリア機能増強作用を評価した。
(i)ヒト(n=17)の上腕内側部(被験部位)のTEWLを、携帯型閉鎖チャンバー方式水分蒸散量測定装置(VAPO SCAN AS-VT100RS:株式会社アサヒテクノラボ製)で測定する。
(ii)SDSの4%水溶液を不織布(15mm×15mm)に含浸させて、これを上記被験部位に30分間貼付し、その後に剥がす。これを4日間繰り返し、被験部位の肌を荒らす。
(iii)4日後、被験部位のTEWLを再度測定する。
(iv)1週間、被験試料(実施例1〜4、比較例1)の適量(約0.1g/回)を1日2回(朝の起床後と夜の入浴後)、被験部位に塗布する。
(v)塗布開始から1週間後、被験部位のTEWLを再度測定する。
各被験試料による処理群の修了後のTEWL値と未処置群の修了後のTEWL値を統計処理して、有意水準5%で有意差の有無を判断する(Wilcoxonの符号付順位和検定(対応のあるt検定)。
結果を表2に合わせて示す。
表4に記載する組成からなる皮膚外用組成物(クリーム剤)を皮膚バリア機能増強剤として調製した。具体的には、まず表3に記載するA相の成分を表3記載の割合でとり80℃に加熱する。次いでB相の成分を表3記載の割合でとり80℃に加熱する。次いでA相成分の混合物にB相成分の混合物を加えて攪拌する。次いでこれを30℃まで冷却(自然放冷)しながら攪拌して表4に記載の組成からなる乳化物(クリーム剤)を調製した。
Claims (6)
- 高級脂肪酸、高級脂肪酸塩、及び高級アルコールを含有する皮膚バリア機能増強剤。
- 高級脂肪酸の含有量が5〜25重量%、高級脂肪酸塩の含有量が2〜10重量%、及び高級アルコールの含有量が0.5〜8重量%である、請求項1記載の皮膚バリア機能増強剤。
- 前記高級脂肪酸及び前記高級脂肪酸塩の高級脂肪酸が、それぞれ同一又は異なって、炭素数14〜18の飽和又は不飽和脂肪酸である請求項1または2に記載する皮膚バリア機能増強剤。
- 前記高級アルコールが炭素数14〜18の飽和または不飽和の一価のアルコールである請求項1〜3のいずれかに記載する皮膚バリア機能増強剤。
- 鹸化率が20〜40%である、請求項1〜4のいずれかに記載する皮膚バリア機能増強剤。
- 原料として少なくとも高級脂肪酸、アルカリ、及び高級アルコールを用いて、これらを混合する工程を有する、請求項1〜5のいずれかに記載する皮膚バリア機能増強剤の製造方法。
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