JP2018046872A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018046872A5 JP2018046872A5 JP2018000123A JP2018000123A JP2018046872A5 JP 2018046872 A5 JP2018046872 A5 JP 2018046872A5 JP 2018000123 A JP2018000123 A JP 2018000123A JP 2018000123 A JP2018000123 A JP 2018000123A JP 2018046872 A5 JP2018046872 A5 JP 2018046872A5
- Authority
- JP
- Japan
- Prior art keywords
- binding protein
- antigen
- domain
- protein according
- antigen binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000025171 antigen binding proteins Human genes 0.000 claims 20
- 108091000831 antigen binding proteins Proteins 0.000 claims 20
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 5
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 5
- 229920001184 polypeptide Polymers 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 2
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 230000000392 somatic effect Effects 0.000 claims 2
- 238000007792 addition Methods 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36990910P | 2010-08-02 | 2010-08-02 | |
| US61/369,909 | 2010-08-02 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016009916A Division JP2016054746A (ja) | 2010-08-02 | 2016-01-21 | Vlドメインを含む結合タンパク質を作製するマウス |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018212094A Division JP6759303B2 (ja) | 2010-08-02 | 2018-11-12 | Vlドメインを含む結合タンパク質を作製するマウス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018046872A JP2018046872A (ja) | 2018-03-29 |
| JP2018046872A5 true JP2018046872A5 (OSRAM) | 2018-12-20 |
| JP7078400B2 JP7078400B2 (ja) | 2022-05-31 |
Family
ID=44543797
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013523258A Active JP6146913B2 (ja) | 2010-08-02 | 2011-08-02 | Vlドメインを含む結合タンパク質を作製するマウス |
| JP2016009916A Withdrawn JP2016054746A (ja) | 2010-08-02 | 2016-01-21 | Vlドメインを含む結合タンパク質を作製するマウス |
| JP2018000123A Active JP7078400B2 (ja) | 2010-08-02 | 2018-01-04 | Vlドメインを含む結合タンパク質を作製するマウス |
| JP2018212094A Active JP6759303B2 (ja) | 2010-08-02 | 2018-11-12 | Vlドメインを含む結合タンパク質を作製するマウス |
| JP2020023076A Active JP7110257B2 (ja) | 2010-08-02 | 2020-02-14 | Vlドメインを含む結合タンパク質を作製するマウス |
| JP2021084769A Pending JP2021119792A (ja) | 2010-08-02 | 2021-05-19 | Vlドメインを含む結合タンパク質を作製するマウス |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013523258A Active JP6146913B2 (ja) | 2010-08-02 | 2011-08-02 | Vlドメインを含む結合タンパク質を作製するマウス |
| JP2016009916A Withdrawn JP2016054746A (ja) | 2010-08-02 | 2016-01-21 | Vlドメインを含む結合タンパク質を作製するマウス |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018212094A Active JP6759303B2 (ja) | 2010-08-02 | 2018-11-12 | Vlドメインを含む結合タンパク質を作製するマウス |
| JP2020023076A Active JP7110257B2 (ja) | 2010-08-02 | 2020-02-14 | Vlドメインを含む結合タンパク質を作製するマウス |
| JP2021084769A Pending JP2021119792A (ja) | 2010-08-02 | 2021-05-19 | Vlドメインを含む結合タンパク質を作製するマウス |
Country Status (27)
| Country | Link |
|---|---|
| US (7) | US9516868B2 (OSRAM) |
| EP (3) | EP2601298B1 (OSRAM) |
| JP (6) | JP6146913B2 (OSRAM) |
| KR (4) | KR102434557B1 (OSRAM) |
| CN (4) | CN118791596A (OSRAM) |
| AU (1) | AU2011285919C1 (OSRAM) |
| BR (1) | BR112013002695B1 (OSRAM) |
| CA (2) | CA3250882A1 (OSRAM) |
| CY (1) | CY1118562T1 (OSRAM) |
| DK (1) | DK2601298T3 (OSRAM) |
| ES (1) | ES2612459T3 (OSRAM) |
| HK (1) | HK1217511A1 (OSRAM) |
| HR (1) | HRP20170322T1 (OSRAM) |
| HU (1) | HUE031903T2 (OSRAM) |
| IL (4) | IL315833A (OSRAM) |
| LT (1) | LT2601298T (OSRAM) |
| MX (5) | MX345251B (OSRAM) |
| MY (1) | MY172618A (OSRAM) |
| NZ (2) | NZ606824A (OSRAM) |
| PL (1) | PL2601298T3 (OSRAM) |
| PT (1) | PT2601298T (OSRAM) |
| RS (1) | RS55495B1 (OSRAM) |
| RU (2) | RU2612903C2 (OSRAM) |
| SG (3) | SG187673A1 (OSRAM) |
| SI (1) | SI2601298T1 (OSRAM) |
| SM (2) | SMT201700023T1 (OSRAM) |
| WO (1) | WO2012018764A1 (OSRAM) |
Families Citing this family (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009143472A2 (en) * | 2008-05-23 | 2009-11-26 | Aliva Biopharmaceuticals, Inc. | Method of generating single vl domain antibodies in transgenic animals |
| PT2564695E (pt) | 2009-07-08 | 2015-06-03 | Kymab Ltd | Modelos animais e moléculas terapêuticas |
| US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| DK2505654T4 (da) | 2010-02-08 | 2020-07-27 | Regeneron Pharma | Mus med fælles letkæde |
| US10793829B2 (en) | 2010-07-26 | 2020-10-06 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
| AU2011286185B2 (en) | 2010-07-26 | 2014-08-14 | Trianni, Inc. | Transgenic animals and methods of use |
| US10662256B2 (en) | 2010-07-26 | 2020-05-26 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
| CA3250882A1 (en) | 2010-08-02 | 2025-11-29 | Regeneron Pharamaceuticals, Inc. | Mice that Make Binding Proteins Comprising VL Domains |
| MY172718A (en) | 2011-08-05 | 2019-12-11 | Regeneron Pharma | Humanized universal light chain mice |
| EP3741862A1 (en) | 2011-09-19 | 2020-11-25 | Kymab Limited | Animals, repertoires & methods for the production of human antibodies |
| WO2013041844A2 (en) | 2011-09-19 | 2013-03-28 | Kymab Limited | Antibodies, variable domains & chains tailored for human use |
| WO2013045916A1 (en) | 2011-09-26 | 2013-04-04 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
| MY172946A (en) | 2011-10-17 | 2019-12-16 | Regeneron Pharma | Restricted immunoglobulin heavy chain mice |
| US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| KR102081657B1 (ko) | 2011-12-20 | 2020-02-26 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 경쇄 마우스 |
| EP3597038B1 (en) * | 2012-02-01 | 2021-04-21 | Regeneron Pharmaceuticals, Inc. | Humanized rodents that express heavy chains containing vl domains |
| US9718871B2 (en) | 2012-03-14 | 2017-08-01 | Innovative Targeting Solutions Inc. | Generating targeted sequence diversity in proteins |
| US9914929B2 (en) | 2012-03-14 | 2018-03-13 | Innovative Targeting Solutions Inc. | Generating targeted sequence diversity in fusion proteins |
| US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| HUE055617T2 (hu) | 2012-06-12 | 2021-12-28 | Regeneron Pharma | Korlátozott immunglobulin nehézlánc lókuszokkal rendelkezõ, humanizált, nem humán élõlények |
| US20150203591A1 (en) | 2012-08-02 | 2015-07-23 | Regeneron Pharmaceuticals, Inc. | Mutivalent antigen-binding proteins |
| ES2678221T3 (es) | 2013-02-20 | 2018-08-09 | Regeneron Pharmaceuticals, Inc. | Animales no humanos con secuencias de cadena pesada de inmunoglobulina modificadas |
| LT3501272T (lt) * | 2013-03-13 | 2023-03-27 | Regeneron Pharmaceuticals, Inc. | Pelės, vykdančios imunoglobulino lengvosios grandinės riboto rinkinio raišką |
| BR112015022585B1 (pt) | 2013-03-15 | 2023-04-04 | Regeneron Pharmaceuticals, Inc | Composto, composição farmacêutica, conjugado droga-anticorpo, e, uso dos mesmos |
| US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| US9783618B2 (en) | 2013-05-01 | 2017-10-10 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
| US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
| US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| JP6608823B2 (ja) | 2013-08-26 | 2019-11-20 | レゲネロン ファーマシューティカルス,インコーポレーテッド | マクロライドジアステレオマーを含む医薬組成物、その合成方法、及び治療上の使用 |
| FR3011249A1 (OSRAM) * | 2013-10-01 | 2015-04-03 | Kymab Ltd | |
| NL2013554B1 (en) | 2013-10-01 | 2016-01-08 | Kymab Ltd | Animal models and therapeutic molecules. |
| BR112016021572A2 (pt) * | 2014-03-21 | 2017-10-03 | Regeneron Pharma | Métodos para preparar um animal não humano geneticamente modificado e para produzir proteínas de ligação, hibridoma, ácido nucleico, célula, e, proteína de ligação |
| BR112016021679A2 (pt) * | 2014-03-21 | 2018-12-04 | Regeneron Pharmaceuticals, Inc. | proteína de ligação ao antígeno, métodos de produção de uma proteína de ligação ao antígeno e de identificação de uma ou mais proteínas de ligação ao antígeno, hibridoma, ácido nucleico, célula, e, animal não humano geneticamente modificado. |
| CA2979702A1 (en) * | 2015-03-19 | 2016-09-22 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
| KR20240142591A (ko) | 2015-03-27 | 2024-09-30 | 리제너론 파아마슈티컬스, 인크. | 메이탄시노이드 유도체, 이의 컨주게이트, 및 사용 방법 |
| JP6793134B2 (ja) * | 2015-06-05 | 2020-12-02 | ジェネンテック, インコーポレイテッド | 抗tau抗体及び使用方法 |
| WO2017095939A1 (en) | 2015-12-03 | 2017-06-08 | Trianni, Inc. | Enhanced immunoglobulin diversity |
| AU2017211120C1 (en) | 2016-01-25 | 2021-10-07 | Regeneron Pharmaceuticals, Inc. | Maytansinoid derivatives, conjugates thereof, and methods of use |
| US11053288B2 (en) | 2016-02-04 | 2021-07-06 | Trianni, Inc. | Enhanced production of immunoglobulins |
| JP7324583B2 (ja) | 2016-05-20 | 2023-08-10 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 複数のガイドrnaを使用して免疫寛容を破綻させるための方法 |
| PT3462853T (pt) | 2016-06-03 | 2023-04-21 | Regeneron Pharma | Animais não humanos que expressam desoxinucleotidiltransferase terminal exógena |
| KR20250114431A (ko) | 2016-11-08 | 2025-07-29 | 리제너론 파마슈티칼스 인코포레이티드 | 스테로이드 및 이의 단백질-접합체 |
| MY198942A (en) | 2016-12-07 | 2023-10-03 | Genentech Inc | Anti-tau antibodies and methods of use |
| CN110248959B (zh) | 2016-12-07 | 2023-06-30 | 基因泰克公司 | 抗tau抗体和使用方法 |
| JP2020505037A (ja) * | 2017-01-19 | 2020-02-20 | オープン モノクローナル テクノロジー,インコーポレイテッド | 複数の重鎖免疫グロブリン遺伝子座を有するトランスジェニックげっ歯類由来のヒト抗体 |
| CN110944718A (zh) | 2017-05-18 | 2020-03-31 | 里珍纳龙药品有限公司 | 环糊精蛋白质药物偶联物 |
| BR112020004458A2 (pt) | 2017-09-07 | 2020-10-06 | Augusta University Research Institute, Inc | Anticorpo ou seu fragmento de ligação ao antígeno eao epítopo ou proteína de fusão, ácido nucleico, composição farmacêutica, e, usos de um anticorpo ou fragmento de ligação ao antígeno ou uma composição farmacêutica para preparar um medicamento para induzir, promover ou aumentar uma resposta imune, para tratar o câncer, para reduzir a carga tumoral e para tratar uma infecção em um sujeito em necessidade |
| CA3080857A1 (en) | 2017-11-07 | 2019-05-16 | Regeneron Pharmaceuticals, Inc. | Hydrophilic linkers for antibody drug conjugates |
| JP7366028B2 (ja) | 2018-01-08 | 2023-10-20 | レゲネロン ファーマシューティカルス,インコーポレーテッド | ステロイド及びその抗体コンジュゲート |
| LT3772927T (lt) | 2018-03-24 | 2025-02-10 | Regeneron Pharmaceuticals, Inc. | Genetiškai modifikuotos pelės arba žiurkės, skirtos gaminti terapinius antikūnus prieš peptidų- mhc kompleksus, jų gamybos būdai ir panaudojimas |
| CN116420679B (zh) | 2018-03-26 | 2025-10-03 | 瑞泽恩制药公司 | 用于测试治疗剂的人源化啮齿动物 |
| KR20210008008A (ko) | 2018-05-09 | 2021-01-20 | 리제너론 파마슈티칼스 인코포레이티드 | 항-msr1 항체 및 이의 사용 방법 |
| IL318469A (en) | 2018-06-14 | 2025-03-01 | Regeneron Pharma | Non-human animals capable of reorganizing transgenic DH-DH, and their uses |
| JP2020146309A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146313A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146300A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146305A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146310A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146317A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146304A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146315A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146316A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146299A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146314A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146297A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146306A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146312A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146301A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146307A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146308A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146298A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146318A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146302A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146303A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| IL297027B2 (en) | 2020-04-16 | 2025-08-01 | Regeneron Pharma | Antibody-drug conjugates prepared using diels-alder conjugation methods |
| IL299153A (en) | 2020-07-13 | 2023-02-01 | Regeneron Pharma | Camptothecin analogs conjugated to a glutamine residue in protein, and their uses |
| IL301137A (en) | 2020-09-11 | 2023-05-01 | Regeneron Pharma | Identification and production of antigen-specific antibodies |
| EP4210767A1 (en) | 2020-09-14 | 2023-07-19 | Regeneron Pharmaceuticals, Inc. | Antibody-drug conjugates comprising glp1 peptidomimetics and uses thereof |
| WO2022132943A1 (en) | 2020-12-16 | 2022-06-23 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized fc alpha receptors |
| CA3165366A1 (en) | 2020-12-23 | 2022-06-30 | Regeneron Pharmaceuticals, Inc. | Nucleic acids encoding anchor modified antibodies and uses thereof |
| CN118829449A (zh) | 2022-01-12 | 2024-10-22 | 瑞泽恩制药公司 | 与蛋白中的谷氨酰胺残基缀合的喜树碱类似物及其用途 |
| JP2025504020A (ja) | 2022-01-28 | 2025-02-06 | ジョージアミューン・インコーポレイテッド | Pd-1アゴニストであるプログラム細胞死タンパク質1に対する抗体 |
| KR20250133813A (ko) | 2022-12-21 | 2025-09-08 | 리제너론 파마슈티칼스 인코포레이티드 | Adc 접합을 위한 토포이소머라아제 i 억제제의 전구약물 및 이의 사용 방법 |
| US20250171516A1 (en) | 2023-11-03 | 2025-05-29 | Regeneron Pharmaceuticals, Inc. | Peptide acids as a glp1r agonist and antibody-drug conjugates thereof |
Family Cites Families (135)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4977081A (en) | 1987-05-04 | 1990-12-11 | Adi Diagnostics, Inc. | Stable rabbit-mouse hybridomas and secretion products thereof |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5075181A (en) | 1989-05-05 | 1991-12-24 | Kennametal Inc. | High hardness/high compressive stress multilayer coated tool |
| WO1991000906A1 (en) | 1989-07-12 | 1991-01-24 | Genetics Institute, Inc. | Chimeric and transgenic animals capable of producing human antibodies |
| US6657103B1 (en) | 1990-01-12 | 2003-12-02 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| ATE356869T1 (de) | 1990-01-12 | 2007-04-15 | Amgen Fremont Inc | Bildung von xenogenen antikörpern |
| DE69130702T2 (de) | 1990-07-10 | 1999-05-27 | Nkk Corp., Tokio/Tokyo | Geflügelspezifischen immunglobulin g produzierende hybridomas |
| US6255458B1 (en) | 1990-08-29 | 2001-07-03 | Genpharm International | High affinity human antibodies and human antibodies against digoxin |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US7041871B1 (en) | 1995-10-10 | 2006-05-09 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| JP2835787B2 (ja) | 1991-03-22 | 1998-12-14 | キヤノン株式会社 | 強誘電性液晶素子 |
| AU669124B2 (en) * | 1991-09-18 | 1996-05-30 | Kyowa Hakko Kirin Co., Ltd. | Process for producing humanized chimera antibody |
| US5150584A (en) | 1991-09-26 | 1992-09-29 | General Motors Corporation | Method and apparatus for detecting low refrigerant charge |
| SG48760A1 (en) | 1992-07-24 | 2003-03-18 | Abgenix Inc | Generation of xenogenetic antibodies |
| EP0583980A1 (en) | 1992-08-20 | 1994-02-23 | Eli Lilly And Company | Method for generating monoclonal antibodies from rabbits |
| US6005079A (en) | 1992-08-21 | 1999-12-21 | Vrije Universiteit Brussels | Immunoglobulins devoid of light chains |
| US6765087B1 (en) | 1992-08-21 | 2004-07-20 | Vrije Universiteit Brussel | Immunoglobulins devoid of light chains |
| ATE452975T1 (de) | 1992-08-21 | 2010-01-15 | Univ Bruxelles | Immunoglobuline ohne leichte ketten |
| RU2151612C1 (ru) | 1992-12-01 | 2000-06-27 | Протеин Дизайн Лэбс, Инк. | Гуманизированный иммуноглобулин, специфичный для белка l-селектина человека |
| DE4309308C1 (de) | 1993-03-23 | 1994-04-14 | Siemens Nixdorf Inf Syst | Belüftungssystem für Schränke mit stark wärmeerzeugenden elektronischen Funktionseinheiten |
| IL109168A0 (en) * | 1993-04-01 | 1994-06-24 | Univ Columbia | A retroviral vector capable of transducing the aldehyde dehydrogenase-1 gene and making cells resistant to the chemotherapeutic agent cyclophosphamide and its derivatives and analogs |
| AU6819494A (en) | 1993-04-26 | 1994-11-21 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5523226A (en) | 1993-05-14 | 1996-06-04 | Biotechnology Research And Development Corp. | Transgenic swine compositions and methods |
| EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
| US6632976B1 (en) | 1995-08-29 | 2003-10-14 | Kirin Beer Kabushiki Kaisha | Chimeric mice that are produced by microcell mediated chromosome transfer and that retain a human antibody gene |
| WO1997016537A1 (en) | 1995-10-30 | 1997-05-09 | Spectral Diagnostics, Inc. | Stable chicken b-cell line and method of use thereof |
| AU3507297A (en) | 1996-06-26 | 1998-01-14 | Baylor College Of Medicine | Chromosomal rearrangement by insertion of two recombination substrates |
| EP2314625B1 (en) | 1996-12-03 | 2014-05-07 | Amgen Fremont Inc. | Transgenic mammals having human Ig loci including plural VH and Vkappa regions and antibodies produced therefrom |
| CN1203922A (zh) | 1997-03-21 | 1999-01-06 | 三共株式会社 | 人源化抗人fas抗体 |
| US20020062010A1 (en) | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| US6774279B2 (en) | 1997-05-30 | 2004-08-10 | Carnegie Institution Of Washington | Use of FLP recombinase in mice |
| GB9823930D0 (en) | 1998-11-03 | 1998-12-30 | Babraham Inst | Murine expression of human ig\ locus |
| EP1183344A4 (en) | 1999-05-27 | 2003-06-25 | Human Genome Sciences Inc | ADAM POLYNUCLEOTIDES AND POLYPEPTIDES |
| GB0001448D0 (en) | 2000-01-21 | 2000-03-08 | Novartis Ag | Organic compounds |
| EA007958B1 (ru) | 2000-08-03 | 2007-02-27 | Терапеутик Хьюман Поликлоналз Инк. | ТРАНСГЕННЫЙ ВЕКТОР, СОДЕРЖАЩИЙ ГУМАНИЗИРОВАННЫЙ ЛОКУС Ig, И ЕГО ПРИМЕНЕНИЕ ДЛЯ ПОЛУЧЕНИЯ ТРАНСГЕННЫХ ЖИВОТНЫХ |
| US7105348B2 (en) | 2000-10-31 | 2006-09-12 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6596541B2 (en) * | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| TWI255272B (en) | 2000-12-06 | 2006-05-21 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| GB0110029D0 (en) | 2001-04-24 | 2001-06-13 | Grosveld Frank | Transgenic animal |
| US7034134B2 (en) | 2001-04-26 | 2006-04-25 | Bristol-Myers Squibb Company | Polynucleotide encoding a novel metalloprotease highly expressed in the testis, MMP-29 |
| CN1789416B (zh) | 2001-05-11 | 2011-11-16 | 协和发酵麒麟株式会社 | 含人抗体λ轻链基因的人类人工染色体 |
| GB0115256D0 (en) | 2001-06-21 | 2001-08-15 | Babraham Inst | Mouse light chain locus |
| DE60237282D1 (de) | 2001-06-28 | 2010-09-23 | Domantis Ltd | Doppelspezifischer ligand und dessen verwendung |
| FR2827302B1 (fr) * | 2001-07-13 | 2003-10-10 | Genoway | Cellule et animal transgenique modelisant la presentation antigenique humaine et leurs utilisations |
| US20060199204A1 (en) | 2001-10-05 | 2006-09-07 | U.S. Epa | Genetic testing for male factor infertility |
| WO2003031656A1 (en) | 2001-10-05 | 2003-04-17 | United States Environmental Protection Agency | Genetic testing for male factor infertility |
| EP2319301B1 (en) | 2001-11-30 | 2017-09-06 | Amgen Fremont Inc. | Transgenic animals bearing human Ig lambda light chain genes |
| US7771951B2 (en) | 2001-12-03 | 2010-08-10 | Amgen Fremont Inc. | Antibody categorization based on binding characteristics |
| WO2003081993A2 (en) | 2002-03-22 | 2003-10-09 | Origen Therapeutics | Transgenic aves producing human polyclonal antibodies |
| US20030182675A1 (en) | 2002-03-22 | 2003-09-25 | Origen Therapeutics | Functional disruption of avian immunoglobulin genes |
| EP2135879A3 (en) | 2002-06-28 | 2010-06-23 | Domantis Limited | Ligand |
| FI117110B (fi) | 2002-07-05 | 2006-06-15 | Outokumpu Oy | Anodin syöttö sulatusreaktoriin |
| SI1523496T1 (sl) | 2002-07-18 | 2011-11-30 | Merus B V | Rekombinantno proizvajanje zmesi protiteles |
| US20040101920A1 (en) | 2002-11-01 | 2004-05-27 | Czeslaw Radziejewski | Modification assisted profiling (MAP) methodology |
| GB0228210D0 (en) * | 2002-12-03 | 2003-01-08 | Babraham Inst | Single chain antibodies |
| CA2511910A1 (en) | 2002-12-27 | 2004-07-15 | Domantis Limited | Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand |
| GB0230203D0 (en) * | 2002-12-27 | 2003-02-05 | Domantis Ltd | Fc fusion |
| GB0230201D0 (en) | 2002-12-27 | 2003-02-05 | Domantis Ltd | Retargeting |
| GB2398784B (en) | 2003-02-26 | 2005-07-27 | Babraham Inst | Removal and modification of the immunoglobulin constant region gene cluster of a non-human mammal |
| EP2395017A3 (en) * | 2003-05-30 | 2012-12-19 | Merus B.V. | Design and use of paired variable regions of specific binding molecules |
| US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
| WO2005001087A2 (en) | 2003-06-11 | 2005-01-06 | Regeneron Pharmaceuticals, Inc. | Methods of modifying genes in eukaryotic cells |
| ES2473596T3 (es) | 2003-07-15 | 2014-07-07 | Therapeutic Human Polyclonals, Inc. | Loci de inmunoglobulina humanizada |
| WO2005019463A1 (en) | 2003-08-11 | 2005-03-03 | Therapeutic Human Polyclonals, Inc. | Improved transgenesis with humanized immunoglobulin loci |
| RU2251699C1 (ru) | 2003-09-25 | 2005-05-10 | Киселев Всеволод Иванович | Способ ранней и доклинической диагностики цервикального рака |
| WO2005038001A2 (en) | 2003-10-14 | 2005-04-28 | Therapeutic Human Polyclonals, Inc. | Improved transgenesis by sperm-mediated gene transfer |
| FR2861255B1 (fr) | 2003-10-24 | 2006-02-17 | Centre Nat Rech Scient | Mammifere non-humain transgenique pour la region constante de la chaine lourde des immunoglobulines humaines de classe a et ses applications. |
| CA2556963A1 (en) | 2004-02-20 | 2005-09-01 | Woodwelding Ag | Implant that can be implanted in osseous tissue, method for producing said implant and corresponding implant |
| EP4353819A3 (en) * | 2004-07-22 | 2024-07-17 | Erasmus University Medical Center Rotterdam | Binding molecules |
| PT2767161T (pt) | 2004-10-19 | 2018-04-20 | Regeneron Pharma | Método para gerar um animal homozigótico para uma modificação genética |
| CA2584814A1 (en) | 2004-10-22 | 2006-05-04 | Therapeutic Human Polyclonals, Inc. | Suppression of endogenous immunoglobulin expression in non-human transgenic animals |
| GB0618345D0 (en) * | 2006-09-18 | 2006-10-25 | Univ Erasmus | Binding molecules |
| KR101481843B1 (ko) | 2006-01-25 | 2015-01-12 | 에라스무스 유니버시티 메디컬 센터 로테르담 | 형질전환 동물 내에서의 중쇄만의 항체의 생성 |
| EP2505058A1 (en) | 2006-03-31 | 2012-10-03 | Medarex, Inc. | Transgenic animals expressing chimeric antibodies for use in preparing human antibodies |
| NZ573557A (en) | 2006-06-02 | 2010-08-27 | Regeneron Pharma | High affinity antibodies to human il-6 receptor |
| CN101506235B (zh) | 2006-09-01 | 2012-07-25 | 人类多细胞株治疗学公司 | 人或人源化免疫球蛋白在非人转基因动物中增强的表达 |
| DK2769992T3 (da) * | 2006-10-02 | 2021-03-22 | Regeneron Pharma | Humane antistoffer med høj affinitet for human IL-4-receptor |
| NO347649B1 (no) | 2006-12-14 | 2024-02-12 | Regeneron Pharma | Humant antistoff eller antistoff fragment som spesifikt binder human deltaliknende ligand 4 (hDII4), nukleinsyremolekyl som koder for slike og vektor og vert-vektorsystemer, samt fremgangsmåte for fremstilling, sammensetning og anvendelse. |
| PT2336329E (pt) | 2007-06-01 | 2012-12-24 | Omt Inc | Composições e métodos para inibição de genes de imunoglobulina endógena e produção de anticorpos transgénicos humanos idiotípicos |
| WO2009013620A2 (en) | 2007-06-11 | 2009-01-29 | Erasmus University Medical Center Rotterdam | Homologous recombination |
| ITMI20071522A1 (it) * | 2007-07-27 | 2009-01-28 | Areta Internat S R L | Vaccino idiotipico |
| US20090155275A1 (en) * | 2007-07-31 | 2009-06-18 | Medimmune, Llc | Multispecific epitope binding proteins and uses thereof |
| EP3255144A1 (en) | 2007-08-10 | 2017-12-13 | E. R. Squibb & Sons, L.L.C. | Recombineering construct for preparing transgenic mice capable of producing human immunoglobulin |
| BRPI0815848A2 (pt) | 2007-08-30 | 2017-06-06 | The Burnet Inst | composto, linhagem de célula que produz anticorpo estável, composição, métodos para modular uma resposta imune em um indivíduo e para tratar e/ou prevenir uma doença, usos de um composto e/ou uma composição e de células dendríticas ou precursores das mesmas, métodos para enriquecer e detectar células dendríticas ou um subconjunto ou precursores das mesmas, polipeptídeo, polinucleotídeo vetor, célula hospedeira, planta transgênica, animal não humano transgênico, extrato, processo para preparar um composto ou um polipeptídeo, população enriquecida de células dendríticas e/ou precursores das mesmas, população de célula dendrítica expandida e/ou precursores das mesmas, métodos para identificar uma molécula que se liga a um polipeptídeo e para triar quanto a um composto que se liga a um polipeptídeo, uso de um polipeptídeo, um polinucleotídeo, um vetor, uma célula hospedeira, uma planta transgênica, um extrato, uma população de célula e/ou uma composição, método para produzir um composto, e, kit. |
| CL2008002886A1 (es) | 2007-09-26 | 2009-12-04 | Chugai Pharmaceutical Co Ltd | Region constante de un anticuerpo humano; anticuerpo anti-receptor de interleucina-6 (il-6) y composicion farmaceutica que la comprende. |
| EP2050764A1 (en) * | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
| CA2721231C (en) | 2008-04-14 | 2015-10-06 | Innovative Targeting Solutions Inc. | Sequence diversity generation in immunoglobulins |
| WO2009143472A2 (en) | 2008-05-23 | 2009-11-26 | Aliva Biopharmaceuticals, Inc. | Method of generating single vl domain antibodies in transgenic animals |
| US20100122358A1 (en) | 2008-06-06 | 2010-05-13 | Crescendo Biologics Limited | H-Chain-only antibodies |
| EP2556747B1 (en) | 2008-06-27 | 2020-12-02 | Merus N.V. | Antibody producing transgenic mice |
| KR101987351B1 (ko) | 2008-09-30 | 2019-06-10 | 아블렉시스, 엘엘씨 | 키메라 항체의 제조를 위한 인간 이외의 포유동물 |
| RU2011129459A (ru) | 2008-12-18 | 2013-01-27 | Эрасмус Юниверсити Медикал Сентр Роттердам | Трансгенные животные (не человек), экспрессирующие гуманизированные антитела, и их применение |
| US9085795B2 (en) | 2009-02-04 | 2015-07-21 | Molecular Innovations, Inc. | Methods for screening candidate agents for modulating prorenin and renin, assays for detecting prorenin and antibodies |
| GB0905023D0 (en) | 2009-03-24 | 2009-05-06 | Univ Erasmus Medical Ct | Binding molecules |
| EP2417160A1 (en) * | 2009-04-07 | 2012-02-15 | Roche Glycart AG | Bispecific anti-erbb-1/anti-c-met antibodies |
| SI2975051T1 (sl) | 2009-06-26 | 2021-08-31 | Regeneron Pharmaceuticals, Inc. | Zlahka izolirana bispecifična protitelesa z nativnim imunoglobulinskim formatom |
| US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
| PT2564695E (pt) * | 2009-07-08 | 2015-06-03 | Kymab Ltd | Modelos animais e moléculas terapêuticas |
| RU2425880C2 (ru) | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Способ получения трансгенных мышей |
| CN101620635A (zh) * | 2009-08-07 | 2010-01-06 | 中兴通讯股份有限公司 | 页面数据获取方法及服务器、页面更新方法及服务器 |
| CN104131035A (zh) | 2009-12-10 | 2014-11-05 | 瑞泽恩制药公司 | 生产重链抗体的小鼠 |
| DK2505654T4 (da) | 2010-02-08 | 2020-07-27 | Regeneron Pharma | Mus med fælles letkæde |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| US20130185821A1 (en) | 2010-02-08 | 2013-07-18 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
| US20120021409A1 (en) | 2010-02-08 | 2012-01-26 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
| AU2011266843C9 (en) | 2010-06-17 | 2018-03-01 | Kymab Limited | Animal models and therapeutic molecules |
| RU2601297C2 (ru) | 2010-06-22 | 2016-10-27 | Ридженерон Фармасьютикалз, Инк. | Мыши, экспрессирующие гибридную легкую цепь иммуноглобулина |
| CA3250882A1 (en) | 2010-08-02 | 2025-11-29 | Regeneron Pharamaceuticals, Inc. | Mice that Make Binding Proteins Comprising VL Domains |
| WO2012063048A1 (en) | 2010-11-08 | 2012-05-18 | Kymab Limited | Cells & vertebrates for enhanced somatic hypermutation and class switch recombination |
| SI2738258T2 (sl) | 2011-02-25 | 2023-05-31 | Regeneron Pharmaceuticals, Inc. | Miši ADAM6 |
| BR112013019975A2 (pt) | 2011-02-28 | 2017-08-01 | Hoffmann La Roche | proteínas de ligação de antígeno, composição farmacêutica, uso de uma proteína de ligação de antígeno, método para o tratamento de um paciente e método para a preparação de uma proteína de ligação de antígeno, ácido nucleico, vetor e célula hospedeira" |
| CA2824824A1 (en) | 2011-02-28 | 2012-09-07 | F. Hoffmann-La Roche Ag | Monovalent antigen binding proteins |
| US20120310284A1 (en) | 2011-06-03 | 2012-12-06 | Royal Oak Industries | Polyaxial pedicle screw |
| MY172718A (en) | 2011-08-05 | 2019-12-11 | Regeneron Pharma | Humanized universal light chain mice |
| WO2013041844A2 (en) | 2011-09-19 | 2013-03-28 | Kymab Limited | Antibodies, variable domains & chains tailored for human use |
| EP3741862A1 (en) | 2011-09-19 | 2020-11-25 | Kymab Limited | Animals, repertoires & methods for the production of human antibodies |
| WO2013045916A1 (en) | 2011-09-26 | 2013-04-04 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
| MY172946A (en) | 2011-10-17 | 2019-12-16 | Regeneron Pharma | Restricted immunoglobulin heavy chain mice |
| GB2496375A (en) | 2011-10-28 | 2013-05-15 | Kymab Ltd | A non-human assay vertebrate comprising human antibody loci and human epitope knock-in, and uses thereof |
| GB201122047D0 (en) | 2011-12-21 | 2012-02-01 | Kymab Ltd | Transgenic animals |
| US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| KR102081657B1 (ko) | 2011-12-20 | 2020-02-26 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 경쇄 마우스 |
| EP3597038B1 (en) | 2012-02-01 | 2021-04-21 | Regeneron Pharmaceuticals, Inc. | Humanized rodents that express heavy chains containing vl domains |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| TWI635098B (zh) | 2013-02-01 | 2018-09-11 | 再生元醫藥公司 | 含嵌合恆定區之抗體 |
| US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| RS62263B1 (sr) | 2013-04-16 | 2021-09-30 | Regeneron Pharma | Ciljana modifikacija genoma pacova |
| BR112016021679A2 (pt) | 2014-03-21 | 2018-12-04 | Regeneron Pharmaceuticals, Inc. | proteína de ligação ao antígeno, métodos de produção de uma proteína de ligação ao antígeno e de identificação de uma ou mais proteínas de ligação ao antígeno, hibridoma, ácido nucleico, célula, e, animal não humano geneticamente modificado. |
| BR112016021572A2 (pt) | 2014-03-21 | 2017-10-03 | Regeneron Pharma | Métodos para preparar um animal não humano geneticamente modificado e para produzir proteínas de ligação, hibridoma, ácido nucleico, célula, e, proteína de ligação |
| CA2979702A1 (en) | 2015-03-19 | 2016-09-22 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
-
2011
- 2011-08-02 CA CA3250882A patent/CA3250882A1/en active Pending
- 2011-08-02 KR KR1020217030387A patent/KR102434557B1/ko active Active
- 2011-08-02 EP EP11741730.3A patent/EP2601298B1/en active Active
- 2011-08-02 EP EP21174332.3A patent/EP3960865A1/en active Pending
- 2011-08-02 RU RU2013109068A patent/RU2612903C2/ru active
- 2011-08-02 LT LTEP11741730.3T patent/LT2601298T/lt unknown
- 2011-08-02 AU AU2011285919A patent/AU2011285919C1/en active Active
- 2011-08-02 JP JP2013523258A patent/JP6146913B2/ja active Active
- 2011-08-02 KR KR1020207027965A patent/KR102306967B1/ko active Active
- 2011-08-02 SI SI201131072A patent/SI2601298T1/sl unknown
- 2011-08-02 MX MX2013001360A patent/MX345251B/es active IP Right Grant
- 2011-08-02 CN CN202410984383.4A patent/CN118791596A/zh active Pending
- 2011-08-02 CN CN201180045609.5A patent/CN103154255B/zh active Active
- 2011-08-02 MX MX2016014021A patent/MX350591B/es unknown
- 2011-08-02 HR HRP20170322TT patent/HRP20170322T1/hr unknown
- 2011-08-02 WO PCT/US2011/046196 patent/WO2012018764A1/en not_active Ceased
- 2011-08-02 SG SG2013007893A patent/SG187673A1/en unknown
- 2011-08-02 KR KR1020197022706A patent/KR102163138B1/ko active Active
- 2011-08-02 CN CN202110412459.2A patent/CN113150121B9/zh active Active
- 2011-08-02 ES ES11741730.3T patent/ES2612459T3/es active Active
- 2011-08-02 CA CA2807282A patent/CA2807282A1/en active Pending
- 2011-08-02 HU HUE11741730A patent/HUE031903T2/en unknown
- 2011-08-02 CN CN201610124564.5A patent/CN105753979B/zh active Active
- 2011-08-02 KR KR1020137004960A patent/KR102008655B1/ko active Active
- 2011-08-02 MX MX2018014787A patent/MX2018014787A/es unknown
- 2011-08-02 US US13/195,951 patent/US9516868B2/en active Active
- 2011-08-02 DK DK11741730.3T patent/DK2601298T3/en active
- 2011-08-02 RU RU2017106292A patent/RU2750219C2/ru active
- 2011-08-02 BR BR112013002695-2A patent/BR112013002695B1/pt active IP Right Grant
- 2011-08-02 SG SG10201504971QA patent/SG10201504971QA/en unknown
- 2011-08-02 PT PT117417303T patent/PT2601298T/pt unknown
- 2011-08-02 PL PL11741730T patent/PL2601298T3/pl unknown
- 2011-08-02 SM SM20170023T patent/SMT201700023T1/it unknown
- 2011-08-02 EP EP15173007.4A patent/EP2947151A1/en not_active Ceased
- 2011-08-02 IL IL315833A patent/IL315833A/en unknown
- 2011-08-02 MX MX2017006698A patent/MX363084B/es unknown
- 2011-08-02 NZ NZ606824A patent/NZ606824A/en unknown
- 2011-08-02 SG SG10201912639SA patent/SG10201912639SA/en unknown
- 2011-08-02 RS RS20161086A patent/RS55495B1/sr unknown
- 2011-08-02 NZ NZ707327A patent/NZ707327A/en unknown
- 2011-08-02 IL IL271804A patent/IL271804B2/en unknown
- 2011-08-02 MY MYPI2013000340A patent/MY172618A/en unknown
-
2013
- 2013-01-31 IL IL224523A patent/IL224523B/en active IP Right Grant
- 2013-02-01 MX MX2023001793A patent/MX2023001793A/es unknown
- 2013-12-19 US US14/135,518 patent/US20140130194A1/en not_active Abandoned
- 2013-12-19 US US14/135,510 patent/US9686970B2/en active Active
-
2016
- 2016-01-21 JP JP2016009916A patent/JP2016054746A/ja not_active Withdrawn
- 2016-05-10 HK HK16105319.5A patent/HK1217511A1/en unknown
-
2017
- 2017-01-04 CY CY20171100009T patent/CY1118562T1/el unknown
- 2017-01-16 SM SM201700023T patent/SMT201700023B/it unknown
- 2017-04-25 US US15/497,043 patent/US20170226231A1/en not_active Abandoned
- 2017-04-25 US US15/497,075 patent/US10954310B2/en active Active
-
2018
- 2018-01-04 JP JP2018000123A patent/JP7078400B2/ja active Active
- 2018-03-25 IL IL258338A patent/IL258338B/en active IP Right Grant
- 2018-11-12 JP JP2018212094A patent/JP6759303B2/ja active Active
-
2020
- 2020-02-14 JP JP2020023076A patent/JP7110257B2/ja active Active
-
2021
- 2021-02-05 US US17/168,708 patent/US20210163628A1/en active Pending
- 2021-05-19 JP JP2021084769A patent/JP2021119792A/ja active Pending
- 2021-12-14 US US17/550,839 patent/US12486335B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018046872A5 (OSRAM) | ||
| JP2020039360A5 (OSRAM) | ||
| JP2020508655A5 (OSRAM) | ||
| JP2023052214A5 (OSRAM) | ||
| JP2020510646A5 (OSRAM) | ||
| JP2020514277A5 (OSRAM) | ||
| RU2019129511A (ru) | Белки, связывающие gd2, nkg2d и cd16 | |
| IL277355B1 (en) | Humanized rodents for testing therapeutic agents | |
| TR201901929T4 (tr) | TGFBeta'ya antikorlar. | |
| RU2011148913A (ru) | Иммуноглобулин с двумя вариабельными доменами и его применение | |
| JP2020508997A5 (OSRAM) | ||
| JP2018522888A5 (OSRAM) | ||
| JP2020507577A5 (OSRAM) | ||
| JP2020022482A5 (OSRAM) | ||
| JP2020513759A5 (OSRAM) | ||
| RU2019121086A (ru) | Иммунотерапия с применением антител, связывающих лиганд 1 белка программируемой смерти клеток (PD-L1) | |
| JP2017504578A5 (OSRAM) | ||
| RU2019124709A (ru) | КОМПОЗИЦИИ И СПОСОБЫ, СВЯЗАННЫЕ СО СКОНСТРУИРОВАННЫМИ КОНСТРУКЦИЯМИ НА ОСНОВЕ Fc-АНТИГЕНСВЯЗЫВАЮЩЕГО ДОМЕНА | |
| RU2018137110A (ru) | Антитела против psma и их применение | |
| JP2019534277A5 (OSRAM) | ||
| HRP20201785T1 (hr) | Multivalentni i multispecifični fuzijski proteini koji vežu dr5 | |
| RU2019128204A (ru) | Белки, связывающиеся с psma, nkg2d и cd16 | |
| JP2019505477A5 (OSRAM) | ||
| JP2017129381A5 (OSRAM) | ||
| RU2019121106A (ru) | Иммунотерапия с применением антител, связывающих белок 1 программируемой смерти клеток (pd-1) |