JP2017538659A5 - - Google Patents
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- JP2017538659A5 JP2017538659A5 JP2017512982A JP2017512982A JP2017538659A5 JP 2017538659 A5 JP2017538659 A5 JP 2017538659A5 JP 2017512982 A JP2017512982 A JP 2017512982A JP 2017512982 A JP2017512982 A JP 2017512982A JP 2017538659 A5 JP2017538659 A5 JP 2017538659A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cancer
- tumor
- group
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462048773P | 2014-09-10 | 2014-09-10 | |
| US62/048,773 | 2014-09-10 | ||
| US201562146799P | 2015-04-13 | 2015-04-13 | |
| US62/146,799 | 2015-04-13 | ||
| PCT/US2015/049221 WO2016040505A1 (en) | 2014-09-10 | 2015-09-09 | Smyd inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020013314A Division JP2020090520A (ja) | 2014-09-10 | 2020-01-30 | Smyd阻害剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017538659A JP2017538659A (ja) | 2017-12-28 |
| JP2017538659A5 true JP2017538659A5 (https=) | 2018-10-18 |
Family
ID=55459528
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017512982A Pending JP2017538659A (ja) | 2014-09-10 | 2015-09-09 | Smyd阻害剤 |
| JP2020013314A Pending JP2020090520A (ja) | 2014-09-10 | 2020-01-30 | Smyd阻害剤 |
| JP2022118248A Pending JP2022163087A (ja) | 2014-09-10 | 2022-07-25 | Smyd阻害剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020013314A Pending JP2020090520A (ja) | 2014-09-10 | 2020-01-30 | Smyd阻害剤 |
| JP2022118248A Pending JP2022163087A (ja) | 2014-09-10 | 2022-07-25 | Smyd阻害剤 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US10266526B2 (https=) |
| EP (1) | EP3193600A4 (https=) |
| JP (3) | JP2017538659A (https=) |
| KR (2) | KR102496364B1 (https=) |
| CN (2) | CN107072205B (https=) |
| AU (1) | AU2015315174B2 (https=) |
| BR (1) | BR112017004612A2 (https=) |
| CA (1) | CA2960275A1 (https=) |
| EA (1) | EA201790317A1 (https=) |
| IL (2) | IL250891A0 (https=) |
| MX (2) | MX2017002985A (https=) |
| SG (2) | SG10201901192TA (https=) |
| WO (1) | WO2016040505A1 (https=) |
Families Citing this family (38)
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|---|---|---|---|---|
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| MX353408B (es) | 2010-04-22 | 2018-01-11 | Vertex Pharma | Proceso para producir compuestos de cicloalquilcarboxamido-indol. |
| RU2744460C2 (ru) | 2014-04-15 | 2021-03-09 | Вертекс Фармасьютикалз Инкорпорейтед | Фармацевтические композиции для лечения заболеваний, опосредованных муковисцидозным трансмембранным регулятором проводимости |
| AU2015315171A1 (en) | 2014-09-10 | 2017-03-16 | Epizyme, Inc. | Substituted cyclohexylamine compounds |
| JP2017526706A (ja) | 2014-09-10 | 2017-09-14 | エピザイム,インコーポレイティド | イソオキサゾールカルボキサミド化合物 |
| CA2960280A1 (en) | 2014-09-10 | 2016-03-17 | Epizyme, Inc. | Substituted piperidine compounds |
| JP2017528460A (ja) | 2014-09-10 | 2017-09-28 | エピザイム インコーポレイテッド | 不可逆的smyd阻害剤としてのイソオキサゾールカルボキサミド |
| WO2018030550A1 (en) | 2016-08-09 | 2018-02-15 | Takeda Pharmaceutical Company Limited | Heterocyclic compounds with an ror(gamma)t modulating activity |
| WO2018151678A1 (en) * | 2017-02-15 | 2018-08-23 | Agency For Science, Technology And Research | Compounds for treatment of cancer and epigenetics |
| CN110770224B (zh) * | 2017-03-10 | 2022-11-18 | 罗格斯新泽西州立大学 | 作为外排泵抑制剂的吲哚衍生物 |
| US20200138827A1 (en) * | 2017-06-22 | 2020-05-07 | Curadev Pharma Limited | Small molecule modulators of human sting |
| PE20200696A1 (es) | 2017-06-22 | 2020-06-16 | Curadev Pharma Ltd | Moduladores de moleculas pequenas de sting humana |
| JP2020530844A (ja) | 2017-08-14 | 2020-10-29 | エピザイム,インコーポレイティド | Setd2を阻害することにより癌を処置する方法 |
| CN112585119A (zh) * | 2018-08-14 | 2021-03-30 | Epizyme股份有限公司 | 经取代的吲哚及其使用方法 |
| EP4541422A3 (en) | 2018-10-30 | 2025-06-25 | Gilead Sciences, Inc. | Quinoline derivatives as alpha4beta7 integrin inhibitors |
| AU2019373242B2 (en) | 2018-10-30 | 2023-07-13 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
| CN112969700B (zh) | 2018-10-30 | 2024-08-20 | 吉利德科学公司 | 作为α4β7整合素抑制剂的咪唑并吡啶衍生物 |
| KR102659859B1 (ko) | 2018-10-30 | 2024-04-25 | 길리애드 사이언시즈, 인코포레이티드 | 알파4β7 인테그린의 억제를 위한 화합물 |
| WO2021023858A1 (en) * | 2019-08-08 | 2021-02-11 | Université De Strasbourg | TrkB POSITIVE ALLOSTERIC MODULATORS |
| KR102908219B1 (ko) | 2019-08-14 | 2026-01-08 | 길리애드 사이언시즈, 인코포레이티드 | 알파 4 베타 7 인테그린의 저해용 화합물 |
| CA3164134A1 (en) | 2019-12-06 | 2021-06-10 | Vertex Pharmaceuticals Incorporated | Substituted tetrahydrofurans as modulators of sodium channels |
| IL294214B2 (en) * | 2019-12-27 | 2026-04-01 | Schrodinger Inc | Cyclic compounds and methods for using them |
| WO2021168313A1 (en) * | 2020-02-19 | 2021-08-26 | Epizyme, Inc. | Setd2 inhibitors and related methods and uses, including combination therapies |
| EP4164622A4 (en) | 2020-06-16 | 2024-09-11 | Icahn School of Medicine at Mount Sinai | SOX11 INHIBITORS FOR THE TREATMENT OF MANTLE CELL LYMPHOMA |
| CN116745291A (zh) | 2020-12-17 | 2023-09-12 | 阿斯利康(瑞典)有限公司 | N-(2-(4-氰基噻唑烷-3-基)-2-氧代乙基)-喹啉-4-甲酰胺 |
| SI4347031T1 (sl) | 2021-06-04 | 2026-01-30 | Vertex Pharmaceuticals Incorporated | N-(hidroksialkil (hetero)aril) tetrahidrofuran karboksamidi kot modulatorji natrijevih kanalčkov |
| CN114246851B (zh) * | 2021-11-09 | 2024-01-26 | 澳门科技大学 | 一种组蛋白甲基转移酶smyd3小分子抑制剂的合成方法及用途 |
| CN114702552B (zh) * | 2022-03-11 | 2024-05-31 | 苏州思萃免疫技术研究所有限公司 | mTORC2抑制剂 |
| WO2023192665A2 (en) * | 2022-04-01 | 2023-10-05 | Praxis Precision Medicines, Inc. | T-type calcium channel modulators and methods of use thereof |
| GB2620976B (en) * | 2022-07-28 | 2024-07-24 | Jones Paul | Amido-amine hardener |
| WO2024108155A2 (en) * | 2022-11-17 | 2024-05-23 | Denali Therapeutics Inc. | Compounds, compositions, and methods |
| WO2024108147A1 (en) * | 2022-11-17 | 2024-05-23 | Denali Therapeutics Inc. | Compounds, compositions, and methods |
| WO2024158863A1 (en) * | 2023-01-25 | 2024-08-02 | The Rockefeller University | Sulfonamide-1h-pyrrole-2-carboxamide inhibitors of sars-cov-2 nsp14 methyltransferase and derivatives thereof |
| CN116327748B (zh) * | 2023-04-21 | 2024-09-17 | 武汉科技大学 | 联合用药物在制备抗肿瘤药物中的用途 |
| WO2025165834A1 (en) * | 2024-01-31 | 2025-08-07 | Ensem Therapeutics, Inc. | Urea derivatives of tricyclic compounds, and compositions and methods thereof |
| WO2025264278A1 (en) * | 2024-06-18 | 2025-12-26 | Memorial Sloan-Kettering Cancer Center | Erk2 degraders |
| WO2026006505A1 (en) * | 2024-06-26 | 2026-01-02 | Virginia Commonwealth University | Compounds as nlrp3 inhibitors and compositions and uses thereof |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1441195A (en) * | 1993-12-30 | 1995-07-17 | Smithkline Beecham Corporation | Phenylmethyl hexanamides, and the use thereof |
| WO1998022432A1 (en) * | 1996-11-18 | 1998-05-28 | Yamanouchi Pharmaceutical Co., Ltd. | Novel acylamino-substituted acylanilide derivatives or pharmaceutical composition comprising the same |
| US7709479B1 (en) * | 1999-09-21 | 2010-05-04 | Astrazeneca | Quinazoline derivatives and their use as pharmaceuticals |
| US6867299B2 (en) * | 2000-02-24 | 2005-03-15 | Hoffmann-La Roche Inc. | Oxamide IMPDH inhibitors |
| TWI290136B (en) * | 2000-04-05 | 2007-11-21 | Daiichi Seiyaku Co | Ethylenediamine derivatives |
| KR20040101564A (ko) | 2000-07-19 | 2004-12-02 | 다케다 야쿠힌 고교 가부시키가이샤 | 1-치환-1,2,3-트리아졸 유도체, 그 중간체, 및 이들의제조 방법 |
| AUPR034000A0 (en) * | 2000-09-25 | 2000-10-19 | Fujisawa Pharmaceutical Co., Ltd. | Aminoalcohol derivatives |
| WO2002080928A1 (en) * | 2001-04-03 | 2002-10-17 | Merck & Co., Inc. | N-substituted nonaryl-heterocyclo amidyl nmda/nr2b antagonists |
| EP1314733A1 (en) * | 2001-11-22 | 2003-05-28 | Aventis Pharma Deutschland GmbH | Indole-2-carboxamides as factor Xa inhibitors |
| GB0205176D0 (en) * | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
| JP2004175739A (ja) * | 2002-11-28 | 2004-06-24 | Tanabe Seiyaku Co Ltd | 医薬組成物 |
| JP2004315395A (ja) * | 2003-04-14 | 2004-11-11 | Yamanouchi Pharmaceut Co Ltd | 新規な安息香酸誘導体又はその塩 |
| GB0317516D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as PDE4 inhibitors |
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| WO2005073224A2 (en) * | 2004-01-23 | 2005-08-11 | Amgen Inc | Quinoline quinazoline pyridine and pyrimidine counds and their use in the treatment of inflammation angiogenesis and cancer |
| JP4989976B2 (ja) * | 2004-02-13 | 2012-08-01 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | 翻訳開始阻害剤としての3−3−二置換オキシインドール |
| JP2006089485A (ja) * | 2004-08-24 | 2006-04-06 | Santen Pharmaceut Co Ltd | ジヒドロオロテートデヒドロゲナーゼ阻害活性を有する新規複素環アミド誘導体 |
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| JP2008534664A (ja) * | 2005-04-06 | 2008-08-28 | アストラゼネカ アクチボラグ | 置換複素環およびchk1、pdk1及びpak阻害剤としてのそれらの使用 |
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| WO2008016666A2 (en) * | 2006-08-02 | 2008-02-07 | Cytokinetics, Incorporated | Certain chemical entities, compositions, and methods |
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| CN103209982B (zh) * | 2010-10-14 | 2016-03-16 | Jw制药公司 | 反转模拟物的化合物、其制造方法及其用途 |
| AU2011338302A1 (en) * | 2010-12-08 | 2013-07-11 | Lycera Corporation | Cycloalkyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof |
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| EP2532661A1 (en) * | 2011-06-10 | 2012-12-12 | Syngenta Participations AG | Novel insecticides |
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| US9145412B2 (en) * | 2012-11-02 | 2015-09-29 | Acetylon Pharmaceuticals, Inc. | Selective HDAC1 and HDAC2 inhibitors |
| CN103877078B (zh) * | 2012-12-20 | 2017-03-15 | 上海交通大学医学院 | Senp2小分子抑制剂及其应用 |
| US20170253601A1 (en) | 2014-09-10 | 2017-09-07 | Epizyme, Inc. | Substituted Pyrrolidine Compounds |
| CA2960277A1 (en) | 2014-09-10 | 2016-03-17 | Epizyme, Inc. | Substituted pyrrolidine carboxamide compounds |
| JP2017526706A (ja) | 2014-09-10 | 2017-09-14 | エピザイム,インコーポレイティド | イソオキサゾールカルボキサミド化合物 |
| CA2960280A1 (en) | 2014-09-10 | 2016-03-17 | Epizyme, Inc. | Substituted piperidine compounds |
| AU2015315171A1 (en) | 2014-09-10 | 2017-03-16 | Epizyme, Inc. | Substituted cyclohexylamine compounds |
| JP2017528460A (ja) | 2014-09-10 | 2017-09-28 | エピザイム インコーポレイテッド | 不可逆的smyd阻害剤としてのイソオキサゾールカルボキサミド |
-
2015
- 2015-09-09 WO PCT/US2015/049221 patent/WO2016040505A1/en not_active Ceased
- 2015-09-09 US US15/510,586 patent/US10266526B2/en active Active
- 2015-09-09 CN CN201580060859.4A patent/CN107072205B/zh not_active Expired - Fee Related
- 2015-09-09 SG SG10201901192TA patent/SG10201901192TA/en unknown
- 2015-09-09 KR KR1020177009602A patent/KR102496364B1/ko active Active
- 2015-09-09 SG SG11201701598PA patent/SG11201701598PA/en unknown
- 2015-09-09 EA EA201790317A patent/EA201790317A1/ru unknown
- 2015-09-09 MX MX2017002985A patent/MX2017002985A/es unknown
- 2015-09-09 CA CA2960275A patent/CA2960275A1/en active Pending
- 2015-09-09 JP JP2017512982A patent/JP2017538659A/ja active Pending
- 2015-09-09 EP EP15840789.0A patent/EP3193600A4/en not_active Withdrawn
- 2015-09-09 AU AU2015315174A patent/AU2015315174B2/en not_active Ceased
- 2015-09-09 KR KR1020237003762A patent/KR20230026515A/ko not_active Ceased
- 2015-09-09 BR BR112017004612-1A patent/BR112017004612A2/pt not_active Application Discontinuation
- 2015-09-09 CN CN202210734932.3A patent/CN115028619A/zh active Pending
-
2017
- 2017-03-02 IL IL250891A patent/IL250891A0/en unknown
- 2017-03-07 MX MX2023006257A patent/MX2023006257A/es unknown
-
2019
- 2019-02-06 US US16/269,338 patent/US20190322660A1/en not_active Abandoned
-
2020
- 2020-01-30 JP JP2020013314A patent/JP2020090520A/ja active Pending
- 2020-05-01 US US16/864,891 patent/US20210198252A1/en not_active Abandoned
-
2021
- 2021-10-10 IL IL287113A patent/IL287113A/en unknown
- 2021-11-22 US US17/532,422 patent/US20230101819A1/en not_active Abandoned
-
2022
- 2022-07-25 JP JP2022118248A patent/JP2022163087A/ja active Pending
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