JP2020090520A5 - - Google Patents
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- JP2020090520A5 JP2020090520A5 JP2020013314A JP2020013314A JP2020090520A5 JP 2020090520 A5 JP2020090520 A5 JP 2020090520A5 JP 2020013314 A JP2020013314 A JP 2020013314A JP 2020013314 A JP2020013314 A JP 2020013314A JP 2020090520 A5 JP2020090520 A5 JP 2020090520A5
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- -1 1-imidazolyl Chemical group 0.000 claims 88
- 206010028980 Neoplasm Diseases 0.000 claims 31
- 239000008194 pharmaceutical composition Substances 0.000 claims 31
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 26
- 229910052739 hydrogen Inorganic materials 0.000 claims 24
- 239000001257 hydrogen Substances 0.000 claims 24
- 125000001072 heteroaryl group Chemical group 0.000 claims 23
- 125000003118 aryl group Chemical group 0.000 claims 22
- 206010039491 Sarcoma Diseases 0.000 claims 21
- 125000003282 alkyl amino group Chemical group 0.000 claims 21
- 125000004663 dialkyl amino group Chemical group 0.000 claims 21
- 150000001875 compounds Chemical class 0.000 claims 18
- 125000003710 aryl alkyl group Chemical group 0.000 claims 17
- 150000003839 salts Chemical class 0.000 claims 16
- 150000002431 hydrogen Chemical class 0.000 claims 13
- 125000006652 (C3-C12) cycloalkyl group Chemical group 0.000 claims 12
- 125000000753 cycloalkyl group Chemical group 0.000 claims 12
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 12
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 11
- 201000011510 cancer Diseases 0.000 claims 11
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- 229910052799 carbon Inorganic materials 0.000 claims 10
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- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Substances C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 6
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- UWYZHKAOTLEWKK-UHFFFAOYSA-N 1,2,3,4-tetrahydroisoquinoline Chemical compound C1=CC=C2CNCCC2=C1 UWYZHKAOTLEWKK-UHFFFAOYSA-N 0.000 claims 4
- 125000001399 1,2,3-triazolyl group Chemical group N1N=NC(=C1)* 0.000 claims 4
- 230000001154 acute effect Effects 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
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- 125000001376 1,2,4-triazolyl group Chemical group N1N=C(N=C1)* 0.000 claims 3
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 3
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- 125000004504 1,2,4-oxadiazolyl group Chemical group 0.000 claims 2
- KOFIDSXHWGFEMO-UHFFFAOYSA-N 1-(2-methylpropyl)pyrrolidine Chemical compound CC(C)CN1CCCC1 KOFIDSXHWGFEMO-UHFFFAOYSA-N 0.000 claims 2
- MCMFEZDRQOJKMN-UHFFFAOYSA-N 1-butylimidazole Chemical compound CCCCN1C=CN=C1 MCMFEZDRQOJKMN-UHFFFAOYSA-N 0.000 claims 2
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims 2
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 2
- 125000004485 2-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])C1([H])* 0.000 claims 2
- QVTTWNXAJRQQHZ-UHFFFAOYSA-N 5-prop-1-enyl-1h-imidazole Chemical compound CC=CC1=CN=CN1 QVTTWNXAJRQQHZ-UHFFFAOYSA-N 0.000 claims 2
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- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- VQLOEDJRIKSWII-UHFFFAOYSA-N ClC1=CC=C(CN2N=CC(=C2)CN2CC(C2)NC(=O)C=2N=NC=C(C=2)C2CC2)C=C1 Chemical compound ClC1=CC=C(CN2N=CC(=C2)CN2CC(C2)NC(=O)C=2N=NC=C(C=2)C2CC2)C=C1 VQLOEDJRIKSWII-UHFFFAOYSA-N 0.000 claims 2
- MOWCUCXGYVJUHU-UHFFFAOYSA-N ClC1=CC=C(CN2N=CC(=C2)CN2CC(C2)NC(=O)C=2N=NN(C=2)C2CC2)C=C1 Chemical compound ClC1=CC=C(CN2N=CC(=C2)CN2CC(C2)NC(=O)C=2N=NN(C=2)C2CC2)C=C1 MOWCUCXGYVJUHU-UHFFFAOYSA-N 0.000 claims 2
- FAONROFAUHXDEW-UHFFFAOYSA-N ClC1=CC=C(CN2N=CC(=C2)CN2CC(C2)NC(=O)C=2NC=C(N=2)C2CC2)C=C1 Chemical compound ClC1=CC=C(CN2N=CC(=C2)CN2CC(C2)NC(=O)C=2NC=C(N=2)C2CC2)C=C1 FAONROFAUHXDEW-UHFFFAOYSA-N 0.000 claims 2
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- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 2
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- 125000001691 aryl alkyl amino group Chemical group 0.000 claims 2
- 125000005160 aryl oxy alkyl group Chemical group 0.000 claims 2
- INSSHDIMRIMVLZ-UHFFFAOYSA-N butan-2-ylcyclopropane Chemical compound CCC(C)C1CC1 INSSHDIMRIMVLZ-UHFFFAOYSA-N 0.000 claims 2
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- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 2
- YOXHCYXIAVIFCZ-UHFFFAOYSA-N cyclopropanol Chemical compound OC1CC1 YOXHCYXIAVIFCZ-UHFFFAOYSA-N 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
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- NPUKKLNOJTXUGO-UHFFFAOYSA-N n-[1-(4-acetamidophenyl)sulfonylpiperidin-4-yl]benzamide Chemical compound C1=CC(NC(=O)C)=CC=C1S(=O)(=O)N1CCC(NC(=O)C=2C=CC=CC=2)CC1 NPUKKLNOJTXUGO-UHFFFAOYSA-N 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 201000008968 osteosarcoma Diseases 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 claims 2
- 125000004307 pyrazin-2-yl group Chemical group [H]C1=C([H])N=C(*)C([H])=N1 0.000 claims 2
- 125000002098 pyridazinyl group Chemical group 0.000 claims 2
- 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 claims 2
- 125000004528 pyrimidin-5-yl group Chemical group N1=CN=CC(=C1)* 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- 125000000168 pyrrolyl group Chemical group 0.000 claims 2
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- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- QNRATNLHPGXHMA-XZHTYLCXSA-N (r)-(6-ethoxyquinolin-4-yl)-[(2s,4s,5r)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]methanol;hydrochloride Chemical compound Cl.C([C@H]([C@H](C1)CC)C2)CN1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OCC)C=C21 QNRATNLHPGXHMA-XZHTYLCXSA-N 0.000 claims 1
- XXBQLHATYQHJQC-UHFFFAOYSA-N 1,2-dihydroquinoxaline Chemical compound C1=CC=C2N=CCNC2=C1 XXBQLHATYQHJQC-UHFFFAOYSA-N 0.000 claims 1
- HYTIPJFUWHYQON-UHFFFAOYSA-N 3,4-dihydro-1h-quinoxalin-2-one Chemical compound C1=CC=C2NC(=O)CNC2=C1 HYTIPJFUWHYQON-UHFFFAOYSA-N 0.000 claims 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- CWDWFSXUQODZGW-UHFFFAOYSA-N 5-thiazolyl Chemical group [C]1=CN=CS1 CWDWFSXUQODZGW-UHFFFAOYSA-N 0.000 claims 1
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022118248A JP2022163087A (ja) | 2014-09-10 | 2022-07-25 | Ｓｍｙｄ阻害剤 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462048773P | 2014-09-10 | 2014-09-10 | |
| US62/048,773 | 2014-09-10 | ||
| US201562146799P | 2015-04-13 | 2015-04-13 | |
| US62/146,799 | 2015-04-13 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017512982A Division JP2017538659A (ja) | 2014-09-10 | 2015-09-09 | Ｓｍｙｄ阻害剤 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022118248A Division JP2022163087A (ja) | 2014-09-10 | 2022-07-25 | Ｓｍｙｄ阻害剤 |
Publications (2)
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|---|---|
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| RU2744460C2 (ru) | 2014-04-15 | 2021-03-09 | Вертекс Фармасьютикалз Инкорпорейтед | Фармацевтические композиции для лечения заболеваний, опосредованных муковисцидозным трансмембранным регулятором проводимости |
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-
2015
- 2015-09-09 WO PCT/US2015/049221 patent/WO2016040505A1/en not_active Ceased
- 2015-09-09 US US15/510,586 patent/US10266526B2/en active Active
- 2015-09-09 CN CN201580060859.4A patent/CN107072205B/zh not_active Expired - Fee Related
- 2015-09-09 SG SG10201901192TA patent/SG10201901192TA/en unknown
- 2015-09-09 KR KR1020177009602A patent/KR102496364B1/ko active Active
- 2015-09-09 SG SG11201701598PA patent/SG11201701598PA/en unknown
- 2015-09-09 EA EA201790317A patent/EA201790317A1/ru unknown
- 2015-09-09 MX MX2017002985A patent/MX2017002985A/es unknown
- 2015-09-09 CA CA2960275A patent/CA2960275A1/en active Pending
- 2015-09-09 JP JP2017512982A patent/JP2017538659A/ja active Pending
- 2015-09-09 EP EP15840789.0A patent/EP3193600A4/en not_active Withdrawn
- 2015-09-09 AU AU2015315174A patent/AU2015315174B2/en not_active Ceased
- 2015-09-09 KR KR1020237003762A patent/KR20230026515A/ko not_active Ceased
- 2015-09-09 BR BR112017004612-1A patent/BR112017004612A2/pt not_active Application Discontinuation
- 2015-09-09 CN CN202210734932.3A patent/CN115028619A/zh active Pending
-
2017
- 2017-03-02 IL IL250891A patent/IL250891A0/en unknown
- 2017-03-07 MX MX2023006257A patent/MX2023006257A/es unknown
-
2019
- 2019-02-06 US US16/269,338 patent/US20190322660A1/en not_active Abandoned
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2020
- 2020-01-30 JP JP2020013314A patent/JP2020090520A/ja active Pending
- 2020-05-01 US US16/864,891 patent/US20210198252A1/en not_active Abandoned
-
2021
- 2021-10-10 IL IL287113A patent/IL287113A/en unknown
- 2021-11-22 US US17/532,422 patent/US20230101819A1/en not_active Abandoned
-
2022
- 2022-07-25 JP JP2022118248A patent/JP2022163087A/ja active Pending
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