JP2017537969A5 - - Google Patents
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- Publication number
- JP2017537969A5 JP2017537969A5 JP2017532678A JP2017532678A JP2017537969A5 JP 2017537969 A5 JP2017537969 A5 JP 2017537969A5 JP 2017532678 A JP2017532678 A JP 2017532678A JP 2017532678 A JP2017532678 A JP 2017532678A JP 2017537969 A5 JP2017537969 A5 JP 2017537969A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- protecting group
- formula
- acceptable salt
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims description 82
- 125000006239 protecting group Chemical group 0.000 claims description 60
- 150000003839 salts Chemical class 0.000 claims description 48
- 238000000034 method Methods 0.000 claims description 16
- 239000008194 pharmaceutical composition Substances 0.000 claims description 16
- 206010028980 Neoplasm Diseases 0.000 claims description 14
- 201000011510 cancer Diseases 0.000 claims description 14
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims description 12
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims description 12
- 238000000634 powder X-ray diffraction Methods 0.000 claims description 10
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 10
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 208000017805 post-transplant lymphoproliferative disease Diseases 0.000 claims description 8
- 230000005855 radiation Effects 0.000 claims description 8
- -1 1-methyl-1H-pyrazol-4-yl Chemical group 0.000 claims description 6
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims description 6
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims description 6
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims description 4
- 206010025323 Lymphomas Diseases 0.000 claims description 4
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims description 4
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims description 4
- 208000027190 Peripheral T-cell lymphomas Diseases 0.000 claims description 4
- 208000031672 T-Cell Peripheral Lymphoma Diseases 0.000 claims description 4
- 239000003153 chemical reaction reagent Substances 0.000 claims description 4
- 230000003111 delayed effect Effects 0.000 claims description 4
- 239000002552 dosage form Substances 0.000 claims description 4
- 201000003444 follicular lymphoma Diseases 0.000 claims description 4
- 208000032839 leukemia Diseases 0.000 claims description 4
- 208000020968 mature T-cell and NK-cell non-Hodgkin lymphoma Diseases 0.000 claims description 4
- 206010006187 Breast cancer Diseases 0.000 claims description 2
- 208000026310 Breast neoplasm Diseases 0.000 claims description 2
- 229910002483 Cu Ka Inorganic materials 0.000 claims description 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 2
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims description 2
- 208000001894 Nasopharyngeal Neoplasms Diseases 0.000 claims description 2
- 206010061306 Nasopharyngeal cancer Diseases 0.000 claims description 2
- 206010033128 Ovarian cancer Diseases 0.000 claims description 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- 230000001684 chronic effect Effects 0.000 claims description 2
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims description 2
- 239000012351 deprotecting agent Substances 0.000 claims description 2
- 238000010511 deprotection reaction Methods 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000022244 formylation Effects 0.000 claims description 2
- 238000006170 formylation reaction Methods 0.000 claims description 2
- 206010017758 gastric cancer Diseases 0.000 claims description 2
- 201000005202 lung cancer Diseases 0.000 claims description 2
- 208000020816 lung neoplasm Diseases 0.000 claims description 2
- 201000011549 stomach cancer Diseases 0.000 claims description 2
- 239000000126 substance Substances 0.000 description 22
- 0 *[C@@]1[C@@](*c(nc(c(C(N2)=O)c3C2O)Cl)c3F)CCCC1 Chemical compound *[C@@]1[C@@](*c(nc(c(C(N2)=O)c3C2O)Cl)c3F)CCCC1 0.000 description 1
- OJKXBPMNEIRBIC-UHFFFAOYSA-N OC(c(c1c(nc2F)Cl)c2F)NC1=O Chemical compound OC(c(c1c(nc2F)Cl)c2F)NC1=O OJKXBPMNEIRBIC-UHFFFAOYSA-N 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020080282A JP6974534B2 (ja) | 2014-12-18 | 2020-04-30 | 縮合複素芳香族ピロリジノンの固体状態形態 |
| JP2021180105A JP2022017477A (ja) | 2014-12-18 | 2021-11-04 | 縮合複素芳香族ピロリジノンの固体状態形態 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462093564P | 2014-12-18 | 2014-12-18 | |
| US62/093,564 | 2014-12-18 | ||
| US201562115223P | 2015-02-12 | 2015-02-12 | |
| US62/115,223 | 2015-02-12 | ||
| US201562180222P | 2015-06-16 | 2015-06-16 | |
| US62/180,222 | 2015-06-16 | ||
| PCT/IB2015/002489 WO2016097862A2 (en) | 2014-12-18 | 2015-12-17 | Solid state forms of fused heteroaromatic pyrrolidinones |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020080282A Division JP6974534B2 (ja) | 2014-12-18 | 2020-04-30 | 縮合複素芳香族ピロリジノンの固体状態形態 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017537969A JP2017537969A (ja) | 2017-12-21 |
| JP2017537969A5 true JP2017537969A5 (OSRAM) | 2019-02-14 |
| JP6778195B2 JP6778195B2 (ja) | 2020-10-28 |
Family
ID=55299676
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017532678A Active JP6778195B2 (ja) | 2014-12-18 | 2015-12-17 | 縮合複素芳香族ピロリジノンの固体状態形態 |
| JP2020080282A Active JP6974534B2 (ja) | 2014-12-18 | 2020-04-30 | 縮合複素芳香族ピロリジノンの固体状態形態 |
| JP2021180105A Pending JP2022017477A (ja) | 2014-12-18 | 2021-11-04 | 縮合複素芳香族ピロリジノンの固体状態形態 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020080282A Active JP6974534B2 (ja) | 2014-12-18 | 2020-04-30 | 縮合複素芳香族ピロリジノンの固体状態形態 |
| JP2021180105A Pending JP2022017477A (ja) | 2014-12-18 | 2021-11-04 | 縮合複素芳香族ピロリジノンの固体状態形態 |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US10676473B2 (OSRAM) |
| EP (2) | EP3233857B1 (OSRAM) |
| JP (3) | JP6778195B2 (OSRAM) |
| KR (1) | KR102037502B1 (OSRAM) |
| CN (1) | CN107108609B (OSRAM) |
| AU (1) | AU2015365580B2 (OSRAM) |
| BR (1) | BR112017013149B1 (OSRAM) |
| CA (1) | CA2970864C (OSRAM) |
| CL (1) | CL2017001561A1 (OSRAM) |
| CO (1) | CO2017005910A2 (OSRAM) |
| CR (1) | CR20170249A (OSRAM) |
| DK (1) | DK3233857T3 (OSRAM) |
| DO (1) | DOP2017000130A (OSRAM) |
| EA (1) | EA032291B1 (OSRAM) |
| EC (1) | ECSP17038100A (OSRAM) |
| ES (1) | ES2788454T3 (OSRAM) |
| GE (1) | GEP20197050B (OSRAM) |
| IL (1) | IL252941B (OSRAM) |
| MX (1) | MX373586B (OSRAM) |
| MY (1) | MY199935A (OSRAM) |
| NZ (1) | NZ732371A (OSRAM) |
| PE (1) | PE20171179A1 (OSRAM) |
| PH (1) | PH12017501123A1 (OSRAM) |
| PL (1) | PL3233857T3 (OSRAM) |
| SG (1) | SG11201701911QA (OSRAM) |
| TN (1) | TN2017000080A1 (OSRAM) |
| UA (1) | UA120632C2 (OSRAM) |
| WO (1) | WO2016097862A2 (OSRAM) |
| ZA (1) | ZA201701800B (OSRAM) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3233857T3 (pl) * | 2014-12-18 | 2020-07-27 | Takeda Pharmaceutical Company Limited | Stałe postacie skondensowanych heteroaromatycznych pirolidynonów |
| CA3030630A1 (en) * | 2016-07-13 | 2018-01-18 | Takeda Pharmaceutical Company Limited | Combination of spleen tyrosine kinase inhibitors and other therapeutic agents |
| JP2020537678A (ja) | 2017-10-19 | 2020-12-24 | バイエル・アニマル・ヘルス・ゲーエムベーハー | 動物における疾患の治療および予防のための縮合ヘテロ芳香族ピロリドンの使用 |
| WO2019088039A1 (en) | 2017-10-30 | 2019-05-09 | Takeda Pharmaceutical Company Limited | Treatment of acute myeloid leukemia |
| ES2971892T3 (es) * | 2018-12-14 | 2024-06-10 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | Formas cristalinas del inhibidor de Syk sal hidrocloruro de 5-fluoro-1-metil-3-[[5-[4-(3-oxetanil)-1-piperazinil]-2-piridinil]amino]-6-(1H-pirazol-3-il)-2(1H)-quinolinona (1:1) |
| CN113453680A (zh) | 2019-02-07 | 2021-09-28 | 詹森生物科技公司 | 二氢乳清酸脱氢酶抑制剂 |
| TW202104207A (zh) | 2019-04-17 | 2021-02-01 | 美商健生生物科技公司 | 二氫乳清酸脫氫酶抑制劑 |
| WO2021070132A1 (en) | 2019-10-10 | 2021-04-15 | Janssen Biotech, Inc. | Bi-aryl dihydroorotate dehydrogenase inhibitors |
| AU2020404305A1 (en) | 2019-12-19 | 2022-08-04 | Janssen Pharmaceutica Nv | Substituted straight chain spiro derivatives |
| WO2022074534A1 (en) | 2020-10-05 | 2022-04-14 | Janssen Biotech, Inc. | Combinations of dihydroorotate dehydrogenase inhibitors and hypomethylating agents |
| WO2022127753A1 (zh) * | 2020-12-18 | 2022-06-23 | 山东轩竹医药科技有限公司 | 稠环类AhR抑制剂 |
| JP2024518497A (ja) | 2021-05-11 | 2024-05-01 | ヤンセン ファーマシューティカ エヌ．ベー． | 併用療法 |
| KR20240006638A (ko) | 2021-05-11 | 2024-01-15 | 얀센 파마슈티카 엔브이 | 조합 요법 |
| CN120322230A (zh) | 2022-11-30 | 2025-07-15 | 詹森药业有限公司 | 包含多发性内分泌癌蛋白-mll抑制剂和至少一种其他治疗剂的组合 |
| WO2024114666A1 (en) | 2022-11-30 | 2024-06-06 | Janssen Pharmaceutica Nv | Combinations comprising a menin-mll inhibitor and a bcl-2 inhibitor |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1960372B1 (en) * | 2005-12-15 | 2015-12-09 | Rigel Pharmaceuticals, Inc. | Kinase inhibitors and their uses |
| US8440689B2 (en) | 2009-12-23 | 2013-05-14 | Takeda Pharmaceutical Company Limited | Fused heteroaromatic pyrrolidinones |
| EP2723739B1 (en) | 2011-06-22 | 2016-08-24 | Takeda Pharmaceutical Company Limited | Substituted 6-aza-isoindolin-1-one derivatives |
| TW201625263A (zh) * | 2014-09-24 | 2016-07-16 | 千禧製藥公司 | 利用ＰＩ３Ｋα抑制劑與紫杉烷之組合治療 |
| PL3233857T3 (pl) * | 2014-12-18 | 2020-07-27 | Takeda Pharmaceutical Company Limited | Stałe postacie skondensowanych heteroaromatycznych pirolidynonów |
-
2015
- 2015-12-17 PL PL15831150T patent/PL3233857T3/pl unknown
- 2015-12-17 MY MYPI2017702209A patent/MY199935A/en unknown
- 2015-12-17 PE PE2017000944A patent/PE20171179A1/es unknown
- 2015-12-17 EP EP15831150.6A patent/EP3233857B1/en active Active
- 2015-12-17 CN CN201580068971.2A patent/CN107108609B/zh active Active
- 2015-12-17 TN TN2017000080A patent/TN2017000080A1/en unknown
- 2015-12-17 WO PCT/IB2015/002489 patent/WO2016097862A2/en not_active Ceased
- 2015-12-17 AU AU2015365580A patent/AU2015365580B2/en active Active
- 2015-12-17 BR BR112017013149-8A patent/BR112017013149B1/pt not_active IP Right Cessation
- 2015-12-17 GE GEAP201514545A patent/GEP20197050B/en unknown
- 2015-12-17 EP EP20156863.1A patent/EP3677582B1/en active Active
- 2015-12-17 DK DK15831150.6T patent/DK3233857T3/da active
- 2015-12-17 KR KR1020177019929A patent/KR102037502B1/ko active Active
- 2015-12-17 SG SG11201701911QA patent/SG11201701911QA/en unknown
- 2015-12-17 MX MX2017007162A patent/MX373586B/es active IP Right Grant
- 2015-12-17 NZ NZ732371A patent/NZ732371A/en not_active IP Right Cessation
- 2015-12-17 EA EA201791369A patent/EA032291B1/ru unknown
- 2015-12-17 US US14/973,180 patent/US10676473B2/en active Active
- 2015-12-17 JP JP2017532678A patent/JP6778195B2/ja active Active
- 2015-12-17 ES ES15831150T patent/ES2788454T3/es active Active
- 2015-12-17 CA CA2970864A patent/CA2970864C/en active Active
- 2015-12-17 UA UAA201707489A patent/UA120632C2/uk unknown
- 2015-12-17 CR CR20170249A patent/CR20170249A/es unknown
-
2017
- 2017-03-13 ZA ZA2017/01800A patent/ZA201701800B/en unknown
- 2017-05-31 DO DO2017000130A patent/DOP2017000130A/es unknown
- 2017-06-15 PH PH12017501123A patent/PH12017501123A1/en unknown
- 2017-06-15 CO CONC2017/0005910A patent/CO2017005910A2/es unknown
- 2017-06-15 IL IL252941A patent/IL252941B/en active IP Right Grant
- 2017-06-15 CL CL2017001561A patent/CL2017001561A1/es unknown
- 2017-06-16 EC ECIEPI201738100A patent/ECSP17038100A/es unknown
-
2020
- 2020-04-30 JP JP2020080282A patent/JP6974534B2/ja active Active
- 2020-05-08 US US16/870,653 patent/US11352355B2/en active Active
-
2021
- 2021-11-04 JP JP2021180105A patent/JP2022017477A/ja active Pending
-
2022
- 2022-12-23 US US18/088,286 patent/US20230348461A1/en active Pending
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