JP2017537611A5 - - Google Patents
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- JP2017537611A5 JP2017537611A5 JP2017522083A JP2017522083A JP2017537611A5 JP 2017537611 A5 JP2017537611 A5 JP 2017537611A5 JP 2017522083 A JP2017522083 A JP 2017522083A JP 2017522083 A JP2017522083 A JP 2017522083A JP 2017537611 A5 JP2017537611 A5 JP 2017537611A5
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- JP
- Japan
- Prior art keywords
- domain
- dna binding
- atr
- operably linked
- binding domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021213691A JP7623272B2 (ja) | 2014-10-24 | 2021-12-28 | 持続的エピジェネティック遺伝子サイレンシング |
| JP2025005873A JP2025063201A (ja) | 2014-10-24 | 2025-01-16 | 持続的エピジェネティック遺伝子サイレンシング |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1418965.8 | 2014-10-24 | ||
| GBGB1418965.8A GB201418965D0 (https=) | 2014-10-24 | 2014-10-24 | |
| PCT/IB2015/058202 WO2016063264A1 (en) | 2014-10-24 | 2015-10-23 | Permanent epigenetic gene silencing |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021213691A Division JP7623272B2 (ja) | 2014-10-24 | 2021-12-28 | 持続的エピジェネティック遺伝子サイレンシング |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017537611A JP2017537611A (ja) | 2017-12-21 |
| JP2017537611A5 true JP2017537611A5 (https=) | 2018-12-06 |
| JP7002936B2 JP7002936B2 (ja) | 2022-02-04 |
Family
ID=52103358
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017522083A Active JP7002936B2 (ja) | 2014-10-24 | 2015-10-23 | 持続的エピジェネティック遺伝子サイレンシング |
| JP2021213691A Active JP7623272B2 (ja) | 2014-10-24 | 2021-12-28 | 持続的エピジェネティック遺伝子サイレンシング |
| JP2025005873A Pending JP2025063201A (ja) | 2014-10-24 | 2025-01-16 | 持続的エピジェネティック遺伝子サイレンシング |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021213691A Active JP7623272B2 (ja) | 2014-10-24 | 2021-12-28 | 持続的エピジェネティック遺伝子サイレンシング |
| JP2025005873A Pending JP2025063201A (ja) | 2014-10-24 | 2025-01-16 | 持続的エピジェネティック遺伝子サイレンシング |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US12152240B2 (https=) |
| EP (2) | EP3995584A1 (https=) |
| JP (3) | JP7002936B2 (https=) |
| CN (2) | CN107109433B (https=) |
| AU (3) | AU2015334469B2 (https=) |
| CA (1) | CA2965591A1 (https=) |
| DK (1) | DK3209783T3 (https=) |
| ES (1) | ES2906263T3 (https=) |
| GB (1) | GB201418965D0 (https=) |
| HU (1) | HUE057846T2 (https=) |
| PL (1) | PL3209783T3 (https=) |
| PT (1) | PT3209783T (https=) |
| WO (1) | WO2016063264A1 (https=) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3597741A1 (en) | 2012-04-27 | 2020-01-22 | Duke University | Genetic correction of mutated genes |
| US9828582B2 (en) | 2013-03-19 | 2017-11-28 | Duke University | Compositions and methods for the induction and tuning of gene expression |
| GB201418965D0 (https=) | 2014-10-24 | 2014-12-10 | Ospedale San Raffaele And Fond Telethon | |
| WO2016073955A2 (en) * | 2014-11-06 | 2016-05-12 | President And Fellows Of Harvard College | Cells lacking b2m surface expression and methods for allogeneic administration of such cells |
| US10676726B2 (en) | 2015-02-09 | 2020-06-09 | Duke University | Compositions and methods for epigenome editing |
| KR20260048600A (ko) * | 2015-03-27 | 2026-04-10 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 변형된 t 세포 및 이의 제조 및 사용 방법 |
| US11674144B2 (en) * | 2015-04-16 | 2023-06-13 | California Institute Of Technology | Fractional regulation of transcription |
| EP3294342A4 (en) | 2015-05-08 | 2018-11-07 | President and Fellows of Harvard College | Universal donor stem cells and related methods |
| EP4089175A1 (en) | 2015-10-13 | 2022-11-16 | Duke University | Genome engineering with type i crispr systems in eukaryotic cells |
| EA201891317A3 (ru) | 2015-11-30 | 2019-04-30 | Дьюк Юниверсити | Терапевтические мишени для коррекции гена дистрофина человека с помощью редактирования генов и способы их применения |
| EA201891338A1 (ru) | 2015-12-04 | 2018-12-28 | Новартис Аг | Композиции и способы для иммуноонкологии |
| US20190127713A1 (en) | 2016-04-13 | 2019-05-02 | Duke University | Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use |
| US11286493B2 (en) | 2016-05-27 | 2022-03-29 | The Regents Of The University Of California | Methods and compositions for targeting RNA polymerases and non-coding RNA biogenesis to specific loci |
| WO2017208247A1 (en) * | 2016-06-02 | 2017-12-07 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Assay for the removal of methyl-cytosine residues from dna |
| WO2018017754A1 (en) | 2016-07-19 | 2018-01-25 | Duke University | Therapeutic applications of cpf1-based genome editing |
| JP7308143B2 (ja) | 2016-08-19 | 2023-07-13 | ホワイトヘッド・インスティテュート・フォー・バイオメディカル・リサーチ | Ｄｎａメチル化の編集方法 |
| JP7682604B2 (ja) | 2016-09-07 | 2025-05-26 | フラッグシップ パイオニアリング イノベーションズ ブイ， インコーポレイテッド | 遺伝子発現をモジュレートするための方法および組成物 |
| WO2018111944A1 (en) * | 2016-12-12 | 2018-06-21 | Whitehead Institute For Biomedical Research | Regulation of transcription through ctcf loop anchors |
| EP3565891B1 (en) | 2017-01-09 | 2023-04-12 | Whitehead Institute for Biomedical Research | Methods of altering gene expression by perturbing transcription factor multimers that structure regulatory loops |
| EP3589330A4 (en) * | 2017-03-03 | 2021-01-06 | Flagship Pioneering Innovations V, Inc. | METHODS AND SYSTEMS FOR THE MODIFICATION OF DNA |
| WO2018175636A2 (en) | 2017-03-22 | 2018-09-27 | Novartis Ag | Compositions and methods for immunooncology |
| MX2019013514A (es) | 2017-05-12 | 2020-01-20 | Crispr Therapeutics Ag | Materiales y metodos para modificar celulas por ingenieria genetica y usos de los mismos en inmunooncologia. |
| US11166985B2 (en) | 2017-05-12 | 2021-11-09 | Crispr Therapeutics Ag | Materials and methods for engineering cells and uses thereof in immuno-oncology |
| US11072782B2 (en) | 2017-07-24 | 2021-07-27 | Albert-Ludwigs-Universitaet Freiburg | Construct for epigenetic modification and its use in the silencing of genes |
| CN107759673B (zh) * | 2017-09-27 | 2021-06-04 | 复旦大学 | 可对hbv的dna进行表观甲基化修饰的蛋白分子及其应用 |
| US11629342B2 (en) | 2017-10-17 | 2023-04-18 | President And Fellows Of Harvard College | Cas9-based transcription modulation systems |
| WO2019144061A1 (en) | 2018-01-19 | 2019-07-25 | Duke University | Genome engineering with crispr-cas systems in eukaryotes |
| JP7555822B2 (ja) * | 2018-04-19 | 2024-09-25 | ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア | ゲノム編集のための組成物および方法 |
| US12227763B2 (en) | 2018-05-11 | 2025-02-18 | Crispr Therapeutics Ag | Methods and compositions for treating cancer |
| CA3122131A1 (en) * | 2018-09-21 | 2020-03-26 | Zonghai Li | Method for gene editing of cell on the basis of crispr/cas system |
| GB201817821D0 (en) * | 2018-10-31 | 2018-12-19 | Ospedale San Raffaele Srl | TCR and peptides |
| US12428639B2 (en) | 2019-03-05 | 2025-09-30 | Ramot At Tel-Aviv University Ltd. | Plant DNA methyltransferases and uses thereof |
| MX2021012836A (es) | 2019-04-23 | 2021-12-10 | Sangamo Therapeutics Inc | Moduladores de la expresion del gen del marco de lectura abierto 72 del cromosoma 9 y usos de los mismos. |
| US20220249558A1 (en) | 2019-04-30 | 2022-08-11 | Crispr Therapeutics Ag | Allogeneic cell therapy of b cell malignancies using genetically engineered t cells targeting cd19 |
| CN114729376A (zh) | 2019-09-23 | 2022-07-08 | 欧米茄治疗公司 | 用于调节肝细胞核因子4α(HNF4α)基因表达的组合物和方法 |
| BR112022009137A2 (pt) * | 2019-11-13 | 2022-07-26 | Crispr Therapeutics Ag | Métodos de fabricação de células t com receptor de antígeno quimérico (car) |
| TW202132333A (zh) * | 2019-11-13 | 2021-09-01 | 瑞士商Ｃｒｉｓｐｒ治療公司 | 製造可表達嵌合抗原受體的ｔ細胞製法 |
| AU2021350024A1 (en) * | 2020-09-24 | 2023-05-04 | Flagship Pioneering Innovations V, Inc. | Compositions and methods for inhibiting gene expression |
| CA3202977A1 (en) * | 2020-12-22 | 2022-06-30 | Chroma Medicine, Inc. | Compositions and methods for epigenetic editing |
| KR20230152689A (ko) * | 2021-02-01 | 2023-11-03 | 엡실렌 바이오 에스.알.엘. | 유전자 침묵 |
| KR20230171424A (ko) * | 2021-02-15 | 2023-12-20 | 오스페달레 산 라파엘 에스.알.엘. | 암의 치료를 위한 후성적 침묵 |
| JP2024534523A (ja) | 2021-09-21 | 2024-09-20 | スクライブ・セラピューティクス・インコーポレイテッド | 操作されたｃａｓｘリプレッサー系 |
| CN115247175B (zh) * | 2021-11-25 | 2025-10-17 | 南京启真基因工程有限公司 | 构建setdb1基因突变的表观遗传失调模型猪核移植供体细胞的基因编辑系统及其应用 |
| TW202346588A (zh) * | 2022-03-04 | 2023-12-01 | 大陸商益杰立科（上海）生物科技有限公司 | 基因組編輯的組成物和方法 |
| WO2023240076A1 (en) | 2022-06-07 | 2023-12-14 | Scribe Therapeutics Inc. | Compositions and methods for the targeting of pcsk9 |
| US20250387514A1 (en) * | 2022-06-23 | 2025-12-25 | Nchroma Bio, Inc. | Compositions and methods for epigenetic regulation of trac expression |
| WO2023250148A1 (en) * | 2022-06-23 | 2023-12-28 | Chroma Medicine, Inc. | Compositions and methods for epigenetic editing |
| EP4544058A1 (en) * | 2022-06-23 | 2025-04-30 | Chroma Medicine, Inc. | Compositions and methods for epigenetic regulation of ciita expression |
| WO2023250509A1 (en) * | 2022-06-23 | 2023-12-28 | Chroma Medicine, Inc. | Compositions and methods for epigenetic regulation of b2m expression |
| IL317874A (en) | 2022-06-24 | 2025-02-01 | Tune Therapeutics Inc | Compounds, systems and methods for reducing low density lipoproteins through targeted gene suppression |
| JP2025527567A (ja) | 2022-08-19 | 2025-08-22 | チューン セラピューティクス インコーポレイテッド | ターゲティングされた遺伝子抑制によるｂ型肝炎ウイルスの調節のための組成物、システム、および方法 |
| KR20250110209A (ko) * | 2022-09-23 | 2025-07-18 | 엔크로마 바이오, 인크. | Hbv 유전자 발현의 에피제네틱 조절을 위한 조성물 및 방법 |
| WO2024081879A1 (en) * | 2022-10-14 | 2024-04-18 | Chroma Medicine, Inc. | Compositions and methods for epigenetic regulation of cd247 expression |
| GB2643476A (en) | 2023-02-17 | 2026-02-18 | Whitehead Inst Biomedical Res | Compositions and methods for making epigenetic modifications |
| WO2024220857A1 (en) * | 2023-04-20 | 2024-10-24 | Chroma Medicine, Inc. | Fusion proteins for epigenetic regulation |
| WO2024238700A1 (en) * | 2023-05-15 | 2024-11-21 | Chroma Medicine, Inc. | Compositions and methods for epigenetic regulation of hbv gene expression |
| IL324634A (en) | 2023-05-15 | 2026-01-01 | Nchroma Bio Inc | Compositions and methods for epigenetic regulation of hbv gene expression |
| IT202300011790A1 (it) | 2023-06-08 | 2024-12-08 | Fond Telethon Ets | Protocolli di manipolazione genica in cellule immunitarie |
| WO2025031446A1 (zh) * | 2023-08-09 | 2025-02-13 | 厦门大学 | 瓜氨酸化setdb1多肽及其在诊断类风湿性关节炎中的应用 |
| WO2025160155A1 (en) | 2024-01-22 | 2025-07-31 | The Broad Institute, Inc. | Epigenetic targeting of prion diseases |
| CN121605133A (zh) * | 2024-06-21 | 2026-03-03 | 益杰立科(上海)生物科技有限公司 | 工程化基因转录阻抑工具及其用途 |
| EP4696705A1 (en) * | 2024-08-13 | 2026-02-18 | Fondazione Telethon ETS | Engineered transcription repressors and uses thereof |
| WO2026064753A1 (en) | 2024-09-23 | 2026-03-26 | Tune Therapeutics, Inc. | Dna methyltransferase-like protein (dnmt3l) or dna methyltransferase 3a (dnmt3a) repressor systems for epigenetic editing |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5723315A (en) | 1996-08-23 | 1998-03-03 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
| DE69729007T2 (de) | 1996-08-07 | 2005-04-07 | Darwin Discovery Ltd., Slough | Hydroxamsäure- und carbonsäure-derivate mit mmp und tnf hemmender wirkung |
| US6126939A (en) | 1996-09-03 | 2000-10-03 | Yeda Research And Development Co. Ltd. | Anti-inflammatory dipeptide and pharmaceutical composition thereof |
| GB9803351D0 (en) | 1998-02-17 | 1998-04-15 | Oxford Biomedica Ltd | Anti-viral vectors |
| US20020188103A1 (en) | 1998-10-09 | 2002-12-12 | Timothy H. Bestor | Chimeric dna-binding/dna methyltransferase nucleic acid and polypeptide and uses thereof |
| US6534261B1 (en) | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
| GB0009760D0 (en) | 2000-04-19 | 2000-06-07 | Oxford Biomedica Ltd | Method |
| EP1276859B1 (en) * | 2000-04-28 | 2007-02-07 | Sangamo Biosciences Inc. | Targeted modification of chromatin structure |
| US6919204B2 (en) | 2000-09-29 | 2005-07-19 | Sangamo Biosciences, Inc. | Modulation of gene expression using localization domains |
| WO2003072788A1 (en) * | 2002-02-21 | 2003-09-04 | The Wistar Institute Of Anatomy And Biology | Methods and compositions for reversibly controlling expression of target genes in cells |
| WO2005028630A2 (en) | 2003-09-19 | 2005-03-31 | Sangamo Biosciences, Inc. | Engineered zinc finger proteins for regulation of gene expression |
| US20070192880A1 (en) | 2003-10-03 | 2007-08-16 | University Of Rochester | Horming response element binding transregulators |
| JP2008506359A (ja) | 2004-04-08 | 2008-03-06 | サンガモ バイオサイエンシズ インコーポレイテッド | ジンクフィンガータンパク質による神経因性疼痛の処置 |
| GB0526449D0 (en) | 2005-12-23 | 2006-02-08 | Medical Res Council | Polypeptide targeting |
| KR100756055B1 (ko) | 2006-01-27 | 2007-09-07 | 연세대학교 산학협력단 | 신생혈관 생성을 조절하는 재조합 아데노바이러스 |
| GB0607063D0 (en) | 2006-04-07 | 2006-05-17 | Cellcentric Ltd | Compositions and methods for epigenetic modification of nucleic acid sequences in vivo |
| GB0700374D0 (en) | 2007-01-09 | 2007-02-14 | Oncomethylome Sciences S A | NDRG family methylation markers |
| US20120207744A1 (en) | 2009-03-19 | 2012-08-16 | Mendlein John D | Reprogramming compositions and methods of using the same |
| JP5866283B2 (ja) | 2009-07-28 | 2016-02-17 | サンガモ バイオサイエンシーズ， インコーポレイテッド | トリヌクレオチド反復疾患を治療するための方法および組成物 |
| RU2013120302A (ru) | 2010-10-01 | 2014-11-20 | Модерна Терапьютикс, Инк. | Сконструированные нуклеиновые кислоты и способы их применения |
| JP6261500B2 (ja) | 2011-07-22 | 2018-01-17 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ヌクレアーゼ切断特異性の評価および改善 |
| US8450107B1 (en) | 2011-11-30 | 2013-05-28 | The Broad Institute Inc. | Nucleotide-specific recognition sequences for designer TAL effectors |
| GB201121924D0 (en) | 2011-12-20 | 2012-02-01 | Fahy Gurteen Labs Ltd | Detection of breast cancer |
| CN105658792B (zh) | 2012-02-28 | 2020-11-10 | 西格马-奥尔德里奇有限责任公司 | 靶向组蛋白乙酰化 |
| CN108285491B (zh) | 2012-02-29 | 2021-08-10 | 桑格摩生物科学股份有限公司 | 治疗亨廷顿氏病的方法和组合物 |
| EP2825889A4 (en) | 2012-03-14 | 2015-10-28 | Salk Inst For Biological Studi | ADENOVIRAL TUMOR DIAGNOSIS |
| WO2013141680A1 (en) | 2012-03-20 | 2013-09-26 | Vilnius University | RNA-DIRECTED DNA CLEAVAGE BY THE Cas9-crRNA COMPLEX |
| EP3241902B1 (en) | 2012-05-25 | 2018-02-28 | The Regents of The University of California | Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription |
| EP4357457B1 (en) | 2012-10-23 | 2024-10-16 | Toolgen Incorporated | Composition for cleaving a target dna comprising a guide rna specific for the target dna and cas protein-encoding nucleic acid or cas protein, and use thereof |
| EP3363902B1 (en) | 2012-12-06 | 2019-11-27 | Sigma Aldrich Co. LLC | Crispr-based genome modification and regulation |
| DK2931898T3 (en) | 2012-12-12 | 2016-06-20 | Massachusetts Inst Technology | CONSTRUCTION AND OPTIMIZATION OF SYSTEMS, PROCEDURES AND COMPOSITIONS FOR SEQUENCE MANIPULATION WITH FUNCTIONAL DOMAINS |
| WO2014093694A1 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Crispr-cas nickase systems, methods and compositions for sequence manipulation in eukaryotes |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| CN105121648B (zh) | 2012-12-12 | 2021-05-07 | 布罗德研究所有限公司 | 用于序列操纵的系统、方法和优化的指导组合物的工程化 |
| AU2013359262C1 (en) | 2012-12-12 | 2021-05-13 | Massachusetts Institute Of Technology | CRISPR-Cas component systems, methods and compositions for sequence manipulation |
| CA2894684A1 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Engineering and optimization of improved crispr-cas systems, methods and enzyme compositions for sequence manipulation in eukaryotes |
| CA2895155C (en) | 2012-12-17 | 2021-07-06 | President And Fellows Of Harvard College | Rna-guided human genome engineering |
| AU2014227653B2 (en) | 2013-03-15 | 2017-04-20 | The General Hospital Corporation | Using RNA-guided foki nucleases (RFNs) to increase specificity for RNA-guided genome editing |
| US10760064B2 (en) | 2013-03-15 | 2020-09-01 | The General Hospital Corporation | RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci |
| US20140356956A1 (en) | 2013-06-04 | 2014-12-04 | President And Fellows Of Harvard College | RNA-Guided Transcriptional Regulation |
| EP3004370B1 (en) | 2013-06-05 | 2024-08-21 | Duke University | Rna-guided gene editing and gene regulation |
| WO2015006294A2 (en) | 2013-07-10 | 2015-01-15 | President And Fellows Of Harvard College | Orthogonal cas9 proteins for rna-guided gene regulation and editing |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US20150191744A1 (en) | 2013-12-17 | 2015-07-09 | University Of Massachusetts | Cas9 effector-mediated regulation of transcription, differentiation and gene editing/labeling |
| CA2942915A1 (en) | 2014-03-20 | 2015-09-24 | Universite Laval | Crispr-based methods and products for increasing frataxin levels and uses thereof |
| WO2016011070A2 (en) | 2014-07-14 | 2016-01-21 | The Regents Of The University Of California | A protein tagging system for in vivo single molecule imaging and control of gene transcription |
| ES3047792T3 (en) | 2014-07-14 | 2025-12-04 | Univ California | Crispr/cas transcriptional modulation |
| US20170233762A1 (en) | 2014-09-29 | 2017-08-17 | The Regents Of The University Of California | Scaffold rnas |
| US10583201B2 (en) | 2014-10-10 | 2020-03-10 | Massachusetts Eye And Ear Infirmary | Efficient delivery of therapeutic molecules in vitro and in vivo |
| GB201418965D0 (https=) | 2014-10-24 | 2014-12-10 | Ospedale San Raffaele And Fond Telethon | |
| EP3250691B9 (en) | 2015-01-28 | 2023-08-02 | Caribou Biosciences, Inc. | Crispr hybrid dna/rna polynucleotides and methods of use |
| US10676726B2 (en) | 2015-02-09 | 2020-06-09 | Duke University | Compositions and methods for epigenome editing |
| WO2017015637A1 (en) | 2015-07-22 | 2017-01-26 | Duke University | High-throughput screening of regulatory element function with epigenome editing technologies |
| CN108243607A (zh) | 2015-09-09 | 2018-07-03 | 西雅图儿童医院（Dba西雅图儿童研究所） | 用于免疫疗法的巨噬细胞的遗传工程 |
| EP3147363B1 (en) | 2015-09-26 | 2019-10-16 | B.R.A.I.N. Ag | Activation of taste receptor genes in mammalian cells using crispr-cas-9 |
| US10612044B2 (en) | 2015-11-25 | 2020-04-07 | National University Corporation Gunma University | DNA methylation editing kit and DNA methylation editing method |
-
2014
- 2014-10-24 GB GBGB1418965.8A patent/GB201418965D0/en not_active Ceased
-
2015
- 2015-10-23 ES ES15794644T patent/ES2906263T3/es active Active
- 2015-10-23 PL PL15794644T patent/PL3209783T3/pl unknown
- 2015-10-23 EP EP21197502.4A patent/EP3995584A1/en active Pending
- 2015-10-23 PT PT157946443T patent/PT3209783T/pt unknown
- 2015-10-23 HU HUE15794644A patent/HUE057846T2/hu unknown
- 2015-10-23 DK DK15794644.3T patent/DK3209783T3/da active
- 2015-10-23 CN CN201580057762.8A patent/CN107109433B/zh active Active
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