CN116789846A - 永久性表观遗传基因沉默 - Google Patents

永久性表观遗传基因沉默 Download PDF

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Publication number
CN116789846A
CN116789846A CN202211663401.6A CN202211663401A CN116789846A CN 116789846 A CN116789846 A CN 116789846A CN 202211663401 A CN202211663401 A CN 202211663401A CN 116789846 A CN116789846 A CN 116789846A
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atr
domain
cells
dna binding
tetr
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Chinese (zh)
Inventor
L.纳尔迪尼
A.L.隆巴尔多
A.阿马比尔
A.米格利亚拉
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Ospedale San Raffaele SRL
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Ospedale San Raffaele SRL
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Application filed by Ospedale San Raffaele SRL filed Critical Ospedale San Raffaele SRL
Publication of CN116789846A publication Critical patent/CN116789846A/zh
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1007—Methyltransferases (general) (2.1.1.)
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C07K14/4703—Inhibitors; Suppressors
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • C—CHEMISTRY; METALLURGY
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    • C12Y—ENZYMES
    • C12Y201/00—Transferases transferring one-carbon groups (2.1)
    • C12Y201/01—Methyltransferases (2.1.1)
    • C12Y201/01037—DNA (cytosine-5-)-methyltransferase (2.1.1.37)
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    • C12Y201/00—Transferases transferring one-carbon groups (2.1)
    • C12Y201/01—Methyltransferases (2.1.1)
    • C12Y201/01043—Histone-lysine N-methyltransferase (2.1.1.43)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites

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  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN202211663401.6A 2014-10-24 2015-10-23 永久性表观遗传基因沉默 Pending CN116789846A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB1418965.8A GB201418965D0 (https=) 2014-10-24 2014-10-24
GB1418965.8 2014-10-24
PCT/IB2015/058202 WO2016063264A1 (en) 2014-10-24 2015-10-23 Permanent epigenetic gene silencing
CN201580057762.8A CN107109433B (zh) 2014-10-24 2015-10-23 永久性表观遗传基因沉默

Related Parent Applications (1)

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CN201580057762.8A Division CN107109433B (zh) 2014-10-24 2015-10-23 永久性表观遗传基因沉默

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CN116789846A true CN116789846A (zh) 2023-09-22

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CN202211663401.6A Pending CN116789846A (zh) 2014-10-24 2015-10-23 永久性表观遗传基因沉默
CN201580057762.8A Active CN107109433B (zh) 2014-10-24 2015-10-23 永久性表观遗传基因沉默

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US (1) US12152240B2 (https=)
EP (2) EP3209783B1 (https=)
JP (3) JP7002936B2 (https=)
CN (2) CN116789846A (https=)
AU (3) AU2015334469B2 (https=)
CA (1) CA2965591A1 (https=)
DK (1) DK3209783T3 (https=)
ES (1) ES2906263T3 (https=)
GB (1) GB201418965D0 (https=)
HU (1) HUE057846T2 (https=)
PL (1) PL3209783T3 (https=)
PT (1) PT3209783T (https=)
WO (1) WO2016063264A1 (https=)

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