JP2017536111A5 - - Google Patents
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- JP2017536111A5 JP2017536111A5 JP2017522640A JP2017522640A JP2017536111A5 JP 2017536111 A5 JP2017536111 A5 JP 2017536111A5 JP 2017522640 A JP2017522640 A JP 2017522640A JP 2017522640 A JP2017522640 A JP 2017522640A JP 2017536111 A5 JP2017536111 A5 JP 2017536111A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- antibody
- binding fragment
- tim
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims description 134
- 102000036639 antigens Human genes 0.000 claims description 134
- 108091007433 antigens Proteins 0.000 claims description 134
- 239000012634 fragment Substances 0.000 claims description 129
- 229940126547 T-cell immunoglobulin mucin-3 Drugs 0.000 claims description 48
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims description 47
- 101710083479 Hepatitis A virus cellular receptor 2 homolog Proteins 0.000 claims description 47
- 229920001184 polypeptide Polymers 0.000 claims description 46
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 46
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 46
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 45
- 238000000338 in vitro Methods 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 17
- 206010028980 Neoplasm Diseases 0.000 claims description 11
- 201000011510 cancer Diseases 0.000 claims description 11
- 230000003915 cell function Effects 0.000 claims description 9
- 210000004027 cell Anatomy 0.000 claims description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 8
- 230000004064 dysfunction Effects 0.000 claims description 8
- 208000035473 Communicable disease Diseases 0.000 claims description 7
- 230000017274 T cell anergy Effects 0.000 claims description 7
- 231100000433 cytotoxic Toxicity 0.000 claims description 7
- 230000001472 cytotoxic effect Effects 0.000 claims description 7
- 230000001747 exhibiting effect Effects 0.000 claims description 7
- 208000015181 infectious disease Diseases 0.000 claims description 7
- 230000015572 biosynthetic process Effects 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 239000013598 vector Substances 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 5
- 238000012258 culturing Methods 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 150000007523 nucleic acids Chemical class 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 3
- 210000004369 blood Anatomy 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 239000000032 diagnostic agent Substances 0.000 claims description 2
- 229940039227 diagnostic agent Drugs 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000002708 enhancing effect Effects 0.000 claims description 2
- 230000011664 signaling Effects 0.000 claims description 2
- 208000035475 disorder Diseases 0.000 claims 3
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 description 12
- 125000003275 alpha amino acid group Chemical group 0.000 description 6
- 238000001727 in vivo Methods 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 238000013160 medical therapy Methods 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1419092.0 | 2014-10-27 | ||
| GB1419089.6 | 2014-10-27 | ||
| GB201419089A GB201419089D0 (en) | 2014-10-27 | 2014-10-27 | Anti-TIM-3 antibodies |
| GB201419092A GB201419092D0 (en) | 2014-10-27 | 2014-10-27 | Anti-TIM-3 antibodies |
| PCT/SG2015/050415 WO2016068803A1 (en) | 2014-10-27 | 2015-10-27 | Anti-tim-3 antibodies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017536111A JP2017536111A (ja) | 2017-12-07 |
| JP2017536111A5 true JP2017536111A5 (OSRAM) | 2018-12-13 |
| JP6709215B2 JP6709215B2 (ja) | 2020-06-10 |
Family
ID=55857945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017522640A Active JP6709215B2 (ja) | 2014-10-27 | 2015-10-27 | 抗ｔｉｍ−３抗体 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10259874B2 (OSRAM) |
| EP (1) | EP3212231B1 (OSRAM) |
| JP (1) | JP6709215B2 (OSRAM) |
| KR (1) | KR20170075778A (OSRAM) |
| CN (2) | CN107405397B (OSRAM) |
| AU (1) | AU2015340056A1 (OSRAM) |
| CA (1) | CA2965960A1 (OSRAM) |
| SG (2) | SG11201703403TA (OSRAM) |
| WO (1) | WO2016068803A1 (OSRAM) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201419094D0 (en) | 2014-10-27 | 2014-12-10 | Agency Science Tech & Res | Anti-TIM-3-antibodies |
| CN107405397B (zh) * | 2014-10-27 | 2020-08-25 | 新加坡科技研究局 | 抗tim-3抗体 |
| JP2018510151A (ja) * | 2015-03-06 | 2018-04-12 | ソレント・セラピューティクス・インコーポレイテッド | Ｔｉｍ３に結合する抗体医薬 |
| EP3337826A1 (en) | 2015-08-20 | 2018-06-27 | Sutro Biopharma, Inc. | Anti-tim-3 antibodies, compositions comprising anti-tim-3 antibodies and methods of making and using anti-tim-3 antibodies |
| TWI895621B (zh) | 2016-05-27 | 2025-09-01 | 美商艾吉納斯公司 | 抗-tim-3抗體及其使用方法 |
| JP7461741B2 (ja) | 2016-06-20 | 2024-04-04 | カイマブ・リミテッド | 抗ｐｄ－ｌ１およびｉｌ－２サイトカイン |
| EP4512829A3 (en) | 2016-07-14 | 2025-06-11 | Bristol-Myers Squibb Company | Antibodies against tim3 and uses thereof |
| JOP20190013A1 (ar) * | 2016-08-25 | 2019-01-31 | Lilly Co Eli | أجسام مضادة لـ (تي آي ام -3) |
| SG10201912199XA (en) * | 2016-08-26 | 2020-02-27 | Beigene Ltd | Anti-tim-3 antibodies and use thereof |
| WO2018075954A2 (en) * | 2016-10-21 | 2018-04-26 | Adimab, Llc | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
| CN110035771B (zh) | 2016-10-21 | 2024-03-08 | 阿迪马布有限责任公司 | 抗呼吸道合胞病毒抗体及其产生和使用方法 |
| JOP20190133A1 (ar) * | 2016-12-08 | 2019-06-02 | Innovent Biologics Suzhou Co Ltd | أجسام مضادة لـ Tim-3 لمزجها بأجسام مضادة لـ PD-1 |
| CN108264557B (zh) * | 2016-12-30 | 2021-08-24 | 惠和生物技术(上海)有限公司 | 一种结合cd3和t细胞负共刺激分子的双功能分子及其应用 |
| EP3565598A4 (en) * | 2017-01-03 | 2020-10-28 | Trellis Bioscience, LLC | NATIVE HUMAN ANTIBODIES FOR TIM-3 AND B7-H3 IMMUNE CHECKPOINT MODULATION TARGETS |
| CN110234662A (zh) | 2017-01-26 | 2019-09-13 | 瑟罗泽恩公司 | 组织特异性wnt信号增强分子和其用途 |
| US11214615B2 (en) | 2017-07-28 | 2022-01-04 | Phanes Therapeutics, Inc. | Anti-TIM-3 antibodies and uses thereof |
| KR20200044899A (ko) | 2017-08-28 | 2020-04-29 | 브리스톨-마이어스 스큅 컴퍼니 | 암의 치료 및 진단을 위한 tim-3 길항제 |
| CN111954680B (zh) | 2017-11-10 | 2024-03-15 | 新加坡科技研究局 | IL2Rβ/共同γ链抗体 |
| CN120192415A (zh) * | 2018-01-12 | 2025-06-24 | 百时美施贵宝公司 | 抗tim3抗体及其用途 |
| EP3740506A1 (en) | 2018-01-16 | 2020-11-25 | Bristol-Myers Squibb Company | Methods of treating cancer with antibodies against tim3 |
| WO2019165982A1 (en) * | 2018-02-28 | 2019-09-06 | WuXi Biologics Ireland Limited | Monoclonal antibody against human lag-3, method for preparing same, and use thereof |
| CN110272489B (zh) * | 2018-03-15 | 2023-08-22 | 上海健信生物医药科技有限公司 | 一种针对tim-3的全人源化抗体分子, 抗原结合片段及其医药用途 |
| CN110305216B (zh) * | 2018-03-20 | 2022-09-02 | 无锡智康弘义生物科技有限公司 | 新型抗tim-3抗体 |
| PE20210665A1 (es) | 2018-03-23 | 2021-03-31 | Bristol Myers Squibb Co | Anticuerpos contra mica y/o micb y sus usos |
| US11807683B2 (en) | 2018-04-12 | 2023-11-07 | Nanjing Leads Biolabs Co., Ltd. | Antibody binding TIM-3 and use thereof |
| AU2019258468B2 (en) * | 2018-04-24 | 2023-06-29 | Ampsource Biopharma Shanghai Inc. | Antibody against TIM-3 and application thereof |
| CN112638375A (zh) | 2018-06-15 | 2021-04-09 | 旗舰创业创新五公司 | 通过后细胞信号传导因子的调节来增加免疫活性 |
| MA52966A (fr) * | 2018-06-19 | 2021-04-28 | Regeneron Pharma | Anticorps anti-facteur xii/xiia et leurs utilisations |
| EP3820499A4 (en) | 2018-07-09 | 2022-07-13 | Surrozen Operating, Inc. | TISSUE SPECIFIC WNT SIGNAL ENHANCEMENT MOLECULES AND USES |
| EP3873611A1 (en) * | 2018-11-01 | 2021-09-08 | Merck Patent GmbH | Anti-tim-3 antibodies |
| WO2020097336A1 (en) * | 2018-11-09 | 2020-05-14 | Beth Israel Deaconess Medical Center | Cdcp1-targeted therapies |
| TW202039557A (zh) | 2018-11-09 | 2020-11-01 | 新加坡商優其洛伊生物私人有限公司 | 介白素2受體β(IL2Rβ)/共同γ鏈抗體 |
| WO2020094834A1 (en) | 2018-11-09 | 2020-05-14 | Euchloe Bio Pte. Ltd. | Il2rbeta/common gamma chain antibodies |
| EP3962493A2 (en) | 2019-05-03 | 2022-03-09 | Flagship Pioneering Innovations V, Inc. | Methods of modulating immune activity/level of irf or sting or of treating cancer, comprising the administration of a sting modulator and/or purinergic receptor modulator or postcellular signaling factor |
| CN114174538A (zh) | 2019-05-30 | 2022-03-11 | 百时美施贵宝公司 | 适合于免疫肿瘤学疗法的多肿瘤基因特征 |
| KR20220016155A (ko) | 2019-05-30 | 2022-02-08 | 브리스톨-마이어스 스큅 컴퍼니 | 면역-종양학 (i-o) 요법에 적합한 대상체를 확인하는 방법 |
| EP3977132A1 (en) | 2019-05-30 | 2022-04-06 | Bristol-Myers Squibb Company | Cell localization signature and combination therapy |
| CN110498855A (zh) * | 2019-07-25 | 2019-11-26 | 钟小泉 | 一种tim-3抗体及其用途 |
| CN110922478B (zh) * | 2019-12-07 | 2021-07-30 | 中国人民解放军军事科学院军事医学研究院 | 针对特异表位的抗基孔肯雅热的全人源单克隆抗体及应用 |
| WO2021127217A1 (en) | 2019-12-17 | 2021-06-24 | Flagship Pioneering Innovations V, Inc. | Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly |
| WO2021169948A1 (zh) * | 2020-02-24 | 2021-09-02 | 苏州恒康生命科学有限公司 | Tim3结合分子及其应用 |
| KR102536302B1 (ko) * | 2020-02-25 | 2023-05-26 | 국립암센터 | Tim-3 에 특이적으로 결합하는 단일클론항체 및 이의 용도 |
| EP4172323A1 (en) | 2020-06-29 | 2023-05-03 | Flagship Pioneering Innovations V, Inc. | Viruses engineered to promote thanotransmission and their use in treating cancer |
| CA3190660A1 (en) | 2020-08-31 | 2022-03-03 | George C. Lee | Cell localization signature and immunotherapy |
| CN112094348B (zh) * | 2020-09-22 | 2021-11-30 | 首都医科大学附属北京胸科医院 | 抗人Tim3抗体或其功能性片段及其应用 |
| TW202233656A (zh) | 2020-11-16 | 2022-09-01 | 美商蘇羅森營運公司 | 肝特異性wnt訊號增強分子及其用途 |
| WO2022120179A1 (en) | 2020-12-03 | 2022-06-09 | Bristol-Myers Squibb Company | Multi-tumor gene signatures and uses thereof |
| SMT202500208T1 (it) | 2020-12-28 | 2025-07-22 | Bristol Myers Squibb Co | Composizioni anticorpali e metodi per il loro uso |
| CA3196999A1 (en) | 2020-12-28 | 2022-07-07 | Masano HUANG | Methods of treating tumors |
| EP4281470A4 (en) * | 2021-01-22 | 2024-11-27 | Elpis Biopharmaceuticals | BISPECIFIC CHIMERIC ANTIGEN RECEPTORS BINDING TO CD19 AND CD22 |
| EP4083065A1 (en) * | 2021-01-28 | 2022-11-02 | NantBio, Inc. | Anti-tim3 monoclonal antibodies and chimeric antigen receptors |
| KR20230165276A (ko) | 2021-03-31 | 2023-12-05 | 플래그쉽 파이어니어링 이노베이션스 브이, 인크. | 타노트랜스미션 폴리펩티드 및 암의 치료에서의 이의 용도 |
| EP4314068A1 (en) | 2021-04-02 | 2024-02-07 | The Regents Of The University Of California | Antibodies against cleaved cdcp1 and uses thereof |
| AU2022303363A1 (en) | 2021-06-29 | 2024-01-18 | Flagship Pioneering Innovations V, Inc. | Immune cells engineered to promote thanotransmission and uses thereof |
| CN114181311B (zh) * | 2021-12-20 | 2023-06-20 | 华东师范大学 | 一种全人源抗DLL3 scFv及其在CART细胞治疗中的应用 |
| WO2023168195A2 (en) * | 2022-03-04 | 2023-09-07 | The Scripps Research Institute | Human broadly neutralizing antibodies against betacoronaviruses |
| KR20240159621A (ko) | 2022-03-18 | 2024-11-05 | 브리스톨-마이어스 스큅 컴퍼니 | 폴리펩티드를 단리하는 방법 |
| WO2023235847A1 (en) | 2022-06-02 | 2023-12-07 | Bristol-Myers Squibb Company | Antibody compositions and methods of use thereof |
| US20240174732A1 (en) | 2022-10-05 | 2024-05-30 | Flagship Pioneering Innovations V, Inc. | Nucleic acid molecules encoding trif and additional polypeptides and their use in treating cancer |
| US20240269251A1 (en) | 2023-01-09 | 2024-08-15 | Flagship Pioneering Innovations V, Inc. | Genetic switches and their use in treating cancer |
| WO2024163477A1 (en) | 2023-01-31 | 2024-08-08 | University Of Rochester | Immune checkpoint blockade therapy for treating staphylococcus aureus infections |
| WO2025038763A1 (en) | 2023-08-15 | 2025-02-20 | Bristol-Myers Squibb Company | Ceramic hydroxyapatite chromatography flow through method |
| US20250215087A1 (en) | 2023-12-29 | 2025-07-03 | Bristol-Myers Squibb Company | Combination therapy of kras inhibitor and treg depleting agent |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6113396A (en) | 1995-06-14 | 1997-01-15 | Regents Of The University Of California, The | Novel high affinity human antibodies to tumor antigens |
| US20030103978A1 (en) | 2000-02-23 | 2003-06-05 | Amgen Inc. | Selective binding agents of osteoprotegerin binding protein |
| ES2192426B1 (es) | 2000-05-11 | 2005-02-16 | Universidad De Vigo | Anticuerpo monoclonal humano sm50/20 que reconoce leucocitos humanos, y su uso en terapia. |
| MXPA05005921A (es) | 2002-12-02 | 2005-10-19 | Abgenix Inc | Anticuerpos dirigidos a factor de necrosis tumoral y sus usos. |
| DK1613750T3 (en) | 2003-03-19 | 2016-01-18 | Amgen Fremont Inc | ANTIBODIES TO T CELL AND MUCINDO immunoglobulin-binding domain 1 (TIM-1) antigen and uses thereof |
| CN1902227A (zh) | 2003-10-03 | 2007-01-24 | 布赖汉姆妇女医院 | Tim－3配体及其方法 |
| CA2680945C (en) | 2005-06-17 | 2014-03-18 | Imclone Systems Incorporated | Anti-pdgfralpha antibodies |
| JP2009515897A (ja) | 2005-11-10 | 2009-04-16 | キュラジェン コーポレイション | Ｔ細胞の免疫グロブリンドメインおよびムチンドメイン１（ｔｉｍ−１）抗原に対する抗体を用いて卵巣癌および腎臓癌を処置する方法 |
| EP2252319A2 (en) * | 2008-01-29 | 2010-11-24 | The Brigham and Women's Hospital, Inc. | Methods for modulating a population of myeloid-derived suppressor cells and uses thereof |
| WO2010014854A2 (en) | 2008-07-31 | 2010-02-04 | The Regents Of The University Of California | Antibodies that neutralize botulinum neurotoxins |
| CA2742968C (en) | 2008-11-07 | 2020-06-09 | Fabrus Llc | Combinatorial antibody libraries and uses thereof |
| JP5748653B2 (ja) | 2009-04-10 | 2015-07-15 | 協和発酵キリン株式会社 | 抗ｔｉｍ−３抗体を用いた血液腫瘍治療法 |
| JP2013523184A (ja) | 2010-04-15 | 2013-06-17 | アムジエン・インコーポレーテツド | ヒトＦＧＦ受容体およびβ−ＫＬＯＴＨＯ結合性タンパク質 |
| CN103079644B (zh) * | 2010-06-11 | 2017-02-15 | 协和发酵麒麟株式会社 | 抗tim‑3抗体 |
| JP2013532153A (ja) * | 2010-06-18 | 2013-08-15 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド | 慢性免疫病に対する免疫治療のためのｔｉｍ−３およびｐｄ−１に対する二重特異性抗体 |
| WO2012092539A2 (en) | 2010-12-31 | 2012-07-05 | Takeda Pharmaceutical Company Limited | Antibodies to dll4 and uses thereof |
| WO2013006490A2 (en) * | 2011-07-01 | 2013-01-10 | Cellerant Therapeutics, Inc. | Antibodies that specifically bind to tim3 |
| EP2543680A1 (en) * | 2011-07-07 | 2013-01-09 | Centre National de la Recherche Scientifique | Multispecific mutated antibody Fab fragments |
| CN102392038B (zh) | 2011-11-01 | 2013-04-17 | 浙江大学 | 一种删除转基因水稻精米中的外源基因的表达载体及其应用 |
| CN102492038B (zh) * | 2011-12-09 | 2014-05-28 | 中国人民解放军军事医学科学院基础医学研究所 | 抗人Tim-3的中和性单克隆抗体L3D及其用途 |
| WO2014022332A1 (en) | 2012-07-31 | 2014-02-06 | The Brigham And Women's Hospital, Inc. | Modulation of the immune response |
| WO2014028560A2 (en) * | 2012-08-14 | 2014-02-20 | Ibc Pharmaceuticals, Inc. | T-cell redirecting bispecific antibodies for treatment of disease |
| CN103665164A (zh) * | 2012-10-24 | 2014-03-26 | 中国人民解放军军事医学科学院基础医学研究所 | 一种检测Tim-3的ELISA试剂盒 |
| US20150284459A1 (en) | 2012-10-31 | 2015-10-08 | The Brigham And Women's Hospital, Inc. | Methods for modulating immune responses during chronic immune conditions by targeting il-27 induced pathways |
| WO2014116846A2 (en) | 2013-01-23 | 2014-07-31 | Abbvie, Inc. | Methods and compositions for modulating an immune response |
| JP2014162739A (ja) * | 2013-02-22 | 2014-09-08 | National Institute Of Biomedical Innovation | 二重特異性抗体及び医薬組成物 |
| RU2016129959A (ru) | 2013-12-30 | 2018-02-02 | Эпимаб Биотерепьютикс Инк. | Иммуноглобулин с тандемным расположением fab-фрагментов и его применение |
| CN103936853B (zh) * | 2014-01-26 | 2016-08-17 | 中国人民解放军军事医学科学院基础医学研究所 | 一种检测tim-3试剂盒及其使用方法 |
| JOP20200096A1 (ar) * | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | جزيئات جسم مضاد لـ tim-3 واستخداماتها |
| GB201419094D0 (en) | 2014-10-27 | 2014-12-10 | Agency Science Tech & Res | Anti-TIM-3-antibodies |
| CN107405397B (zh) | 2014-10-27 | 2020-08-25 | 新加坡科技研究局 | 抗tim-3抗体 |
| CN104592388B (zh) * | 2015-03-02 | 2017-05-31 | 中国人民解放军总医院 | 一种抗人Tim‑3的单克隆抗体的抗原结合部分 |
-
2015
- 2015-10-27 CN CN201580071169.9A patent/CN107405397B/zh active Active
- 2015-10-27 WO PCT/SG2015/050415 patent/WO2016068803A1/en not_active Ceased
- 2015-10-27 CN CN201910641759.0A patent/CN110294807B/zh active Active
- 2015-10-27 US US15/521,685 patent/US10259874B2/en active Active
- 2015-10-27 SG SG11201703403TA patent/SG11201703403TA/en unknown
- 2015-10-27 KR KR1020177014444A patent/KR20170075778A/ko not_active Withdrawn
- 2015-10-27 AU AU2015340056A patent/AU2015340056A1/en not_active Abandoned
- 2015-10-27 SG SG10201803042PA patent/SG10201803042PA/en unknown
- 2015-10-27 EP EP15855010.3A patent/EP3212231B1/en active Active
- 2015-10-27 CA CA2965960A patent/CA2965960A1/en not_active Abandoned
- 2015-10-27 JP JP2017522640A patent/JP6709215B2/ja active Active
-
2019
- 2019-03-06 US US16/294,474 patent/US11142574B2/en active Active
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