JP2017535526A5 - - Google Patents
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- Publication number
- JP2017535526A5 JP2017535526A5 JP2017517647A JP2017517647A JP2017535526A5 JP 2017535526 A5 JP2017535526 A5 JP 2017535526A5 JP 2017517647 A JP2017517647 A JP 2017517647A JP 2017517647 A JP2017517647 A JP 2017517647A JP 2017535526 A5 JP2017535526 A5 JP 2017535526A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- group
- compound
- alkyl
- defined above
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 33
- 238000000034 method Methods 0.000 claims 21
- 125000000217 alkyl group Chemical group 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 14
- 125000003545 alkoxy group Chemical group 0.000 claims 12
- 229910052736 halogen Inorganic materials 0.000 claims 12
- 150000002367 halogens Chemical class 0.000 claims 12
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 12
- 125000001424 substituent group Chemical group 0.000 claims 12
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 11
- 125000002947 alkylene group Chemical group 0.000 claims 10
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims 7
- 229920006395 saturated elastomer Polymers 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 239000007787 solid Substances 0.000 claims 3
- WJQDJDVDXAAXSB-UHFFFAOYSA-N 5-sulfanylidenepyrrolidin-2-one Chemical compound O=C1CCC(=S)N1 WJQDJDVDXAAXSB-UHFFFAOYSA-N 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 230000021615 conjugation Effects 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000003301 hydrolyzing effect Effects 0.000 claims 2
- YUOCYTRGANSSRY-UHFFFAOYSA-N pyrrolo[2,3-i][1,2]benzodiazepine Chemical compound C1=CN=NC2=C3C=CN=C3C=CC2=C1 YUOCYTRGANSSRY-UHFFFAOYSA-N 0.000 claims 2
- 238000006845 Michael addition reaction Methods 0.000 claims 1
- 102000004243 Tubulin Human genes 0.000 claims 1
- 108090000704 Tubulin Proteins 0.000 claims 1
- 108010044540 auristatin Proteins 0.000 claims 1
- 230000001268 conjugating effect Effects 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- DASWEROEPLKSEI-UIJRFTGLSA-N monomethyl auristatin e Chemical compound CN[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)C1=CC=CC=C1 DASWEROEPLKSEI-UIJRFTGLSA-N 0.000 claims 1
- MFRNYXJJRJQHNW-NARUGQRUSA-N monomethyl auristatin f Chemical compound CN[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)C([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 MFRNYXJJRJQHNW-NARUGQRUSA-N 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 0 CNCCC1OC1C* Chemical compound CNCCC1OC1C* 0.000 description 6
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462058502P | 2014-10-01 | 2014-10-01 | |
| US62/058,502 | 2014-10-01 | ||
| PCT/US2015/053397 WO2016054315A1 (en) | 2014-10-01 | 2015-10-01 | Method of conjugating a polypeptide |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017535526A JP2017535526A (ja) | 2017-11-30 |
| JP2017535526A5 true JP2017535526A5 (enExample) | 2018-11-08 |
| JP6863888B2 JP6863888B2 (ja) | 2021-04-21 |
Family
ID=54337383
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017517647A Active JP6863888B2 (ja) | 2014-10-01 | 2015-10-01 | ポリペプチドをコンジュゲートさせる方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20170304460A1 (enExample) |
| EP (1) | EP3200829B1 (enExample) |
| JP (1) | JP6863888B2 (enExample) |
| CN (1) | CN106922129B (enExample) |
| AU (1) | AU2015324924B2 (enExample) |
| BR (1) | BR112017006602A2 (enExample) |
| CA (1) | CA2962783A1 (enExample) |
| ES (1) | ES2969960T3 (enExample) |
| RU (1) | RU2715905C2 (enExample) |
| WO (1) | WO2016054315A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3394096A1 (en) | 2015-12-21 | 2018-10-31 | Bristol-Myers Squibb Company | Variant antibodies for site-specific conjugation |
| GB201602356D0 (en) * | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| CN109641051A (zh) | 2016-06-17 | 2019-04-16 | 美真达治疗公司 | 用于耗尽细胞的组合物和方法 |
| SG11201906319XA (en) | 2017-01-20 | 2019-08-27 | Magenta Therapeutics Inc | Compositions and methods for the depletion of cd137+ cells |
| CN108358995B (zh) * | 2017-01-25 | 2021-07-06 | 四川大学 | CP-iRGD多肽、iDPP纳米粒、载药复合物及其制备方法和应用 |
| US11925691B2 (en) | 2017-02-07 | 2024-03-12 | Hanmi Pharm. Co., Ltd. | Non-peptidic polymeric linker compound, conjugate comprising same linker compound, and methods for preparing same linker compound and conjugate |
| WO2018146199A1 (en) | 2017-02-08 | 2018-08-16 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
| CN108864258A (zh) * | 2017-05-12 | 2018-11-23 | 北京康明海慧生物科技有限公司 | 具有抑制肿瘤功能的peg化多肽及其制备方法与应用 |
| US12018087B2 (en) | 2018-08-02 | 2024-06-25 | Dyne Therapeutics, Inc. | Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject |
| CA3139378A1 (en) | 2019-05-06 | 2020-11-12 | Seekyo | New therapeutic vectors and prodrugs for treating cancers |
| WO2021154477A1 (en) | 2020-01-31 | 2021-08-05 | Dyne Therapeutics, Inc. | Anti-transferrin receptor (tfr) antibody and uses thereof |
| KR20230117182A (ko) * | 2020-12-04 | 2023-08-07 | 다인 세라퓨틱스, 인크. | 항체-올리고뉴클레오티드 복합체 및 그의 용도 |
| IL316143A (en) | 2022-04-15 | 2024-12-01 | Dyne Therapeutics Inc | Muscle targeting complexes and formulations for the treatment of myotonic dystrophy |
| WO2024102603A1 (en) * | 2022-11-07 | 2024-05-16 | Merck Sharp & Dohme Llc | Bisecting-glycan bridged conjugation for producing glycoprotein conjugates |
| WO2025096716A1 (en) | 2023-11-01 | 2025-05-08 | Incyte Corporation | Anti-mutant calreticulin (calr) antibody-drug conjugates and uses thereof |
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| US3896111A (en) | 1973-02-20 | 1975-07-22 | Research Corp | Ansa macrolides |
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| JPS55164687A (en) | 1979-06-11 | 1980-12-22 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
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| JPS57192389A (en) | 1981-05-20 | 1982-11-26 | Takeda Chem Ind Ltd | Novel maytansinoid |
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| US5635483A (en) | 1992-12-03 | 1997-06-03 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Tumor inhibiting tetrapeptide bearing modified phenethyl amides |
| US5780588A (en) | 1993-01-26 | 1998-07-14 | Arizona Board Of Regents | Elucidation and synthesis of selected pentapeptides |
| ES2201097T3 (es) | 1994-01-31 | 2004-03-16 | Trustees Of Boston University | Bibliotecas de anticuerpos policlonales. |
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| DE602006006199D1 (de) | 2005-10-05 | 2009-05-20 | Spirogen Ltd | 4-ä4-(5-oxo-2,3,5,11a-tetrahydro-5h-pyrrolo ä2, 1-cüä1,4übenzodiazepin-8-yloxy)-butyrylaminoü-1h-pyrrol-2-carbonsäurealkylesterderivate und verwandte verbindung zur behandlung einer proliferativen erkrankung |
| CN101952312A (zh) | 2007-07-31 | 2011-01-19 | 米迪缪尼有限公司 | 多特异性表位结合蛋白及其应用 |
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| KR20130056870A (ko) | 2010-04-13 | 2013-05-30 | 메디뮨 엘엘씨 | 피브로넥틴 ⅲ형 도메인에 기초한 다량체 스캐폴드 |
| US8889880B2 (en) | 2010-08-06 | 2014-11-18 | Endocyte, Inc. | Processes for preparing tubulysins |
| EP2729488A4 (en) | 2011-07-06 | 2015-01-14 | Medimmune Llc | PROCESS FOR PREPARING MULTIMANT POLYPEPTIDES |
| CN103906533A (zh) | 2011-11-07 | 2014-07-02 | 米迪缪尼有限公司 | 多特异性和多价结合蛋白及其用途 |
| US9527927B2 (en) | 2011-12-20 | 2016-12-27 | Medimmune, Llc | Modified polypeptides for bispecific antibody scaffolds |
| US10010623B2 (en) | 2012-02-16 | 2018-07-03 | Ucl Business Plc | Lysosome-cleavable linker |
| CN104822656B (zh) * | 2012-05-15 | 2018-05-01 | 西雅图基因公司 | 自稳定接头偶联物 |
| CN104530235A (zh) * | 2012-12-21 | 2015-04-22 | 百奥泰生物科技(广州)有限公司 | 一种抑制肿瘤生长的抗体药物衍生物及其制备方法和用途 |
| CN103333246B (zh) * | 2012-12-21 | 2015-09-16 | 百奥泰生物科技(广州)有限公司 | 一种抗egfr受体的肿瘤生长抑制剂及其制备方法和用途 |
-
2015
- 2015-10-01 RU RU2017114343A patent/RU2715905C2/ru active
- 2015-10-01 WO PCT/US2015/053397 patent/WO2016054315A1/en not_active Ceased
- 2015-10-01 CA CA2962783A patent/CA2962783A1/en not_active Abandoned
- 2015-10-01 ES ES15782151T patent/ES2969960T3/es active Active
- 2015-10-01 US US15/516,298 patent/US20170304460A1/en not_active Abandoned
- 2015-10-01 CN CN201580053082.9A patent/CN106922129B/zh active Active
- 2015-10-01 AU AU2015324924A patent/AU2015324924B2/en not_active Ceased
- 2015-10-01 JP JP2017517647A patent/JP6863888B2/ja active Active
- 2015-10-01 EP EP15782151.3A patent/EP3200829B1/en active Active
- 2015-10-01 BR BR112017006602A patent/BR112017006602A2/pt not_active IP Right Cessation
-
2021
- 2021-11-16 US US17/527,829 patent/US20220160882A1/en not_active Abandoned
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