JP2017534658A5 - - Google Patents

Info

Publication number

JP2017534658A5

JP2017534658A5 JP2017526551A JP2017526551A JP2017534658A5 JP 2017534658 A5 JP2017534658 A5 JP 2017534658A5 JP 2017526551 A JP2017526551 A JP 2017526551A JP 2017526551 A JP2017526551 A JP 2017526551A JP 2017534658 A5 JP2017534658 A5 JP 2017534658A5

Authority

JP

Japan

Prior art keywords

hydroxyhexahydrofuro

nitrooxy

furan

compound

bis

Prior art date

2015-11-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 150000001875 compounds Chemical class 0.000 claims 15
• MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims 14
• 125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 claims 12
• 239000000203 mixture Substances 0.000 claims 12
• KLDXJTOLSGUMSJ-BXKVDMCESA-N (3s,3as,6s,6as)-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3,6-diol Chemical class O[C@H]1CO[C@H]2[C@@H](O)CO[C@H]21 KLDXJTOLSGUMSJ-BXKVDMCESA-N 0.000 claims 7
• 150000003169 prostaglandin F2α derivatives Chemical class 0.000 claims 7
• BQLNOTPAELUOHK-UHFFFAOYSA-N 5,6-dinitrooxyhexanoic acid Chemical compound OC(=O)CCCC(O[N+]([O-])=O)CO[N+]([O-])=O BQLNOTPAELUOHK-UHFFFAOYSA-N 0.000 claims 5
• -1 5,6-bis (nitrooxy) hexyl carbonate Chemical compound 0.000 claims 3
• 229960002470 bimatoprost Drugs 0.000 claims 3
• AQOKCDNYWBIDND-FTOWTWDKSA-N bimatoprost Chemical compound CCNC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)CCC1=CC=CC=C1 AQOKCDNYWBIDND-FTOWTWDKSA-N 0.000 claims 3
• 229960002368 travoprost Drugs 0.000 claims 3
• MKPLKVHSHYCHOC-AHTXBMBWSA-N travoprost Chemical compound CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)COC1=CC=CC(C(F)(F)F)=C1 MKPLKVHSHYCHOC-AHTXBMBWSA-N 0.000 claims 3
• MEKOFIRRDATTAG-UHFFFAOYSA-N 2,2,5,8-tetramethyl-3,4-dihydrochromen-6-ol Chemical compound C1CC(C)(C)OC2=C1C(C)=C(O)C=C2C MEKOFIRRDATTAG-UHFFFAOYSA-N 0.000 claims 1
• SNPDKBFMQHFHFY-UHFFFAOYSA-N 3-(2,3-dinitrooxypropoxy)propanoic acid Chemical compound OC(=O)CCOCC(O[N+]([O-])=O)CO[N+]([O-])=O SNPDKBFMQHFHFY-UHFFFAOYSA-N 0.000 claims 1
• QRLKMDKMYKQBJQ-UHFFFAOYSA-N 4,5-dinitrooxyhexanoic acid Chemical compound CC(O[N+]([O-])=O)C(CCC(O)=O)O[N+]([O-])=O QRLKMDKMYKQBJQ-UHFFFAOYSA-N 0.000 claims 1
• ZETOHPSSBWBMED-UHFFFAOYSA-N 4-nitrooxybutanoic acid Chemical compound OC(=O)CCCO[N+]([O-])=O ZETOHPSSBWBMED-UHFFFAOYSA-N 0.000 claims 1
• CBSFPBTYVIYRQZ-UHFFFAOYSA-N 6-nitrooxyhexanoic acid Chemical compound OC(=O)CCCCCO[N+]([O-])=O CBSFPBTYVIYRQZ-UHFFFAOYSA-N 0.000 claims 1
• 206010018307 Glaucoma and ocular hypertension Diseases 0.000 claims 1
• 125000000217 alkyl group Chemical group 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 208000030533 eye disease Diseases 0.000 claims 1
• 230000004410 intraocular pressure Effects 0.000 claims 1
• XXUPXHKCPIKWLR-JHUOEJJVSA-N isopropyl unoprostone Chemical compound CCCCCCCC(=O)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(=O)OC(C)C XXUPXHKCPIKWLR-JHUOEJJVSA-N 0.000 claims 1
• 229960001160 latanoprost Drugs 0.000 claims 1
• GGXICVAJURFBLW-CEYXHVGTSA-N latanoprost Chemical compound CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCC1=CC=CC=C1 GGXICVAJURFBLW-CEYXHVGTSA-N 0.000 claims 1
• 239000008217 ophthalmic excipient Substances 0.000 claims 1
• 239000000825 pharmaceutical preparation Substances 0.000 claims 1
• 229960004458 tafluprost Drugs 0.000 claims 1
• WSNODXPBBALQOF-VEJSHDCNSA-N tafluprost Chemical compound CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\C(F)(F)COC1=CC=CC=C1 WSNODXPBBALQOF-VEJSHDCNSA-N 0.000 claims 1
• 229950008081 unoprostone isopropyl Drugs 0.000 claims 1