HRP20170007T1 - Kombinacija, komplet i metoda za smanjivanje intraokularnog tlaka - Google Patents
Kombinacija, komplet i metoda za smanjivanje intraokularnog tlaka Download PDFInfo
- Publication number
- HRP20170007T1 HRP20170007T1 HRP20170007TT HRP20170007T HRP20170007T1 HR P20170007 T1 HRP20170007 T1 HR P20170007T1 HR P20170007T T HRP20170007T T HR P20170007TT HR P20170007 T HRP20170007 T HR P20170007T HR P20170007 T1 HRP20170007 T1 HR P20170007T1
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- Croatia
- Prior art keywords
- combination
- substance
- subject
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- eye
- Prior art date
Links
- 230000004410 intraocular pressure Effects 0.000 title 1
- 239000000126 substance Substances 0.000 claims 10
- 230000004406 elevated intraocular pressure Effects 0.000 claims 4
- 229960001160 latanoprost Drugs 0.000 claims 3
- GGXICVAJURFBLW-CEYXHVGTSA-N latanoprost Chemical compound CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCC1=CC=CC=C1 GGXICVAJURFBLW-CEYXHVGTSA-N 0.000 claims 3
- AQLVRTWKJDTWQQ-SDBHATRESA-N [(2r,3s,4r,5r)-5-[6-(cyclopentylamino)purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl nitrate Chemical compound O[C@@H]1[C@H](O)[C@@H](CO[N+]([O-])=O)O[C@H]1N1C2=NC=NC(NC3CCCC3)=C2N=C1 AQLVRTWKJDTWQQ-SDBHATRESA-N 0.000 claims 2
- 229960002470 bimatoprost Drugs 0.000 claims 2
- AQOKCDNYWBIDND-FTOWTWDKSA-N bimatoprost Chemical compound CCNC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)CCC1=CC=CC=C1 AQOKCDNYWBIDND-FTOWTWDKSA-N 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229960002368 travoprost Drugs 0.000 claims 2
- MKPLKVHSHYCHOC-AHTXBMBWSA-N travoprost Chemical compound CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)COC1=CC=CC(C(F)(F)F)=C1 MKPLKVHSHYCHOC-AHTXBMBWSA-N 0.000 claims 2
- 229960004317 unoprostone Drugs 0.000 claims 2
- TVHAZVBUYQMHBC-SNHXEXRGSA-N unoprostone Chemical compound CCCCCCCC(=O)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O TVHAZVBUYQMHBC-SNHXEXRGSA-N 0.000 claims 2
- 206010030043 Ocular hypertension Diseases 0.000 claims 1
- 206010030348 Open-Angle Glaucoma Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 201000006366 primary open angle glaucoma Diseases 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Claims (10)
1. Oftalmička kombinacija sadrži
[image]
i)
((2R,3S,4R,5R)-5-(6-(ciklopentilamino)-9H-purin-9-il)-3,4-dihidroksitetrahidrofuran-2-il)metil nitrat, ili njegovu farmaceutski prihvatljivu sol, i
ii) tvar odabranu iz grupe koja se sastoji od latanoprosta, travoprosta, unoprostona i bimatoprosta, za uporabu u snižavanju povišenog intraokularnog tlaka u oku subjekta.
2. Kombinacija za uporabu u skladu s patentnim zahtjevom 1, pri čemu je tvar (ii) latanoprost.
3. Kombinacija za uporabu u skladu s bilo kojim od patentnih zahtjeva 1 do 2, pri čemu se tvar (i) primjenjuje u oko subjekta istovremeno, odvojeno ili za redom u odnosu na primjenu tvari (ii) u oko subjekta.
4. Kombinacija za uporabu u skladu s patentnim zahtjevom 1, pri čemu se jedna ili više kapi od otprilike 0.05 mg/mL do otprilike 0.07 mg/mL tvari (i) primjenjuje s otprilike 30 µg/mL do otprilike 50 µg/mL tvari (ii) u oko subjekta od 1 do 4 puta na dan.
5. Kombinacija za uporabu u skladu s patentnim zahtjevom 4, pri čemu se otprilike 20-700 µg, ili 20-350 µg tvari (i) primjenjuje u oko subjekta od 1 do 2 puta na dan.
6. Kombinacija za uporabu u skladu s bilo kojim od patentnih zahtjeva 1 do 5, pri čemu se tvar (i) i tvar (ii) primjenjuju topički kao jedna ili više kapi u oko subjekta.
7. Kombinacija za uporabu u skladu s bilo kojim od patentnih zahtjeva 1 do 6 za uporabu u liječenju bolesti uzrokovanih povišenim intraokularnim tlakom kod subjekta.
8. Kombinacija za uporabu u skladu s patentnim zahtjevom 7, pri čemu su bolesti i stanja uzrokovana povišenim intraokularnim tlakom u čovjeka odabrana iz grupe koja se sastoji od okularne hipertenzije i primarnog glaukoma otvorenog kuta.
9. Komplet za uporabu iz bilo kojeg od patentnih zahtjeva 1 do 8 za uporabu u smanjivanju povišenog intraokularnog tlaka u oku subjekta.
10. Kombinacija koja sadrži i) ((2R,3S,4R,5R)-5-(6-(ciklopentilamino)-9H-purin-9-il)-3,4-dihidroksitetrahidrofuran-2-il)metil nitrat, ili njegovu farmaceutski prihvatljivu sol i ii) tvar odabranu iz grupe koja se sastoji od latanoprosta, travoprosta, unoprostona i bimatoprosta, za uporabu kao lijek.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29380610P | 2010-01-11 | 2010-01-11 | |
PCT/US2011/020808 WO2011085361A1 (en) | 2010-01-11 | 2011-01-11 | Combination, kit and method of reducing intraocular pressure |
EP11732309.7A EP2523669B1 (en) | 2010-01-11 | 2011-01-11 | Combination, kit and method of reducing intraocular pressure |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20170007T1 true HRP20170007T1 (hr) | 2017-03-10 |
Family
ID=44258984
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20170007TT HRP20170007T1 (hr) | 2010-01-11 | 2017-01-04 | Kombinacija, komplet i metoda za smanjivanje intraokularnog tlaka |
Country Status (28)
Country | Link |
---|---|
US (3) | US8877732B2 (hr) |
EP (1) | EP2523669B1 (hr) |
JP (2) | JP2013516495A (hr) |
KR (1) | KR20120115344A (hr) |
CN (1) | CN102711771B (hr) |
AU (1) | AU2011203897B2 (hr) |
BR (1) | BR112012017106A2 (hr) |
CA (1) | CA2784908A1 (hr) |
CL (1) | CL2012001912A1 (hr) |
CO (1) | CO6571924A2 (hr) |
CY (1) | CY1118510T1 (hr) |
DK (1) | DK2523669T3 (hr) |
EA (1) | EA025415B1 (hr) |
ES (1) | ES2613698T3 (hr) |
HR (1) | HRP20170007T1 (hr) |
HU (1) | HUE030566T2 (hr) |
IL (1) | IL220604A (hr) |
IN (1) | IN2012DN06592A (hr) |
LT (1) | LT2523669T (hr) |
ME (1) | ME02608B (hr) |
MX (1) | MX2012007661A (hr) |
PL (1) | PL2523669T3 (hr) |
PT (1) | PT2523669T (hr) |
RS (1) | RS55615B1 (hr) |
SG (2) | SG182285A1 (hr) |
SI (1) | SI2523669T1 (hr) |
SM (1) | SMT201700017B (hr) |
WO (1) | WO2011085361A1 (hr) |
Families Citing this family (8)
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CA2762064A1 (en) * | 2009-05-01 | 2010-11-04 | Inotek Pharmaceuticals Corporation | Method of reducing intraocular pressure in humans |
SG182285A1 (en) * | 2010-01-11 | 2012-08-30 | Inotek Pharmaceuticals Corp | Combination, kit and method of reducing intraocular pressure |
AU2011230580A1 (en) | 2010-03-26 | 2012-10-11 | Inotek Pharmaceuticals Corporation | Method of reducing intraocular pressure in humans using N6 -cyclopentyladenosine (CPA), CPA derivatives or prodrugs thereof |
DK2807178T3 (en) * | 2012-01-26 | 2017-09-04 | Inotek Pharmaceuticals Corp | Anhydrous polymorphs of (2R, 3S, 4R, 5R) -5- (6- (cyclopentylamino) -9H-purin-9-yl) -3,4-dihydroxytetrahydrofuran-2-yl) methyl nitrate and processes for their preparation |
AU2014239232A1 (en) * | 2013-03-15 | 2015-10-01 | Inotek Pharmaceuticals Corporation | A method of providing ocular neuroprotection |
NZ630759A (en) * | 2013-03-15 | 2017-07-28 | Inotek Pharmaceuticals Corp | Ophthalmic formulations comprising an a1 agonist |
CN107108485B (zh) | 2014-10-24 | 2020-06-12 | 小野药品工业株式会社 | Kcnq2~5通道活化剂 |
US20160158267A1 (en) * | 2014-12-03 | 2016-06-09 | Inotek Pharmaceuticals Corporation | Methods of preventing, reducing or treating macular degeneration |
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