ES2613698T3 - Combinación, kit y método de reducción de la presión intraocular - Google Patents

Combinación, kit y método de reducción de la presión intraocular Download PDF

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Publication number
ES2613698T3
ES2613698T3 ES11732309.7T ES11732309T ES2613698T3 ES 2613698 T3 ES2613698 T3 ES 2613698T3 ES 11732309 T ES11732309 T ES 11732309T ES 2613698 T3 ES2613698 T3 ES 2613698T3
Authority
ES
Spain
Prior art keywords
intraocular pressure
combination
kit
pressure reduction
dihydroxytetrahydrofuran
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES11732309.7T
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English (en)
Inventor
Norman N. Kim
William K. Mcvicar
Thomas Mccauley
Rudolf A. Baumgartner
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Rocket Pharmaceuticals Inc
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Inotek Pharmaceuticals Corp
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Application filed by Inotek Pharmaceuticals Corp filed Critical Inotek Pharmaceuticals Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Abstract

Una combinación oftálmica que comprende i)**Fórmula** ((2R,3S,4R,5R)-5-(6-(ciclopentilamino)-9H-purin-9-il)-3,4-dihidroxitetrahidrofuran-2-il)metil nitrato, o una sal farmacéuticamente aceptable del mismo, y ii) un compuesto seleccionado entre el grupo que consiste en latanoprost, travoprost, unoprostona y bimatoprost, para su uso en la reducción de la presión intraocular elevada en un ojo de un sujeto.
ES11732309.7T 2010-01-11 2011-01-11 Combinación, kit y método de reducción de la presión intraocular Active ES2613698T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29380610P 2010-01-11 2010-01-11
US293806P 2010-01-11
PCT/US2011/020808 WO2011085361A1 (en) 2010-01-11 2011-01-11 Combination, kit and method of reducing intraocular pressure

Publications (1)

Publication Number Publication Date
ES2613698T3 true ES2613698T3 (es) 2017-05-25

Family

ID=44258984

Family Applications (1)

Application Number Title Priority Date Filing Date
ES11732309.7T Active ES2613698T3 (es) 2010-01-11 2011-01-11 Combinación, kit y método de reducción de la presión intraocular

Country Status (28)

Country Link
US (3) US8877732B2 (es)
EP (1) EP2523669B1 (es)
JP (2) JP2013516495A (es)
KR (1) KR20120115344A (es)
CN (1) CN102711771B (es)
AU (1) AU2011203897B2 (es)
BR (1) BR112012017106A2 (es)
CA (1) CA2784908A1 (es)
CL (1) CL2012001912A1 (es)
CO (1) CO6571924A2 (es)
CY (1) CY1118510T1 (es)
DK (1) DK2523669T3 (es)
EA (1) EA025415B1 (es)
ES (1) ES2613698T3 (es)
HR (1) HRP20170007T1 (es)
HU (1) HUE030566T2 (es)
IL (1) IL220604A (es)
IN (1) IN2012DN06592A (es)
LT (1) LT2523669T (es)
ME (1) ME02608B (es)
MX (1) MX2012007661A (es)
PL (1) PL2523669T3 (es)
PT (1) PT2523669T (es)
RS (1) RS55615B1 (es)
SG (2) SG182285A1 (es)
SI (1) SI2523669T1 (es)
SM (1) SMT201700017B (es)
WO (1) WO2011085361A1 (es)

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EA024042B1 (ru) * 2009-05-01 2016-08-31 Инотек Фармасьютикалз Корпорейшн Способ снижения внутриглазного давления у людей
AU2011203897B2 (en) * 2010-01-11 2016-11-17 Inotek Pharmaceuticals Corporation Combination, kit and method of reducing intraocular pressure
US8476247B2 (en) 2010-03-26 2013-07-02 Inotek Pharmaceuticals Corporation Method of reducing intraocular pressure in humans
SG11201403979TA (en) * 2012-01-26 2014-08-28 Inotek Pharmaceuticals Corp Anhydrous polymorphs of (2r,3s,4r,5r)-5-(6-(cyclopentylamino)-9h-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl) } methyl nitrate and processes of preparation thereof
AU2014239232A1 (en) * 2013-03-15 2015-10-01 Inotek Pharmaceuticals Corporation A method of providing ocular neuroprotection
WO2014152723A1 (en) 2013-03-15 2014-09-25 Inotek Pharmaceuticals Corporation Ophthalmic formulations
BR112017008178A2 (pt) 2014-10-24 2017-12-19 Ono Pharmaceutical Co ativador do canal de kcnq2-5
CN107406479A (zh) * 2014-12-03 2017-11-28 伊诺泰克制药公司 预防、减轻或治疗黄斑变性的方法

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