WO2004091630A8 - 眼に適用する疾患治療剤 - Google Patents

眼に適用する疾患治療剤

Info

Publication number
WO2004091630A8
WO2004091630A8 PCT/JP2004/005479 JP2004005479W WO2004091630A8 WO 2004091630 A8 WO2004091630 A8 WO 2004091630A8 JP 2004005479 W JP2004005479 W JP 2004005479W WO 2004091630 A8 WO2004091630 A8 WO 2004091630A8
Authority
WO
WIPO (PCT)
Prior art keywords
eye
remedies
estrogen
diseases
serm
Prior art date
Application number
PCT/JP2004/005479
Other languages
English (en)
French (fr)
Other versions
WO2004091630A1 (ja
Inventor
Shinseiro Okamoto
Original Assignee
Advanced Medicine Res Inst
Shinseiro Okamoto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP2004/004709 external-priority patent/WO2004093882A1/ja
Priority to CA002527175A priority Critical patent/CA2527175A1/en
Priority to DE602004030103T priority patent/DE602004030103D1/de
Priority to EP04727990A priority patent/EP1621199B8/en
Priority to AU2004229291A priority patent/AU2004229291A1/en
Priority to JP2005505476A priority patent/JP4564920B2/ja
Application filed by Advanced Medicine Res Inst, Shinseiro Okamoto filed Critical Advanced Medicine Res Inst
Priority to AT04727990T priority patent/ATE488240T1/de
Publication of WO2004091630A1 publication Critical patent/WO2004091630A1/ja
Priority to US11/252,013 priority patent/US20060111318A1/en
Publication of WO2004091630A8 publication Critical patent/WO2004091630A8/ja
Priority to US13/039,147 priority patent/US20110223269A1/en
Priority to US13/039,140 priority patent/US20110212200A1/en
Priority to US13/039,127 priority patent/US20110212199A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

　エストロゲンまたはその代謝物などの性ステロイドホルモン、その誘導体、構造類似体、エストロゲン作用物質またはＳＥＲＭ又はノンフェミナイジングエストロゲン（ノンホルモナールエストロゲン）を含有する点眼剤または洗眼剤等の形態にある各種疾患の治療剤。優れた治療効果を有し、副作用の低減された、眼に適用する疾患治療剤を提供できる。
PCT/JP2004/005479 2003-04-18 2004-04-16 眼に適用する疾患治療剤 WO2004091630A1 (ja)

Priority Applications (10)

Application Number Priority Date Filing Date Title
AT04727990T ATE488240T1 (de) 2003-04-18 2004-04-16 Mittel zur behanldung von krankheiten zur aufbringung auf das auge
DE602004030103T DE602004030103D1 (de) 2003-04-18 2004-04-16 Mittel zur behanldung von krankheiten zur aufbringung auf das auge
EP04727990A EP1621199B8 (en) 2003-04-18 2004-04-16 Remedies for diseases to be applied to eye
AU2004229291A AU2004229291A1 (en) 2003-04-18 2004-04-16 Remedies for diseases to be applied to eye
JP2005505476A JP4564920B2 (ja) 2003-04-18 2004-04-16 眼に適用する疾患治療剤
CA002527175A CA2527175A1 (en) 2003-04-18 2004-04-16 Remedies for diseases to be applied to eye
US11/252,013 US20060111318A1 (en) 2003-04-18 2005-10-18 Agent for treating eye diseases
US13/039,147 US20110223269A1 (en) 2003-04-18 2011-03-02 Agent for treating eye diseases
US13/039,140 US20110212200A1 (en) 2003-04-18 2011-03-02 Agent for treating eye diseases
US13/039,127 US20110212199A1 (en) 2003-04-18 2011-03-02 Agent for treating eye diseases

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
JP2003114969 2003-04-18
JP2003-114969 2003-04-18
JP2003-132910 2003-05-12
JP2003132910 2003-05-12
JP2003329165 2003-09-19
JP2003-329165 2003-09-19
JP2003354135 2003-10-14
JP2003-354135 2003-10-14
PCT/JP2004/004709 WO2004093882A1 (ja) 2003-04-18 2004-03-31 眼に適用する疾患治療剤
JPPCT/JP04/004709 2004-03-31

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/252,013 Continuation-In-Part US20060111318A1 (en) 2003-04-18 2005-10-18 Agent for treating eye diseases

Publications (2)

Publication Number Publication Date
WO2004091630A1 WO2004091630A1 (ja) 2004-10-28
WO2004091630A8 true WO2004091630A8 (ja) 2005-11-24

Family

ID=33304160

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2004/005479 WO2004091630A1 (ja) 2003-04-18 2004-04-16 眼に適用する疾患治療剤

Country Status (7)

Country Link
EP (6) EP1621199B8 (ja)
JP (2) JP4564920B2 (ja)
AT (1) ATE488240T1 (ja)
AU (1) AU2004229291A1 (ja)
CA (1) CA2527175A1 (ja)
DE (1) DE602004030103D1 (ja)
WO (1) WO2004091630A1 (ja)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004229291A1 (en) * 2003-04-18 2004-10-28 Advanced Medicine Research Institute Remedies for diseases to be applied to eye
MX2007010359A (es) * 2005-02-24 2008-04-04 Diffusion Pharmaceuticals Llc Trans carotenoides, su sintesis, formulacion y usos.
CA2609549A1 (en) * 2005-05-25 2006-11-30 Sirtris Pharmaceuticals, Inc. Treatment of eye disorders with sirtuin modulators
WO2006127945A1 (en) 2005-05-26 2006-11-30 Neuron Systems Compositions and methods of treating retinal disease
WO2010148352A1 (en) * 2009-06-19 2010-12-23 Altos Vision Limited Time-release and micro-dose formulations for topical application of estrogen and estrogen analogs or other estrogen receptor modulators in the treatment of dry eye syndrome, and methods of preparation and application
EP2445339B1 (en) 2009-06-22 2019-08-07 Diffusion Pharmaceuticals LLC Diffusion enhancing compound and its use with a thrombolytic
WO2011072141A1 (en) * 2009-12-11 2011-06-16 Neuron Systems, Inc. Compositions and methods for the treatment of macular degeneration
EP2575487B1 (en) 2010-06-02 2017-10-18 Diffusion Pharmaceuticals Llc Oral formulations of bipolar trans carotenoids
CA2896032A1 (en) 2012-12-20 2014-06-26 Aldeyra Therapeutics, Inc. Peri-carbinols
SG11201505587YA (en) 2013-01-23 2015-08-28 Aldeyra Therapeutics Inc Toxic aldehyde related diseases and treatment
EP2948436A4 (en) 2013-01-25 2016-07-13 Aldeyra Therapeutics Inc NOVEL CASES IN THE TREATMENT OF MACULAR GENERATION
CA2996183A1 (en) 2015-08-21 2017-03-02 Aldeyra Therapeutics, Inc. Deuterated compounds and uses thereof
US10426790B2 (en) 2016-02-28 2019-10-01 Aldeyra Therapeutics, Inc. Treatment of allergic eye conditions with cyclodextrins
JP7032320B2 (ja) 2016-03-24 2022-03-08 ディフュージョン・ファーマシューティカルズ・エルエルシー 癌を処置するための、化学療法及び放射線療法を伴う二極性トランスカロテノイドの使用
CA3022665A1 (en) 2016-05-09 2017-11-16 Aldeyra Therapeutics, Inc. Combination treatment of ocular inflammatory disorders and diseases
WO2018170476A1 (en) 2017-03-16 2018-09-20 Aldeyra Therapeutics, Inc. Polymorphic compounds and uses thereof
JP6923917B2 (ja) * 2017-09-21 2021-08-25 国立大学法人福井大学 白内障の予防剤および治療剤、ならびに、これらを製造するためのｈｉｆ経路阻害剤の使用
CN111356451A (zh) 2017-10-10 2020-06-30 奥尔德拉医疗公司 炎性病症的治疗
EP3833660A4 (en) 2018-08-06 2022-05-11 Aldeyra Therapeutics, Inc. POLYMORPHIC COMPOUNDS AND THEIR USES
JP2022502499A (ja) 2018-09-25 2022-01-11 アルデイラ セラピューティクス， インコーポレイテッド ドライアイ疾患を処置するための製剤
US11786518B2 (en) 2019-03-26 2023-10-17 Aldeyra Therapeutics, Inc. Ophthalmic formulations and uses thereof
WO2022255282A1 (ja) * 2021-05-31 2022-12-08 国立大学法人大阪大学 動体視力向上用組成物
CN115105512A (zh) * 2022-08-29 2022-09-27 中山大学中山眼科中心 脱氢表雄酮在制备预防、治疗眼部近视的药物中的用途及其剂型和制备方法

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4383992A (en) * 1982-02-08 1983-05-17 Lipari John M Water-soluble steroid compounds
SE8305864D0 (sv) * 1983-10-25 1983-10-25 L E Medical Ogondroppar
US4617299A (en) * 1983-12-19 1986-10-14 Knepper Paul A Method for the prevention of ocular hypertension, treatment of glaucoma and treatment of ocular hypertension
US4877774A (en) * 1987-09-09 1989-10-31 The United States Of America As Represented By The Department Of Health And Human Services Administration of steroid hormones
US5002935A (en) * 1987-12-30 1991-03-26 University Of Florida Improvements in redox systems for brain-targeted drug delivery
IE62095B1 (en) * 1988-03-29 1994-12-14 Univ Florida Pharmaceutical formulations for parenteral use
US5376645A (en) * 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
KR960002739B1 (ko) * 1990-08-31 1996-02-26 데루오 니시다 각막 장해 치료제
DK0593520T3 (da) * 1991-06-18 2000-04-03 Theramex Forbindelser med indhold af steroider og deres anvendelse til behandling af glaucom
JP2531558B2 (ja) * 1991-08-17 1996-09-04 ルブキン、バージニア ドライアイ症処置用の性ステロイド膏薬、同薬の調製法および適用法
DK0614463T3 (da) * 1991-11-22 2003-03-31 Alcon Lab Inc Angiostatiske steroider
US6107289A (en) * 1992-04-21 2000-08-22 The Schepens Eye Research Institute, Inc. Ocular therapy in keratoconjunctivitis sicca using topically applied androgens or TGF-β
EP0674528A4 (en) * 1992-12-02 1996-06-26 Insite Vision Inc DRUG DELIVERY SYSTEM BASED ON CYCLODEXTRIN AND A POLYMER.
US5494901A (en) * 1993-01-05 1996-02-27 Javitt; Jonathan C. Topical compositions for the eye comprising a β-cyclodextrin derivative and a therapeutic agent
US6142989A (en) * 1993-05-03 2000-11-07 O'donnell, Jr.; Francis E. Apparatus and method for customized laser correction of refractive error
US5556395A (en) * 1993-05-07 1996-09-17 Visx Incorporated Method and system for laser treatment of refractive error using an offset image of a rotatable mask
ZA949715B (en) * 1993-12-14 1996-06-06 Lilly Co Eli Aqueous solution inclusion complexes of benzothiophene compounds with water soluble cyclodextrins and pharmaceutical formulations and methods thereof
US5521168A (en) * 1994-10-13 1996-05-28 Alcon Laboratories, Inc. Estrogen metabolites for lowering intraocular pressure
EP0840612A1 (en) * 1995-07-24 1998-05-13 Trustees Of Boston University Inhibition of nmda receptor activity by pregnenolone sulfate derivatives
DE69707509D1 (de) * 1996-07-12 2001-11-22 Novo Nordisk As 2-phenyl-3-azoylbenzothiophene zur minderung des intraokularen drucks
DE69731302T3 (de) * 1996-07-22 2011-01-20 Renovo Ltd. Verwendung von substanzen, die die östrogen wirkung fördern, zur behandlung von wunden
AUPO427196A0 (en) * 1996-12-19 1997-01-23 University Of Sydney, The A method for preventing or controlling cataract
IL138033A0 (en) * 1998-03-12 2001-10-31 Genentech Inc Method of preventing the death of retinal neurons and treating ocular diseases
EP1142585A4 (en) * 1999-01-12 2005-08-03 Santen Pharmaceutical Co Ltd DRUGS AGAINST CORNEAL DISORDERS
US20010041745A1 (en) * 1999-04-08 2001-11-15 Bryant Henry Uhlman Methods for increasing levels of acetylcholine
TR200200406T2 (tr) * 1999-06-11 2002-06-21 Watson Pharmaceuticals, Inc. Kadınlara oral olmayan yollarla androjenik steroidlerin uygulanması
AU1735001A (en) * 1999-12-10 2001-06-18 Senju Pharmaceutical Co., Ltd. Cyclodextrin-containing pharmaceutical composition
EP1177787A3 (en) * 2000-07-28 2003-09-10 Pfizer Products Inc. Use of an estrogen agonist/antagonist for treating cataracts
US6605640B2 (en) * 2001-01-31 2003-08-12 Gerard M. Nolan Method of treating certain eye diseases
US20020132802A1 (en) 2000-11-17 2002-09-19 Washington Univeristy Cytoprotective polycyclic compounds
WO2002078680A1 (de) * 2001-02-13 2002-10-10 Dr. Gerhard Mann Chem.-Pharm. Fabrik Gmbh Gaba-rezeptor-modulatoren zur behandlung neurodegenerativer erkrankungen des auges
TWI320712B (en) * 2001-09-05 2010-02-21 Alcon Inc The use of non-feminizing estrogens as retinoprotective agents for the treatment of glaucoma
AU2004229291A1 (en) * 2003-04-18 2004-10-28 Advanced Medicine Research Institute Remedies for diseases to be applied to eye

Also Published As

Publication number Publication date
CA2527175A1 (en) 2004-10-28
ATE488240T1 (de) 2010-12-15
AU2004229291A1 (en) 2004-10-28
EP2311465A1 (en) 2011-04-20
EP1621199B1 (en) 2010-11-17
EP1621199A1 (en) 2006-02-01
EP2301549A1 (en) 2011-03-30
EP1621199A4 (en) 2006-09-27
EP2305308A1 (en) 2011-04-06
WO2004091630A1 (ja) 2004-10-28
JP4564920B2 (ja) 2010-10-20
DE602004030103D1 (de) 2010-12-30
JP2010184927A (ja) 2010-08-26
JPWO2004091630A1 (ja) 2006-08-17
EP2289488A3 (en) 2011-03-30
EP2292239A3 (en) 2011-03-30
EP2289488A2 (en) 2011-03-02
EP1621199B8 (en) 2011-01-19
EP2292239A2 (en) 2011-03-09

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