JP2017534638A5 - - Google Patents
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- JP2017534638A5 JP2017534638A5 JP2017524049A JP2017524049A JP2017534638A5 JP 2017534638 A5 JP2017534638 A5 JP 2017534638A5 JP 2017524049 A JP2017524049 A JP 2017524049A JP 2017524049 A JP2017524049 A JP 2017524049A JP 2017534638 A5 JP2017534638 A5 JP 2017534638A5
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- 241000124008 Mammalia Species 0.000 claims description 37
- 206010064930 age-related macular degeneration Diseases 0.000 claims description 28
- 238000000034 method Methods 0.000 claims description 25
- 201000006165 Kuhnt-Junius degeneration Diseases 0.000 claims description 23
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims description 23
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims description 23
- 208000000208 Wet Macular Degeneration Diseases 0.000 claims description 23
- 239000005557 antagonist Substances 0.000 claims description 23
- 230000009266 disease activity Effects 0.000 claims description 20
- 208000031513 cyst Diseases 0.000 claims description 14
- 239000012530 fluid Substances 0.000 claims description 14
- 230000004304 visual acuity Effects 0.000 claims description 14
- 210000001525 retina Anatomy 0.000 claims description 12
- 206010011732 Cyst Diseases 0.000 claims description 10
- 238000002347 injection Methods 0.000 claims description 4
- 239000007924 injection Substances 0.000 claims description 4
- 238000011156 evaluation Methods 0.000 claims description 2
- 230000000007 visual effect Effects 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 29
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000006467 substitution reaction Methods 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462076770P | 2014-11-07 | 2014-11-07 | |
| US62/076,770 | 2014-11-07 | ||
| US201462088061P | 2014-12-05 | 2014-12-05 | |
| US62/088,061 | 2014-12-05 | ||
| PCT/US2015/059575 WO2016073918A1 (en) | 2014-11-07 | 2015-11-06 | Methods for treating ocular diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020138531A Division JP2020193212A (ja) | 2014-11-07 | 2020-08-19 | 眼疾患を処置する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017534638A JP2017534638A (ja) | 2017-11-24 |
| JP2017534638A5 true JP2017534638A5 (Direct) | 2018-12-06 |
| JP6753848B2 JP6753848B2 (ja) | 2020-09-09 |
Family
ID=54697654
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017523878A Active JP6667519B2 (ja) | 2014-11-07 | 2015-11-06 | 高濃度の抗ｖｅｇｆ抗体を含有する安定状態のタンパク質溶液製剤 |
| JP2017524049A Active JP6753848B2 (ja) | 2014-11-07 | 2015-11-06 | 眼疾患を処置する方法 |
| JP2020000823A Active JP7080263B2 (ja) | 2014-11-07 | 2020-01-07 | 高濃度の抗ｖｅｇｆ抗体を含有する安定状態のタンパク質溶液製剤 |
| JP2020138531A Withdrawn JP2020193212A (ja) | 2014-11-07 | 2020-08-19 | 眼疾患を処置する方法 |
| JP2022119423A Pending JP2022141923A (ja) | 2014-11-07 | 2022-07-27 | 眼疾患を処置する方法 |
| JP2024170733A Pending JP2025004075A (ja) | 2014-11-07 | 2024-09-30 | 眼疾患を処置する方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017523878A Active JP6667519B2 (ja) | 2014-11-07 | 2015-11-06 | 高濃度の抗ｖｅｇｆ抗体を含有する安定状態のタンパク質溶液製剤 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020000823A Active JP7080263B2 (ja) | 2014-11-07 | 2020-01-07 | 高濃度の抗ｖｅｇｆ抗体を含有する安定状態のタンパク質溶液製剤 |
| JP2020138531A Withdrawn JP2020193212A (ja) | 2014-11-07 | 2020-08-19 | 眼疾患を処置する方法 |
| JP2022119423A Pending JP2022141923A (ja) | 2014-11-07 | 2022-07-27 | 眼疾患を処置する方法 |
| JP2024170733A Pending JP2025004075A (ja) | 2014-11-07 | 2024-09-30 | 眼疾患を処置する方法 |
Country Status (25)
| Country | Link |
|---|---|
| US (5) | US10689438B2 (Direct) |
| EP (3) | EP4684797A2 (Direct) |
| JP (6) | JP6667519B2 (Direct) |
| KR (4) | KR102724014B1 (Direct) |
| CN (4) | CN106999581A (Direct) |
| AU (6) | AU2015342815B2 (Direct) |
| BR (2) | BR112017008093A2 (Direct) |
| CA (1) | CA2966646A1 (Direct) |
| CL (2) | CL2017001115A1 (Direct) |
| CO (1) | CO2017004596A2 (Direct) |
| EA (1) | EA201790989A1 (Direct) |
| EC (1) | ECSP17034829A (Direct) |
| ES (1) | ES3051145T3 (Direct) |
| GT (1) | GT201700096A (Direct) |
| IL (5) | IL251642B (Direct) |
| MX (3) | MX383808B (Direct) |
| MY (2) | MY193913A (Direct) |
| NZ (1) | NZ730821A (Direct) |
| PE (1) | PE20170780A1 (Direct) |
| PH (3) | PH12021550147A1 (Direct) |
| RU (1) | RU2722643C2 (Direct) |
| SG (3) | SG10201913565RA (Direct) |
| TN (1) | TN2017000128A1 (Direct) |
| TW (4) | TWI705827B (Direct) |
| WO (2) | WO2016073915A1 (Direct) |
Families Citing this family (60)
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| CA2648284C (en) | 2006-04-07 | 2016-08-16 | The Procter & Gamble Company | Antibodies that bind human protein tyrosine phosphatase beta (hptpbeta) and uses thereof |
| US7622593B2 (en) | 2006-06-27 | 2009-11-24 | The Procter & Gamble Company | Human protein tyrosine phosphatase inhibitors and methods of use |
| EP2307457B2 (en) | 2008-06-25 | 2022-06-22 | Novartis AG | Stable and soluble antibodies inhibiting tnf |
| TR201808591T4 (tr) | 2008-06-25 | 2018-07-23 | Esbatech Alcon Biomed Res Unit | Bir evrensel bir antikor iskeleti kullanılarak tavşan antikorların insanlaştırılması. |
| AU2010271105C1 (en) | 2009-01-12 | 2014-08-21 | Aerpio Therapeutics, Inc. | Compounds, compositions, and methods for preventing metastasis of cancer cells |
| EP2663325A1 (en) | 2011-01-13 | 2013-11-20 | Regeneron Pharmaceuticals, Inc. | Use of a vegf antagonist to treat angiogenic eye disorders |
| CN104039351A (zh) | 2011-10-13 | 2014-09-10 | 阿尔皮奥治疗学股份有限公司 | 用于治疗血管渗漏综合征和癌症的方法 |
| US20150050277A1 (en) | 2013-03-15 | 2015-02-19 | Aerpio Therapeutics Inc. | Compositions and methods for treating ocular diseases |
| CN106456614A (zh) | 2014-03-14 | 2017-02-22 | 爱尔皮奥治疗有限公司 | HPTP‑β抑制剂 |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| TWI705827B (zh) | 2014-11-07 | 2020-10-01 | 瑞士商諾華公司 | 治療眼部疾病之方法 |
| AU2016210918A1 (en) | 2015-01-28 | 2017-07-13 | Pfizer Inc., | Stable aqueous anti- vascular endothelial growth factor (VEGF) antibody formulation |
| US9879080B2 (en) | 2015-01-28 | 2018-01-30 | Prothena Biosciences Limited | Anti-transthyretin antibodies |
| US10464999B2 (en) | 2015-01-28 | 2019-11-05 | Prothena Biosciences Limited | Anti-transthyretin antibodies |
| US10633433B2 (en) | 2015-01-28 | 2020-04-28 | Prothena Biosciences Limited | Anti-transthyretin antibodies |
| EP3977994B1 (en) | 2015-09-23 | 2024-04-24 | EyePoint Pharmaceuticals, Inc. | Activators of tie-2 for use in treating intraocular pressure |
| HK1257295A1 (zh) | 2015-12-04 | 2019-10-18 | Novartis Ag | 用於免疫肿瘤学的组合物和方法 |
| NZ783685A (en) | 2015-12-30 | 2025-09-26 | Kodiak Sciences Inc | Antibodies and conjugates thereof |
| WO2018017714A1 (en) | 2016-07-20 | 2018-01-25 | Aerpio Therapeutics, Inc. | HUMANIZED MONOCLONAL ANTIBODIES THAT TARGET VE-PTP (HPTP-ß) |
| KR102124286B1 (ko) * | 2016-09-07 | 2020-06-18 | 삭신 라이프사이언스 피브이티 엘티디 | Vegf에 대한 합성 항체 및 이들의 용도 |
| WO2018063963A1 (en) * | 2016-09-28 | 2018-04-05 | Board Of Regents, The University Of Texas System | Antibody and protein therapeutic formulations and uses thereof |
| RU2767793C2 (ru) | 2016-11-18 | 2022-03-21 | Астеллас Фарма Инк. | НОВЫЙ Fab-ФРАГМЕНТ АНТИТЕЛА ПРОТИВ MUC1 ЧЕЛОВЕКА |
| CN110832075A (zh) | 2017-03-22 | 2020-02-21 | 诺华股份有限公司 | 用于免疫肿瘤学的组合物和方法 |
| JOP20190245A1 (ar) | 2017-04-20 | 2019-10-15 | Novartis Ag | أنظمة توصيل إطلاق مستدام تتضمن روابط بلا أثر لنقطة الربط |
| CN109562166B (zh) * | 2017-04-28 | 2021-04-02 | 苏州思坦维生物技术股份有限公司 | 一种眼用药物组合物及其用途 |
| TWI795415B (zh) | 2017-07-07 | 2023-03-11 | 日商安斯泰來製藥股份有限公司 | 新穎的抗人類ＣＥＡＣＡＭ５抗體Ｆａｂ片段 |
| WO2019020777A1 (en) * | 2017-07-26 | 2019-01-31 | Formycon Ag | LIQUID FORMULATION OF A VEGF ANTAGONIST |
| EP3691626A4 (en) | 2017-10-06 | 2021-06-30 | Prothena Biosciences Limited | METHODS OF DETECTION OF TRANSTHYRETINE |
| AU2018345806A1 (en) | 2017-10-06 | 2020-03-12 | Novo Nordisk A/S | Anti-transthyretin antibodies |
| BR112020010483A2 (pt) | 2017-11-29 | 2020-10-20 | Prothena Biosciences Limited | formulação liofilizada de um anticorpo monoclonal contra transtirretina |
| SG11202004268PA (en) | 2017-11-30 | 2020-06-29 | Regeneron Pharma | Use of a vegf antagonist to treat angiogenic eye disorders |
| WO2019147944A1 (en) | 2018-01-26 | 2019-08-01 | The Regents Of The University Of California | Methods and compositions for treatment of angiogenic disordres using anti-vegf agents |
| EP3749359A1 (en) * | 2018-02-06 | 2020-12-16 | F. Hoffmann-La Roche AG | Treatment of ophthalmologic diseases |
| SG11202008242XA (en) | 2018-03-02 | 2020-09-29 | Kodiak Sciences Inc | Il-6 antibodies and fusion constructs and conjugates thereof |
| MX2020009140A (es) * | 2018-03-16 | 2020-09-28 | Novartis Ag | Metodos para el tratamiento de enfermedades oculares. |
| AU2019237252A1 (en) * | 2018-03-23 | 2020-10-22 | AbbVie Deutschland GmbH & Co. KG | Stable aqueous anti-tau antibody formulations |
| EP3775267A4 (en) * | 2018-04-10 | 2022-05-18 | Askgene Pharma, Inc. | NOVEL ANGIOPOIETIN-2, VEGF DUAL ANTAGONISTS |
| CN118948760A (zh) | 2018-05-10 | 2024-11-15 | 瑞泽恩制药公司 | 含有高浓度vegf受体融合蛋白的制剂 |
| MX2020012351A (es) | 2018-05-17 | 2021-01-29 | Astellas Pharma Inc | Complejo que tiene fragmento fab de anticuerpo anti-muc1 de humano, enlazador peptido y/o ligando. |
| JP7695187B2 (ja) | 2018-09-24 | 2025-06-18 | アイポイント ファーマシューティカルズ， インコーポレイテッド | ＨＰＴＰ－β（ＶＥ－ＰＴＰ）およびＶＥＧＦを標的にする多特異性抗体 |
| TW202027794A (zh) | 2018-10-03 | 2020-08-01 | 瑞士商諾華公司 | 血管生成素樣３多肽之持續遞送 |
| SG11202103670XA (en) * | 2018-10-10 | 2021-05-28 | Astellas Pharma Inc | Pharmaceutical composition containing tagged site-antihuman antibody fab fragment complex |
| MA54052A (fr) | 2018-10-29 | 2022-02-09 | Hoffmann La Roche | Formulation d'anticorps |
| WO2020096695A1 (en) | 2018-11-07 | 2020-05-14 | Applied Molecular Transport Inc. | Cholix-derived carriers for oral delivery of heterologous payload |
| CA3119241A1 (en) * | 2018-12-18 | 2020-06-25 | Novartis Ag | Protein solution formulation containing high concentration of an anti-vegf antibody |
| US11634485B2 (en) | 2019-02-18 | 2023-04-25 | Eli Lilly And Company | Therapeutic antibody formulation |
| TW202532428A (zh) | 2019-04-26 | 2025-08-16 | 美商愛德維仁生物科技公司 | 用於玻璃體內遞送之變異體aav蛋白殼 |
| EP3962482A4 (en) | 2019-04-29 | 2023-01-11 | EyePoint Pharmaceuticals, Inc. | TIE 2 ACTIVATORS FACING THE SCHLEMM CHANNEL |
| PH12022550330A1 (en) | 2019-08-16 | 2023-02-06 | Applied Molecular Transport Inc | Compositions, formulations, and interleukin production and purification |
| AU2020364071A1 (en) | 2019-10-10 | 2022-05-26 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| CA3168512A1 (en) | 2019-11-25 | 2021-06-03 | Napoleone Ferrara | Long-acting vegf inhibitors for intraocular neovascularization |
| CN111217834B (zh) * | 2020-02-21 | 2021-10-26 | 维眸生物科技（上海）有限公司 | Rock激酶抑制剂的硝基氧衍生物 |
| US20230192832A1 (en) * | 2020-03-04 | 2023-06-22 | Shanghai Henlius Biotech, Inc. | Pharmaceutical formulation comprising bevacizumab |
| CN113698478B (zh) * | 2020-05-21 | 2025-11-18 | 迈威(上海)生物科技股份有限公司 | 抗α-溶血素的抗体及其稳定制剂 |
| KR20220001106A (ko) * | 2020-06-29 | 2022-01-05 | (주)메디톡스 | 고농도 항-ｖｅｇｆ 항체 제제 및 이에 사용하기 위한 항-ｖｅｇｆ 항체 |
| PH12023550015A1 (en) | 2020-07-16 | 2024-03-11 | Novartis Ag | Anti-betacellulin antibodies, fragments thereof, and multi-specific binding molecules |
| LT4185318T (lt) * | 2021-05-17 | 2025-11-10 | Prailginto atpalaidavimo, didelės dozės vegf antagonisto režimai, skirti akių angiogeninių sutrikimų gydymui | |
| CN113940997B (zh) * | 2021-12-21 | 2022-04-08 | 迈威(上海)生物科技股份有限公司 | 一种双特异性抗体的稳定制剂 |
| JP2025529465A (ja) * | 2022-09-16 | 2025-09-04 | チールー ファーマシューティカル カンパニー、リミテッド | 安定な高濃度自己緩衝医薬組成物 |
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-
2015
- 2015-10-26 TW TW104135104A patent/TWI705827B/zh active
- 2015-10-26 TW TW104135105A patent/TWI738632B/zh active
- 2015-10-26 TW TW109132401A patent/TWI761959B/zh active
- 2015-10-26 TW TW110133255A patent/TWI806150B/zh active
- 2015-11-06 EP EP25187400.4A patent/EP4684797A2/en active Pending
- 2015-11-06 KR KR1020237014727A patent/KR102724014B1/ko active Active
- 2015-11-06 EP EP15798609.2A patent/EP3215122B1/en active Active
- 2015-11-06 NZ NZ73082115A patent/NZ730821A/en unknown
- 2015-11-06 JP JP2017523878A patent/JP6667519B2/ja active Active
- 2015-11-06 ES ES15798609T patent/ES3051145T3/es active Active
- 2015-11-06 CN CN201580060665.4A patent/CN106999581A/zh active Pending
- 2015-11-06 MX MX2017005874A patent/MX383808B/es unknown
- 2015-11-06 EA EA201790989A patent/EA201790989A1/ru unknown
- 2015-11-06 AU AU2015342815A patent/AU2015342815B2/en active Active
- 2015-11-06 CN CN202511153148.3A patent/CN120938921A/zh active Pending
- 2015-11-06 CN CN201580060416.5A patent/CN107635580A/zh active Pending
- 2015-11-06 SG SG10201913565RA patent/SG10201913565RA/en unknown
- 2015-11-06 RU RU2017119647A patent/RU2722643C2/ru active
- 2015-11-06 US US14/934,666 patent/US10689438B2/en active Active
- 2015-11-06 MX MX2017005875A patent/MX383399B/es unknown
- 2015-11-06 KR KR1020177014978A patent/KR102588846B1/ko active Active
- 2015-11-06 PE PE2017000812A patent/PE20170780A1/es unknown
- 2015-11-06 EP EP15807721.4A patent/EP3215123A1/en active Pending
- 2015-11-06 KR KR1020247035792A patent/KR20240161204A/ko not_active Ceased
- 2015-11-06 CA CA2966646A patent/CA2966646A1/en active Pending
- 2015-11-06 BR BR112017008093-1A patent/BR112017008093A2/pt not_active Application Discontinuation
- 2015-11-06 CN CN202111376360.8A patent/CN114081951A/zh active Pending
- 2015-11-06 MY MYPI2020002268A patent/MY193913A/en unknown
- 2015-11-06 BR BR112017008660A patent/BR112017008660A2/pt not_active Application Discontinuation
- 2015-11-06 SG SG11201702909QA patent/SG11201702909QA/en unknown
- 2015-11-06 JP JP2017524049A patent/JP6753848B2/ja active Active
- 2015-11-06 TN TN2017000128A patent/TN2017000128A1/en unknown
- 2015-11-06 US US14/934,731 patent/US10035850B2/en active Active
- 2015-11-06 PH PH1/2021/550147A patent/PH12021550147A1/en unknown
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