JP2017533891A5 - - Google Patents
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- JP2017533891A5 JP2017533891A5 JP2017516489A JP2017516489A JP2017533891A5 JP 2017533891 A5 JP2017533891 A5 JP 2017533891A5 JP 2017516489 A JP2017516489 A JP 2017516489A JP 2017516489 A JP2017516489 A JP 2017516489A JP 2017533891 A5 JP2017533891 A5 JP 2017533891A5
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- 229920001184 polypeptide Polymers 0.000 claims 45
- 102000004196 processed proteins & peptides Human genes 0.000 claims 45
- 108090000765 processed proteins & peptides Proteins 0.000 claims 45
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 35
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 35
- 125000003275 alpha amino acid group Chemical group 0.000 claims 27
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 6
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 5
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 5
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 5
- 239000000833 heterodimer Substances 0.000 claims 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 2
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 2
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 2
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 2
- 208000025316 Richter syndrome Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 2
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- WEVYNIUIFUYDGI-UHFFFAOYSA-N 3-[6-[4-(trifluoromethoxy)anilino]-4-pyrimidinyl]benzamide Chemical compound NC(=O)C1=CC=CC(C=2N=CN=C(NC=3C=CC(OC(F)(F)F)=CC=3)C=2)=C1 WEVYNIUIFUYDGI-UHFFFAOYSA-N 0.000 claims 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 208000025321 B-lymphoblastic leukemia/lymphoma Diseases 0.000 claims 1
- 208000032800 BCR-ABL1 positive blast phase chronic myelogenous leukemia Diseases 0.000 claims 1
- 208000004860 Blast Crisis Diseases 0.000 claims 1
- 208000011691 Burkitt lymphomas Diseases 0.000 claims 1
- 102000009109 Fc receptors Human genes 0.000 claims 1
- 108010087819 Fc receptors Proteins 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 108700020796 Oncogene Proteins 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 241000288906 Primates Species 0.000 claims 1
- 201000008736 Systemic mastocytosis Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 208000035269 cancer or benign tumor Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 201000003444 follicular lymphoma Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 208000003747 lymphoid leukemia Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 210000005134 plasmacytoid dendritic cell Anatomy 0.000 claims 1
- 208000017426 precursor B-cell acute lymphoblastic leukemia Diseases 0.000 claims 1
- 230000005945 translocation Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462055695P | 2014-09-26 | 2014-09-26 | |
| US62/055,695 | 2014-09-26 | ||
| PCT/US2015/051314 WO2016048938A1 (en) | 2014-09-26 | 2015-09-22 | Bi-specific monovalent diabodies that are capable of binding cd19 and cd3, and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017533891A JP2017533891A (ja) | 2017-11-16 |
| JP2017533891A5 true JP2017533891A5 (enExample) | 2018-11-01 |
| JP6839075B2 JP6839075B2 (ja) | 2021-03-03 |
Family
ID=55581876
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017516489A Active JP6839075B2 (ja) | 2014-09-26 | 2015-09-22 | Ｃｄ１９及びｃｄ３に結合できる二重特異性１価ダイアボディ並びにその使用 |
Country Status (29)
| Country | Link |
|---|---|
| US (4) | US10633443B2 (enExample) |
| EP (1) | EP3197917B1 (enExample) |
| JP (1) | JP6839075B2 (enExample) |
| KR (1) | KR20170063755A (enExample) |
| CN (1) | CN107484416A (enExample) |
| AP (1) | AP2017009823A0 (enExample) |
| AR (1) | AR101997A1 (enExample) |
| AU (1) | AU2015321546B2 (enExample) |
| CA (1) | CA2962603A1 (enExample) |
| CL (1) | CL2017000711A1 (enExample) |
| CO (1) | CO2017002793A2 (enExample) |
| CR (1) | CR20170109A (enExample) |
| CU (1) | CU20170041A7 (enExample) |
| DO (1) | DOP2017000083A (enExample) |
| EA (1) | EA201790719A1 (enExample) |
| ES (1) | ES2935062T3 (enExample) |
| IL (1) | IL251377B (enExample) |
| MA (1) | MA40573A (enExample) |
| MD (1) | MD20170040A2 (enExample) |
| MX (1) | MX375669B (enExample) |
| NI (1) | NI201700037A (enExample) |
| PE (1) | PE20170894A1 (enExample) |
| PH (1) | PH12017500544A1 (enExample) |
| SG (1) | SG11201702310QA (enExample) |
| TN (1) | TN2017000106A1 (enExample) |
| TW (1) | TWI706960B (enExample) |
| UY (1) | UY36316A (enExample) |
| WO (1) | WO2016048938A1 (enExample) |
| ZA (1) | ZA201701985B (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9963510B2 (en) | 2005-04-15 | 2018-05-08 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
| MX375669B (es) * | 2014-09-26 | 2025-03-06 | Macrogenics Inc | Diacuerpos monovalentes biespecificos que son capaces de unir cd19 y cd3, y usos de los mismos. |
| WO2016054101A1 (en) | 2014-09-29 | 2016-04-07 | Duke University | Bispecific molecules comprising an hiv-1 envelope targeting arm |
| AR106188A1 (es) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | Anticuerpos anti-cd19 humano humanizados y métodos de utilización |
| CR20180318A (es) | 2015-12-14 | 2018-09-19 | Macrogenics Inc | Moléculas biespecíficas que tienen inmunorreactividad con pd-1 y ctla-4, y métodos de uso de las mismas |
| EP4215548A1 (en) | 2016-12-21 | 2023-07-26 | Teneobio, Inc. | Anti-bcma heavy chain-only antibodies |
| WO2018156740A1 (en) | 2017-02-24 | 2018-08-30 | Macrogenics, Inc. | Bispecific binding molecules that are capable of binding cd137 and tumor antigens, and uses thereof |
| CN117866097A (zh) | 2017-06-20 | 2024-04-12 | 特尼奥生物股份有限公司 | 仅有重链的抗bcma抗体 |
| IL273217B2 (en) | 2017-09-22 | 2025-04-01 | Wuxi Biologics Ireland Ltd | Novel bispecific polypeptide complexes |
| IL273424B2 (en) * | 2017-09-22 | 2024-09-01 | Wuxi Biologics Ireland Ltd | Novel bispecific cd3/cd19 polypeptide complexes |
| EP3688033A4 (en) * | 2017-09-29 | 2021-06-23 | Janssen Biotech, Inc. | Novel formulations which stabilize low dose antibody compositions |
| CN109706163A (zh) * | 2017-10-26 | 2019-05-03 | 深圳新诺微环生物科技有限公司 | 微环dna表达连接人与动物靶细胞与效应细胞的桥接分子及其应用 |
| CN109957026A (zh) * | 2017-12-22 | 2019-07-02 | 成都恩沐生物科技有限公司 | 共价多特异性抗体 |
| WO2019160904A1 (en) * | 2018-02-15 | 2019-08-22 | Macrogenics, Inc. | Variant cd3-binding domains and their use in combination therapies for the treatment of disease |
| KR20210032311A (ko) * | 2018-07-20 | 2021-03-24 | 테네오바이오, 인코포레이티드 | Cd19에 결합하는 중쇄 항체 |
| CN109402168A (zh) * | 2018-10-30 | 2019-03-01 | 深圳新诺微环生物科技有限公司 | 微环dna表达连接her2阳性细胞与效应细胞的桥接分子及其应用 |
| PE20211867A1 (es) * | 2018-11-01 | 2021-09-21 | Shandong New Time Pharmaceutical Co Ltd | Anticuerpos biespecificos y su uso |
| CN113396161A (zh) * | 2018-12-04 | 2021-09-14 | 诺华股份有限公司 | 针对cd3的结合分子及其用途 |
| CN114341176A (zh) * | 2019-04-08 | 2022-04-12 | 纪念斯隆凯特琳癌症中心 | Cd19抗体及其使用方法 |
| UY38701A (es) | 2019-05-21 | 2020-12-31 | Novartis Ag | Moléculas de unión a cd19, conjugados, composiciones que las comprenden y usos de las mismas |
| CN112111012B (zh) * | 2019-06-20 | 2023-07-04 | 成都恩沐生物科技有限公司 | 共价多特异性抗体 |
| CN115279403A (zh) | 2020-02-21 | 2022-11-01 | 宏观基因有限公司 | Cd137结合分子及其用途 |
| FI4284512T3 (fi) | 2021-01-28 | 2025-05-22 | Regeneron Pharma | Koostumuksia ja menetelmiä sytokiinien vapautumisoireyhtymän hoitamiseksi |
| CN113488112A (zh) * | 2021-06-10 | 2021-10-08 | 五邑大学 | 一种共价结合预测方法及装置 |
| JP2024533488A (ja) * | 2021-09-13 | 2024-09-12 | シャンドン シムセレ バイオファーマシューティカル カンパニー リミテッド | 抗ヒトｃｄ３抗体及びその応用 |
| AU2023254191A1 (en) | 2022-04-11 | 2024-10-17 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for universal tumor cell killing |
| EP4665385A2 (en) | 2023-02-17 | 2025-12-24 | Regeneron Pharmaceuticals, Inc. | Induced nk cells responsive to cd3/taa bispecific antibodies |
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| MX375669B (es) * | 2014-09-26 | 2025-03-06 | Macrogenics Inc | Diacuerpos monovalentes biespecificos que son capaces de unir cd19 y cd3, y usos de los mismos. |
| WO2016054101A1 (en) * | 2014-09-29 | 2016-04-07 | Duke University | Bispecific molecules comprising an hiv-1 envelope targeting arm |
| RU2017129236A (ru) | 2015-01-26 | 2019-03-07 | Макродженикс, Инк. | Мультивалентные молекулы, содержащие dr5-связывающие домены |
| CA2995709A1 (en) * | 2015-08-17 | 2017-02-23 | Macrogenics,Inc. | Bispecific monovalent diabodies that are capable of binding b7-h3 and cd3, and uses thereof |
| TW201720458A (zh) * | 2015-12-04 | 2017-06-16 | 宏觀基因股份有限公司 | 能夠結合cd19 和cd3 的雙特異性單價雙抗體以及其用途 |
| EP3448427A1 (en) * | 2016-04-29 | 2019-03-06 | CureVac AG | Rna encoding an antibody |
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| WO2018156740A1 (en) * | 2017-02-24 | 2018-08-30 | Macrogenics, Inc. | Bispecific binding molecules that are capable of binding cd137 and tumor antigens, and uses thereof |
| BR112020011810A2 (pt) * | 2017-12-12 | 2020-11-17 | Macrogenics, Inc. | molécula de ligação cd16 x antígeno de doença, composição farmacêutica, uso da composição farmacêutica, e método para o tratamento de uma doença |
| WO2019160904A1 (en) * | 2018-02-15 | 2019-08-22 | Macrogenics, Inc. | Variant cd3-binding domains and their use in combination therapies for the treatment of disease |
| EP3794027A4 (en) * | 2018-05-18 | 2022-02-09 | MacroGenics, Inc. | OPTIMIZED GP41 BINDING MOLECULES AND THEIR USES |
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