JP2017533891A5 - - Google Patents
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- JP2017533891A5 JP2017533891A5 JP2017516489A JP2017516489A JP2017533891A5 JP 2017533891 A5 JP2017533891 A5 JP 2017533891A5 JP 2017516489 A JP2017516489 A JP 2017516489A JP 2017516489 A JP2017516489 A JP 2017516489A JP 2017533891 A5 JP2017533891 A5 JP 2017533891A5
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- 229920001184 polypeptide Polymers 0.000 claims 45
- 102000004196 processed proteins & peptides Human genes 0.000 claims 45
- 108090000765 processed proteins & peptides Proteins 0.000 claims 45
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 35
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 35
- 125000003275 alpha amino acid group Chemical group 0.000 claims 27
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 6
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 5
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 5
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 5
- 239000000833 heterodimer Substances 0.000 claims 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 2
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 2
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 2
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 2
- 208000025316 Richter syndrome Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 2
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- WEVYNIUIFUYDGI-UHFFFAOYSA-N 3-[6-[4-(trifluoromethoxy)anilino]-4-pyrimidinyl]benzamide Chemical compound NC(=O)C1=CC=CC(C=2N=CN=C(NC=3C=CC(OC(F)(F)F)=CC=3)C=2)=C1 WEVYNIUIFUYDGI-UHFFFAOYSA-N 0.000 claims 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 208000025321 B-lymphoblastic leukemia/lymphoma Diseases 0.000 claims 1
- 208000032800 BCR-ABL1 positive blast phase chronic myelogenous leukemia Diseases 0.000 claims 1
- 208000004860 Blast Crisis Diseases 0.000 claims 1
- 208000011691 Burkitt lymphomas Diseases 0.000 claims 1
- 102000009109 Fc receptors Human genes 0.000 claims 1
- 108010087819 Fc receptors Proteins 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 108700020796 Oncogene Proteins 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 241000288906 Primates Species 0.000 claims 1
- 201000008736 Systemic mastocytosis Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 208000035269 cancer or benign tumor Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 201000003444 follicular lymphoma Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 208000003747 lymphoid leukemia Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 210000005134 plasmacytoid dendritic cell Anatomy 0.000 claims 1
- 208000017426 precursor B-cell acute lymphoblastic leukemia Diseases 0.000 claims 1
- 230000005945 translocation Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462055695P | 2014-09-26 | 2014-09-26 | |
| US62/055,695 | 2014-09-26 | ||
| PCT/US2015/051314 WO2016048938A1 (en) | 2014-09-26 | 2015-09-22 | Bi-specific monovalent diabodies that are capable of binding cd19 and cd3, and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017533891A JP2017533891A (ja) | 2017-11-16 |
| JP2017533891A5 true JP2017533891A5 (enExample) | 2018-11-01 |
| JP6839075B2 JP6839075B2 (ja) | 2021-03-03 |
Family
ID=55581876
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017516489A Active JP6839075B2 (ja) | 2014-09-26 | 2015-09-22 | Ｃｄ１９及びｃｄ３に結合できる二重特異性１価ダイアボディ並びにその使用 |
Country Status (29)
| Country | Link |
|---|---|
| US (4) | US10633443B2 (enExample) |
| EP (1) | EP3197917B1 (enExample) |
| JP (1) | JP6839075B2 (enExample) |
| KR (1) | KR20170063755A (enExample) |
| CN (1) | CN107484416A (enExample) |
| AP (1) | AP2017009823A0 (enExample) |
| AR (1) | AR101997A1 (enExample) |
| AU (1) | AU2015321546B2 (enExample) |
| CA (1) | CA2962603A1 (enExample) |
| CL (1) | CL2017000711A1 (enExample) |
| CO (1) | CO2017002793A2 (enExample) |
| CR (1) | CR20170109A (enExample) |
| CU (1) | CU20170041A7 (enExample) |
| DO (1) | DOP2017000083A (enExample) |
| EA (1) | EA201790719A1 (enExample) |
| ES (1) | ES2935062T3 (enExample) |
| IL (1) | IL251377B (enExample) |
| MA (1) | MA40573A (enExample) |
| MD (1) | MD20170040A2 (enExample) |
| MX (1) | MX375669B (enExample) |
| NI (1) | NI201700037A (enExample) |
| PE (1) | PE20170894A1 (enExample) |
| PH (1) | PH12017500544A1 (enExample) |
| SG (1) | SG11201702310QA (enExample) |
| TN (1) | TN2017000106A1 (enExample) |
| TW (1) | TWI706960B (enExample) |
| UY (1) | UY36316A (enExample) |
| WO (1) | WO2016048938A1 (enExample) |
| ZA (1) | ZA201701985B (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9963510B2 (en) | 2005-04-15 | 2018-05-08 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
| AU2015321546B2 (en) * | 2014-09-26 | 2020-09-03 | Macrogenics, Inc. | Bi-specific monovalent diabodies that are capable of binding CD19 and CD3, and uses thereof |
| CN107108721B (zh) | 2014-09-29 | 2021-09-07 | 杜克大学 | 包含hiv-1包膜靶向臂的双特异性分子 |
| AR106188A1 (es) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | Anticuerpos anti-cd19 humano humanizados y métodos de utilización |
| TW202208440A (zh) | 2015-12-14 | 2022-03-01 | 美商宏觀基因股份有限公司 | 對於pd-1和ctla-4具有免疫反應性的雙特異性分子及其使用方法 |
| IL267485B2 (en) | 2016-12-21 | 2024-01-01 | Teneobio Inc | Anti-bcma heavy chain-only antibodies and uses thereof |
| EP3585431A4 (en) | 2017-02-24 | 2020-12-16 | MacroGenics, Inc. | BISPECIFIC BINDING MOLECULES CAPABLE OF BINDING TO CD137 AND TUMOR ANTIGENS, AND THEIR USES |
| KR20250007003A (ko) | 2017-06-20 | 2025-01-13 | 테네오바이오, 인코포레이티드 | 항-bcma 중쇄-단독 항체 |
| MY202919A (en) | 2017-09-22 | 2024-05-29 | Wuxi Biologics Ireland Ltd | Novel bispecific polypeptide complexes |
| MA50185A (fr) * | 2017-09-22 | 2020-07-29 | Wuxi Biologics Ireland Ltd | Nouveaux complexes polypeptidiques cd3/cd19 bispécifiques |
| JP2020535181A (ja) * | 2017-09-29 | 2020-12-03 | ヤンセン バイオテツク，インコーポレーテツド | 低用量抗体組成物を安定化する新規製剤 |
| CN109706163A (zh) * | 2017-10-26 | 2019-05-03 | 深圳新诺微环生物科技有限公司 | 微环dna表达连接人与动物靶细胞与效应细胞的桥接分子及其应用 |
| CN109957026A (zh) * | 2017-12-22 | 2019-07-02 | 成都恩沐生物科技有限公司 | 共价多特异性抗体 |
| AU2019222666B2 (en) | 2018-02-15 | 2025-12-04 | Macrogenics, Inc. | Variant CD3-binding domains and their use in combination therapies for the treatment of disease |
| CN112351997B (zh) * | 2018-07-20 | 2023-05-26 | 坦尼奥第二公司 | 与cd19结合的重链抗体 |
| CN109402168A (zh) * | 2018-10-30 | 2019-03-01 | 深圳新诺微环生物科技有限公司 | 微环dna表达连接her2阳性细胞与效应细胞的桥接分子及其应用 |
| PE20211867A1 (es) * | 2018-11-01 | 2021-09-21 | Shandong New Time Pharmaceutical Co Ltd | Anticuerpos biespecificos y su uso |
| JP7621948B2 (ja) * | 2018-12-04 | 2025-01-27 | ノバルティス アーゲー | Ｃｄ３に対する結合分子及びその使用 |
| CA3136251A1 (en) * | 2019-04-08 | 2020-10-15 | Memorial Sloan Kettering Cancer Center | Cd19 antibodies and methods of using the same |
| BR112021023048A2 (pt) | 2019-05-21 | 2022-04-19 | Novartis Ag | Moléculas de ligação a cd19 e usos das mesmas |
| CN112111012B (zh) * | 2019-06-20 | 2023-07-04 | 成都恩沐生物科技有限公司 | 共价多特异性抗体 |
| EP4106813A4 (en) | 2020-02-21 | 2024-03-27 | MacroGenics, Inc. | CD137 BINDING MOLECULES AND THEIR USES |
| HRP20250696T1 (hr) | 2021-01-28 | 2025-08-01 | Regeneron Pharmaceuticals, Inc. | Sastavi i postupci za liječenje sindroma oslobađanja citokina |
| CN113488112A (zh) * | 2021-06-10 | 2021-10-08 | 五邑大学 | 一种共价结合预测方法及装置 |
| WO2023201226A1 (en) | 2022-04-11 | 2023-10-19 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for universal tumor cell killing |
| KR20250151441A (ko) | 2023-02-17 | 2025-10-21 | 리제너론 파마슈티칼스 인코포레이티드 | Cd3/taa 이중특이적 항체에 대해 반응성인 유도된 nk 세포 |
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| AU2015380455A1 (en) | 2015-01-26 | 2017-08-03 | Macrogenics, Inc. | Multivalent molecules comprising DR5-binding domains |
| MA42665A (fr) * | 2015-08-17 | 2018-06-27 | Macrogenics Inc | Dianticorps monovalents bispécifiques capables de se lier à b7-h3 et à cd3 et leurs utilisations |
| AR106935A1 (es) * | 2015-12-04 | 2018-03-07 | Macrogenics Inc | Diacuerpos monovalentes biespecíficos que son capaces de unir cd19 y cd3, y usos de los mismos |
| WO2017186928A1 (en) * | 2016-04-29 | 2017-11-02 | Curevac Ag | Rna encoding an antibody |
| BR112018075303A2 (pt) * | 2016-06-07 | 2019-04-30 | Macrogenics, Inc. | resumo método para tratar uma doença ou condição inflamatória, e método de redução ou inibição de uma resposta imune |
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| WO2019222104A1 (en) * | 2018-05-18 | 2019-11-21 | Macrogenics, Inc. | Optimized gp41-binding molecules and uses thereof |
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