JP6839075B2 - Cd19及びcd3に結合できる二重特異性1価ダイアボディ並びにその使用 - Google Patents

Cd19及びcd3に結合できる二重特異性1価ダイアボディ並びにその使用 Download PDF

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JP6839075B2
JP6839075B2 JP2017516489A JP2017516489A JP6839075B2 JP 6839075 B2 JP6839075 B2 JP 6839075B2 JP 2017516489 A JP2017516489 A JP 2017516489A JP 2017516489 A JP2017516489 A JP 2017516489A JP 6839075 B2 JP6839075 B2 JP 6839075B2
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レスリー エス. ジョンソン
レスリー エス. ジョンソン
エツィオ ボンビニ
エツィオ ボンビニ
チャーイン カオ ラム
チャーイン カオ ラム
ポール エー. ムーア
ポール エー. ムーア
リキン リュウ
リキン リュウ
スコット ケーニヒ
スコット ケーニヒ
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マクロジェニクス,インコーポレーテッド
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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • AHUMAN NECESSITIES
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    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
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JP2017516489A 2014-09-26 2015-09-22 Cd19及びcd3に結合できる二重特異性1価ダイアボディ並びにその使用 Active JP6839075B2 (ja)

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US201462055695P 2014-09-26 2014-09-26
US62/055,695 2014-09-26
PCT/US2015/051314 WO2016048938A1 (en) 2014-09-26 2015-09-22 Bi-specific monovalent diabodies that are capable of binding cd19 and cd3, and uses thereof

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