JP2017533706A5 - - Google Patents

Download PDF

Info

Publication number
JP2017533706A5
JP2017533706A5 JP2017523266A JP2017523266A JP2017533706A5 JP 2017533706 A5 JP2017533706 A5 JP 2017533706A5 JP 2017523266 A JP2017523266 A JP 2017523266A JP 2017523266 A JP2017523266 A JP 2017523266A JP 2017533706 A5 JP2017533706 A5 JP 2017533706A5
Authority
JP
Japan
Prior art keywords
cell
cells
modified
tcr
disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2017523266A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2016070061A5 (Direct
JP2017533706A (ja
JP7372728B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2015/058339 external-priority patent/WO2016070061A1/en
Publication of JP2017533706A publication Critical patent/JP2017533706A/ja
Publication of JP2017533706A5 publication Critical patent/JP2017533706A5/ja
Priority to JP2021084334A priority Critical patent/JP2021121208A/ja
Priority to JP2023088510A priority patent/JP7757343B2/ja
Publication of JPWO2016070061A5 publication Critical patent/JPWO2016070061A5/ja
Application granted granted Critical
Publication of JP7372728B2 publication Critical patent/JP7372728B2/ja
Priority to JP2025169833A priority patent/JP2025188145A/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2017523266A 2014-10-31 2015-10-30 改変t細胞に関する方法および組成物 Active JP7372728B2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2021084334A JP2021121208A (ja) 2014-10-31 2021-05-19 改変t細胞に関する方法および組成物
JP2023088510A JP7757343B2 (ja) 2014-10-31 2023-05-30 改変t細胞に関する方法および組成物
JP2025169833A JP2025188145A (ja) 2014-10-31 2025-10-08 改変t細胞に関する方法および組成物

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201462073681P 2014-10-31 2014-10-31
US201462073343P 2014-10-31 2014-10-31
US201462073144P 2014-10-31 2014-10-31
US201462073467P 2014-10-31 2014-10-31
US201462073540P 2014-10-31 2014-10-31
US62/073,343 2014-10-31
US62/073,144 2014-10-31
US62/073,467 2014-10-31
US62/073,540 2014-10-31
US62/073,681 2014-10-31
PCT/US2015/058339 WO2016070061A1 (en) 2014-10-31 2015-10-30 Methods and compositions for modified t cells

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2021084334A Division JP2021121208A (ja) 2014-10-31 2021-05-19 改変t細胞に関する方法および組成物
JP2023088510A Division JP7757343B2 (ja) 2014-10-31 2023-05-30 改変t細胞に関する方法および組成物

Publications (4)

Publication Number Publication Date
JP2017533706A JP2017533706A (ja) 2017-11-16
JP2017533706A5 true JP2017533706A5 (Direct) 2018-12-06
JPWO2016070061A5 JPWO2016070061A5 (Direct) 2023-06-08
JP7372728B2 JP7372728B2 (ja) 2023-11-01

Family

ID=55858404

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2017523266A Active JP7372728B2 (ja) 2014-10-31 2015-10-30 改変t細胞に関する方法および組成物
JP2021084334A Withdrawn JP2021121208A (ja) 2014-10-31 2021-05-19 改変t細胞に関する方法および組成物
JP2023088510A Active JP7757343B2 (ja) 2014-10-31 2023-05-30 改変t細胞に関する方法および組成物
JP2025169833A Pending JP2025188145A (ja) 2014-10-31 2025-10-08 改変t細胞に関する方法および組成物

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2021084334A Withdrawn JP2021121208A (ja) 2014-10-31 2021-05-19 改変t細胞に関する方法および組成物
JP2023088510A Active JP7757343B2 (ja) 2014-10-31 2023-05-30 改変t細胞に関する方法および組成物
JP2025169833A Pending JP2025188145A (ja) 2014-10-31 2025-10-08 改変t細胞に関する方法および組成物

Country Status (9)

Country Link
US (1) US20170258835A1 (Direct)
EP (2) EP3212225B1 (Direct)
JP (4) JP7372728B2 (Direct)
KR (1) KR20170074243A (Direct)
CN (1) CN107106670A (Direct)
AU (1) AU2015338984A1 (Direct)
CA (1) CA2964958A1 (Direct)
HK (1) HK1243333A1 (Direct)
WO (1) WO2016070061A1 (Direct)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3466967A1 (en) 2015-05-18 2019-04-10 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
US11059880B2 (en) 2015-06-30 2021-07-13 Arizona Board Of Regents On Behalf Of The University Of Arizona Redirected cells with MHC chimeric receptors and methods of use in immunotherapy
US11649435B2 (en) 2015-08-28 2023-05-16 The Trustees Of The University Of Pennsylvania Methods and compositions for cells expressing a chimeric intracellular signaling molecule
HK1257441A1 (zh) 2015-08-28 2019-10-18 The Trustees Of The University Of Pennsylvania 表达嵌合细胞内信号传导分子的细胞的方法和组合物
CN109310744A (zh) 2015-09-23 2019-02-05 赛通免疫有限责任公司 用于免疫治疗的flt3定向car细胞
US12241053B2 (en) 2015-10-09 2025-03-04 The Brigham And Women's Hospital, Inc. Modulation of novel immune checkpoint targets
WO2017075465A1 (en) 2015-10-28 2017-05-04 The Broad Institute Inc. Compositions and methods for evaluating and modulating immune responses by detecting and targeting gata3
WO2017075451A1 (en) 2015-10-28 2017-05-04 The Broad Institute Inc. Compositions and methods for evaluating and modulating immune responses by detecting and targeting pou2af1
US11001622B2 (en) 2015-11-19 2021-05-11 The Brigham And Women's Hospital, Inc. Method of treating autoimmune disease with lymphocyte antigen CD5-like (CD5L) protein
CN109072194B (zh) * 2015-12-09 2022-12-27 纪念斯隆-凯特林癌症中心 免疫细胞组合物及其使用方法
JP2019509753A (ja) * 2016-03-31 2019-04-11 ライオン ティーシーアール ピーティーイー.エルティーディー. 外因性ウイルス特異的t細胞受容体(tcr)を発現する非活性化t細胞
MX2018012468A (es) * 2016-04-15 2019-06-06 Zymeworks Inc Construcciones de union a antigeno multiespecificas dirigidas a agentes inmunoterapeuticos.
CN107522786A (zh) * 2016-06-20 2017-12-29 深圳市体内生物医药科技有限公司 一种分子、表达其的细胞及其制备方法和用途
CN107586341A (zh) * 2016-07-08 2018-01-16 生命序有限公司 重组免疫检查点受体及免疫检查点抑制分子的共表达及应用
CN107586342A (zh) * 2016-07-08 2018-01-16 生命序有限公司 重组免疫检查点受体及其应用
US11242376B2 (en) 2016-08-02 2022-02-08 TCR2 Therapeutics Inc. Compositions and methods for TCR reprogramming using fusion proteins
CA3034691A1 (en) 2016-08-30 2018-03-08 Memorial Sloan Kettering Cancer Center Immune cell compositions and methods of use for treating viral and other infections
US20190262399A1 (en) 2016-09-07 2019-08-29 The Broad Institute, Inc. Compositions and methods for evaluating and modulating immune responses
WO2018067991A1 (en) 2016-10-07 2018-04-12 The Brigham And Women's Hospital, Inc. Modulation of novel immune checkpoint targets
GB2564823B8 (en) 2016-10-07 2022-06-29 Tcr2 Therapeutics Inc Compositions and methods for TCR reprogramming using fusion proteins
WO2018089386A1 (en) 2016-11-11 2018-05-17 The Broad Institute, Inc. Modulation of intestinal epithelial cell differentiation, maintenance and/or function through t cell action
CA3044593A1 (en) 2016-11-22 2018-05-31 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
WO2018120842A1 (zh) * 2016-12-30 2018-07-05 上海欣百诺生物科技有限公司 一种双功能分子及其应用
CN108264562B (zh) * 2016-12-30 2021-08-10 惠和生物技术(上海)有限公司 一种结合cd3和t细胞正共刺激分子的双功能分子及其应用
US12473343B2 (en) 2017-01-10 2025-11-18 The General Hospital Corporation Targeted t cells with cytotoxicity toward immunosuppressive cells
WO2018183908A1 (en) 2017-03-31 2018-10-04 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating ovarian tumors
US11913075B2 (en) 2017-04-01 2024-02-27 The Broad Institute, Inc. Methods and compositions for detecting and modulating an immunotherapy resistance gene signature in cancer
WO2018191553A1 (en) 2017-04-12 2018-10-18 Massachusetts Eye And Ear Infirmary Tumor signature for metastasis, compositions of matter methods of use thereof
CA3059444A1 (en) * 2017-04-14 2018-10-18 The General Hospital Corporation Chimeric antigen receptor t cells targeting the tumor microenvironment
CN110868853A (zh) * 2017-04-26 2020-03-06 纪念斯隆-凯特琳癌症中心 即用型冷冻保存细胞
WO2018209324A2 (en) 2017-05-11 2018-11-15 The Broad Institute, Inc. Methods and compositions of use of cd8+ tumor infiltrating lymphocyte subtypes and gene signatures thereof
KR102379189B1 (ko) 2017-06-13 2022-03-25 엘지디스플레이 주식회사 연성 표시 패널을 포함하는 롤러블 디스플레이 장치
WO2018232195A1 (en) 2017-06-14 2018-12-20 The Broad Institute, Inc. Compositions and methods targeting complement component 3 for inhibiting tumor growth
WO2019014581A1 (en) 2017-07-14 2019-01-17 The Broad Institute, Inc. METHODS AND COMPOSITIONS FOR MODULATING THE ACTIVITY OF A CYTOTOXIC LYMPHOCYTE
CN111315403A (zh) * 2017-09-15 2020-06-19 凯德药业股份有限公司 用于进行具有监管链和身份链生物样品跟踪的患者特异性免疫疗法规程的方法和系统
US10849966B2 (en) 2017-09-18 2020-12-01 Trustees Of Boston University Methods for treating netosis and neutrophil activation
BR112020005676A2 (pt) * 2017-09-22 2020-10-20 WuXi Biologics Ireland Limited novos complexos polipeptídicos biespecíficos
US12043870B2 (en) 2017-10-02 2024-07-23 The Broad Institute, Inc. Methods and compositions for detecting and modulating an immunotherapy resistance gene signature in cancer
US11732257B2 (en) 2017-10-23 2023-08-22 Massachusetts Institute Of Technology Single cell sequencing libraries of genomic transcript regions of interest in proximity to barcodes, and genotyping of said libraries
WO2019094955A1 (en) 2017-11-13 2019-05-16 The Broad Institute, Inc. Methods and compositions for targeting developmental and oncogenic programs in h3k27m gliomas
EP3710039A4 (en) 2017-11-13 2021-08-04 The Broad Institute, Inc. METHODS AND COMPOSITIONS FOR TREATMENT OF CANCER BY TARGETING THE CLEC2D-KLRB1 PATH
CN109970864A (zh) * 2017-12-28 2019-07-05 上海细胞治疗研究院 一种双向激活共刺激分子受体及其用途
US11994512B2 (en) 2018-01-04 2024-05-28 Massachusetts Institute Of Technology Single-cell genomic methods to generate ex vivo cell systems that recapitulate in vivo biology with improved fidelity
US12178872B2 (en) 2018-01-19 2024-12-31 Miltenyi Biotec B.V. & Co. KG Regulatory T cell expressing a chimeric antigen receptor
CN112004832A (zh) * 2018-02-23 2020-11-27 H·李·莫菲特癌症中心研究所公司 结合cd83的嵌合抗原受体
CN112119086A (zh) 2018-03-01 2020-12-22 堪萨斯大学 用于使用重组t细胞受体基因生成基于细胞的治疗剂的技术
WO2019178342A1 (en) * 2018-03-15 2019-09-19 Fundamental Solutions Corporation Programmable immunocyte receptor complex system
US11957695B2 (en) 2018-04-26 2024-04-16 The Broad Institute, Inc. Methods and compositions targeting glucocorticoid signaling for modulating immune responses
WO2019222642A1 (en) * 2018-05-18 2019-11-21 Senti Biosciences, Inc. Engineered immune cells and methods of use
WO2019232542A2 (en) 2018-06-01 2019-12-05 Massachusetts Institute Of Technology Methods and compositions for detecting and modulating microenvironment gene signatures from the csf of metastasis patients
US12036240B2 (en) 2018-06-14 2024-07-16 The Broad Institute, Inc. Compositions and methods targeting complement component 3 for inhibiting tumor growth
US20200038443A1 (en) * 2018-08-04 2020-02-06 AbCyte Therapeutics Inc. Multi-function and multi-targeting car system and methods for use thereof
WO2020033366A1 (en) * 2018-08-08 2020-02-13 Nantbio, Inc. Recombinant cd1-restricted t cells and methods
US20210382068A1 (en) 2018-10-02 2021-12-09 Dana-Farber Cancer Institute, Inc. Hla single allele lines
WO2020081730A2 (en) 2018-10-16 2020-04-23 Massachusetts Institute Of Technology Methods and compositions for modulating microenvironment
WO2020131586A2 (en) 2018-12-17 2020-06-25 The Broad Institute, Inc. Methods for identifying neoantigens
CN109722437B (zh) * 2018-12-29 2020-01-07 广州百暨基因科技有限公司 一种通用型car-t细胞及其制备方法和用途
CN111378622B (zh) * 2018-12-29 2022-12-02 华东师范大学 核酸编码的car-t细胞及其制备方法和应用
US11739156B2 (en) 2019-01-06 2023-08-29 The Broad Institute, Inc. Massachusetts Institute of Technology Methods and compositions for overcoming immunosuppression
WO2020156405A1 (en) * 2019-01-28 2020-08-06 Wuxi Biologics (Shanghai) Co. Ltd. Novel bispecific cd3/cd20 polypeptide complexes
US20220154282A1 (en) 2019-03-12 2022-05-19 The Broad Institute, Inc. Detection means, compositions and methods for modulating synovial sarcoma cells
US20220142948A1 (en) 2019-03-18 2022-05-12 The Broad Institute, Inc. Compositions and methods for modulating metabolic regulators of t cell pathogenicity
EP3952887A4 (en) * 2019-04-12 2023-05-03 Emory University COMPOSITIONS AND METHODS FOR PROMOTING THE CYTOTOXICITY OF HEMATOPOIETIC CELLS
US20220235340A1 (en) 2019-05-20 2022-07-28 The Broad Institute, Inc. Novel crispr-cas systems and uses thereof
US20220226464A1 (en) 2019-05-28 2022-07-21 Massachusetts Institute Of Technology Methods and compositions for modulating immune responses
WO2021030627A1 (en) 2019-08-13 2021-02-18 The General Hospital Corporation Methods for predicting outcomes of checkpoint inhibition and treatment thereof
US12421557B2 (en) 2019-08-16 2025-09-23 The Broad Institute, Inc. Methods for predicting outcomes and treating colorectal cancer using a cell atlas
US12018081B1 (en) * 2019-08-28 2024-06-25 The Regents Of The University Of Colorado, A Body Corporate Photoconjugation reactions for modification of specific proteins on live cells
US20220298501A1 (en) 2019-08-30 2022-09-22 The Broad Institute, Inc. Crispr-associated mu transposase systems
JP7682859B2 (ja) * 2019-09-11 2025-05-26 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 前立腺幹細胞抗原(psca)キメラ抗原受容体(car)を含む組成物および方法
CN112500492B (zh) * 2019-09-13 2023-08-04 中国科学院分子细胞科学卓越创新中心 一种嵌合抗原受体及其用途
US12297426B2 (en) 2019-10-01 2025-05-13 The Broad Institute, Inc. DNA damage response signature guided rational design of CRISPR-based systems and therapies
US12394502B2 (en) 2019-10-02 2025-08-19 The General Hospital Corporation Method for predicting HLA-binding peptides using protein structural features
US12195725B2 (en) 2019-10-03 2025-01-14 Dana-Farber Cancer Institute, Inc. Compositions and methods for modulating and detecting tissue specific TH17 cell pathogenicity
US11981922B2 (en) 2019-10-03 2024-05-14 Dana-Farber Cancer Institute, Inc. Methods and compositions for the modulation of cell interactions and signaling in the tumor microenvironment
US11793787B2 (en) 2019-10-07 2023-10-24 The Broad Institute, Inc. Methods and compositions for enhancing anti-tumor immunity by targeting steroidogenesis
US11844800B2 (en) 2019-10-30 2023-12-19 Massachusetts Institute Of Technology Methods and compositions for predicting and preventing relapse of acute lymphoblastic leukemia
US12165747B2 (en) 2020-01-23 2024-12-10 The Broad Institute, Inc. Molecular spatial mapping of metastatic tumor microenvironment
JP2023522330A (ja) 2020-04-17 2023-05-30 シティ・オブ・ホープ Flt3陽性悪性腫瘍を処置するためのflt3標的化キメラ抗原受容体改変細胞
CN111574616B (zh) * 2020-06-17 2021-02-02 深圳豪石生物科技有限公司 分离的t细胞受体和应用
WO2022036495A1 (en) 2020-08-17 2022-02-24 Utc Therapeutics Inc. Lymphocytes-antigen presenting cells co-stimulators and uses thereof
WO2022111562A1 (zh) * 2020-11-26 2022-06-02 上海医药集团生物治疗技术有限公司 一种经修饰的免疫细胞及其应用
WO2022192662A1 (en) * 2021-03-12 2022-09-15 Adaptive Biotechnologies Corporation Crohn's disease-associated t cell receptor-related methods
EP4310188A1 (en) 2021-03-17 2024-01-24 Daiichi Sankyo Company, Limited Gene coding for chimeric receptor for anti-acetylcholine receptor autoantibody
CN115505572B (zh) * 2021-06-22 2025-11-14 康立泰生物医药(青岛)有限公司 一种增强型抗肿瘤nk细胞及其制备方法和应用
KR20250020432A (ko) * 2022-06-06 2025-02-11 카리부 바이오사이언시스 인코포레이티드 조작 면역 세포를 이용한 자가면역 질환의 치료
CN116083369B (zh) * 2022-09-01 2025-05-09 华中科技大学同济医学院附属同济医院 双特异性抗体修饰囊泡、双特异性抗体、核酸、重组载体、基因工程细胞、方法和应用
EP4598949A1 (en) 2022-10-07 2025-08-13 The General Hospital Corporation Methods and compositions for high-throughput discovery of peptide-mhc targeting binding proteins
WO2024124044A1 (en) 2022-12-07 2024-06-13 The Brigham And Women’S Hospital, Inc. Compositions and methods targeting sat1 for enhancing anti¬ tumor immunity during tumor progression
WO2025059533A1 (en) 2023-09-13 2025-03-20 The Broad Institute, Inc. Crispr enzymes and systems
WO2025064482A2 (en) * 2023-09-19 2025-03-27 Ginkgo Bioworks, Inc. Chimeric immune cell receptors
CN117106035B (zh) * 2023-10-25 2024-04-23 烟台药物研究所 一种肿瘤靶向多肽、多肽偶联药物及制备与应用
WO2025097055A2 (en) 2023-11-02 2025-05-08 The Broad Institute, Inc. Compositions and methods of use of t cells in immunotherapy
WO2025117544A1 (en) 2023-11-29 2025-06-05 The Broad Institute, Inc. Engineered omega guide molecule and iscb compositions, systems, and methods of use thereof

Family Cites Families (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA120409A (en) 1909-05-13 1909-09-07 Hiram Lucas Piper Signal lamp
FR901228A (fr) 1943-01-16 1945-07-20 Deutsche Edelstahlwerke Ag Système d'aimant à entrefer annulaire
US4444887A (en) 1979-12-10 1984-04-24 Sloan-Kettering Institute Process for making human antibody producing B-lymphocytes
US4716111A (en) 1982-08-11 1987-12-29 Trustees Of Boston University Process for producing human antibodies
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4694778A (en) 1984-05-04 1987-09-22 Anicon, Inc. Chemical vapor deposition wafer boat
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US6548640B1 (en) 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US5567610A (en) 1986-09-04 1996-10-22 Bioinvent International Ab Method of producing human monoclonal antibodies and kit therefor
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5413923A (en) 1989-07-25 1995-05-09 Cell Genesys, Inc. Homologous recombination for universal donor cells and chimeric mammalian hosts
US5585362A (en) 1989-08-22 1996-12-17 The Regents Of The University Of Michigan Adenovirus vectors for gene therapy
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
DK0463151T3 (da) 1990-01-12 1996-07-01 Cell Genesys Inc Frembringelse af xenogene antistoffer
US5229275A (en) 1990-04-26 1993-07-20 Akzo N.V. In-vitro method for producing antigen-specific human monoclonal antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
DE69127627T2 (de) 1990-08-29 1998-02-19 Genpharm Int Produktion und Nützung nicht-menschliche transgentiere zur Produktion heterologe Antikörper
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
EP0519596B1 (en) 1991-05-17 2005-02-23 Merck & Co. Inc. A method for reducing the immunogenicity of antibody variable domains
US5199942A (en) 1991-06-07 1993-04-06 Immunex Corporation Method for improving autologous transplantation
ES2136092T3 (es) 1991-09-23 1999-11-16 Medical Res Council Procedimientos para la produccion de anticuerpos humanizados.
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
GB9125768D0 (en) 1991-12-04 1992-02-05 Hale Geoffrey Therapeutic method
US6080840A (en) 1992-01-17 2000-06-27 Slanetz; Alfred E. Soluble T cell receptors
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US5350674A (en) 1992-09-04 1994-09-27 Becton, Dickinson And Company Intrinsic factor - horse peroxidase conjugates and a method for increasing the stability thereof
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
US5993434A (en) 1993-04-01 1999-11-30 Genetronics, Inc. Method of treatment using electroporation mediated delivery of drugs and genes
ATE274340T1 (de) 1993-08-10 2004-09-15 Gore & Ass Zelleinkapselungsvorrichtung
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
KR100654645B1 (ko) 1995-04-27 2007-04-04 아브게닉스, 인크. 면역화된 제노마우스 유래의 인간 항체
AU2466895A (en) 1995-04-28 1996-11-18 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5626561A (en) 1995-06-07 1997-05-06 Gore Hybrid Technologies, Inc. Implantable containment apparatus for a therapeutical device and method for loading and reloading the device therein
JPH10503964A (ja) 1995-06-07 1998-04-14 ゴア ハイブリッド テクノロジーズ,インコーポレイティド 治療用デバイスのための移植可能な閉じ込め装置並びにその中にそのデバイスを装填及び再装填する方法
WO1997010807A1 (en) 1995-09-22 1997-03-27 Gore Hybrid Technologies, Inc. Improved cell encapsulation device
US5916771A (en) 1996-10-11 1999-06-29 Abgenix, Inc. Production of a multimeric protein by cell fusion method
JP4215172B2 (ja) 1996-12-03 2009-01-28 アムジェン フレモント インク. 複数のV▲下H▼およびV▲下κ▼領域を含むヒトIg遺伝子座を有するトランスジェニック哺乳動物、ならびにそれから産生される抗体
US6261281B1 (en) 1997-04-03 2001-07-17 Electrofect As Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells
ES2172149T3 (es) 1997-04-14 2002-09-16 Micromet Ag Nuevo metodo para la produccion de receptores de antigeno anti-humano y sus usos.
US6235883B1 (en) 1997-05-05 2001-05-22 Abgenix, Inc. Human monoclonal antibodies to epidermal growth factor receptor
US6055453A (en) 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
US6241701B1 (en) 1997-08-01 2001-06-05 Genetronics, Inc. Apparatus for electroporation mediated delivery of drugs and genes
US6678556B1 (en) 1998-07-13 2004-01-13 Genetronics, Inc. Electrical field therapy with reduced histopathological change in muscle
US7171264B1 (en) 1999-05-10 2007-01-30 Genetronics, Inc. Intradermal delivery of active agents by needle-free injection and electroporation
JP4987205B2 (ja) 2000-03-03 2012-07-25 ジェネトロニクス, インコーポレイテッド 遺伝子送達用核酸製剤および使用方法
PL357939A1 (en) 2000-04-11 2004-08-09 Genentech, Inc. Multivalent antibodies and uses therefor
EP1188825A1 (en) * 2000-09-18 2002-03-20 Universiteit Leiden T cell receptor transfer into a candidate effector cell or a precursor thereof
DE10109854A1 (de) * 2001-03-01 2002-09-12 Thomas Stanislawski Polypeptide eines hdm2-Protein spezifischen murinen alpha/beta T-Zell Rezeptors, diese kodierende Nukleinsäuren und deren Verwendung
US8209006B2 (en) 2002-03-07 2012-06-26 Vgx Pharmaceuticals, Inc. Constant current electroporation device and methods of use
JP2006506954A (ja) * 2002-04-29 2006-03-02 ゲンパト77 ファーマコジェネティクス エージー Tcr及びtirc7に結合する新規な抗体、並びに治療及び診断におけるその使用
US20040014645A1 (en) 2002-05-28 2004-01-22 Advisys, Inc. Increased delivery of a nucleic acid construct in vivo by the poly-L-glutamate ("PLG") system
US7446190B2 (en) * 2002-05-28 2008-11-04 Sloan-Kettering Institute For Cancer Research Nucleic acids encoding chimeric T cell receptors
US7328064B2 (en) 2002-07-04 2008-02-05 Inovio As Electroporation device and injection apparatus
US20050070841A1 (en) 2002-07-04 2005-03-31 Inovio As Electroporation device and injection apparatus
DE10244457A1 (de) * 2002-09-24 2004-04-01 Johannes-Gutenberg-Universität Mainz Verfahren zur rationalen Mutagenese von alpha/beta T-Zell Rezeptoren und entsprechend mutierte MDM2-Protein spezifische alpha/beta T-Zell Rezeptoren
ES2319426T3 (es) 2003-07-04 2009-05-07 Affibody Ab Polipeptidos que presentan afinidad de union por her-2.
US8642743B2 (en) 2004-04-06 2014-02-04 Affibody Ab Method for reducing the immune response to a biologically active protein
EP1611850A1 (fr) * 2004-06-28 2006-01-04 Cardio Life Research S.A. Dispositif d'occlusion et de ponction étanche pour structure anatomique.
US20060003452A1 (en) * 2004-07-01 2006-01-05 Virxsys Corporation Vector packaging cell line
US7585960B2 (en) 2005-05-11 2009-09-08 Theramab Gmbh Nucleic acids encoding superagonistic anti-CD28 antibodies
CN105330741B (zh) 2005-07-01 2023-01-31 E.R.施贵宝&圣斯有限责任公司 抗程序性死亡配体1(pd-l1)的人单克隆抗体
GB0524788D0 (en) 2005-12-05 2006-01-11 Affibody Ab Polypeptides
WO2007120234A2 (en) 2005-12-07 2007-10-25 Genetronics, Inc Variable volume electroporation chamber and methods therefore
EP2183275B1 (en) 2007-08-03 2014-10-29 Affibody AB Igf-1r binding polypeptides and their use
EP2072525A1 (en) 2007-12-21 2009-06-24 Affibody AB New polypeptides having affinity for HER2
AU2009204501B2 (en) 2008-01-07 2015-02-12 Amgen Inc. Method for making antibody Fc-heterodimeric molecules using electrostatic steering effects
MX2011004467A (es) * 2008-10-31 2011-07-28 Biogen Idec Inc Moleculas de objetivo light y usos de las mismas.
JO3096B1 (ar) 2008-11-07 2017-03-15 Imclone Llc الأجسام المضادة لمستقبل ii مضاد tgfb
GB0911566D0 (en) * 2009-07-03 2009-08-12 Immunocore Ltd T cell receptors
GB0917090D0 (en) * 2009-09-29 2009-11-11 Ucl Biomedica Plc T-cell receptor
CA2796379A1 (en) * 2009-10-27 2011-05-05 Immunicum Ab Method for proliferation of antigen-specific t cells
US20120294874A1 (en) * 2009-11-19 2012-11-22 Paul Anthony Macary Method for Producing T Cell Receptor-Like Monoclonal Antibodies and Uses Thereof
WO2012040012A1 (en) * 2010-09-21 2012-03-29 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-ssx-2 t cell receptors and related materials and methods of use
CN104114233B (zh) * 2011-07-29 2021-11-12 宾夕法尼亚大学董事会 转换共刺激受体
JP5737082B2 (ja) 2011-08-31 2015-06-17 富士通株式会社 ポインタ位置補正方法、ポインタ位置補正プログラムおよびサーバ装置
BR112014006176A8 (pt) * 2011-09-16 2017-09-12 Univ Pennsylvania Rna transcrito in vitro ou rna sintético, composição, método para gerar uma população de células t geneticamente modificadas por rna, e, uso de uma célula t geneticamente modificada
EP2814846B1 (en) * 2012-02-13 2020-01-08 Seattle Children's Hospital d/b/a Seattle Children's Research Institute Bispecific chimeric antigen receptors and therapeutic uses thereof
MX2015000426A (es) * 2012-07-13 2015-07-14 Univ Pennsylvania Incremento de actividad de celulas t car mediante cointroduccion de un anticuerpo biespecifico.
SG11201502598SA (en) * 2012-10-02 2015-05-28 Sloan Kettering Inst Cancer Compositions and methods for immunotherapy
SI2961831T1 (sl) * 2013-02-26 2020-10-30 Memorial Sloan Kettering Cancer Center Sestavki in postopki za imunoterapijo
AU2014225788B2 (en) * 2013-03-05 2018-03-29 Baylor College Of Medicine Engager cells for immunotherapy
MA41538A (fr) * 2014-10-17 2017-12-26 Baylor College Medicine Cellules immunitaires bipartites et tripartites de signalisation

Similar Documents

Publication Publication Date Title
JP2017533706A5 (Direct)
JP2017535261A5 (Direct)
Liu et al. Adoptive cellular immunotherapy for solid neoplasms beyond CAR-T
US11679132B2 (en) Methods for enhancing efficacy of therapeutic immune cells
Zhang et al. Chimeric antigen receptor-based natural killer cell immunotherapy in cancer: from bench to bedside
JP7273421B2 (ja) ナチュラルキラー細胞の活性化および拡大のための方法ならびにその使用
JP2021058196A5 (Direct)
Rezvani et al. Engineering natural killer cells for cancer immunotherapy
JP7146397B2 (ja) 改変γδT細胞
JP2017533707A5 (Direct)
Bollino et al. Chimeric antigen receptor–engineered natural killer and natural killer T cells for cancer immunotherapy
Kriegsmann et al. NKT cells—New players in CAR cell immunotherapy?
JP2018504910A5 (Direct)
IL320642A (en) Preparations and methods for engineering T cells
CN105848484A (zh) 用于免疫治疗的多克隆γδ T细胞
JP2017535292A5 (Direct)
CN110072533A (zh) 选择性扩增γδT细胞群的方法及其组合物
JP2021525518A (ja) 細胞をゲノム編集及び活性化するための方法
TWI899050B (zh) 通用抗原呈現細胞及其用途
JP2014533928A5 (Direct)
US20160237407A1 (en) Universal donor chimeric antigen receptor cells
CA3189677A1 (en) Chimeric molecules providing targeted costimulation for adoptive cell therapy
CN115916963A (zh) 白血病来源的经修饰细胞用于增强过继性细胞治疗的效力的离体用途
WO2022037562A1 (en) Engineered immunoresponsive cells and uses thereof
JP2025535365A (ja) Il18と結合した新規cd19結合体を含むcar-t構築物およびその使用方法