JP2017531648A5 - - Google Patents
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- JP2017531648A5 JP2017531648A5 JP2017518131A JP2017518131A JP2017531648A5 JP 2017531648 A5 JP2017531648 A5 JP 2017531648A5 JP 2017518131 A JP2017518131 A JP 2017518131A JP 2017518131 A JP2017518131 A JP 2017518131A JP 2017531648 A5 JP2017531648 A5 JP 2017531648A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- heteroaryl
- hydrogen
- compound according
- substituents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14290299.8 | 2014-10-03 | ||
| EP14290299 | 2014-10-03 | ||
| EP15162641.3 | 2015-04-07 | ||
| EP15162641 | 2015-04-07 | ||
| EP15171036 | 2015-06-08 | ||
| EP15171036.5 | 2015-06-08 | ||
| PCT/EP2015/072868 WO2016050975A1 (en) | 2014-10-03 | 2015-10-02 | Fused pentacyclic imidazole derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017531648A JP2017531648A (ja) | 2017-10-26 |
| JP2017531648A5 true JP2017531648A5 (enExample) | 2018-11-08 |
| JP6629847B2 JP6629847B2 (ja) | 2020-01-15 |
Family
ID=54238452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017518131A Active JP6629847B2 (ja) | 2014-10-03 | 2015-10-02 | 縮合五員環イミダゾール誘導体 |
Country Status (36)
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2885432T3 (es) * | 2014-10-03 | 2021-12-13 | Ucb Biopharma Sprl | Derivados de imidazol pentacíclicos condensados |
| AR104291A1 (es) | 2015-04-17 | 2017-07-12 | Abbvie Inc | Moduladores tricíclicos de la señalización por tnf |
| UY36629A (es) | 2015-04-17 | 2016-11-30 | Abbvie Inc | Indazolonas como moduladores de la señalización de tnf |
| EP3286195A1 (en) | 2015-04-17 | 2018-02-28 | AbbVie Inc. | Indazolones as modulators of tnf signaling |
| GB201510758D0 (en) | 2015-06-18 | 2015-08-05 | Ucb Biopharma Sprl | Novel TNFa structure for use in therapy |
| CA3019245A1 (en) * | 2016-04-01 | 2017-10-05 | Ucb Biopharma Sprl | Fused pentacyclic imidazole derivatives as modulators of tnf activity |
| CN109219609B (zh) * | 2016-04-01 | 2022-02-01 | Ucb生物制药私人有限公司 | 作为tnf活性调节剂的稠合六环咪唑衍生物 |
| WO2017167996A1 (en) | 2016-04-01 | 2017-10-05 | Ucb Biopharma Sprl | Fused pentacyclic imidazole derivatives as modulators of tnf activity |
| WO2017167993A1 (en) | 2016-04-01 | 2017-10-05 | Ucb Biopharma Sprl | Fused pentacyclic imidazole derivatives as modulators of tnf activity |
| GB201620948D0 (en) | 2016-12-09 | 2017-01-25 | Ucb Biopharma Sprl | Therapeutic agents |
| GB201621907D0 (en) | 2016-12-21 | 2017-02-01 | Ucb Biopharma Sprl And Sanofi | Antibody epitope |
| EP3824906A1 (en) | 2016-12-21 | 2021-05-26 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| WO2018167176A1 (en) | 2017-03-15 | 2018-09-20 | Ucb Biopharma Sprl | Fused pentacyclic imidazole derivatives as modulators of tnf activity |
| PH12019502182B1 (en) * | 2017-04-25 | 2024-01-31 | Sanofi Sa | Fused pentacyclic imidazole derivatives as modulators of tnf activity |
| TWI805727B (zh) * | 2018-04-04 | 2023-06-21 | 日商日本煙草產業股份有限公司 | 經雜芳基取代之吡唑化合物及其醫藥用途 |
| CA3117344A1 (en) * | 2018-10-24 | 2020-04-30 | UCB Biopharma SRL | Fused pentacyclic imidazole derivatives as modulators of tnf activity |
| CN113683505A (zh) * | 2021-09-29 | 2021-11-23 | 厦门大华本安化工安全研究院有限公司 | 一种含氧代环丁基的羧酸酯类化合物的制备方法 |
| JP2025540024A (ja) * | 2022-11-23 | 2025-12-11 | フォワード セラピューティクス， インコーポレイテッド | ＴＮＦ－α活性の調節因子 |
| WO2024129763A1 (en) * | 2022-12-13 | 2024-06-20 | Forward Therapeutics, Inc. | MODULATORS OF TNF-α ACTIVITY |
| WO2024148191A1 (en) * | 2023-01-05 | 2024-07-11 | Forward Therapeutics, Inc. | MODULATORS OF TNF-α ACTIVITY |
| WO2024223740A1 (en) | 2023-04-26 | 2024-10-31 | Sanofi | Treating psoriasis using a small molecule inhibitor of tumor necrosis factor alpha |
| TW202513567A (zh) * | 2023-06-09 | 2025-04-01 | 大陸商上海翰森生物醫藥科技有限公司 | 五環類衍生物抑制劑、其製備方法與應用 |
| WO2025038927A1 (en) * | 2023-08-16 | 2025-02-20 | Raythera, Inc. | Modulators of tnf alpha activity and uses thereof |
| CN121925420A (zh) | 2023-09-29 | 2026-04-24 | 赛诺菲 | 作为tnf活性的调节剂的桥联五环咪唑衍生物的制备、中间体及其制备 |
| WO2025137267A1 (en) * | 2023-12-21 | 2025-06-26 | Forward Therapeutics, Inc. | Modulators of tnf-alpha activity |
| WO2025201449A1 (zh) * | 2024-03-27 | 2025-10-02 | 海思科医药集团股份有限公司 | 一种杂环衍生物及其在医药上的应用 |
| WO2025212627A1 (en) * | 2024-04-03 | 2025-10-09 | Forward Therapeutics, Inc. | Modulators of tnf-alpha activity |
| TW202604511A (zh) * | 2024-04-17 | 2026-02-01 | 大陸商上海翰森生物醫藥科技有限公司 | 五環類衍生物抑制劑、其製備方法與應用 |
| TW202604535A (zh) * | 2024-05-15 | 2026-02-01 | 美商弗沃德醫療公司 | 自體免疫或發炎疾病之治療 |
| WO2025244936A1 (en) * | 2024-05-20 | 2025-11-27 | Forward Therapeutics, Inc. | Modulators of tnf-alpha activity |
| WO2025247401A1 (zh) * | 2024-05-31 | 2025-12-04 | 海思科医药集团股份有限公司 | 一种稠合杂环衍生物及其在医药上的应用 |
| WO2025255096A1 (en) * | 2024-06-03 | 2025-12-11 | Dana-Farber Cancer Institute, Inc. | Cycloalkyl and heterocyclic modulators of tnf activity |
| WO2025252251A1 (zh) * | 2024-06-07 | 2025-12-11 | 上海翰森生物医药科技有限公司 | 含氧杂环类衍生物抑制剂、其制备方法和应用 |
| WO2026022134A1 (en) | 2024-07-23 | 2026-01-29 | Sanofi | Novel aminocarbonylation processes |
| WO2026021586A1 (zh) * | 2024-07-26 | 2026-01-29 | 上海瀚辰星泰医药科技有限公司 | 一种多环化合物及其制备方法和应用 |
| WO2026027449A1 (en) | 2024-07-29 | 2026-02-05 | Sanofi | Fused pentacyclic imidazole derivatives |
| TW202611047A (zh) * | 2024-09-04 | 2026-03-16 | 大陸商蘇州湃玥生物科技有限公司 | 一種作為tnf活性調節劑的稠合五環苯並咪唑衍生物及其製備方法和應用 |
| WO2026055519A1 (en) | 2024-09-06 | 2026-03-12 | Rapt Therapeutics, Inc. | Fused ring imidazole compounds |
| WO2026064273A1 (en) * | 2024-09-17 | 2026-03-26 | Forward Therapeutics, Inc. | Inhibitors of tnf alpha activity |
| WO2026068677A1 (en) * | 2024-09-27 | 2026-04-02 | Sanofi | Processes for the preparation of fused pentacyclic imidazoles and intermediates |
| WO2026086865A1 (zh) * | 2024-10-24 | 2026-04-30 | 宜昌人福药业有限责任公司 | 小分子TNF-α抑制剂及其用途 |
| WO2026112363A1 (en) | 2024-11-21 | 2026-05-28 | Rapt Therapeutics, Inc. | Fused heterocyclic aromatic compounds and uses thereof |
| WO2026145553A1 (zh) * | 2024-12-30 | 2026-07-09 | 无锡奕拓医药科技有限责任公司 | 多环类化合物、其药物组合物及其应用 |
| WO2026145487A1 (zh) * | 2024-12-30 | 2026-07-09 | 上海翊石医药科技有限公司 | 一类芳杂环化合物及其制备方法和应用 |
| WO2026145577A1 (zh) * | 2024-12-31 | 2026-07-09 | 无锡奕拓医药科技有限责任公司 | 桥环类化合物、其药物组合物及其应用 |
| WO2026149469A1 (zh) * | 2025-01-08 | 2026-07-16 | 上海瀚辰星泰医药科技有限公司 | 一种多环化合物及其制备方法和应用 |
| WO2026158438A1 (zh) * | 2025-01-24 | 2026-07-30 | 苏州朗睿生物医药有限公司 | 一种五环衍生物及其制备方法和用途 |
| EP4785940A1 (en) | 2025-01-31 | 2026-08-05 | Abivax | Combination of obefazimod and its derivatives with a tnf alpha-inhibitor |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0449649A3 (en) | 1990-03-30 | 1992-09-02 | Arizona Board Of Regents, Arizona State University | Antineoplastic quinones and methods of using same |
| FR2832711B1 (fr) | 2001-11-26 | 2004-01-30 | Warner Lambert Co | Derives de triazolo [4,3-a] pyrido [2,3-d] pyrimidin-5-ones, compositions les contenant, procede de preparation et utilisation |
| WO2004087720A1 (en) | 2003-03-10 | 2004-10-14 | Pfizer Inc. | Phosphate/sulfate ester compounds and pharmaceutical compositions for inhibiting protein interacting nima (pin1) |
| DE102008030206A1 (de) | 2008-06-25 | 2009-12-31 | Bayer Schering Pharma Aktiengesellschaft | 3-Cyanoalky- und 3-Hydroxyalkyl-Indole und ihre Verwendung |
| TW201242953A (en) | 2011-03-25 | 2012-11-01 | Bristol Myers Squibb Co | Imidazole prodrug LXR modulators |
| ES2576298T3 (es) | 2011-06-20 | 2016-07-06 | Vertex Pharmaceuticals Incorporated | Ésteres de fosfato de inhibidores de girasa y topoisomerasa |
| CA2874303C (en) * | 2012-06-11 | 2020-10-13 | Ucb Biopharma Sprl | Tnf -alpha modulating benz imidazoles |
| ES2689429T3 (es) * | 2012-07-13 | 2018-11-14 | Ucb Biopharma Sprl | Derivados de imidazopiridina como moduladores de actividad de TNF |
| GB201212513D0 (en) * | 2012-07-13 | 2012-08-29 | Ucb Pharma Sa | Therapeutic agents |
| CN105683188B (zh) | 2013-10-25 | 2018-02-09 | 诺华股份有限公司 | 作为fgfr4抑制剂的稠环二环吡啶基衍生物 |
| GB201321729D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| GB201321728D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| PL3925607T5 (pl) | 2014-04-15 | 2026-06-01 | Vertex Pharmaceuticals Incorporated | Kompozycje farmaceutyczne do leczenia chorób, w których pośredniczy mukowiscydozowy przezbłonowy regulator przewodnictwa |
| ES2885432T3 (es) * | 2014-10-03 | 2021-12-13 | Ucb Biopharma Sprl | Derivados de imidazol pentacíclicos condensados |
-
2015
- 2015-10-02 ES ES15771976T patent/ES2885432T3/es active Active
- 2015-10-02 EA EA201790734A patent/EA032839B1/ru not_active IP Right Cessation
- 2015-10-02 CA CA2962826A patent/CA2962826C/en active Active
- 2015-10-02 PE PE2017000544A patent/PE20170693A1/es unknown
- 2015-10-02 BR BR112017006669-6A patent/BR112017006669B1/pt active IP Right Grant
- 2015-10-02 UY UY0001036341A patent/UY36341A/es not_active Application Discontinuation
- 2015-10-02 CN CN201580053711.8A patent/CN107108672B/zh active Active
- 2015-10-02 PL PL15771976T patent/PL3201196T3/pl unknown
- 2015-10-02 EP EP15771976.6A patent/EP3201196B1/en active Active
- 2015-10-02 HU HUE15771976A patent/HUE056133T2/hu unknown
- 2015-10-02 MX MX2017004201A patent/MX380578B/es unknown
- 2015-10-02 AP AP2017009809A patent/AP2017009809A0/en unknown
- 2015-10-02 AU AU2015326798A patent/AU2015326798B2/en active Active
- 2015-10-02 JP JP2017518131A patent/JP6629847B2/ja active Active
- 2015-10-02 LT LTEPPCT/EP2015/072868T patent/LT3201196T/lt unknown
- 2015-10-02 MY MYPI2017701132A patent/MY181019A/en unknown
- 2015-10-02 UA UAA201702002A patent/UA120764C2/uk unknown
- 2015-10-02 US US15/513,357 patent/US10202405B2/en active Active
- 2015-10-02 MA MA40770A patent/MA40770B1/fr unknown
- 2015-10-02 TN TN2017000083A patent/TN2017000083A1/en unknown
- 2015-10-02 HR HRP20211605TT patent/HRP20211605T1/hr unknown
- 2015-10-02 DK DK15771976.6T patent/DK3201196T3/da active
- 2015-10-02 CR CR20170167A patent/CR20170167A/es unknown
- 2015-10-02 TW TW104132631A patent/TWI719949B/zh active
- 2015-10-02 SI SI201531711T patent/SI3201196T1/sl unknown
- 2015-10-02 SG SG11201701796XA patent/SG11201701796XA/en unknown
- 2015-10-02 RS RS20211235A patent/RS62423B1/sr unknown
- 2015-10-02 WO PCT/EP2015/072868 patent/WO2016050975A1/en not_active Ceased
- 2015-10-02 KR KR1020177011958A patent/KR102442235B1/ko active Active
-
2017
- 2017-03-06 PH PH12017500414A patent/PH12017500414B1/en unknown
- 2017-03-07 GT GT201700044A patent/GT201700044A/es unknown
- 2017-03-14 IL IL251147A patent/IL251147B/en active IP Right Grant
- 2017-03-20 ZA ZA2017/01946A patent/ZA201701946B/en unknown
- 2017-03-31 CL CL2017000787A patent/CL2017000787A1/es unknown
- 2017-04-06 CO CONC2017/0003331A patent/CO2017003331A2/es unknown
- 2017-05-03 EC ECIEPI201727306A patent/ECSP17027306A/es unknown
-
2018
- 2018-12-14 US US16/220,847 patent/US10906919B2/en active Active
-
2020
- 2020-11-24 US US17/102,790 patent/US11912721B2/en active Active
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