MA49055B1 - Dérivés d'imidazoles pentacycliques fusionnés en tant que modulateurs de l'activité de tnf - Google Patents

Dérivés d'imidazoles pentacycliques fusionnés en tant que modulateurs de l'activité de tnf

Info

Publication number
MA49055B1
MA49055B1 MA49055A MA49055A MA49055B1 MA 49055 B1 MA49055 B1 MA 49055B1 MA 49055 A MA49055 A MA 49055A MA 49055 A MA49055 A MA 49055A MA 49055 B1 MA49055 B1 MA 49055B1
Authority
MA
Morocco
Prior art keywords
disorders
modulators
imidazole derivatives
tnf activity
fused pentacyclic
Prior art date
Application number
MA49055A
Other languages
English (en)
Other versions
MA49055A (fr
Inventor
Haro Garcia Teresa De
Mengyang Xuan
Zhaoning Zhu
Daniel Christopher Brookings
Martin Clive Hutchings
James Andrew Johnson
Yann Foricher
Malcolm Maccoss
Helen Tracey Horsley
Original Assignee
Sanofi Sa
UCB Biopharma SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=58632834&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA49055(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Sa, UCB Biopharma SRL filed Critical Sanofi Sa
Publication of MA49055A publication Critical patent/MA49055A/fr
Publication of MA49055B1 publication Critical patent/MA49055B1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18Bridged systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05Isotopically modified compounds, e.g. labelled
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

L'invention concerne un composé de formule (i), ou un sel pharmaceutiquement acceptable de celui-ci, qui sont de puissants modulateurs de l'activité du tnfa humain, et trouvent ainsi une utilité dans le traitement et/ou la prévention de diverses affections humaines, notamment les troubles auto-immuns et inflammatoires ; les troubles neurologiques et neurodégénératifs ; la douleur et les troubles nociceptifs ; les troubles cardiovasculaires ; les troubles métaboliques ; les troubles oculaires ; et les troubles oncologiques.
MA49055A 2017-04-25 2018-04-24 Dérivés d'imidazoles pentacycliques fusionnés en tant que modulateurs de l'activité de tnf MA49055B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17168027 2017-04-25
PCT/EP2018/060489 WO2018197503A1 (fr) 2017-04-25 2018-04-24 Dérivés d'imidazole pentacycliques fusionnés utilisés en tant que modulateurs de l'activité du tnf

Publications (2)

Publication Number Publication Date
MA49055A MA49055A (fr) 2021-05-05
MA49055B1 true MA49055B1 (fr) 2021-12-31

Family

ID=58632834

Family Applications (2)

Application Number Title Priority Date Filing Date
MA49055A MA49055B1 (fr) 2017-04-25 2018-04-24 Dérivés d'imidazoles pentacycliques fusionnés en tant que modulateurs de l'activité de tnf
MA57699A MA57699B1 (fr) 2017-04-25 2018-08-24 Dérivés d'imidazoles pentacycliques condensés en tant que modulateurs de l'activité de tnf

Family Applications After (1)

Application Number Title Priority Date Filing Date
MA57699A MA57699B1 (fr) 2017-04-25 2018-08-24 Dérivés d'imidazoles pentacycliques condensés en tant que modulateurs de l'activité de tnf

Country Status (33)

Country Link
US (3) US10980814B2 (fr)
EP (2) EP3615534B1 (fr)
JP (2) JP7083358B2 (fr)
KR (1) KR102565132B1 (fr)
CN (1) CN110582495B (fr)
AR (1) AR111426A1 (fr)
AU (1) AU2018259040B2 (fr)
BR (1) BR112019020314A2 (fr)
CA (1) CA3058980A1 (fr)
CL (1) CL2019002875A1 (fr)
CO (1) CO2019012856A2 (fr)
CR (1) CR20190526A (fr)
DK (1) DK3615534T3 (fr)
EA (1) EA039049B1 (fr)
ES (2) ES2893807T3 (fr)
HR (1) HRP20211927T1 (fr)
HU (1) HUE056593T2 (fr)
IL (1) IL269890B (fr)
LT (1) LT3615534T (fr)
MA (2) MA49055B1 (fr)
MX (1) MX2019012443A (fr)
MY (1) MY197212A (fr)
PE (1) PE20200662A1 (fr)
PH (1) PH12019502182A1 (fr)
PL (2) PL3615534T3 (fr)
PT (2) PT3615534T (fr)
RS (1) RS62596B1 (fr)
SG (1) SG11201908871SA (fr)
SI (1) SI3615534T1 (fr)
TW (1) TWI801378B (fr)
UY (1) UY37700A (fr)
WO (1) WO2018197503A1 (fr)
ZA (1) ZA201906255B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201892144A1 (ru) * 2016-04-01 2019-04-30 Юсб Байофарма Спрл Конденсированные гексациклические производные имидазола в качестве модуляторов активности tnf
CN113227097B (zh) * 2018-10-24 2023-09-08 Ucb生物制药有限责任公司 作为tnf活性调节剂的稠合五环咪唑衍生物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6359008B2 (ja) 2012-06-11 2018-07-18 ユーシービー バイオファルマ エスピーアールエル Tnf−アルファ調節ベンゾイミダゾール
EA028722B1 (ru) * 2012-07-13 2017-12-29 Юсб Байофарма Спрл Производные имидазопиридина в качестве модуляторов активности tnf
GB201212513D0 (en) * 2012-07-13 2012-08-29 Ucb Pharma Sa Therapeutic agents
GB201321728D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
CN107108672B (zh) 2014-10-03 2019-11-08 Ucb生物制药私人有限公司 稠合的五环咪唑衍生物
UY36630A (es) 2015-04-17 2016-11-30 Abbvie Inc Moduladores tricíclicos de la señalización por tnf

Also Published As

Publication number Publication date
IL269890B (en) 2022-03-01
AU2018259040B2 (en) 2022-04-28
JP7083358B2 (ja) 2022-06-10
JP2022116233A (ja) 2022-08-09
AU2018259040A1 (en) 2019-10-31
HRP20211927T1 (hr) 2022-03-18
PE20200662A1 (es) 2020-06-11
MX2019012443A (es) 2020-01-13
ES2956555T3 (es) 2023-12-22
EP3939980A1 (fr) 2022-01-19
EP3939980B1 (fr) 2023-07-26
WO2018197503A1 (fr) 2018-11-01
PT3939980T (pt) 2023-08-07
KR102565132B1 (ko) 2023-08-08
MA49055A (fr) 2021-05-05
JP2020517637A (ja) 2020-06-18
MY197212A (en) 2023-06-01
CN110582495B (zh) 2022-04-01
CN110582495A (zh) 2019-12-17
ES2893807T3 (es) 2022-02-10
PL3939980T3 (pl) 2024-02-05
TW201841918A (zh) 2018-12-01
JP7299382B2 (ja) 2023-06-27
SI3615534T1 (sl) 2022-01-31
BR112019020314A2 (pt) 2020-04-28
EP3615534A1 (fr) 2020-03-04
EA201992407A1 (ru) 2020-04-06
EP3615534B1 (fr) 2021-09-15
TWI801378B (zh) 2023-05-11
LT3615534T (lt) 2021-11-25
HUE056593T2 (hu) 2022-02-28
CR20190526A (es) 2020-01-07
PL3615534T3 (pl) 2022-01-31
MA57699B1 (fr) 2023-11-30
US20230250105A1 (en) 2023-08-10
CO2019012856A2 (es) 2020-01-17
RS62596B1 (sr) 2021-12-31
EA039049B1 (ru) 2021-11-26
KR20190141200A (ko) 2019-12-23
AR111426A1 (es) 2019-07-10
CA3058980A1 (fr) 2018-11-01
NZ758198A (en) 2024-01-26
PH12019502182A1 (en) 2020-06-08
UY37700A (es) 2018-11-30
PT3615534T (pt) 2021-10-21
CL2019002875A1 (es) 2020-03-06
DK3615534T3 (da) 2021-10-18
US20200046723A1 (en) 2020-02-13
SG11201908871SA (en) 2019-10-30
ZA201906255B (en) 2021-01-27
US10980814B2 (en) 2021-04-20
US20210252012A1 (en) 2021-08-19

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