MX2019012443A - Derivados de imidazol pentaciclico fusionado como moduladores de la actividad del factor de necrosis tumoral (tnf). - Google Patents

Derivados de imidazol pentaciclico fusionado como moduladores de la actividad del factor de necrosis tumoral (tnf).

Info

Publication number
MX2019012443A
MX2019012443A MX2019012443A MX2019012443A MX2019012443A MX 2019012443 A MX2019012443 A MX 2019012443A MX 2019012443 A MX2019012443 A MX 2019012443A MX 2019012443 A MX2019012443 A MX 2019012443A MX 2019012443 A MX2019012443 A MX 2019012443A
Authority
MX
Mexico
Prior art keywords
disorders
modulators
imidazole derivatives
tnf activity
fused pentacyclic
Prior art date
Application number
MX2019012443A
Other languages
English (en)
Inventor
Tracey Horsley Helen
Christopher Brookings Daniel
Clive Hutchings Martin
Andrew Johnson James
Foricher Yann
Xuan Mengyang
Zhu Zhaoning
Maccoss Malcolm
De Haro Garcia Teresa
Original Assignee
Ucb Biopharma Sprl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=58632834&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2019012443(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ucb Biopharma Sprl filed Critical Ucb Biopharma Sprl
Publication of MX2019012443A publication Critical patent/MX2019012443A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Un compuesto de fórmula (I) como se define en la memoria descriptiva, o una sal farmacéuticamente aceptable del mismo, como moduladores potentes de la actividad de TNFa humano, los cuales por consiguiente son beneficiosos para el tratamiento y/o la prevención de diversas enfermedades humanas, incluyendo trastornos autoinmunológicos e inflamatorios; trastornos neurológicos y neurodegenerativos; dolor y trastornos nociceptivos; trastornos cardiovasculares; trastornos metabólicos; trastornos oculares; y trastornos oncológicos.
MX2019012443A 2017-04-25 2018-04-24 Derivados de imidazol pentaciclico fusionado como moduladores de la actividad del factor de necrosis tumoral (tnf). MX2019012443A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17168027 2017-04-25
PCT/EP2018/060489 WO2018197503A1 (en) 2017-04-25 2018-04-24 Fused pentacyclic imidazole derivatives as modulators of tnf activity

Publications (1)

Publication Number Publication Date
MX2019012443A true MX2019012443A (es) 2020-01-13

Family

ID=58632834

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019012443A MX2019012443A (es) 2017-04-25 2018-04-24 Derivados de imidazol pentaciclico fusionado como moduladores de la actividad del factor de necrosis tumoral (tnf).

Country Status (34)

Country Link
US (3) US10980814B2 (es)
EP (2) EP3939980B1 (es)
JP (2) JP7083358B2 (es)
KR (1) KR102565132B1 (es)
CN (1) CN110582495B (es)
AR (1) AR111426A1 (es)
AU (1) AU2018259040B2 (es)
BR (1) BR112019020314A2 (es)
CA (1) CA3058980A1 (es)
CL (1) CL2019002875A1 (es)
CO (1) CO2019012856A2 (es)
CR (1) CR20190526A (es)
DK (1) DK3615534T3 (es)
EA (1) EA039049B1 (es)
ES (2) ES2956555T3 (es)
HR (1) HRP20211927T1 (es)
HU (1) HUE056593T2 (es)
IL (1) IL269890B (es)
LT (1) LT3615534T (es)
MA (2) MA49055B1 (es)
MX (1) MX2019012443A (es)
MY (1) MY197212A (es)
NZ (1) NZ758198A (es)
PE (1) PE20200662A1 (es)
PH (1) PH12019502182A1 (es)
PL (2) PL3939980T3 (es)
PT (2) PT3939980T (es)
RS (1) RS62596B1 (es)
SG (1) SG11201908871SA (es)
SI (1) SI3615534T1 (es)
TW (1) TWI801378B (es)
UY (1) UY37700A (es)
WO (1) WO2018197503A1 (es)
ZA (1) ZA201906255B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109219609B (zh) * 2016-04-01 2022-02-01 Ucb生物制药私人有限公司 作为tnf活性调节剂的稠合六环咪唑衍生物
WO2020084008A1 (en) * 2018-10-24 2020-04-30 UCB Biopharma SRL Fused pentacyclic imidazole derivatives as modulators of tnf activity

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104428293B (zh) * 2012-06-11 2018-06-08 Ucb生物制药私人有限公司 调节TNFα的苯并咪唑类
ES2689429T3 (es) * 2012-07-13 2018-11-14 Ucb Biopharma Sprl Derivados de imidazopiridina como moduladores de actividad de TNF
GB201212513D0 (en) * 2012-07-13 2012-08-29 Ucb Pharma Sa Therapeutic agents
GB201321728D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
EP3201196B1 (en) 2014-10-03 2021-07-28 UCB Biopharma SRL Fused pentacyclic imidazole derivatives
TW201710257A (zh) 2015-04-17 2017-03-16 艾伯維有限公司 Ｔｎｆ信號傳遞之三環調節劑

Also Published As

Publication number Publication date
ES2956555T3 (es) 2023-12-22
PH12019502182A1 (en) 2020-06-08
EP3939980A1 (en) 2022-01-19
WO2018197503A1 (en) 2018-11-01
BR112019020314A2 (pt) 2020-04-28
KR20190141200A (ko) 2019-12-23
SI3615534T1 (sl) 2022-01-31
HUE056593T2 (hu) 2022-02-28
AR111426A1 (es) 2019-07-10
EA039049B1 (ru) 2021-11-26
PE20200662A1 (es) 2020-06-11
EP3615534B1 (en) 2021-09-15
CL2019002875A1 (es) 2020-03-06
MY197212A (en) 2023-06-01
LT3615534T (lt) 2021-11-25
MA57699B1 (fr) 2023-11-30
US10980814B2 (en) 2021-04-20
SG11201908871SA (en) 2019-10-30
DK3615534T3 (da) 2021-10-18
CN110582495A (zh) 2019-12-17
PT3615534T (pt) 2021-10-21
CN110582495B (zh) 2022-04-01
PT3939980T (pt) 2023-08-07
JP7299382B2 (ja) 2023-06-27
US20230250105A1 (en) 2023-08-10
CA3058980A1 (en) 2018-11-01
UY37700A (es) 2018-11-30
JP2022116233A (ja) 2022-08-09
RS62596B1 (sr) 2021-12-31
NZ758198A (en) 2024-01-26
ZA201906255B (en) 2021-01-27
PL3939980T3 (pl) 2024-02-05
JP2020517637A (ja) 2020-06-18
US20200046723A1 (en) 2020-02-13
EP3939980B1 (en) 2023-07-26
EA201992407A1 (ru) 2020-04-06
TWI801378B (zh) 2023-05-11
CO2019012856A2 (es) 2020-01-17
MA49055A (fr) 2021-05-05
KR102565132B1 (ko) 2023-08-08
TW201841918A (zh) 2018-12-01
AU2018259040B2 (en) 2022-04-28
ES2893807T3 (es) 2022-02-10
MA49055B1 (fr) 2021-12-31
AU2018259040A1 (en) 2019-10-31
HRP20211927T1 (hr) 2022-03-18
US20210252012A1 (en) 2021-08-19
IL269890B (en) 2022-03-01
JP7083358B2 (ja) 2022-06-10
PL3615534T3 (pl) 2022-01-31
CR20190526A (es) 2020-01-07
EP3615534A1 (en) 2020-03-04

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