JP2017530964A5 - - Google Patents
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- JP2017530964A5 JP2017530964A5 JP2017514844A JP2017514844A JP2017530964A5 JP 2017530964 A5 JP2017530964 A5 JP 2017530964A5 JP 2017514844 A JP2017514844 A JP 2017514844A JP 2017514844 A JP2017514844 A JP 2017514844A JP 2017530964 A5 JP2017530964 A5 JP 2017530964A5
- Authority
- JP
- Japan
- Prior art keywords
- unsubstituted
- substituted
- chch
- pharmaceutical composition
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462051760P | 2014-09-17 | 2014-09-17 | |
| US62/051,760 | 2014-09-17 | ||
| PCT/US2015/050275 WO2016044331A1 (en) | 2014-09-17 | 2015-09-15 | Bicyclic compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017530964A JP2017530964A (ja) | 2017-10-19 |
| JP2017530964A5 true JP2017530964A5 (enExample) | 2018-11-01 |
| JP6833677B2 JP6833677B2 (ja) | 2021-02-24 |
Family
ID=55454101
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017514844A Expired - Fee Related JP6833677B2 (ja) | 2014-09-17 | 2015-09-15 | 二環式化合物 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10308609B2 (enExample) |
| EP (1) | EP3193855B1 (enExample) |
| JP (1) | JP6833677B2 (enExample) |
| KR (1) | KR20170048588A (enExample) |
| CN (1) | CN106999451B (enExample) |
| AR (1) | AR101905A1 (enExample) |
| CA (1) | CA2961605C (enExample) |
| TW (1) | TWI686376B (enExample) |
| WO (1) | WO2016044331A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9447026B2 (en) | 2013-03-14 | 2016-09-20 | Kalyra Pharmaceuticals, Inc. | Bicyclic analgesic compounds |
| CA2932039A1 (en) | 2013-12-12 | 2015-06-18 | Kalyra Pharmaceuticals, Inc. | Bicyclic alkyl compounds and synthesis |
| CN113336653A (zh) | 2014-03-07 | 2021-09-03 | 里科瑞尔姆Ip控股有限责任公司 | 螺桨烷衍生物及合成 |
| US10308609B2 (en) | 2014-09-17 | 2019-06-04 | Zeno Royalties & Milestones, LLC | Bicyclic compounds |
| PL3456717T3 (pl) | 2015-07-06 | 2021-10-25 | Gilead Sciences, Inc. | Pochodna 4,6-diaminochinolino-3-karbonitrylu jako modulator cot (cancer osaka thyroid) do leczenia choroby zapalnej |
| US11242327B2 (en) * | 2017-05-15 | 2022-02-08 | Recurium Ip Holdings, Llc | Analgesic compounds |
| CN118239937A (zh) * | 2017-08-09 | 2024-06-25 | 戴纳立制药公司 | 化合物、组合物及方法 |
| DK3676297T3 (da) | 2017-09-01 | 2023-08-14 | Denali Therapeutics Inc | Forbindelser, sammensætninger og fremgangsmåder |
| IL272875B2 (en) * | 2017-09-11 | 2023-10-01 | Recurium Ip Holdings Llc | Continuous flow processes for the preparation of bicyclic compounds |
| KR20200108301A (ko) * | 2018-01-10 | 2020-09-17 | 리커리엄 아이피 홀딩스, 엘엘씨 | 벤즈아미드 화합물 |
| US11478461B2 (en) | 2018-04-19 | 2022-10-25 | Merck Sharp & Dohme Llc | [1.1.1] bicyclo compounds as indoleamine 2,3-dioxygenase inhibitors |
| WO2019231870A1 (en) * | 2018-05-31 | 2019-12-05 | Merck Sharp & Dohme Corp. | Novel substituted [1.1.1] bicyclo compounds as indoleamine 2,3-dioxygenase inhibitors |
| US12091392B2 (en) | 2019-02-13 | 2024-09-17 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| MA54953A (fr) | 2019-02-13 | 2021-12-22 | Denali Therapeutics Inc | Composés, compositions et procédés |
| TWI770527B (zh) | 2019-06-14 | 2022-07-11 | 美商基利科學股份有限公司 | Cot 調節劑及其使用方法 |
| WO2021046515A1 (en) | 2019-09-06 | 2021-03-11 | Board Of Regents, The University Of Texas System | Inhibitors of receptor interacting protein kinase i for the treatment of disease |
| IL291665B2 (en) * | 2019-09-27 | 2025-07-01 | Univ Texas | Inhibitors of receptor interacting protein kinase i for the treatment of disease |
| BR112022010082A2 (pt) | 2019-11-26 | 2022-08-30 | Univ Texas | Composto de fórmula estrutural i ou sal do mesmo, composição farmacêutica, uso do composto e uso da composição farmacêutica |
| CA3175541A1 (en) | 2020-03-30 | 2021-10-07 | Gilead Sciences, Inc. | Solid forms of (s)-6-(((1-(bicyclo[1.1.1]pentan-1-yl)-1h-1,2,3-triazol-4-yl)2-methyl-1-oxo-1,2- dihydroisoquinolin-5-yl)methyl)))amino)8-chloro-(neopentylamino)quinoline-3-carb onitrile a cot inhibitor compound |
| JP7446475B2 (ja) | 2020-04-02 | 2024-03-08 | ギリアード サイエンシーズ， インコーポレイテッド | Ｃｏｔ阻害剤化合物を調製するためのプロセス |
| CN114349774B (zh) * | 2021-12-23 | 2024-06-04 | 凯美克(上海)医药科技有限公司 | 一种双环[1.1.1]戊基角位硼酸酯类化合物的制备方法 |
| CN115010593B (zh) * | 2022-07-15 | 2023-08-25 | 上海毕得医药科技股份有限公司 | 一种3-甲基双环[1.1.1]戊烷-1-羧酸的合成方法 |
| CN116082201B (zh) * | 2023-02-22 | 2024-06-21 | 浙江工业大学 | 一种氯代双环［1.1.1］戊胺衍生物的合成方法 |
| WO2026004939A1 (ja) * | 2024-06-28 | 2026-01-02 | キッセイ薬品工業株式会社 | ジ置換ビシクロ［１．１．１］ペンタン化合物 |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL54795A (en) | 1978-05-26 | 1980-10-26 | Yeda Res & Dev | Analgesic compositions comprising substituted bicyclic and spiroaliphatic amines and certain novel compounds of these types |
| KR900701960A (ko) | 1988-06-03 | 1990-12-05 | 한스 마크 | [1,1,1]프로펠란을 기본으로하는 화합물 및 제조방법 |
| JPH04502317A (ja) | 1988-12-06 | 1992-04-23 | ジ・アップジョン・カンパニー | 抗菌性キノロン化合物 |
| AU626949B2 (en) | 1988-12-06 | 1992-08-13 | Warner-Lambert Company | 2-amino-4 or 5-methoxycyclohexyl amides useful as analgesics |
| US5262417A (en) * | 1988-12-06 | 1993-11-16 | The Upjohn Company | Antibacterial quinolone compounds |
| PT1064256E (pt) | 1998-03-17 | 2004-10-29 | Pfizer Prod Inc | Biciclo[2.2.1] heptanos e compostos relacionados |
| AU3898000A (en) | 1999-03-19 | 2000-10-09 | Knoll Pharmaceutical Company | Treatment of neuropathic pain or fibromyalgia |
| DE10025946A1 (de) | 2000-05-26 | 2001-11-29 | Gruenenthal Gmbh | Wirkstoffkombination |
| JP2003535061A (ja) | 2000-05-31 | 2003-11-25 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | エンドセリン受容体拮抗剤および疼痛軽減特性を有する抗癲癇化合物または鎮痛剤の複合物 |
| EP1660058A2 (en) | 2003-07-28 | 2006-05-31 | Merz Pharma GmbH & Co. KGaA | The use of 1-amino-alkylcyclohexane compounds in the treatment of pain hypersensitivity |
| EA010132B1 (ru) * | 2003-12-22 | 2008-06-30 | Пфайзер Инк. | Производные триазола в качестве антагонистов вазопрессина |
| GB0329693D0 (en) * | 2003-12-22 | 2004-01-28 | Pfizer Ltd | Compounds useful in therapy |
| US20060052370A1 (en) | 2004-08-24 | 2006-03-09 | Meyerson Laurence R | Methods and compositions for treating nociceptive pain |
| US7763607B2 (en) | 2006-04-27 | 2010-07-27 | Solvay Pharmaceuticals Gmbh | Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators |
| JP2008120797A (ja) | 2006-10-19 | 2008-05-29 | Dainippon Sumitomo Pharma Co Ltd | Ｎ−置換フェニルアセトアミド誘導体からなる医薬 |
| RU2468011C2 (ru) | 2006-12-27 | 2012-11-27 | Санофи-Авентис | Замещенные циклоалкиламином производные изохинолина и изохинолинона |
| WO2008096218A1 (en) | 2007-02-06 | 2008-08-14 | Pfizer Inc. | 2-amin0-5, 7-dihydr0-6h- pyrrolo [3, 4-d] pyrimidine derivatives as hsp-90 inhibitors for treating cancer |
| WO2009046025A1 (en) | 2007-10-01 | 2009-04-09 | Comentis, Inc. | Quinuclidin-4-ylmethyl 1h-indole-3-carboxylate derivatives as alpha 7 nicotinic acetylcholine receptor ligands for the treatment of alzheimer's disease |
| TW201010997A (en) * | 2008-06-18 | 2010-03-16 | Pfizer Ltd | Nicotinamide derivatives |
| CN102762534A (zh) | 2009-09-18 | 2012-10-31 | 扎里卡斯药品有限公司 | 作为钙通道阻断剂的芳基砜衍生物 |
| AU2011271429B2 (en) | 2010-06-30 | 2016-04-21 | Upsher-Smith Laboratories, Llc | Sustained release composition comprising an amine as active agent and a salt of a cyclic organic acid |
| RU2013120966A (ru) | 2010-10-08 | 2014-11-20 | Эббви Инк. | ФУРО[3,2-d]ПИРИМИДИНОВЫЕ СОЕДИНЕНИЯ |
| TW201305178A (zh) | 2010-10-29 | 2013-02-01 | Glenmark Pharmaceuticals Sa | 作為ｍＰＧＥＳ－１抑制物的三環化合物 |
| PH12013502020A1 (en) | 2011-04-05 | 2018-04-11 | Pfizer Ltd | Pyrrolo [2,3-d] pyrimidine derivatives as inhibitors of tropomyosin-related kinases |
| AU2012245996B2 (en) | 2011-04-22 | 2016-09-01 | Pfizer Inc. | Pyrazolospiroketone derivatives for use as acetyl-CoA carboxylase inhibitors |
| US9139534B2 (en) | 2011-04-22 | 2015-09-22 | Signal Pharmaceuticals, Llc | Substituted diaminocarboxamide and diaminocarbonitrile pyrimidines, compositions thereof, and methods of treatment therewith |
| AU2012295802B2 (en) | 2011-08-12 | 2017-03-30 | Nissan Chemical Industries, Ltd. | Tricyclic heterocyclic compounds and JAK inhibitors |
| US9326973B2 (en) * | 2012-01-13 | 2016-05-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US9493481B2 (en) * | 2012-02-23 | 2016-11-15 | Vanderbilt University | Substituted 5-aminothieno[2,3—C]pyridazine-6-carboxamide analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M4 |
| WO2013131018A1 (en) | 2012-03-02 | 2013-09-06 | Zalicus Pharmaceuticals Ltd. | Biaryl inhibitors of the sodium channel |
| KR20150013147A (ko) | 2012-04-27 | 2015-02-04 | 니폰 조키 세야쿠 가부시키가이샤 | 진통제 |
| SG11201503065PA (en) | 2012-10-30 | 2015-05-28 | Gilead Sciences Inc | Therapeutic and diagnostic methods related to lysyl oxidase-like 2 (loxl2) |
| US9447026B2 (en) * | 2013-03-14 | 2016-09-20 | Kalyra Pharmaceuticals, Inc. | Bicyclic analgesic compounds |
| US20160076098A1 (en) | 2013-04-12 | 2016-03-17 | Drexel University | Methods of diagnosing and treating chronic pain |
| CA2914525C (en) | 2013-06-28 | 2021-07-27 | Evotec International Gmbh | Sulfoximine substituted quinazolines for pharmaceutical compositions |
| WO2015003360A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| BR112016008632A8 (pt) | 2013-10-21 | 2020-03-17 | Merck Patent Gmbh | compostos de heteroarila como inibidores de btk, seus usos, e composição farmacêutica |
| CN103588672A (zh) | 2013-10-28 | 2014-02-19 | 史克勇 | 一种治疗癌性疼痛的药物 |
| CN103588668A (zh) | 2013-10-28 | 2014-02-19 | 史克勇 | 化合物 |
| CA2932039A1 (en) | 2013-12-12 | 2015-06-18 | Kalyra Pharmaceuticals, Inc. | Bicyclic alkyl compounds and synthesis |
| US9556126B2 (en) | 2013-12-20 | 2017-01-31 | Signal Pharmaceuticals, Llc | Substituted diaminopyrimidyl compounds, compositions thereof, and methods of treatment therewith |
| CN113336653A (zh) | 2014-03-07 | 2021-09-03 | 里科瑞尔姆Ip控股有限责任公司 | 螺桨烷衍生物及合成 |
| US9555031B2 (en) | 2014-04-11 | 2017-01-31 | The University Of North Carolina At Chapel Hill | Therapeutic uses of selected pyrrolopyrimidine compounds with anti-mer tyrosine kinase activity |
| WO2015159175A1 (en) | 2014-04-15 | 2015-10-22 | Pfizer Inc. | Tropomyosin-related kinase inhibitors containing both a 1h-pyrazole and a pyrimidine moiety |
| CA2945212A1 (en) | 2014-04-24 | 2015-10-29 | Novartis Ag | Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors |
| BR112017002001B1 (pt) | 2014-07-31 | 2022-10-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Compostos e composição farmacêutica |
| US10308609B2 (en) | 2014-09-17 | 2019-06-04 | Zeno Royalties & Milestones, LLC | Bicyclic compounds |
| MX379622B (es) * | 2015-04-03 | 2025-03-11 | Recurium Ip Holdings Llc | Compuestos espirociclicos |
| US20190060257A1 (en) | 2016-03-16 | 2019-02-28 | Zeno Royalties & Milestones, LLC | Analgesic compounds |
-
2015
- 2015-09-15 US US14/855,102 patent/US10308609B2/en active Active
- 2015-09-15 KR KR1020177009800A patent/KR20170048588A/ko not_active Ceased
- 2015-09-15 WO PCT/US2015/050275 patent/WO2016044331A1/en not_active Ceased
- 2015-09-15 EP EP15842230.3A patent/EP3193855B1/en active Active
- 2015-09-15 CA CA2961605A patent/CA2961605C/en active Active
- 2015-09-15 JP JP2017514844A patent/JP6833677B2/ja not_active Expired - Fee Related
- 2015-09-15 CN CN201580061363.9A patent/CN106999451B/zh not_active Expired - Fee Related
- 2015-09-16 TW TW104130651A patent/TWI686376B/zh not_active IP Right Cessation
- 2015-09-17 AR ARP150102980A patent/AR101905A1/es not_active Application Discontinuation
-
2019
- 2019-04-09 US US16/379,487 patent/US10975035B2/en not_active Expired - Fee Related
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