JP2006508137A5 - - Google Patents

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Publication number
JP2006508137A5
JP2006508137A5 JP2004552114A JP2004552114A JP2006508137A5 JP 2006508137 A5 JP2006508137 A5 JP 2006508137A5 JP 2004552114 A JP2004552114 A JP 2004552114A JP 2004552114 A JP2004552114 A JP 2004552114A JP 2006508137 A5 JP2006508137 A5 JP 2006508137A5
Authority
JP
Japan
Prior art keywords
composition
effective amount
mammal
present
reducing pain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2004552114A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006508137A (ja
Filing date
Publication date
Priority claimed from US10/292,105 external-priority patent/US6864271B2/en
Application filed filed Critical
Publication of JP2006508137A publication Critical patent/JP2006508137A/ja
Publication of JP2006508137A5 publication Critical patent/JP2006508137A5/ja
Pending legal-status Critical Current

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JP2004552114A 2002-11-12 2003-11-12 Ｎ−アセチル化４−ヒドロキシフェニラミン誘導体を含む相乗作用性の組み合わせ Pending JP2006508137A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/292,105 US6864271B2 (en) 2002-11-12 2002-11-12 Synergistic combinations including N-acylated 4-hydroxyphenylamine derivatives
PCT/US2003/036039 WO2004043460A1 (en) 2002-11-12 2003-11-12 Synergistic combinations with analgesic properties comprising n-acylated 4-hydroxyphenylamine derivatives

Publications (2)

Publication Number Publication Date
JP2006508137A JP2006508137A (ja) 2006-03-09
JP2006508137A5 true JP2006508137A5 (enExample) 2006-12-28

Family

ID=32229373

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004552114A Pending JP2006508137A (ja) 2002-11-12 2003-11-12 Ｎ−アセチル化４−ヒドロキシフェニラミン誘導体を含む相乗作用性の組み合わせ

Country Status (9)

Country Link
US (1) US6864271B2 (enExample)
EP (2) EP2074996A1 (enExample)
JP (1) JP2006508137A (enExample)
AT (1) ATE429913T1 (enExample)
AU (1) AU2003294259B2 (enExample)
CA (1) CA2509252A1 (enExample)
DE (1) DE60327466D1 (enExample)
ES (1) ES2325369T3 (enExample)
WO (1) WO2004043460A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1009407B1 (en) * 1997-09-04 2004-04-28 Novoneuron, Inc. Noribogaine in the treatment of pain and drug addiction
US7064140B2 (en) * 2002-11-12 2006-06-20 Carlos Sunkel Synergistic combinations including N-acylated 4-Hydroxyphenylamine derivatives and caffeine
US8026266B2 (en) * 2005-11-08 2011-09-27 Arcion Therapeutics, Inc. Treatment of length dependent neuropathy
US8765737B1 (en) 2010-05-11 2014-07-01 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US9394294B2 (en) 2010-05-11 2016-07-19 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US8362007B1 (en) 2010-05-11 2013-01-29 Demerx, Inc. Substituted noribogaine
US8741891B1 (en) 2010-06-22 2014-06-03 Demerx, Inc. N-substituted noribogaine prodrugs
US8637648B1 (en) 2010-06-22 2014-01-28 Demerx, Inc. Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
US9586954B2 (en) 2010-06-22 2017-03-07 Demerx, Inc. N-substituted noribogaine prodrugs
US8802832B2 (en) 2010-06-22 2014-08-12 Demerx, Inc. Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
UA111065C2 (uk) 2010-07-23 2016-03-25 Демеркс, Інк. Композиції норибогаїну
EP2481740B1 (en) 2011-01-26 2015-11-04 DemeRx, Inc. Methods and compositions for preparing noribogaine from voacangine
US9617274B1 (en) 2011-08-26 2017-04-11 Demerx, Inc. Synthetic noribogaine
JP2015500833A (ja) 2011-12-09 2015-01-08 デメレックス， インコーポレイテッド ノルイボガインのリン酸エステル
CN104470516A (zh) 2011-12-11 2015-03-25 瑞克欧制药有限公司 鼻内右美托咪定组合物和其使用方法
US9150584B2 (en) 2012-01-25 2015-10-06 Demerx, Inc. Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them
WO2013112673A1 (en) 2012-01-25 2013-08-01 Demerx, Inc. Synthetic voacangine
US9045481B2 (en) 2012-12-20 2015-06-02 Demerx, Inc. Substituted noribogaine
US8940728B2 (en) 2012-12-20 2015-01-27 Demerx, Inc. Substituted noribogaine
EP2934541A4 (en) 2012-12-20 2016-08-03 Demerx Inc NORIBOGAINE SUBSTITUTE
US9550789B2 (en) 2014-06-18 2017-01-24 Demerx, Inc. Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US554636A (en) * 1896-02-11 Exercising-iviachine
US562110A (en) * 1896-06-16 Relasting-machine
US4681897A (en) 1984-01-16 1987-07-21 The Procter & Gamble Company Pharmaceutical products providing enhanced analgesia
US4599342A (en) 1984-01-16 1986-07-08 The Procter & Gamble Company Pharmaceutical products providing enhanced analgesia
US6127352A (en) * 1988-02-01 2000-10-03 Uribe; Jose R. Pharmaceutical compositions with analgesics containing codeine
ATE169498T1 (de) * 1991-09-06 1998-08-15 Mcneilab Inc Zusammensetzung, die eine tramadol-verbindung und acetaminophen enthält, und ihre verwendung
US5554636A (en) * 1995-04-21 1996-09-10 Lsu Medical Center Foundation N-acylated 4-hydroxphenylamine derivatives with analgesic properties and pharmaceutical compositions containing them
US5840731A (en) 1995-08-02 1998-11-24 Virginia Commonwealth University Pain-alleviating drug composition and method for alleviating pain
WO1998032434A1 (en) 1997-01-29 1998-07-30 Chong Kun Dang Corp. New analgesic composition
FR2770131A1 (fr) * 1997-10-27 1999-04-30 Union Pharma Scient Appl Nouvelle association pharmaceutique a activite analgesique
US6143278A (en) * 1998-02-23 2000-11-07 Elkhoury; George F. Topical application of opioid analgesic drugs such as morphine
GB9804885D0 (en) * 1998-03-06 1998-04-29 Merck Sharp & Dohme Therapeutic combination
AU2001250646A1 (en) * 2000-04-17 2001-10-30 Yamanouchi Pharmaceutical Co..Ltd. Drug delivery system for avoiding pharmacokinetic interaction between drugs and method thereof
US6632217B2 (en) * 2001-04-19 2003-10-14 Microsolutions, Inc. Implantable osmotic pump

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