ATE429913T1 - Synergistische zusammensetzungen mit analgetischen eigenschaften die eine n- acetylierte 4-hydroxyphenylamine derivate enthalten - Google Patents
Synergistische zusammensetzungen mit analgetischen eigenschaften die eine n- acetylierte 4-hydroxyphenylamine derivate enthaltenInfo
- Publication number
- ATE429913T1 ATE429913T1 AT03789740T AT03789740T ATE429913T1 AT E429913 T1 ATE429913 T1 AT E429913T1 AT 03789740 T AT03789740 T AT 03789740T AT 03789740 T AT03789740 T AT 03789740T AT E429913 T1 ATE429913 T1 AT E429913T1
- Authority
- AT
- Austria
- Prior art keywords
- analgesic
- acetylate
- contain
- derivatives
- analgesic properties
- Prior art date
Links
- 230000000202 analgesic effect Effects 0.000 title abstract 4
- PLIKAWJENQZMHA-UHFFFAOYSA-N 4-aminophenol Chemical class NC1=CC=C(O)C=C1 PLIKAWJENQZMHA-UHFFFAOYSA-N 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000002195 synergetic effect Effects 0.000 title 1
- 206010019851 Hepatotoxicity Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 230000023555 blood coagulation Effects 0.000 abstract 1
- 231100000334 hepatotoxic Toxicity 0.000 abstract 1
- 230000003082 hepatotoxic effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229940121367 non-opioid analgesics Drugs 0.000 abstract 1
- 239000000014 opioid analgesic Substances 0.000 abstract 1
- 229940005483 opioid analgesics Drugs 0.000 abstract 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical group C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/292,105 US6864271B2 (en) | 2002-11-12 | 2002-11-12 | Synergistic combinations including N-acylated 4-hydroxyphenylamine derivatives |
| PCT/US2003/036039 WO2004043460A1 (en) | 2002-11-12 | 2003-11-12 | Synergistic combinations with analgesic properties comprising n-acylated 4-hydroxyphenylamine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE429913T1 true ATE429913T1 (de) | 2009-05-15 |
Family
ID=32229373
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03789740T ATE429913T1 (de) | 2002-11-12 | 2003-11-12 | Synergistische zusammensetzungen mit analgetischen eigenschaften die eine n- acetylierte 4-hydroxyphenylamine derivate enthalten |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6864271B2 (de) |
| EP (2) | EP1572204B1 (de) |
| JP (1) | JP2006508137A (de) |
| AT (1) | ATE429913T1 (de) |
| AU (1) | AU2003294259B2 (de) |
| CA (1) | CA2509252A1 (de) |
| DE (1) | DE60327466D1 (de) |
| ES (1) | ES2325369T3 (de) |
| WO (1) | WO2004043460A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE265213T1 (de) * | 1997-09-04 | 2004-05-15 | Novoneuron Inc | Noribogain zur behandlung von schmerzen und drogenabhängigkeit |
| US7064140B2 (en) * | 2002-11-12 | 2006-06-20 | Carlos Sunkel | Synergistic combinations including N-acylated 4-Hydroxyphenylamine derivatives and caffeine |
| US8026266B2 (en) * | 2005-11-08 | 2011-09-27 | Arcion Therapeutics, Inc. | Treatment of length dependent neuropathy |
| US8362007B1 (en) | 2010-05-11 | 2013-01-29 | Demerx, Inc. | Substituted noribogaine |
| US9394294B2 (en) | 2010-05-11 | 2016-07-19 | Demerx, Inc. | Methods and compositions for preparing and purifying noribogaine |
| US8765737B1 (en) | 2010-05-11 | 2014-07-01 | Demerx, Inc. | Methods and compositions for preparing and purifying noribogaine |
| US9586954B2 (en) | 2010-06-22 | 2017-03-07 | Demerx, Inc. | N-substituted noribogaine prodrugs |
| US8802832B2 (en) | 2010-06-22 | 2014-08-12 | Demerx, Inc. | Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier |
| US8741891B1 (en) | 2010-06-22 | 2014-06-03 | Demerx, Inc. | N-substituted noribogaine prodrugs |
| US8637648B1 (en) | 2010-06-22 | 2014-01-28 | Demerx, Inc. | Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier |
| CA2806232A1 (en) | 2010-07-23 | 2012-01-26 | Demerx, Inc. | Noribogaine compositions |
| EP2481740B1 (de) | 2011-01-26 | 2015-11-04 | DemeRx, Inc. | Verfahren und Zusammensetzungen zur Herstellung von Noribogain aus Voacangin |
| US9617274B1 (en) | 2011-08-26 | 2017-04-11 | Demerx, Inc. | Synthetic noribogaine |
| CA2855994A1 (en) | 2011-12-09 | 2013-06-13 | Demerx, Inc. | Phosphate esters of noribogaine |
| WO2013090278A2 (en) | 2011-12-11 | 2013-06-20 | Recro Pharma, Inc. | Intranasal dexmedetomidine compositions and methods of use thereof |
| CA2858820C (en) | 2012-01-25 | 2021-08-17 | Demerx, Inc. | Synthetic voacangine |
| US9150584B2 (en) | 2012-01-25 | 2015-10-06 | Demerx, Inc. | Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them |
| US8940728B2 (en) | 2012-12-20 | 2015-01-27 | Demerx, Inc. | Substituted noribogaine |
| CA2896133A1 (en) | 2012-12-20 | 2014-06-26 | Demerx, Inc. | Substituted noribogaine |
| US9045481B2 (en) | 2012-12-20 | 2015-06-02 | Demerx, Inc. | Substituted noribogaine |
| WO2015195673A2 (en) | 2014-06-18 | 2015-12-23 | Demerx, Inc. | Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US554636A (en) * | 1896-02-11 | Exercising-iviachine | ||
| US562110A (en) * | 1896-06-16 | Relasting-machine | ||
| US4599342A (en) | 1984-01-16 | 1986-07-08 | The Procter & Gamble Company | Pharmaceutical products providing enhanced analgesia |
| US4681897A (en) | 1984-01-16 | 1987-07-21 | The Procter & Gamble Company | Pharmaceutical products providing enhanced analgesia |
| US6127352A (en) * | 1988-02-01 | 2000-10-03 | Uribe; Jose R. | Pharmaceutical compositions with analgesics containing codeine |
| KR100243956B1 (ko) * | 1991-09-06 | 2000-03-02 | 랄프 알. 팔로 | 트라마돌 물질 및 아세트아미노펜을 포함하는 통증 치료용 약제학적 조성물 |
| US5554636A (en) * | 1995-04-21 | 1996-09-10 | Lsu Medical Center Foundation | N-acylated 4-hydroxphenylamine derivatives with analgesic properties and pharmaceutical compositions containing them |
| US5840731A (en) | 1995-08-02 | 1998-11-24 | Virginia Commonwealth University | Pain-alleviating drug composition and method for alleviating pain |
| US6048540A (en) | 1997-01-29 | 2000-04-11 | Chong Kun Dang Corp. | Acetamenophen composition with reduced liver toxicity |
| FR2770131A1 (fr) * | 1997-10-27 | 1999-04-30 | Union Pharma Scient Appl | Nouvelle association pharmaceutique a activite analgesique |
| US6143278A (en) * | 1998-02-23 | 2000-11-07 | Elkhoury; George F. | Topical application of opioid analgesic drugs such as morphine |
| GB9804885D0 (en) * | 1998-03-06 | 1998-04-29 | Merck Sharp & Dohme | Therapeutic combination |
| EP1275373A4 (de) * | 2000-04-17 | 2007-04-04 | Astellas Pharma Inc | Arzneistoffabgabesystem zur vermeidung von pharmakokinetischen wechselwirkungen zwischen wirkstoffen und methode hierzu |
| US6632217B2 (en) * | 2001-04-19 | 2003-10-14 | Microsolutions, Inc. | Implantable osmotic pump |
-
2002
- 2002-11-12 US US10/292,105 patent/US6864271B2/en not_active Expired - Lifetime
-
2003
- 2003-11-12 EP EP03789740A patent/EP1572204B1/de not_active Expired - Lifetime
- 2003-11-12 CA CA002509252A patent/CA2509252A1/en not_active Abandoned
- 2003-11-12 ES ES03789740T patent/ES2325369T3/es not_active Expired - Lifetime
- 2003-11-12 EP EP09157996A patent/EP2074996A1/de not_active Withdrawn
- 2003-11-12 AT AT03789740T patent/ATE429913T1/de not_active IP Right Cessation
- 2003-11-12 AU AU2003294259A patent/AU2003294259B2/en not_active Ceased
- 2003-11-12 DE DE60327466T patent/DE60327466D1/de not_active Expired - Lifetime
- 2003-11-12 WO PCT/US2003/036039 patent/WO2004043460A1/en not_active Ceased
- 2003-11-12 JP JP2004552114A patent/JP2006508137A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1572204A1 (de) | 2005-09-14 |
| ES2325369T3 (es) | 2009-09-02 |
| EP1572204B1 (de) | 2009-04-29 |
| CA2509252A1 (en) | 2004-05-27 |
| EP2074996A1 (de) | 2009-07-01 |
| DE60327466D1 (de) | 2009-06-10 |
| AU2003294259B2 (en) | 2008-12-18 |
| WO2004043460A1 (en) | 2004-05-27 |
| US6864271B2 (en) | 2005-03-08 |
| JP2006508137A (ja) | 2006-03-09 |
| AU2003294259A1 (en) | 2004-06-03 |
| US20040092541A1 (en) | 2004-05-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |