ATE429913T1 - Synergistische zusammensetzungen mit analgetischen eigenschaften die eine n- acetylierte 4-hydroxyphenylamine derivate enthalten - Google Patents

Synergistische zusammensetzungen mit analgetischen eigenschaften die eine n- acetylierte 4-hydroxyphenylamine derivate enthalten

Info

Publication number
ATE429913T1
ATE429913T1 AT03789740T AT03789740T ATE429913T1 AT E429913 T1 ATE429913 T1 AT E429913T1 AT 03789740 T AT03789740 T AT 03789740T AT 03789740 T AT03789740 T AT 03789740T AT E429913 T1 ATE429913 T1 AT E429913T1
Authority
AT
Austria
Prior art keywords
analgesic
acetylate
contain
derivatives
analgesic properties
Prior art date
Application number
AT03789740T
Other languages
German (de)
English (en)
Inventor
Nicolas Bazan
Carlos Sunkel
Julio Builla
Dennis Paul
Original Assignee
Univ Louisiana State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Louisiana State filed Critical Univ Louisiana State
Application granted granted Critical
Publication of ATE429913T1 publication Critical patent/ATE429913T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
AT03789740T 2002-11-12 2003-11-12 Synergistische zusammensetzungen mit analgetischen eigenschaften die eine n- acetylierte 4-hydroxyphenylamine derivate enthalten ATE429913T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/292,105 US6864271B2 (en) 2002-11-12 2002-11-12 Synergistic combinations including N-acylated 4-hydroxyphenylamine derivatives
PCT/US2003/036039 WO2004043460A1 (en) 2002-11-12 2003-11-12 Synergistic combinations with analgesic properties comprising n-acylated 4-hydroxyphenylamine derivatives

Publications (1)

Publication Number Publication Date
ATE429913T1 true ATE429913T1 (de) 2009-05-15

Family

ID=32229373

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03789740T ATE429913T1 (de) 2002-11-12 2003-11-12 Synergistische zusammensetzungen mit analgetischen eigenschaften die eine n- acetylierte 4-hydroxyphenylamine derivate enthalten

Country Status (9)

Country Link
US (1) US6864271B2 (enExample)
EP (2) EP2074996A1 (enExample)
JP (1) JP2006508137A (enExample)
AT (1) ATE429913T1 (enExample)
AU (1) AU2003294259B2 (enExample)
CA (1) CA2509252A1 (enExample)
DE (1) DE60327466D1 (enExample)
ES (1) ES2325369T3 (enExample)
WO (1) WO2004043460A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1009407B1 (en) * 1997-09-04 2004-04-28 Novoneuron, Inc. Noribogaine in the treatment of pain and drug addiction
US7064140B2 (en) * 2002-11-12 2006-06-20 Carlos Sunkel Synergistic combinations including N-acylated 4-Hydroxyphenylamine derivatives and caffeine
US8026266B2 (en) * 2005-11-08 2011-09-27 Arcion Therapeutics, Inc. Treatment of length dependent neuropathy
US8765737B1 (en) 2010-05-11 2014-07-01 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US9394294B2 (en) 2010-05-11 2016-07-19 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US8362007B1 (en) 2010-05-11 2013-01-29 Demerx, Inc. Substituted noribogaine
US8741891B1 (en) 2010-06-22 2014-06-03 Demerx, Inc. N-substituted noribogaine prodrugs
US8637648B1 (en) 2010-06-22 2014-01-28 Demerx, Inc. Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
US9586954B2 (en) 2010-06-22 2017-03-07 Demerx, Inc. N-substituted noribogaine prodrugs
US8802832B2 (en) 2010-06-22 2014-08-12 Demerx, Inc. Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
UA111065C2 (uk) 2010-07-23 2016-03-25 Демеркс, Інк. Композиції норибогаїну
EP2481740B1 (en) 2011-01-26 2015-11-04 DemeRx, Inc. Methods and compositions for preparing noribogaine from voacangine
US9617274B1 (en) 2011-08-26 2017-04-11 Demerx, Inc. Synthetic noribogaine
JP2015500833A (ja) 2011-12-09 2015-01-08 デメレックス， インコーポレイテッド ノルイボガインのリン酸エステル
CN104470516A (zh) 2011-12-11 2015-03-25 瑞克欧制药有限公司 鼻内右美托咪定组合物和其使用方法
US9150584B2 (en) 2012-01-25 2015-10-06 Demerx, Inc. Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them
WO2013112673A1 (en) 2012-01-25 2013-08-01 Demerx, Inc. Synthetic voacangine
US9045481B2 (en) 2012-12-20 2015-06-02 Demerx, Inc. Substituted noribogaine
US8940728B2 (en) 2012-12-20 2015-01-27 Demerx, Inc. Substituted noribogaine
EP2934541A4 (en) 2012-12-20 2016-08-03 Demerx Inc NORIBOGAINE SUBSTITUTE
US9550789B2 (en) 2014-06-18 2017-01-24 Demerx, Inc. Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US554636A (en) * 1896-02-11 Exercising-iviachine
US562110A (en) * 1896-06-16 Relasting-machine
US4681897A (en) 1984-01-16 1987-07-21 The Procter & Gamble Company Pharmaceutical products providing enhanced analgesia
US4599342A (en) 1984-01-16 1986-07-08 The Procter & Gamble Company Pharmaceutical products providing enhanced analgesia
US6127352A (en) * 1988-02-01 2000-10-03 Uribe; Jose R. Pharmaceutical compositions with analgesics containing codeine
ATE169498T1 (de) * 1991-09-06 1998-08-15 Mcneilab Inc Zusammensetzung, die eine tramadol-verbindung und acetaminophen enthält, und ihre verwendung
US5554636A (en) * 1995-04-21 1996-09-10 Lsu Medical Center Foundation N-acylated 4-hydroxphenylamine derivatives with analgesic properties and pharmaceutical compositions containing them
US5840731A (en) 1995-08-02 1998-11-24 Virginia Commonwealth University Pain-alleviating drug composition and method for alleviating pain
WO1998032434A1 (en) 1997-01-29 1998-07-30 Chong Kun Dang Corp. New analgesic composition
FR2770131A1 (fr) * 1997-10-27 1999-04-30 Union Pharma Scient Appl Nouvelle association pharmaceutique a activite analgesique
US6143278A (en) * 1998-02-23 2000-11-07 Elkhoury; George F. Topical application of opioid analgesic drugs such as morphine
GB9804885D0 (en) * 1998-03-06 1998-04-29 Merck Sharp & Dohme Therapeutic combination
AU2001250646A1 (en) * 2000-04-17 2001-10-30 Yamanouchi Pharmaceutical Co..Ltd. Drug delivery system for avoiding pharmacokinetic interaction between drugs and method thereof
US6632217B2 (en) * 2001-04-19 2003-10-14 Microsolutions, Inc. Implantable osmotic pump

Also Published As

Publication number Publication date
US6864271B2 (en) 2005-03-08
EP1572204A1 (en) 2005-09-14
JP2006508137A (ja) 2006-03-09
AU2003294259B2 (en) 2008-12-18
WO2004043460A1 (en) 2004-05-27
EP1572204B1 (en) 2009-04-29
AU2003294259A1 (en) 2004-06-03
EP2074996A1 (en) 2009-07-01
ES2325369T3 (es) 2009-09-02
US20040092541A1 (en) 2004-05-13
DE60327466D1 (de) 2009-06-10
CA2509252A1 (en) 2004-05-27

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