DE60327466D1 - Synergistische zusammensetzungen mit analgetischen eigenschaften die eine n-acetylierte 4-hydroxyphenylamine derivate enthalten - Google Patents
Synergistische zusammensetzungen mit analgetischen eigenschaften die eine n-acetylierte 4-hydroxyphenylamine derivate enthaltenInfo
- Publication number
- DE60327466D1 DE60327466D1 DE60327466T DE60327466T DE60327466D1 DE 60327466 D1 DE60327466 D1 DE 60327466D1 DE 60327466 T DE60327466 T DE 60327466T DE 60327466 T DE60327466 T DE 60327466T DE 60327466 D1 DE60327466 D1 DE 60327466D1
- Authority
- DE
- Germany
- Prior art keywords
- analgical
- acetylated
- analgesic
- derivatives
- synergistic compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- PLIKAWJENQZMHA-UHFFFAOYSA-N 4-aminophenol Chemical class NC1=CC=C(O)C=C1 PLIKAWJENQZMHA-UHFFFAOYSA-N 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000002195 synergetic effect Effects 0.000 title 1
- 230000000202 analgesic effect Effects 0.000 abstract 3
- 206010019851 Hepatotoxicity Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 230000023555 blood coagulation Effects 0.000 abstract 1
- 231100000334 hepatotoxic Toxicity 0.000 abstract 1
- 230000003082 hepatotoxic effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229940121367 non-opioid analgesics Drugs 0.000 abstract 1
- 239000000014 opioid analgesic Substances 0.000 abstract 1
- 229940005483 opioid analgesics Drugs 0.000 abstract 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical group C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/292,105 US6864271B2 (en) | 2002-11-12 | 2002-11-12 | Synergistic combinations including N-acylated 4-hydroxyphenylamine derivatives |
| PCT/US2003/036039 WO2004043460A1 (en) | 2002-11-12 | 2003-11-12 | Synergistic combinations with analgesic properties comprising n-acylated 4-hydroxyphenylamine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60327466D1 true DE60327466D1 (de) | 2009-06-10 |
Family
ID=32229373
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60327466T Expired - Lifetime DE60327466D1 (de) | 2002-11-12 | 2003-11-12 | Synergistische zusammensetzungen mit analgetischen eigenschaften die eine n-acetylierte 4-hydroxyphenylamine derivate enthalten |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6864271B2 (enExample) |
| EP (2) | EP2074996A1 (enExample) |
| JP (1) | JP2006508137A (enExample) |
| AT (1) | ATE429913T1 (enExample) |
| AU (1) | AU2003294259B2 (enExample) |
| CA (1) | CA2509252A1 (enExample) |
| DE (1) | DE60327466D1 (enExample) |
| ES (1) | ES2325369T3 (enExample) |
| WO (1) | WO2004043460A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2435722T3 (es) * | 1997-09-04 | 2013-12-23 | Demerx, Inc. | Noribogaína en el tratamiento del dolor y de la adicción a drogas |
| US7064140B2 (en) * | 2002-11-12 | 2006-06-20 | Carlos Sunkel | Synergistic combinations including N-acylated 4-Hydroxyphenylamine derivatives and caffeine |
| US8026266B2 (en) * | 2005-11-08 | 2011-09-27 | Arcion Therapeutics, Inc. | Treatment of length dependent neuropathy |
| US8765737B1 (en) | 2010-05-11 | 2014-07-01 | Demerx, Inc. | Methods and compositions for preparing and purifying noribogaine |
| US9394294B2 (en) | 2010-05-11 | 2016-07-19 | Demerx, Inc. | Methods and compositions for preparing and purifying noribogaine |
| US8362007B1 (en) | 2010-05-11 | 2013-01-29 | Demerx, Inc. | Substituted noribogaine |
| US9586954B2 (en) | 2010-06-22 | 2017-03-07 | Demerx, Inc. | N-substituted noribogaine prodrugs |
| US8741891B1 (en) | 2010-06-22 | 2014-06-03 | Demerx, Inc. | N-substituted noribogaine prodrugs |
| US8637648B1 (en) | 2010-06-22 | 2014-01-28 | Demerx, Inc. | Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier |
| US8802832B2 (en) | 2010-06-22 | 2014-08-12 | Demerx, Inc. | Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier |
| JP6049615B2 (ja) | 2010-07-23 | 2016-12-21 | デマークス・インコーポレイテッドＤｅｍｅｒｘ，Ｉｎｃ． | ノリボガイン組成物 |
| EP2481740B1 (en) | 2011-01-26 | 2015-11-04 | DemeRx, Inc. | Methods and compositions for preparing noribogaine from voacangine |
| US9617274B1 (en) | 2011-08-26 | 2017-04-11 | Demerx, Inc. | Synthetic noribogaine |
| EP2788003A4 (en) | 2011-12-09 | 2015-05-27 | Demerx Inc | PHOSPHATESTER OF NORIBOGAIN |
| CA2858721C (en) | 2011-12-11 | 2021-03-16 | Recro Pharma, Inc. | Intranasal dexmedetomidine compositions and methods of use thereof |
| US9150584B2 (en) | 2012-01-25 | 2015-10-06 | Demerx, Inc. | Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them |
| CA2858820C (en) | 2012-01-25 | 2021-08-17 | Demerx, Inc. | Synthetic voacangine |
| US9045481B2 (en) | 2012-12-20 | 2015-06-02 | Demerx, Inc. | Substituted noribogaine |
| CA2896133A1 (en) | 2012-12-20 | 2014-06-26 | Demerx, Inc. | Substituted noribogaine |
| US8940728B2 (en) | 2012-12-20 | 2015-01-27 | Demerx, Inc. | Substituted noribogaine |
| WO2015195673A2 (en) | 2014-06-18 | 2015-12-23 | Demerx, Inc. | Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US554636A (en) * | 1896-02-11 | Exercising-iviachine | ||
| US562110A (en) * | 1896-06-16 | Relasting-machine | ||
| US4681897A (en) | 1984-01-16 | 1987-07-21 | The Procter & Gamble Company | Pharmaceutical products providing enhanced analgesia |
| US4599342A (en) | 1984-01-16 | 1986-07-08 | The Procter & Gamble Company | Pharmaceutical products providing enhanced analgesia |
| US6127352A (en) * | 1988-02-01 | 2000-10-03 | Uribe; Jose R. | Pharmaceutical compositions with analgesics containing codeine |
| HU219332B (hu) * | 1991-09-06 | 2001-03-28 | Mcneilab Inc | Transz-(+)-2-[(dimetil-amino)-metil]-1-(3-metoxi-fenil)-ciklohexanolt és acetaminofent tartalmazó szinergetikus gyógyszerkészítmények |
| US5554636A (en) * | 1995-04-21 | 1996-09-10 | Lsu Medical Center Foundation | N-acylated 4-hydroxphenylamine derivatives with analgesic properties and pharmaceutical compositions containing them |
| US5840731A (en) | 1995-08-02 | 1998-11-24 | Virginia Commonwealth University | Pain-alleviating drug composition and method for alleviating pain |
| WO1998032434A1 (en) | 1997-01-29 | 1998-07-30 | Chong Kun Dang Corp. | New analgesic composition |
| FR2770131A1 (fr) * | 1997-10-27 | 1999-04-30 | Union Pharma Scient Appl | Nouvelle association pharmaceutique a activite analgesique |
| US6143278A (en) * | 1998-02-23 | 2000-11-07 | Elkhoury; George F. | Topical application of opioid analgesic drugs such as morphine |
| GB9804885D0 (en) * | 1998-03-06 | 1998-04-29 | Merck Sharp & Dohme | Therapeutic combination |
| JPWO2001078681A1 (ja) * | 2000-04-17 | 2004-01-08 | 山之内製薬株式会社 | 薬物動態学的な薬物相互作用を回避する薬物送達システム及びその方法 |
| US6632217B2 (en) * | 2001-04-19 | 2003-10-14 | Microsolutions, Inc. | Implantable osmotic pump |
-
2002
- 2002-11-12 US US10/292,105 patent/US6864271B2/en not_active Expired - Lifetime
-
2003
- 2003-11-12 AU AU2003294259A patent/AU2003294259B2/en not_active Ceased
- 2003-11-12 CA CA002509252A patent/CA2509252A1/en not_active Abandoned
- 2003-11-12 JP JP2004552114A patent/JP2006508137A/ja active Pending
- 2003-11-12 AT AT03789740T patent/ATE429913T1/de not_active IP Right Cessation
- 2003-11-12 DE DE60327466T patent/DE60327466D1/de not_active Expired - Lifetime
- 2003-11-12 WO PCT/US2003/036039 patent/WO2004043460A1/en not_active Ceased
- 2003-11-12 EP EP09157996A patent/EP2074996A1/en not_active Withdrawn
- 2003-11-12 ES ES03789740T patent/ES2325369T3/es not_active Expired - Lifetime
- 2003-11-12 EP EP03789740A patent/EP1572204B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2325369T3 (es) | 2009-09-02 |
| EP1572204A1 (en) | 2005-09-14 |
| AU2003294259A1 (en) | 2004-06-03 |
| EP1572204B1 (en) | 2009-04-29 |
| JP2006508137A (ja) | 2006-03-09 |
| ATE429913T1 (de) | 2009-05-15 |
| US20040092541A1 (en) | 2004-05-13 |
| US6864271B2 (en) | 2005-03-08 |
| AU2003294259B2 (en) | 2008-12-18 |
| WO2004043460A1 (en) | 2004-05-27 |
| EP2074996A1 (en) | 2009-07-01 |
| CA2509252A1 (en) | 2004-05-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |