AU2003294259B2 - Synergistic combinations with analgesic properties comprising N-acylated 4-hydroxyphenylamine derivatives - Google Patents

Synergistic combinations with analgesic properties comprising N-acylated 4-hydroxyphenylamine derivatives Download PDF

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Publication number
AU2003294259B2
AU2003294259B2 AU2003294259A AU2003294259A AU2003294259B2 AU 2003294259 B2 AU2003294259 B2 AU 2003294259B2 AU 2003294259 A AU2003294259 A AU 2003294259A AU 2003294259 A AU2003294259 A AU 2003294259A AU 2003294259 B2 AU2003294259 B2 AU 2003294259B2
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AU
Australia
Prior art keywords
analgesic
composition according
opioid analgesic
opioid
scp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2003294259A
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English (en)
Other versions
AU2003294259A1 (en
Inventor
Nicolas G. Bazan
Julio Alvarez Builla
Dennis Paul
Carlos Sunkel
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Louisiana State University
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Louisiana State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Louisiana State University filed Critical Louisiana State University
Publication of AU2003294259A1 publication Critical patent/AU2003294259A1/en
Assigned to The Board of Supervisors of Louisiana State Univeristy and Agricultural and Mechanical College reassignment The Board of Supervisors of Louisiana State Univeristy and Agricultural and Mechanical College Request for Assignment Assignors: LSU MEDICAL CENTER FOUNDATION
Application granted granted Critical
Publication of AU2003294259B2 publication Critical patent/AU2003294259B2/en
Assigned to BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE reassignment BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE Alteration of Name(s) of Applicant(s) under S113 Assignors: THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
AU2003294259A 2002-11-12 2003-11-12 Synergistic combinations with analgesic properties comprising N-acylated 4-hydroxyphenylamine derivatives Ceased AU2003294259B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/292,105 2002-11-12
US10/292,105 US6864271B2 (en) 2002-11-12 2002-11-12 Synergistic combinations including N-acylated 4-hydroxyphenylamine derivatives
PCT/US2003/036039 WO2004043460A1 (en) 2002-11-12 2003-11-12 Synergistic combinations with analgesic properties comprising n-acylated 4-hydroxyphenylamine derivatives

Publications (2)

Publication Number Publication Date
AU2003294259A1 AU2003294259A1 (en) 2004-06-03
AU2003294259B2 true AU2003294259B2 (en) 2008-12-18

Family

ID=32229373

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003294259A Ceased AU2003294259B2 (en) 2002-11-12 2003-11-12 Synergistic combinations with analgesic properties comprising N-acylated 4-hydroxyphenylamine derivatives

Country Status (9)

Country Link
US (1) US6864271B2 (enExample)
EP (2) EP2074996A1 (enExample)
JP (1) JP2006508137A (enExample)
AT (1) ATE429913T1 (enExample)
AU (1) AU2003294259B2 (enExample)
CA (1) CA2509252A1 (enExample)
DE (1) DE60327466D1 (enExample)
ES (1) ES2325369T3 (enExample)
WO (1) WO2004043460A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2224430T3 (es) * 1997-09-04 2005-03-01 Novoneuron Inc Noribogaina en el tratamiento del dolor y de la toxicomania.
US7064140B2 (en) * 2002-11-12 2006-06-20 Carlos Sunkel Synergistic combinations including N-acylated 4-Hydroxyphenylamine derivatives and caffeine
US8026266B2 (en) 2005-11-08 2011-09-27 Arcion Therapeutics, Inc. Treatment of length dependent neuropathy
US8362007B1 (en) 2010-05-11 2013-01-29 Demerx, Inc. Substituted noribogaine
US8765737B1 (en) 2010-05-11 2014-07-01 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US9394294B2 (en) 2010-05-11 2016-07-19 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US9586954B2 (en) 2010-06-22 2017-03-07 Demerx, Inc. N-substituted noribogaine prodrugs
US8741891B1 (en) 2010-06-22 2014-06-03 Demerx, Inc. N-substituted noribogaine prodrugs
US8802832B2 (en) 2010-06-22 2014-08-12 Demerx, Inc. Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
US8637648B1 (en) 2010-06-22 2014-01-28 Demerx, Inc. Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
CA2806232A1 (en) 2010-07-23 2012-01-26 Demerx, Inc. Noribogaine compositions
EP2481740B1 (en) 2011-01-26 2015-11-04 DemeRx, Inc. Methods and compositions for preparing noribogaine from voacangine
US9617274B1 (en) 2011-08-26 2017-04-11 Demerx, Inc. Synthetic noribogaine
WO2013085922A1 (en) 2011-12-09 2013-06-13 Demerx, Inc. Phosphate esters of noribogaine
EP2787970B1 (en) 2011-12-11 2018-04-11 Recro Pharma, Inc. Intranasal dexmedetomidine compositions and methods of use thereof
WO2013112673A1 (en) 2012-01-25 2013-08-01 Demerx, Inc. Synthetic voacangine
US9150584B2 (en) 2012-01-25 2015-10-06 Demerx, Inc. Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them
EP2934541A4 (en) 2012-12-20 2016-08-03 Demerx Inc SUBSTITUTED NORIBOGAIN
US9045481B2 (en) 2012-12-20 2015-06-02 Demerx, Inc. Substituted noribogaine
US9550789B2 (en) 2014-06-18 2017-01-24 Demerx, Inc. Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US554636A (en) * 1896-02-11 Exercising-iviachine
US562110A (en) * 1896-06-16 Relasting-machine

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4681897A (en) 1984-01-16 1987-07-21 The Procter & Gamble Company Pharmaceutical products providing enhanced analgesia
US4599342A (en) 1984-01-16 1986-07-08 The Procter & Gamble Company Pharmaceutical products providing enhanced analgesia
US6127352A (en) * 1988-02-01 2000-10-03 Uribe; Jose R. Pharmaceutical compositions with analgesics containing codeine
DE122004000032I2 (de) * 1991-09-06 2006-02-09 Mcneilab Inc Zusammensetzung die eine Tramadol-Verbindung und Acetaminophen enth{lt, und ihre Verwendung
US5554636A (en) * 1995-04-21 1996-09-10 Lsu Medical Center Foundation N-acylated 4-hydroxphenylamine derivatives with analgesic properties and pharmaceutical compositions containing them
US5840731A (en) 1995-08-02 1998-11-24 Virginia Commonwealth University Pain-alleviating drug composition and method for alleviating pain
AU5882298A (en) 1997-01-29 1998-08-18 Chong Kun Dang Corporation New analgesic composition
FR2770131A1 (fr) * 1997-10-27 1999-04-30 Union Pharma Scient Appl Nouvelle association pharmaceutique a activite analgesique
US6143278A (en) * 1998-02-23 2000-11-07 Elkhoury; George F. Topical application of opioid analgesic drugs such as morphine
GB9804885D0 (en) * 1998-03-06 1998-04-29 Merck Sharp & Dohme Therapeutic combination
JPWO2001078681A1 (ja) * 2000-04-17 2004-01-08 山之内製薬株式会社 薬物動態学的な薬物相互作用を回避する薬物送達システム及びその方法
US6632217B2 (en) * 2001-04-19 2003-10-14 Microsolutions, Inc. Implantable osmotic pump

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US554636A (en) * 1896-02-11 Exercising-iviachine
US562110A (en) * 1896-06-16 Relasting-machine

Also Published As

Publication number Publication date
EP1572204B1 (en) 2009-04-29
DE60327466D1 (de) 2009-06-10
ATE429913T1 (de) 2009-05-15
CA2509252A1 (en) 2004-05-27
US20040092541A1 (en) 2004-05-13
ES2325369T3 (es) 2009-09-02
US6864271B2 (en) 2005-03-08
WO2004043460A1 (en) 2004-05-27
EP2074996A1 (en) 2009-07-01
JP2006508137A (ja) 2006-03-09
EP1572204A1 (en) 2005-09-14
AU2003294259A1 (en) 2004-06-03

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Legal Events

Date Code Title Description
PC1 Assignment before grant (sect. 113)

Owner name: THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVER

Free format text: FORMER APPLICANT(S): LSU MEDICAL CENTER FOUNDATION

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired