ES2325369T3 - Composiciones sinergicas, con propiedades analgesicas, que contienen derivados de 4-hidroxifenilamina n-acilados. - Google Patents
Composiciones sinergicas, con propiedades analgesicas, que contienen derivados de 4-hidroxifenilamina n-acilados. Download PDFInfo
- Publication number
- ES2325369T3 ES2325369T3 ES03789740T ES03789740T ES2325369T3 ES 2325369 T3 ES2325369 T3 ES 2325369T3 ES 03789740 T ES03789740 T ES 03789740T ES 03789740 T ES03789740 T ES 03789740T ES 2325369 T3 ES2325369 T3 ES 2325369T3
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- Spain
- Prior art keywords
- analgesic
- opioid analgesic
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 229960004253 dexmedetomidine Drugs 0.000 description 1
- HRLIOXLXPOHXTA-NSHDSACASA-N dexmedetomidine Chemical compound C1([C@@H](C)C=2C(=C(C)C=CC=2)C)=CN=C[N]1 HRLIOXLXPOHXTA-NSHDSACASA-N 0.000 description 1
- -1 dexmetomidine Chemical compound 0.000 description 1
- 229960001985 dextromethorphan Drugs 0.000 description 1
- 229960003461 dezocine Drugs 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 1
- 229940093471 ethyl oleate Drugs 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 229960003180 glutathione Drugs 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 230000036543 hypotension Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 229960003299 ketamine Drugs 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 229940089568 lortab Drugs 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- VPNGEIHDPSLNMU-UHFFFAOYSA-N medetomidine hydrochloride Chemical compound Cl.C=1C=CC(C)=C(C)C=1C(C)C1=CNC=N1 VPNGEIHDPSLNMU-UHFFFAOYSA-N 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 230000000407 monoamine reuptake Effects 0.000 description 1
- 229960000805 nalbuphine Drugs 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229960002748 norepinephrine Drugs 0.000 description 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000002831 pharmacologic agent Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 150000003053 piperidines Chemical class 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 239000002510 pyrogen Substances 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 239000002464 receptor antagonist Substances 0.000 description 1
- 229940044551 receptor antagonist Drugs 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000036280 sedation Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/292,105 US6864271B2 (en) | 2002-11-12 | 2002-11-12 | Synergistic combinations including N-acylated 4-hydroxyphenylamine derivatives |
| US292105 | 2002-11-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2325369T3 true ES2325369T3 (es) | 2009-09-02 |
Family
ID=32229373
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES03789740T Expired - Lifetime ES2325369T3 (es) | 2002-11-12 | 2003-11-12 | Composiciones sinergicas, con propiedades analgesicas, que contienen derivados de 4-hidroxifenilamina n-acilados. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6864271B2 (enExample) |
| EP (2) | EP2074996A1 (enExample) |
| JP (1) | JP2006508137A (enExample) |
| AT (1) | ATE429913T1 (enExample) |
| AU (1) | AU2003294259B2 (enExample) |
| CA (1) | CA2509252A1 (enExample) |
| DE (1) | DE60327466D1 (enExample) |
| ES (1) | ES2325369T3 (enExample) |
| WO (1) | WO2004043460A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1009407B1 (en) * | 1997-09-04 | 2004-04-28 | Novoneuron, Inc. | Noribogaine in the treatment of pain and drug addiction |
| US7064140B2 (en) * | 2002-11-12 | 2006-06-20 | Carlos Sunkel | Synergistic combinations including N-acylated 4-Hydroxyphenylamine derivatives and caffeine |
| US8026266B2 (en) * | 2005-11-08 | 2011-09-27 | Arcion Therapeutics, Inc. | Treatment of length dependent neuropathy |
| US8765737B1 (en) | 2010-05-11 | 2014-07-01 | Demerx, Inc. | Methods and compositions for preparing and purifying noribogaine |
| US9394294B2 (en) | 2010-05-11 | 2016-07-19 | Demerx, Inc. | Methods and compositions for preparing and purifying noribogaine |
| US8362007B1 (en) | 2010-05-11 | 2013-01-29 | Demerx, Inc. | Substituted noribogaine |
| US8741891B1 (en) | 2010-06-22 | 2014-06-03 | Demerx, Inc. | N-substituted noribogaine prodrugs |
| US8637648B1 (en) | 2010-06-22 | 2014-01-28 | Demerx, Inc. | Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier |
| US9586954B2 (en) | 2010-06-22 | 2017-03-07 | Demerx, Inc. | N-substituted noribogaine prodrugs |
| US8802832B2 (en) | 2010-06-22 | 2014-08-12 | Demerx, Inc. | Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier |
| UA111065C2 (uk) | 2010-07-23 | 2016-03-25 | Демеркс, Інк. | Композиції норибогаїну |
| EP2481740B1 (en) | 2011-01-26 | 2015-11-04 | DemeRx, Inc. | Methods and compositions for preparing noribogaine from voacangine |
| US9617274B1 (en) | 2011-08-26 | 2017-04-11 | Demerx, Inc. | Synthetic noribogaine |
| JP2015500833A (ja) | 2011-12-09 | 2015-01-08 | デメレックス， インコーポレイテッド | ノルイボガインのリン酸エステル |
| CN104470516A (zh) | 2011-12-11 | 2015-03-25 | 瑞克欧制药有限公司 | 鼻内右美托咪定组合物和其使用方法 |
| US9150584B2 (en) | 2012-01-25 | 2015-10-06 | Demerx, Inc. | Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them |
| WO2013112673A1 (en) | 2012-01-25 | 2013-08-01 | Demerx, Inc. | Synthetic voacangine |
| US9045481B2 (en) | 2012-12-20 | 2015-06-02 | Demerx, Inc. | Substituted noribogaine |
| US8940728B2 (en) | 2012-12-20 | 2015-01-27 | Demerx, Inc. | Substituted noribogaine |
| EP2934541A4 (en) | 2012-12-20 | 2016-08-03 | Demerx Inc | NORIBOGAINE SUBSTITUTE |
| US9550789B2 (en) | 2014-06-18 | 2017-01-24 | Demerx, Inc. | Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US554636A (en) * | 1896-02-11 | Exercising-iviachine | ||
| US562110A (en) * | 1896-06-16 | Relasting-machine | ||
| US4681897A (en) | 1984-01-16 | 1987-07-21 | The Procter & Gamble Company | Pharmaceutical products providing enhanced analgesia |
| US4599342A (en) | 1984-01-16 | 1986-07-08 | The Procter & Gamble Company | Pharmaceutical products providing enhanced analgesia |
| US6127352A (en) * | 1988-02-01 | 2000-10-03 | Uribe; Jose R. | Pharmaceutical compositions with analgesics containing codeine |
| ATE169498T1 (de) * | 1991-09-06 | 1998-08-15 | Mcneilab Inc | Zusammensetzung, die eine tramadol-verbindung und acetaminophen enthält, und ihre verwendung |
| US5554636A (en) * | 1995-04-21 | 1996-09-10 | Lsu Medical Center Foundation | N-acylated 4-hydroxphenylamine derivatives with analgesic properties and pharmaceutical compositions containing them |
| US5840731A (en) | 1995-08-02 | 1998-11-24 | Virginia Commonwealth University | Pain-alleviating drug composition and method for alleviating pain |
| WO1998032434A1 (en) | 1997-01-29 | 1998-07-30 | Chong Kun Dang Corp. | New analgesic composition |
| FR2770131A1 (fr) * | 1997-10-27 | 1999-04-30 | Union Pharma Scient Appl | Nouvelle association pharmaceutique a activite analgesique |
| US6143278A (en) * | 1998-02-23 | 2000-11-07 | Elkhoury; George F. | Topical application of opioid analgesic drugs such as morphine |
| GB9804885D0 (en) * | 1998-03-06 | 1998-04-29 | Merck Sharp & Dohme | Therapeutic combination |
| AU2001250646A1 (en) * | 2000-04-17 | 2001-10-30 | Yamanouchi Pharmaceutical Co..Ltd. | Drug delivery system for avoiding pharmacokinetic interaction between drugs and method thereof |
| US6632217B2 (en) * | 2001-04-19 | 2003-10-14 | Microsolutions, Inc. | Implantable osmotic pump |
-
2002
- 2002-11-12 US US10/292,105 patent/US6864271B2/en not_active Expired - Lifetime
-
2003
- 2003-11-12 EP EP09157996A patent/EP2074996A1/en not_active Withdrawn
- 2003-11-12 AT AT03789740T patent/ATE429913T1/de not_active IP Right Cessation
- 2003-11-12 WO PCT/US2003/036039 patent/WO2004043460A1/en not_active Ceased
- 2003-11-12 AU AU2003294259A patent/AU2003294259B2/en not_active Ceased
- 2003-11-12 ES ES03789740T patent/ES2325369T3/es not_active Expired - Lifetime
- 2003-11-12 DE DE60327466T patent/DE60327466D1/de not_active Expired - Lifetime
- 2003-11-12 CA CA002509252A patent/CA2509252A1/en not_active Abandoned
- 2003-11-12 EP EP03789740A patent/EP1572204B1/en not_active Expired - Lifetime
- 2003-11-12 JP JP2004552114A patent/JP2006508137A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US6864271B2 (en) | 2005-03-08 |
| EP1572204A1 (en) | 2005-09-14 |
| JP2006508137A (ja) | 2006-03-09 |
| AU2003294259B2 (en) | 2008-12-18 |
| WO2004043460A1 (en) | 2004-05-27 |
| EP1572204B1 (en) | 2009-04-29 |
| AU2003294259A1 (en) | 2004-06-03 |
| EP2074996A1 (en) | 2009-07-01 |
| ATE429913T1 (de) | 2009-05-15 |
| US20040092541A1 (en) | 2004-05-13 |
| DE60327466D1 (de) | 2009-06-10 |
| CA2509252A1 (en) | 2004-05-27 |
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