JP2017529841A5 - - Google Patents
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- JP2017529841A5 JP2017529841A5 JP2017515087A JP2017515087A JP2017529841A5 JP 2017529841 A5 JP2017529841 A5 JP 2017529841A5 JP 2017515087 A JP2017515087 A JP 2017515087A JP 2017515087 A JP2017515087 A JP 2017515087A JP 2017529841 A5 JP2017529841 A5 JP 2017529841A5
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- Japan
- Prior art keywords
- region gene
- constant region
- car
- genetically modified
- locus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000623 proteins and genes Proteins 0.000 claims description 219
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 154
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 102
- 241000283984 Rodentia Species 0.000 claims description 84
- 108091008874 T cell receptors Proteins 0.000 claims description 75
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 75
- 210000004027 cell Anatomy 0.000 claims description 73
- 229920001184 polypeptide Polymers 0.000 claims description 64
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 64
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims description 41
- 150000007523 nucleic acids Chemical group 0.000 claims description 33
- 238000000034 method Methods 0.000 claims description 31
- 108060003951 Immunoglobulin Proteins 0.000 claims description 29
- 102000018358 immunoglobulin Human genes 0.000 claims description 29
- 241000894007 species Species 0.000 claims description 25
- 108020004707 nucleic acids Proteins 0.000 claims description 22
- 102000039446 nucleic acids Human genes 0.000 claims description 22
- 230000001086 cytosolic effect Effects 0.000 claims description 18
- 102000043131 MHC class II family Human genes 0.000 claims description 15
- 108091054438 MHC class II family Proteins 0.000 claims description 15
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 8
- 108010050568 HLA-DM antigens Proteins 0.000 claims description 6
- 101100096028 Mus musculus Smok1 gene Proteins 0.000 claims description 5
- 238000012239 gene modification Methods 0.000 claims description 5
- 230000005017 genetic modification Effects 0.000 claims description 5
- 235000013617 genetically modified food Nutrition 0.000 claims description 5
- 210000004602 germ cell Anatomy 0.000 claims description 5
- 102100028972 HLA class I histocompatibility antigen, A alpha chain Human genes 0.000 claims description 3
- 102100028976 HLA class I histocompatibility antigen, B alpha chain Human genes 0.000 claims description 3
- 102100028971 HLA class I histocompatibility antigen, C alpha chain Human genes 0.000 claims description 3
- 102100028970 HLA class I histocompatibility antigen, alpha chain E Human genes 0.000 claims description 3
- 102100028966 HLA class I histocompatibility antigen, alpha chain F Human genes 0.000 claims description 3
- 102100033079 HLA class II histocompatibility antigen, DM alpha chain Human genes 0.000 claims description 3
- 102100031258 HLA class II histocompatibility antigen, DM beta chain Human genes 0.000 claims description 3
- 102100031547 HLA class II histocompatibility antigen, DO alpha chain Human genes 0.000 claims description 3
- 102100031546 HLA class II histocompatibility antigen, DO beta chain Human genes 0.000 claims description 3
- 102100036243 HLA class II histocompatibility antigen, DQ alpha 1 chain Human genes 0.000 claims description 3
- 102100040505 HLA class II histocompatibility antigen, DR alpha chain Human genes 0.000 claims description 3
- 108010075704 HLA-A Antigens Proteins 0.000 claims description 3
- 108010058607 HLA-B Antigens Proteins 0.000 claims description 3
- 108010052199 HLA-C Antigens Proteins 0.000 claims description 3
- 108010041384 HLA-DPA antigen Proteins 0.000 claims description 3
- 108010086786 HLA-DQA1 antigen Proteins 0.000 claims description 3
- 108010067802 HLA-DR alpha-Chains Proteins 0.000 claims description 3
- 101000937544 Homo sapiens Beta-2-microglobulin Proteins 0.000 claims description 3
- 101000986085 Homo sapiens HLA class I histocompatibility antigen, alpha chain E Proteins 0.000 claims description 3
- 101000986080 Homo sapiens HLA class I histocompatibility antigen, alpha chain F Proteins 0.000 claims description 3
- 101000866278 Homo sapiens HLA class II histocompatibility antigen, DO alpha chain Proteins 0.000 claims description 3
- 101000866281 Homo sapiens HLA class II histocompatibility antigen, DO beta chain Proteins 0.000 claims description 3
- 102000047279 human B2M Human genes 0.000 claims description 3
- 108010024941 iodothyronine deiodinase type II Proteins 0.000 claims description 3
- 108700026220 vif Genes Proteins 0.000 claims description 3
- 210000001161 mammalian embryo Anatomy 0.000 claims description 2
- 210000001744 T-lymphocyte Anatomy 0.000 description 28
- 239000000427 antigen Substances 0.000 description 13
- 108091007433 antigens Proteins 0.000 description 13
- 102000036639 antigens Human genes 0.000 description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 6
- 210000005260 human cell Anatomy 0.000 description 5
- 201000010099 disease Diseases 0.000 description 4
- 208000035475 disorder Diseases 0.000 description 4
- 210000004408 hybridoma Anatomy 0.000 description 4
- 102000043129 MHC class I family Human genes 0.000 description 3
- 108091054437 MHC class I family Proteins 0.000 description 3
- 102100036241 HLA class II histocompatibility antigen, DQ beta 1 chain Human genes 0.000 description 2
- -1 HLA-DPB Proteins 0.000 description 2
- 108010067148 HLA-DQbeta antigen Proteins 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 102000006395 Globulins Human genes 0.000 description 1
- 108010044091 Globulins Proteins 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 210000003289 regulatory T cell Anatomy 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462052947P | 2014-09-19 | 2014-09-19 | |
| US201462052901P | 2014-09-19 | 2014-09-19 | |
| US62/052,947 | 2014-09-19 | ||
| US62/052,901 | 2014-09-19 | ||
| US201462076836P | 2014-11-07 | 2014-11-07 | |
| US62/076,836 | 2014-11-07 | ||
| US201462094603P | 2014-12-19 | 2014-12-19 | |
| US62/094,603 | 2014-12-19 | ||
| US201562167650P | 2015-05-28 | 2015-05-28 | |
| US62/167,650 | 2015-05-28 | ||
| PCT/US2015/050975 WO2016044745A1 (en) | 2014-09-19 | 2015-09-18 | Chimeric antigen receptors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017529841A JP2017529841A (ja) | 2017-10-12 |
| JP2017529841A5 true JP2017529841A5 (cg-RX-API-DMAC7.html) | 2018-10-25 |
Family
ID=54261082
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017515087A Pending JP2017529841A (ja) | 2014-09-19 | 2015-09-18 | キメラ抗原受容体 |
Country Status (13)
Families Citing this family (63)
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| CN110186835B (zh) | 2013-03-15 | 2022-05-31 | Gpb科学有限公司 | 颗粒的片上微流体处理 |
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| CN105247042B (zh) | 2013-03-15 | 2021-06-11 | 普林斯顿大学理事会 | 用于高通量纯化的方法和设备 |
| HUE071755T2 (hu) * | 2014-03-05 | 2025-09-28 | Autolus Ltd | Konjugált antitest vagy bispecifikus T-sejt-kötõanyag, amely szelektiven kötõdik TCR béta 1-es konstans régiójához (TRBC1) vagy TRBC2-höz |
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| US11385233B2 (en) | 2015-03-05 | 2022-07-12 | Autolus Limited | Methods of depleting malignant T-cells |
| FR3029449B1 (fr) * | 2014-12-03 | 2017-10-13 | Pole De Plasturgie De Lest | Dispositif de moulage pour la fabrication de pieces en materiau composite a partir de resine polymere liquide. |
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2015
- 2015-09-18 JP JP2017515087A patent/JP2017529841A/ja active Pending
- 2015-09-18 CA CA2959428A patent/CA2959428A1/en not_active Abandoned
- 2015-09-18 BR BR112017005245A patent/BR112017005245A2/pt not_active Application Discontinuation
- 2015-09-18 CN CN201580050602.0A patent/CN107072184A/zh active Pending
- 2015-09-18 WO PCT/US2015/050975 patent/WO2016044745A1/en not_active Ceased
- 2015-09-18 KR KR1020177010023A patent/KR20170083534A/ko not_active Withdrawn
- 2015-09-18 EP EP15775854.1A patent/EP3193592A1/en not_active Withdrawn
- 2015-09-18 RU RU2017113134A patent/RU2017113134A/ru not_active Application Discontinuation
- 2015-09-18 SG SG11201701040XA patent/SG11201701040XA/en unknown
- 2015-09-18 MX MX2017003640A patent/MX2017003640A/es unknown
- 2015-09-18 US US14/858,597 patent/US20160081314A1/en not_active Abandoned
- 2015-09-18 AU AU2015317370A patent/AU2015317370A1/en not_active Abandoned
-
2017
- 2017-02-09 IL IL250536A patent/IL250536A0/en unknown
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